PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZZZ3 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 TRIM5 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G LZTR1 L3MBTL3 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCK2 LZTR1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL1 LZTR1 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAF11 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 TFAP2B 20211142 biogrid exp G G G LZTR1 PAPOLG 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 RUVBL1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G IFI16 LZTR1 25693804 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUGP2 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SND1 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL2 LZTR1 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 FANK1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G SP100 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G LZTR1 CNOT6L 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 AATF 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ZBTB1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 AXIN2 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 LZTR1 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 POLR1B 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK1E LZTR1 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 EHMT1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZNF584 LZTR1 20211142 biogrid exp G LZTR1 NKD1 19888210 i2d exp G G G G G G G G G G LZTR1 TCF19 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G MCM3 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TBX2 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 MED16 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ZNF714 20211142 biogrid exp LZTR1 RIT2 26186194 biogrid exp G G G G G LZTR1 IKBKG 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2F8 LZTR1 20211142 biogrid exp G G G G G G G G HCLS1 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NR1H3 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ANKRD53 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ASB12 20211142 biogrid exp G G LZTR1 LZTR1 25416956,20211142 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARP1 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SSX4, SSX4B LZTR1 20211142 biogrid exp CHAF1A LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GSK3B LZTR1 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ZNF451 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G POLR2E LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK1A1 LZTR1 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SREBF2 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MED7 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G POLR2B LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAT1 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HDAC4 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAI1 LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 SCMH1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYBL2 LZTR1 20211142 biogrid exp G G G G G G G G G G LZTR1 TUBGCP4 19060904 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEBPZ LZTR1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ZNF490 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 WWP1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 RERE 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 KDM2B 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 NUDT12 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G LZTR1 ZNF175 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G BMPR1B LZTR1 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G NTN1 LZTR1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 ADAM19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NF2 LZTR1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 GOLGA1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM27 LZTR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 SDSL 25402006 pred G G G G SOCS2 LZTR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 FBF1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 BTBD6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 CHIC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 LZTR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ADAMTSL4 LZTR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EFHC2 LZTR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS3 LZTR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R3T8 Q8N653 two hybrid 20211142 direct interaction X 2 Q15544 Q8N653 two hybrid 20211142 direct interaction X 2 A0A024R4E9 Q8N653 two hybrid 20211142 direct interaction X 2 Q7KZF4 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 P14317 two hybrid 20211142 direct interaction X 2 Q8N653 P25205 two hybrid 20211142 direct interaction X 2 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 P23497-7 two hybrid 20211142 direct interaction X 2 Q8N653 A0A024QZ86 two hybrid 20211142 direct interaction X 2 Q8N653 Q92481 two hybrid 20211142 direct interaction X 2 Q8N653 Q9Y2X0 two hybrid 20211142 direct interaction X 2 Q8N653 Q13111 two hybrid 20211142 direct interaction X 2 Q8N653 Q8IX01 two hybrid 20211142 direct interaction X 2 Q8N653 Q9Y4E5-4 two hybrid 20211142 direct interaction X 2 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 Q8NHM5 two hybrid 20211142 direct interaction X 2 Q8N653 Q9C035 two hybrid 20211142 direct interaction X 2 Q8N653 Q8IVC4 two hybrid 20211142 direct interaction X 2 Q03701 Q8N653 two hybrid 20211142 direct interaction X 2 Q9UGJ1-2 Q8N653 two hybrid 19060904 direct interaction X 2 P10244 Q8N653 two hybrid 20211142 direct interaction X 2 Q9Y265 Q8N653 two hybrid 20211142 direct interaction X 2 P56524 Q8N653 two hybrid 20211142 direct interaction X 2 Q8WXK4-2 Q8N653 two hybrid 20211142 direct interaction X 2 O43513 Q8N653 two hybrid 20211142 direct interaction X 2 Q9BWT3 Q8N653 two hybrid 20211142 direct interaction X 2 P42224-2 Q8N653 two hybrid 20211142 direct interaction X 2 Q96LI5 Q8N653 two hybrid 20211142 direct interaction X 2 Q9H0M0 Q8N653 two hybrid 20211142 direct interaction X 2 A0A024R1Q0 Q8N653 two hybrid 20211142 direct interaction X 2 Q7Z5J4 Q8N653 two hybrid 20211142 direct interaction X 2 O60224 Q8N653 two hybrid 20211142 direct interaction X 2 Q9ULM2 Q8N653 two hybrid 20211142 direct interaction X 2 A0AVK6 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q8N653 Q8N653 two hybrid 25416956 direct interaction X 2 Q8N653 Q9Y242 two hybrid 20211142 direct interaction X 2 Q8N653 Q9Y473 two hybrid 20211142 direct interaction X 2 Q8N653 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 F1D8N1 two hybrid 20211142 direct interaction X 2 Q8N653 Q9Y2K1-2 two hybrid 20211142 direct interaction X 2 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 Q9NY61 two hybrid 20211142 direct interaction X 2 Q8N653 Q9H9Y6-2 two hybrid 20211142 direct interaction X 2 Q8N653 Q96JM7-2 two hybrid 20211142 direct interaction X 2 Q8N653 Q8TC84 two hybrid 20211142 direct interaction X 2 Q8N9V6 Q8N653 two hybrid 20211142 direct interaction X 2 Q8IYH5 Q8N653 two hybrid 20211142 direct interaction X 2 Q8N653 two hybrid 20211142 direct interaction X 2 P0CG48 Q8N653 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q8N653 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q8N653 affinity chromatography technology 21906983 physical association X 2 P30876 Q8N653 two hybrid 20211142 direct interaction X 2 O00238 Q8N653 in vivo 15761153 - X 2 O00238 Q8N653 in vivo 15761153 - X 2 Q8N653 pull down 21911578 association C 252 Q9UGJ1 Q8N653 two hybrid array 19060904 physical association X 2 Q9UGJ1 Q8N653 two hybrid pooling approach 19060904 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LZTR1 SCMH1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128768 bait prey CUL3 LZTR1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202096 bait prey LZTR1 L3MBTL3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128779 bait prey LZTR1 CNOT6L MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128786 bait prey RAI1 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128765 prey bait LZTR1 ZNF714 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128784 bait prey HCLS1 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128435 bait prey BMPR1B LZTR1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17400 - - POLR2B LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128623 bait prey LZTR1 WWP1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128766 bait prey LZTR1 IKBKG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128756 bait prey LZTR1 POLR1B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128778 bait prey LZTR1 RUVBL1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128757 bait prey LZTR1 TCF19 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128710 prey bait LZTR1 ZBTB1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128767 bait prey LZTR1 MED16 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128760 bait prey LZTR1 ZNF175 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128746 prey bait LZTR1 EHMT1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128776 bait prey LZTR1 ZNF451 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128770 bait prey LZTR1 RERE MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128295 prey bait SP100 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128664 bait prey UBC LZTR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_168241|BIOGRID_177633|BIOGRID_166409 bait|bait|bait prey|prey|prey HDAC4 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128759 prey bait LZTR1 AATF MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128771 bait prey ZNF584 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128785 prey bait MCM3 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128541 bait prey LZTR1 FANK1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128782 bait prey LZTR1 TFAP2B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128712 prey bait SSX4 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128671 bait prey LZTR1 E2F8 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128775 bait prey SREBF2 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128666 bait prey POLR2E LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128629 bait prey ZZZ3 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128769 prey bait STAT1 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128672 bait prey LZTR1 ASB12 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128783 bait prey TAF11 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128693 bait prey PARP1 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128281 bait prey LZTR1 KDM2B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128780 bait prey MYBL2 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128553 bait prey MED7 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128758 prey bait LZTR1 ANKRD53 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128777 bait prey LZTR1 PAPOLG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128774 bait prey LZTR1 TUBGCP4 MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_97112|UniProt_99287|BIOGRID_262443 prey|prey|prey bait|bait|bait CHAF1A LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128761 prey bait LZTR1 ZNF490 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128773 bait prey LZTR1 TRIM5 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128781 bait prey SUGP2 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128763 prey bait TBX2 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128702 bait prey SND1 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128772 prey bait NR1H3 LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128762 prey bait CEBPZ LZTR1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128764 prey bait

PPI - HINT Gene A Gene B PMID Method Quality NCK2 LZTR1 26186194 0004 HT CUL3 LZTR1 21145461 0004 HT LZTR1 RIT2 26186194 0004 HT LZTR1 NUDT12 26186194 0004 HT NCK2 LZTR1 26186194 0004 HT CUL3 LZTR1 21145461 0004 HT LZTR1 RIT2 26186194 0004 HT LZTR1 NUDT12 26186194 0004 HT E2F8 LZTR1 20211142 0018 HT BMPR1B LZTR1 15761153 0019 HT MED7 LZTR1 20211142 0018 HT SSX4|SSX4B LZTR1 20211142 0018 HT PARP1 LZTR1 20211142 0018 HT MYBL2 LZTR1 20211142 0018 HT HCLS1 LZTR1 20211142 0018 HT POLR2E LZTR1 20211142 0018 HT MCM3 LZTR1 20211142 0018 HT POLR2B LZTR1 20211142 0018 HT STAT1 LZTR1 20211142 0018 HT ZNF137P LZTR1 20211142 0018 HT HDAC4 LZTR1 20211142 0018 HT CEBPZ LZTR1 20211142 0018 HT SREBF2 LZTR1 20211142 0018 HT CHAF1A LZTR1 20211142 0018 HT NR1H3 LZTR1 20211142 0018 HT TBX2 LZTR1 20211142 0018 HT TAF11 LZTR1 20211142 0018 HT CRSP9 LZTR1 20211142 0018 HT FLJ00340 LZTR1 20211142 0018 HT SND1 LZTR1 20211142 0018 HT RAI1 LZTR1 20211142 0018 HT ZNF584 LZTR1 20211142 0018 HT SUGP2 LZTR1 20211142 0018 HT ZZZ3 LZTR1 20211142 0018 HT LZTR1 LZTR1 20211142,25416956 0018,0018 HT LZTR1 ANKRD53 20211142 0018 HT LZTR1 KDM2B 20211142 0018 HT LZTR1 FANK1 20211142 0018 HT LZTR1 ASB12 20211142 0018 HT LZTR1 TFAP2B 20211142 0018 HT LZTR1 SCMH1 20211142 0018 HT LZTR1 L3MBTL3 20211142 0018 HT LZTR1 CNOT6L 20211142 0018 HT LZTR1 ZNF714 20211142 0018 HT LZTR1 PAPOLG 20211142 0018 HT LZTR1 TRIM5 20211142 0018 HT LZTR1 WWP1 20211142 0018 HT LZTR1 EHMT1 20211142 0018 HT LZTR1 POLR1B 20211142 0018 HT LZTR1 AATF 20211142 0018 HT LZTR1 RERE 20211142 0018 HT LZTR1 TUBGCP4 19060904,19060904,19060904 0018,0397,0398 HT LZTR1 ZNF490 20211142 0018 HT LZTR1 TCF19 20211142 0018 HT LZTR1 RUVBL1 20211142 0018 HT LZTR1 ZBTB1 20211142 0018 HT LZTR1 MED16 20211142 0018 HT LZTR1 ZNF175 20211142 0018 HT LZTR1 ZNF451 20211142 0018 HT LZTR1 IKBKG 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N653 P23497 LZTR1 SP100 0.183 20211142 Q8N653 O43639 LZTR1 NCK2 0.126 26186194 Q8N653 A0AVK6 LZTR1 E2F8 0.183 20211142 Q8N653 O43513 LZTR1 MED7 0.183 20211142 Q8N653 P56524 LZTR1 HDAC4 0.183 20211142 Q8N653 Q03701 LZTR1 CEBPZ 0.183 20211142 Q8N653 Q13111 LZTR1 CHAF1A 0.183 20211142 Q8N653 Q13133 LZTR1 NR1H3 0.183 20211142 Q8N653 Q7KZF4 LZTR1 SND1 0.183 20211142 Q8N653 Q7Z5J4 LZTR1 RAI1 0.183 20211142 Q8N653 Q8IVC4 LZTR1 ZNF584 0.183 20211142 Q8N653 Q8IX01 LZTR1 SUGP2 0.183 20211142 Q8N653 Q8IYH5 LZTR1 ZZZ3 0.183 20211142 Q8N9V6 Q8N653 ANKRD53 LZTR1 0.183 20211142 Q8NHM5 Q8N653 KDM2B LZTR1 0.183 20211142 Q8TC84 Q8N653 FANK1 LZTR1 0.183 20211142 Q8WXK4 Q8N653 ASB12 LZTR1 0.183 20211142 Q96GD3 Q8N653 SCMH1 LZTR1 0.183 20211142 Q96JM7 Q8N653 L3MBTL3 LZTR1 0.183 20211142 Q96LI5 Q8N653 CNOT6L LZTR1 0.183 20211142 Q96N38 Q8N653 ZNF714 LZTR1 0.183 20211142 Q9BWT3 Q8N653 PAPOLG LZTR1 0.183 20211142 Q9C035 Q8N653 TRIM5 LZTR1 0.183 20211142 Q9H0M0 Q8N653 WWP1 LZTR1 0.183 20211142 Q9H9B1 Q8N653 EHMT1 LZTR1 0.183 20211142 Q9H9Y6 Q8N653 POLR1B LZTR1 0.183 20211142 Q9NY61 Q8N653 AATF LZTR1 0.183 20211142 Q9ULM2 Q8N653 ZNF490 LZTR1 0.183 20211142 Q9Y265 Q8N653 RUVBL1 LZTR1 0.183 20211142 Q9Y2K1 Q8N653 ZBTB1 LZTR1 0.183 20211142 Q9Y2X0 Q8N653 MED16 LZTR1 0.183 20211142 Q9Y4E5 Q8N653 ZNF451 LZTR1 0.183 20211142 Q9Y6K9 Q8N653 IKBKG LZTR1 0.183 20211142 Q8N653 P25205 LZTR1 MCM3 0.183 20211142 Q8N653 O60224 LZTR1 SSX4B 0.183 20211142 Q9Y473 Q8N653 ZNF175 LZTR1 0.183 20211142 Q9Y242 Q8N653 TCF19 LZTR1 0.183 20211142 Q8N653 P09874 LZTR1 PARP1 0.183 20211142 Q8N653 Q77M19 LZTR1 P 0.126 21911578 Q8N653 P10244 LZTR1 MYBL2 0.183 20211142 Q8N653 P14317 LZTR1 HCLS1 0.183 20211142 Q8N653 Q8N653 LZTR1 LZTR1 0.376 20211142,25416956 Q8N653 P60520 LZTR1 GABARAPL2 0.236 unassigned1304 Q8N653 P30876 LZTR1 POLR2B 0.183 20211142 Q92481 Q8N653 TFAP2B LZTR1 0.183 20211142 Q9BQG2 Q8N653 NUDT12 LZTR1 0.126 26186194 Q99578 Q8N653 RIT2 LZTR1 0.126 26186194 Q9UGJ1 Q8N653 TUBGCP4 LZTR1 0.376 19060904 Q9P2R6 Q8N653 RERE LZTR1 0.183 20211142 Q8N653 Q13618 LZTR1 CUL3 0.126 21145461 Q8N653 Q12772 LZTR1 SREBF2 0.183 20211142 Q8N653 P42224 LZTR1 STAT1 0.183 20211142 Q8N653 P19388 LZTR1 POLR2E 0.183 20211142 Q8N653 Q15544 LZTR1 TAF11 0.183 20211142 Q8N653 Q13207 LZTR1 TBX2 0.183 20211142 Q8N653 Q16666 LZTR1 IFI16 0.126 25693804

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 E2F8 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database BMPR1B LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database MED7 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database NCK2 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database SSX4 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database MYC LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database PARP1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database UBC LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database MYBL2 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database HCLS1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database POLR2E LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database SP100 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database MCM3 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database POLR2B LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database STAT1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database HDAC4 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database MAX LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database CEBPZ LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database SREBF2 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database CHAF1A LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database NR1H3 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database TBX2 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database TAF11 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database IFI16 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database SND1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database RAI1 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF584 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database SUGP2 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database ZZZ3 LZTR1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ANKRD53 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 FANK1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ASB12 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 TFAP2B MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 SCMH1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 L3MBTL3 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 CNOT6L MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ZNF714 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 RIT2 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 NUDT12 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 PAPOLG MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 TRIM5 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 EHMT1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 POLR1B MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 AATF MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 RERE MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 TUBGCP4 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ZNF490 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 TCF19 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 RUVBL1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ZBTB1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 MED16 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ZNF175 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 ZNF451 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 IKBKG MI:0045 experimental interaction detection MI:0461 interaction database