PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CALM1, CALM2, CALM3 PPIL2 15840729 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 PIM2 26496610 biogrid,intact exp G G G G G GP G GP GP G G G GP G G GP GP G G G GP GP G G GP G GP GP G HSP90AA1 PPIL2 15189447 hprd,biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G PPIL2 KLC3 26496610 biogrid,intact exp P G GP P P P P P P P P P P GP P P P PPIL2 MAPK14 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PDGFRA PPIL2 26496610 biogrid,intact exp G G G G GP GP G G G G GP G G G G G GP GP G G GP G G G G G GP G G PPIL2 CRNKL1 15189447 hprd exp G G G G G GP G G GP G G G GP G G GP GP G G G G G GP G GP G GP GP G PPIL2 KLC2 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 ZNF830 22365833 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PPIL2 KANSL2 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI PPIL2 25281560 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM23 PPIL2 25416956 innatedb,biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 BAIAP2 26496610 biogrid,intact exp P P G G GP GP G GP P G GP GP GP GP P GP GP GP G GP GP P P P P GP GP G FGL1 PPIL2 26186194 biogrid exp GP GP G G GP GP G GP P G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NTRK1 PPIL2 25921289 biogrid exp P P P G P P P P P P P P P P P P P P P APP PPIL2 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G FKBP6 PPIL2 26186194 biogrid exp GP G G P G P P P P GP G G P GP G PPIL2 PRCC 22365833 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PPIL2 VPS26B 26496610 biogrid,intact exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G BSG PPIL2 15946952, 21836163 hprd,biogrid,bci exp, pred GP GP G G G GP G GP GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G PPIL2 PPIL2 8660300, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 FOXP3 ortho G G G P P G G G P P PPIL2 PPIL4 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G PPIL2 PPIE 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G PPIL2 PPWD1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIC PPIL2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PPIB PPIL2 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PPIL2 TNPO1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 PPIG 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 PPIL6 23023127 pred G P G P G GP P P P G P GP PPIH PPIL2 23023127, 21836163 pred GP GP G G GP GP G GP GP GP P GP GP G GP GP GP GP G GP G GP G GP GP GP GP G PPIF PPIL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RANBP2 PPIL2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 CWC27 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PPIL2 PPIL3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP PPIL2 LRSAM1 23023127 pred P GP G P GP G P GP G GP GP P GP P GP GP GP G P GP P P P GP P P G PPIL2 PPIL1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPIL2 SMURF1 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G NKTR PPIL2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPID PPIL2 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G TRIM21 PPIL2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIL2 PRPF19 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIAL4G PPIL2 23023127 pred P P P P P P P P P P P P P P P P P P P P PPIA PPIL2 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBE2B PPIL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPIL2 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPIL2 PPIAL4A, PPIAL4B, PPIAL4C 23023127 pred

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSP90AA1 PPIL2 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 15189447 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_166592|HPRD_31944 prey|- bait|- PPIL2 HDAC2 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_192792 prey bait PPIL2 PRCC MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 22365833 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid) BIOGRID_254300|UniProt_123860|BIOGRID_254394 prey|prey|bait bait|bait|prey APP PPIL2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228586 prey bait PPIL2 ZNF830 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22365833 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_255111|BIOGRID_254523|BIOGRID_255085|BIOGRID_254395|UniProt_123916|UniProt_123421 bait|prey|prey|bait|bait|bait prey|bait|bait|prey|prey|prey BSG PPIL2 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15946952 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_17005|BIOGRID_216445|BIOGRID_216443 -|prey|bait -|bait|prey UBC PPIL2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_176516|BIOGRID_171471 bait|bait prey|prey CALM1 PPIL2 MI:0096(pull down) 15840729 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_153836 bait prey PPIL2 CRNKL1 MI:0493(in vivo) 15189447 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_30673 - -

PPI - HINT Gene A Gene B PMID Method Quality FKBP6 PPIL2 26186194 0004 HT PDGFRA PPIL2 26496610,26496610 0007,0004 HT FGL1 PPIL2 26186194 0004 HT PPIL2 MAPK14 26186194 0004 HT PPIL2 VPS26B 26496610,26496610 0007,0004 HT PPIL2 KLC3 26496610,26496610 0007,0004 HT PPIL2 KLC2 26496610,26496610 0007,0004 HT PPIL2 KANSL2 26496610,26496610 0007,0004 HT PPIL2 PIM2 26496610,26496610 0007,0004 HT PPIL2 BAIAP2 26496610,26496610 0007,0004 HT FKBP6 PPIL2 26186194 0004 HT PDGFRA PPIL2 26496610,26496610 0007,0004 HT FGL1 PPIL2 26186194 0004 HT PPIL2 MAPK14 26186194 0004 HT PPIL2 VPS26B 26496610,26496610 0007,0004 HT PPIL2 KLC3 26496610,26496610 0007,0004 HT PPIL2 KLC2 26496610,26496610 0007,0004 HT PPIL2 KANSL2 26496610,26496610 0007,0004 HT PPIL2 PIM2 26496610,26496610 0007,0004 HT PPIL2 BAIAP2 26496610,26496610 0007,0004 HT TRIM23 PPIL2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PPIL2 PPIL2 8660300,PDB_1ZKC 0018,0114 LC PPIL2 PRCC 22365833 0018 HT PPIL2 ZNF830 22365833,22365833,22365833 0004,0018,0007 HT PPIL2 CRNKL1 15189447 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q13356 P62158 PPIL2 CALM3 0.183 15840729 Q13356 P16234 PPIL2 PDGFRA 0.126 26496610 Q9H0B6 Q13356 KLC2 PPIL2 0.126 26496610 Q13356 O75344 PPIL2 FKBP6 0.126 26186194 Q6P597 Q13356 KLC3 PPIL2 0.126 26496610 Q13356 P04629 PPIL2 NTRK1 0.126 25921289 Q9WVM1 Q13356 RACGAP1 PPIL2 0.236 26496610 Q8R344 Q13356 CCDC12 PPIL2 0.236 26496610 Q6PDM2 Q13356 SRSF1 PPIL2 0.236 26496610 Q8BUN5 Q13356 SMAD3 PPIL2 0.236 26496610 Q92733 Q13356 PRCC PPIL2 0.454 22365833 Q96NB3 Q13356 ZNF830 PPIL2 0.554 22365833 Q13356 P35613 PPIL2 BSG 0.376 15946952 Q13356 P36406 PPIL2 TRIM23 0.454 25416956 Q9P1W9 Q13356 PIM2 PPIL2 0.126 26496610 Q9UQB8 Q13356 BAIAP2 PPIL2 0.126 26496610 Q13356 P62807 PPIL2 HIST1H2BI 0.126 25281560 Q13356 G3X8Y3 PPIL2 G3X8Y3 0.126 26496610 Q13356 P05067 PPIL2 APP 0.183 21832049 Q13356 P07900 PPIL2 HSP90AA1 0.21 15189447 Q13356 Q13356 PPIL2 PPIL2 0.332 8660300 Q9H9L4 Q13356 KANSL2 PPIL2 0.126 26496610 Q13356 P63154 PPIL2 CRNKL1 0.569 15189447 Q16539 Q13356 MAPK14 PPIL2 0.126 26186194 Q4G0F5 Q13356 VPS26B PPIL2 0.126 26496610 Q13356 Q08830 PPIL2 FGL1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 FKBP6 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database APP PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database UBC PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database PDGFRA PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database BSG PPIL2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM23 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database BUD31 PPIL2 MI:0362 inference MI:0461 interaction database HNF4A PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database MAX PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database CALM1 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BC PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 PPIL2 MI:0362 inference MI:0461 interaction database SRSF1 PPIL2 MI:0362 inference MI:0461 interaction database FGL1 PPIL2 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 MAPK14 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 VPS26B MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 KLC3 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 CCDC12 MI:0362 inference MI:0461 interaction database PPIL2 PRCC MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 COPS5 MI:0362 inference MI:0461 interaction database PPIL2 ZNF830 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 NAA15 MI:0362 inference MI:0461 interaction database PPIL2 CRNKL1 MI:0362 inference MI:0461 interaction database PPIL2 FOXP3 MI:0362 inference MI:0461 interaction database PPIL2 KLC2 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 RACGAP1 MI:0362 inference MI:0461 interaction database PPIL2 KANSL2 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 PIM2 MI:0045 experimental interaction detection MI:0461 interaction database PPIL2 SRPK3 MI:0362 inference MI:0461 interaction database PPIL2 BAIAP2 MI:0045 experimental interaction detection MI:0461 interaction database