PTM - CPLM Gene Name UniProt ID Type Position Code SF3A1; SAP114 Q15459 Acetylation 55 K SF3A1; SAP114 Q15459 Acetylation 251 K SF3A1; SAP114 Q15459 Ubiquitination 419 K SF3A1; SAP114 Q15459 Ubiquitination 55 K SF3A1; SAP114 Q15459 Ubiquitination 80 K SF3A1; SAP114 Q15459 Ubiquitination 188 K SF3A1; SAP114 Q15459 Ubiquitination 223 K SF3A1; SAP114 Q15459 Ubiquitination 251 K SF3A1; SAP114 Q15459 Ubiquitination 467 K SF3A1; SAP114 Q15459 Ubiquitination 708 K SF3A1; SAP114 Q15459 Ubiquitination 487 K SF3A1; SAP114 Q15459 Ubiquitination 449 K SF3A1; SAP114 Q15459 Ubiquitination 424 K SF3A1; SAP114 Q15459 Ubiquitination 131 K SF3A1; SAP114 Q15459 Ubiquitination 399 K SF3A1; SAP114 Q15459 Ubiquitination 486 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SF3A1; SAP114 Q15459 110 S Homo sapiens(Human) SF3A1; SAP114 Q15459 124 T Homo sapiens(Human) SF3A1; SAP114 Q15459 17 T Homo sapiens(Human) SF3A1; SAP114 Q15459 183 T Homo sapiens(Human) SF3A1; SAP114 Q15459 245 Y Homo sapiens(Human) SF3A1; SAP114 Q15459 28 S Homo sapiens(Human) SF3A1; SAP114 Q15459 29 S Homo sapiens(Human) SF3A1; SAP114 Q15459 320 S Homo sapiens(Human) SF3A1; SAP114 Q15459 329 S Homo sapiens(Human) SF3A1; SAP114 Q15459 344 S Homo sapiens(Human) SF3A1; SAP114 Q15459 350 T Homo sapiens(Human) SF3A1; SAP114 Q15459 359 S Homo sapiens(Human) SF3A1; SAP114 Q15459 374 T Homo sapiens(Human) SF3A1; SAP114 Q15459 383 T Homo sapiens(Human) SF3A1; SAP114 Q15459 410 Y Homo sapiens(Human) SF3A1; SAP114 Q15459 413 S Homo sapiens(Human) SF3A1; SAP114 Q15459 416 T Homo sapiens(Human) SF3A1; SAP114 Q15459 423 S Homo sapiens(Human) SF3A1; SAP114 Q15459 451 S Homo sapiens(Human) SF3A1; SAP114 Q15459 456 Y Homo sapiens(Human) SF3A1; SAP114 Q15459 474 T Homo sapiens(Human) SF3A1; SAP114 Q15459 506 S Homo sapiens(Human) SF3A1; SAP114 Q15459 508 S Homo sapiens(Human) SF3A1; SAP114 Q15459 604 S Homo sapiens(Human) SF3A1; SAP114 Q15459 690 S Homo sapiens(Human) SF3A1; SAP114 Q15459 718 T Homo sapiens(Human) SF3A1; SAP114 Q15459 759 Y Homo sapiens(Human) SF3A1; SAP114 Q15459 93 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q15459 K55-ac Acetylation EVRNIVDkTASFVAR Q15459 K80-ac Acetylation QNEINNPkFNFLNPN Q15459 K131-ac Acetylation tQQQLPQkVQAQVIQ Q15459 K223-ac Acetylation TKILIPPkGLFSKLK Q15459 K251-ac Acetylation CyRVEWAkFQERERK Q15459 K424-ac Acetylation GEkIPAskMQEHMRI Q15459 K486-ac Acetylation VEETAIGkKIGEEEI Q15459 K495-ac Acetylation IGEEEIQkPEEkVTW Q15459 K499-ac Acetylation EIQkPEEkVTWdGHS Q15459 K756-ac Acetylation GMPAGkQkLQyEGIF Q15459 R70-m1 Methylation NGPEFEArIRQNEIN Q15459 R176-m1 Methylation LTAQFVArNGRQFLt Q15459 R578-m1 Methylation PPITSVPrPPTMPPP Q15459 R587-m1 Methylation PTMPPPVrTTVVSAV Q15459 R599-m1 Methylation SAVPVMPrPPMAsVV Q15459 R599-m2 Methylation SAVPVMPrPPMAsVV Q15459 R607-m2 Methylation PPMAsVVrLPPGSVI Q15459 T17-p Phosphorylation PPPPPVPtEPKQPTE Q15459 Y90-p Phosphorylation FLNPNDPyHAyYRHK Q15459 Y93-p Phosphorylation PNDPyHAyYRHKVSE Q15459 S110-p Phosphorylation EGKAQEPsAAIPKVM Q15459 T124-p Phosphorylation MQQQQQTtQQQLPQk Q15459 T183-p Phosphorylation rNGRQFLtQLMQkEQ Q15459 Y245-p Phosphorylation EVLDQVCyRVEWAkF Q15459 S320-p Phosphorylation RYEKFGEsEEVEMEV Q15459 S329-p Phosphorylation EVEMEVEsDEEDDKQ Q15459 S344-p Phosphorylation EKAEEPPsQLDQDTQ Q15459 S359-p Phosphorylation VQDMDEGsDDEEEGQ Q15459 T383-p Phosphorylation MPPPLPPtPDQVIVR Q15459 Y410-p Phosphorylation PAPAPDEyLVsPItG Q15459 S413-p Phosphorylation APDEyLVsPItGEkI Q15459 T416-p Phosphorylation EyLVsPItGEkIPAs Q15459 S423-p Phosphorylation tGEkIPAskMQEHMR Q15459 S451-p Phosphorylation RSIREkQsDDEVyAP Q15459 Y456-p Phosphorylation kQsDDEVyAPGLDIE Q15459 T474-p Phosphorylation kQLAERRtDIFGVEE Q15459 S508-p Phosphorylation TWdGHSGsMARTQQA Q15459 S604-p Phosphorylation MPrPPMAsVVrLPPG Q15459 T718-p Phosphorylation VPNMQDKtEWKLNGQ Q15459 Y759-p Phosphorylation AGkQkLQyEGIFIKD Q15459 K424-sm Sumoylation GEkIPAskMQEHMRI Q15459 K542-sm Sumoylation LVPEDDTkEKIGPSK Q15459 K686-sm Sumoylation EPTSKKLkTEDSLMP Q15459 K55-ub Ubiquitination EVRNIVDkTASFVAR Q15459 K80-ub Ubiquitination QNEINNPkFNFLNPN Q15459 K131-ub Ubiquitination tQQQLPQkVQAQVIQ Q15459 K188-ub Ubiquitination FLtQLMQkEQRNYQF Q15459 K223-ub Ubiquitination TKILIPPkGLFSKLK Q15459 K251-ub Ubiquitination CyRVEWAkFQERERK Q15459 K399-ub Ubiquitination DYDPKASkPLPPAPA Q15459 K419-ub Ubiquitination VsPItGEkIPAskMQ Q15459 K449-ub Ubiquitination RDRSIREkQsDDEVy Q15459 K467-ub Ubiquitination LDIESSLkQLAERRt Q15459 K486-ub Ubiquitination VEETAIGkKIGEEEI Q15459 K708-ub Ubiquitination NKGPVSIkVQVPNMQ Q15459 K743-ub Ubiquitination QVSVIKVkIHEATGM Q15459 K754-ub Ubiquitination ATGMPAGkQkLQyEG

PTM - dbPTM UniProt ID Position Code Type Resources References Q15459 55 K Acetylation Swiss-Prot 1010711 19608861 Q15459 124 T Phosphorylation Swiss-Prot 1010711 17525332 Q15459 251 K Acetylation Swiss-Prot 1010711 19608861 Q15459 320 S Phosphorylation Swiss-Prot 1010711 17287340;19690332 Q15459 329 S Phosphorylation Swiss-Prot 1010711 17081983;17287340;18318008;18669648;19367720;19413330;19690332 Q15459 359 S Phosphorylation Swiss-Prot 1010711 15302935;17081983;17287340;19413330;19690332 Q15459 413 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 Q15459 451 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q15459 456 Y Phosphorylation Swiss-Prot 1010711 15592455 Q15459 759 Y Phosphorylation Swiss-Prot 1010711 15592455 Q15459 320 S Phosphorylation PhosphoELM.10011 17287340 Q15459 329 S Phosphorylation PhosphoELM.10011 18669648;17287340;17081983 Q15459 359 S Phosphorylation PhosphoELM.10011 17287340;17081983;15302935 Q15459 413 S Phosphorylation PhosphoELM.10011 18669648 Q15459 451 S Phosphorylation PhosphoELM.10011 18669648 Q15459 124 T Phosphorylation PhosphoELM.10011 17525332 Q15459 456 Y Phosphorylation PhosphoELM.10011 15592455 Q15459 759 Y Phosphorylation PhosphoELM.10011 15592455 Q15459 503 D Caspase Phosphositeplus.1010730 18722006 Q15459 131 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15459 188 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 223 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 251 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 399 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15459 419 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 Q15459 449 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15459 467 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q15459 486 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15459 55 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 708 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 80 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15459 251 K Acetylation Phosphositeplus.1010730 19608861 Q15459 55 K Acetylation Phosphositeplus.1010730 19608861 Q15459 110 S Phosphorylation Phosphositeplus.1010730 21406692 Q15459 320 S Phosphorylation Phosphositeplus.1010730 19690332;20363803;21406692 Q15459 329 S Phosphorylation Phosphositeplus.1010730 17287340;18318008;18669648;18707149;19367720;19415658;19664995;19690332;20044836;20068231;20166139;20363803;20562096;21406692;21659604;22115753 Q15459 359 S Phosphorylation Phosphositeplus.1010730 15302935;17287340;19664994;19690332;20058876;20068231;20164059;20363803;20562096;21406692;22067460;22115753 Q15459 413 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20562096;22067460 Q15459 451 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20068231;20815410;22067460 Q15459 124 T Phosphorylation Phosphositeplus.1010730 17525332 Q15459 383 T Phosphorylation Phosphositeplus.1010730 22067460 Q15459 245 Y Phosphorylation Phosphositeplus.1010730 21406692 Q15459 456 Y Phosphorylation Phosphositeplus.1010730 15592455;17360941;20562096 Q15459 759 Y Phosphorylation Phosphositeplus.1010730 15592455;21406692 Q15459 55 K Acetylation HPRD 9.0 19608861 Q15459 251 K Acetylation HPRD 9.0 19608861 Q15459 320 S Phosphorylation HPRD 9.0 19651622 Q15459 329 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19415658,17287340,19664995,19651622,18707149,18452278,20166139,20068231 Q15459 359 S Phosphorylation HPRD 9.0 15302935,19413330,17287340,19651622,19664994,18452278,20068231,20058876 Q15459 413 S Phosphorylation HPRD 9.0 18669648,19413330,20068231 Q15459 451 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q15459 690 S Phosphorylation HPRD 9.0 20068231 Q15459 124 T Phosphorylation HPRD 9.0 17525332 Q15459 456 Y Phosphorylation HPRD 9.0 15592455 Q15459 759 Y Phosphorylation HPRD 9.0 15592455 Q15459 329 S Phosphorylation SysPTM 1.1 18318008;18669648;17081983;18707149 Q15459 359 S Phosphorylation SysPTM 1.1 15302935;17081983 Q15459 413 S Phosphorylation SysPTM 1.1 18669648 Q15459 451 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References SF3A1 124 T Phosphorylation 17525332 SF3A1 186 K Acetylation 19608861 SF3A1 251 K Acetylation 19608861 SF3A1 255 S Phosphorylation 19651622 SF3A1 264 S Phosphorylation 17322306,18669648,19413330,19415658,17287340,19664995,19651622,18707149,18452278,20166139,20068231 SF3A1 294 S Phosphorylation 15302935,19413330,17287340,19651622,19664994,18452278,20068231,20058876 SF3A1 320 S Phosphorylation 19651622 SF3A1 329 S Phosphorylation 17322306,18669648,19413330,19415658,17287340,19664995,19651622,18707149,18452278,20166139,20068231 SF3A1 348 S Phosphorylation 18669648,19413330,20068231 SF3A1 359 S Phosphorylation 15302935,19413330,17287340,19651622,19664994,18452278,20068231,20058876 SF3A1 386 S Phosphorylation 18669648,19651622,20068231 SF3A1 391 Y Phosphorylation 15592455 SF3A1 413 S Phosphorylation 18669648,19413330,20068231 SF3A1 451 S Phosphorylation 18669648,19651622,20068231 SF3A1 456 Y Phosphorylation 15592455 SF3A1 55 K Acetylation 19608861 SF3A1 625 S Phosphorylation 20068231 SF3A1 690 S Phosphorylation 20068231 SF3A1 694 Y Phosphorylation 15592455 SF3A1 759 Y Phosphorylation 15592455

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q15459 320 S 17287340 HTP Phosphorylation Q15459 759 Y 15592455 HTP Phosphorylation Q15459 451 S 18669648 HTP Phosphorylation Q15459 359 S 17287340 HTP Phosphorylation Q15459 359 S 17081983 HTP Phosphorylation Q15459 359 S 15302935 HTP Phosphorylation Q15459 456 Y 15592455 HTP Phosphorylation Q15459 329 S 18669648 HTP Phosphorylation Q15459 329 S 17287340 HTP Phosphorylation Q15459 329 S 17081983 HTP Phosphorylation Q15459 124 T 17525332 HTP Phosphorylation Q15459 413 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q15459 55 N6-acetyllysine 19608861 Q15459 320 Phosphoserine 19690332;21406692 Q15459 329 Phosphoserine 17081983;18318008;18669648;19367720;19690332;20068231;21406692;23186163;24275569 Q15459 359 Phosphoserine 17081983;19690332;20068231;21406692;23186163 Q15459 413 Phosphoserine 18669648;20068231;23186163 Q15459 451 Phosphoserine 18669648;19690332;20068231;23186163 Q15459 456 Phosphotyrosine 15592455 Q15459 508 Phosphoserine 23186163 Q15459 759 Phosphotyrosine 15592455

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SF3A1 IPI00017451 K 251 YRVEWAaKFQERER acetylation SF3A1 IPI00017451 K 55 VRNIVDaKTASFVA acetylation SF3A1 IPI00017451 S 329 VEMEVEpSDEEDDK phosphorylation SF3A1 IPI00017451 S 359 QDMDEGpSDDEEEG phosphorylation SF3A1 IPI00017451 S 413 PDEYLVpSPITGEK phosphorylation SF3A1 IPI00017451 S 451 SIREKQpSDDEVYA phosphorylation SF3A1 IPI00017451 S 690 KLKTEDpSLMPEEE phosphorylation SF3A1 IPI00017451 T 383 PPPLPPpTPDQVIV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10291 115580 - K Ubiquitination 22178446 10291 115580 - K Ubiquitination 20639865 10291 115580 - K Sumoylation 21693764 10291 115580 - K Ubiquitination 21139048 10291 115580 - K Ubiquitination 21890473 10291 115580 - K Ubiquitination 21906983 10291 115580 - K Sumoylation 19471022 10291 115580 - K FAT10ylation 22797925 10291 115580 - K Ubiquitination 23000965 10291 115580 - K Ubiquitination 24816145 10291 115580 - K Ubiquitination 19850743

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID SF3A1 Homo sapiens (Human) 223; 55; 80; 251; 188; 419; 467; 708 "223,KILIPPKGLFSKL; 55,VRNIVDKTASFVA; 80,NEINNPKFNFLNP; 251,YRVEWAKFQERER; 188,LTQLMQKEQRNYQ; 419,SPITGEKIPASKM; 467,DIESSLKQLAERR; 708,KGPVSIKVQVPNM" 223:21890473; 55:21890473; 80:21890473; 251:21890473; 188:21890473; 419:21890473; 467:21890473; 708:21890473 SF3A1 Homo sapiens (Human) 186; 55; 80; 158; 354; 402; 123; 643 "186,YRVEWAKFQERER; 55,VRNIVDKTASFVA; 80,NEINNPKFNFLNP; 158,KILIPPKGLFSKL; 354,SPITGEKIPASKM; 402,DIESSLKQLAERR; 123,LTQLMQKEQRNYQ; 643,KGPVSIKVQVPNM" 186:21890473; 55:21890473; 80:21890473; 158:21890473; 354:21890473; 402:21890473; 123:21890473; 643:21890473 SF3A1 Homo sapiens (Human) 154 "154,KGPVSIKVQVPNM" 154:21890473 SF3A1 Homo sapiens (Human) 115 "115,SPITGEKIPASKM" 115:21890473 SF3A1 Homo sapiens (Human) 115 "115,SPITGEKIPASKM" 296:21906983; 316:21906983 SF3A1 Homo sapiens (Human) 223; 55; 399; 80; 251; 188; 131; 419; 486; 467; 708; 449 "223,KILIPPKGLFSKL; 55,VRNIVDKTASFVA; 399,YDPKASKPLPPAP; 80,NEINNPKFNFLNP; 251,YRVEWAKFQERER; 188,LTQLMQKEQRNYQ; 131,QQQLPQKVQAQVI; 419,SPITGEKIPASKM; 486,EETAIGKKIGEEE; 467,DIESSLKQLAERR; 708,KGPVSIKVQVPNM; 449,DRSIREKQSDDEV" "223:21890473; 55:21890473; 399:21906983; 80:21890473; 251:21890473; 188:21890473; 131:21906983; 419:21890473,21906983; 486:21906983; 467:21890473,21906983; 708:21890473; 449:21906983"