PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBXN7 KLHL22 18775313 biogrid,intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 KLHL9 19995937 biogrid exp G G G G G G G GP GP G GP G G G G GP G G GP G G G GP GP GP G GP GP G NEDD8 KLHL22 21145461 biogrid exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 FAF1 18775313 biogrid,intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 COPS6 19615732,21145461 biogrid,intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP G GP G GP GP G PLK1 KLHL22 24067371,23455478 biogrid exp P G G G G GP GP P P G GP G G GP G GP GP GP GP P GP KLHL22 COPS5 19615732,21145461 biogrid,intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 DCUN1D1 21145461 biogrid exp P G G G G G P P G P P P G G GP G GP G P GP GP P GP G NTRK1 KLHL22 25921289 biogrid exp P G P P P P P P P P P P P HSP90AB1 KLHL22 22939624 intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G UBXN1 KLHL22 18775313 biogrid,intact exp G GP G G G G G G GP G GP G GP G G GP G G GP G GP G G GP GP G GP GP G KLHL22 NUDCD3 25036637 intact exp G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G HSP90AA1 KLHL22 22939624 biogrid exp G GP G G G G G G GP G G G G G G G G G G G GP G G G G G G GP G CUL3 KLHL22 19295130,19995937,17543862,21145461, 25402006 innatedb,biogrid exp, pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 KLHL13 19995937,19615732, 23023127 biogrid,intact exp, pred G G G G G GP GP G GP G G G GP G G GP G G GP GP GP GP GP G KLHL22 UBR2 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 BTBD6 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G GP GP G G G G KLHL22 PLAA 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G ZBTB16 KLHL22 23023127 pred G GP G G G G G G GP G G G GP G G GP G G GP G G G GP G GP G G GP G KLHL22 WDR11 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 UBR4 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G VCP KLHL22 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 NPLOC4 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 WDR26 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G SKP1 KLHL22 25402006 pred G GP G G G G G G GP G GP G GP G G GP G G GP G GP G GP G GP G GP GP G CUL2 KLHL22 25402006 pred G GP G G G G G G GP G GP G GP G G G G G GP G GP G GP G G G GP GP G KLHL22 UFD1L 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G G GP GP G G GP G KLHL22 NLRP3 25402006 pred G G P P P P P KLHL22 KLHL14 23023127 pred P G G P P GP P G P P P P P P G P P DDB1 KLHL22 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 BRWD1 25402006 pred G P G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP P GP G KLHL22 KLHDC2 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 KLHL21 23023127 pred G GP G G G GP GP G GP G GP G G GP G G GP G P G G GP GP G GP GP G CUL1 KLHL22 25402006 pred G G G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 ITGA11 21836163 pred G GP G GP GP GP P G G GP G GP G GP G P GP GP G GP GP G FYN KLHL22 21836163 pred G GP G G G G G G GP G GP G G G G G G G G G G G G G G G G G G VHL KLHL22 25402006 pred G G G G G G G G G G GP G GP G G G G G P G G G GP G G G G GP G KLHL22 KLHL36 23023127 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G GRB2 KLHL22 21836163 pred G GP G G G G G G GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G KLHL22 UBR1 25402006 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G CUL4B KLHL22 25402006 pred G GP G G G G G GP GP G GP G G G G GP G G GP G GP G GP GP GP G GP GP G KLHL12 KLHL22 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q53GT1 Q96GG9 affinity chromatography technology 21145461 physical association X 2 Q53GT1 Q15843 affinity chromatography technology 21145461 physical association X 2 Q53GT1 P07900-2 affinity chromatography technology 22939624 physical association X 2 A0A024R539 Q53GT1 affinity chromatography technology 18775313 physical association X 2 Q58EZ4 Q53GT1 affinity chromatography technology 19995937 physical association X 2 Q53GT1 A0A024R475 affinity chromatography technology 17543862 physical association X 2 Q53GT1 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q53GT1 A0A024R7W9 affinity chromatography technology 21145461 physical association X 2 Q53GT1 Q7L5N1 affinity chromatography technology 21145461 physical association X 2 Q53GT1 A0A024R475 affinity chromatography technology 19295130 physical association X 2 Q53GT1 O15205 affinity chromatography technology 22797925 physical association X 2 Q53GT1 P53350 affinity chromatography technology 23455478 physical association X 2 Q53GT1 P53350 affinity chromatography technology 23455478 physical association X 2 Q53GT1 P53350 affinity chromatography technology 24067371 physical association X 2 Q53GT1 P53350 pull down 24067371 direct interaction X 2 Q53GT1 Q96HC9 affinity chromatography technology 19995937 physical association X 2 Q53GT1 A0A024R475 affinity chromatography technology 19995937 physical association X 2 Q53GT1 A0A024R7W9 affinity chromatography technology 19615732 physical association X 2 Q53GT1 Q7L5N1 affinity chromatography technology 19615732 physical association X 2 Q53GT1 Q96HC9 affinity chromatography technology 19615732 physical association X 2 Q53GT1 O94888 affinity chromatography technology 18775313 physical association X 2 Q53GT1 Q9UNN5 affinity chromatography technology 18775313 physical association X 2 P0CG48 Q53GT1 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q53GT1 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q53GT1 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q53GT1 affinity chromatography technology 21906983 physical association X 2 Q53GT1 anti tag coimmunoprecipitation 19615732 physical association C 10 Q53GT1 anti tag coimmunoprecipitation 18775313 association C 23 Q53GT1 anti tag coimmunoprecipitation 18775313 association C 11 Q53GT1 anti tag coimmunoprecipitation 18775313 association C 22 Q53GT1 anti tag coimmunoprecipitation 18775313 association C 18 Q53GT1 anti tag coimmunoprecipitation 19615732 physical association C 35 Q53GT1 anti tag coimmunoprecipitation 18775313 association C 11 Q53GT1 anti tag coimmunoprecipitation 19615732 physical association C 55 Q53GT1 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q53GT1 Q8IVD9 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KLHL22 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205992 prey bait UBC KLHL22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_178186|BIOGRID_176348|BIOGRID_168847 bait|bait|bait prey|prey|prey NEDD8 KLHL22 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206826 bait prey CUL3 KLHL22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17543862,19295130,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_200507|BIOGRID_221283|BIOGRID_201941 bait|bait|bait prey|prey|prey UBD KLHL22 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226605 bait prey CSNK1E KLHL22 MI:0004(affinity chromatography technology) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_277257 bait prey KLHL22 FAF1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact)|(intact) BIOGRID_149366|UniProt_183207|UniProt_183213|UniProt_97409|UniProt_97403 prey|prey|prey|prey|prey bait|bait|bait|bait|bait NRF1 KLHL22 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294721 bait prey PLK1 KLHL22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23455478,23797583,24067371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_258139|BIOGRID_283764|BIOGRID_258140|BIOGRID_289186|BIOGRID_289185 prey|bait|bait|bait|bait bait|prey|prey|prey|prey KLHL22 COPS6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_120750|BIOGRID_205800|UniProt_100633 prey|prey|prey bait|bait|bait KLHL22 KLHL13 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120751|UniProt_100711 prey|prey bait|bait KLHL22 COPS5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_120749|BIOGRID_205313|UniProt_100632 prey|prey|prey bait|bait|bait HSP90AB1 KLHL22 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125035 prey bait UBXN7 KLHL22 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact)|(intact) UniProt_183205|BIOGRID_148853|UniProt_97401|UniProt_97407|UniProt_183211 bait|bait|bait|bait|bait prey|prey|prey|prey|prey HSP90AA1 KLHL22 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255393 bait prey UBXN1 KLHL22 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_183208|UniProt_97404|BIOGRID_149378 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PLK1 KLHL22 23455478,23455478,24067371,24067371 0004,0415,0004,0096 LC CUL3 KLHL22 21145461,19295130,17543862,19995937 0004,0004,0004,0004 HT,LC NEDD8 KLHL22 21145461 0004 HT KLHL22 COPS6 19615732,21145461,19615732 0004,0004,0007 HT KLHL22 COPS5 19615732,21145461,19615732 0004,0004,0007 HT KLHL22 DCUN1D1 21145461 0004 HT KLHL22 KLHL13 19615732,19615732,19995937 0004,0007,0004 HT,LC CUL3 KLHL22 21145461 0004 HT NEDD8 KLHL22 21145461 0004 HT KLHL22 COPS6 19615732,21145461,19615732 0004,0004,0007 HT KLHL22 COPS5 19615732,21145461,19615732 0004,0004,0007 HT KLHL22 DCUN1D1 21145461 0004 HT KLHL22 KLHL13 19615732,19615732 0004,0007 HT PLK1 KLHL22 23455478,23455478,24067371,24067371 0004,0415,0004,0096 LC CUL3 KLHL22 19295130,17543862,19995937 0004,0004,0004 LC KLHL22 KLHL13 19995937 0004 LC HSP90AB1 KLHL22 22939624 0729 HT PLK1 KLHL22 23455478,23455478 0004,0415 LC KLHL22 NUDCD3 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q53GT1 P08238 KLHL22 HSP90AB1 0.126 22939624 Q8IVD9 Q53GT1 NUDCD3 KLHL22 0.126 25036637 Q53GT1 P07900 KLHL22 HSP90AA1 0.126 22939624 Q53GT1 P04629 KLHL22 NTRK1 0.126 25921289 Q9P2N7 Q53GT1 KLHL13 KLHL22 0.236 19615732 Q9UNN5 Q53GT1 FAF1 KLHL22 0.236 18775313 Q53GT1 Q04323 KLHL22 UBXN1 0.236 18775313 Q53GT1 P53350 KLHL22 PLK1 0.765 24067371,23455478 Q53GT1 O94888 KLHL22 UBXN7 0.236 18775313 Q7L5N1 Q53GT1 COPS6 KLHL22 0.332 19615732,21145461 Q53GT1 Q13618 KLHL22 CUL3 0.396 17543862,21145461,19295130 Q92905 Q53GT1 COPS5 KLHL22 0.332 19615732,21145461 Q96GG9 Q53GT1 DCUN1D1 KLHL22 0.126 21145461 Q53GT1 Q15843 KLHL22 NEDD8 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database UBXN7 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database GLUD1 KLHL22 MI:0362 inference MI:0461 interaction database NTRK1 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database PLK1 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 KLHL22 MI:0362 inference MI:1106 pathways database UBXN1 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL22 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEDD8 KLHL22 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 NUDCD3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 L3MBTL2 MI:0362 inference MI:0461 interaction database KLHL22 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 CLCC1 MI:0362 inference MI:0461 interaction database KLHL22 PCGF6 MI:0362 inference MI:0461 interaction database KLHL22 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 KLHL13 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 BAIAP2L1 MI:0362 inference MI:0461 interaction database KLHL22 FAF1 MI:0045 experimental interaction detection MI:0461 interaction database