PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAP1A GGA1 10747088 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G G G LRP3 GGA1 11390366 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPS27A GGA1 15143060 hprd exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FLNB GGA1 26344197 biogrid exp GP GP G G GP GP G G GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G AFTPH GGA1 14665628 hprd exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G AKT2 GGA1 26344197 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ARF6 GGA1 23603394,11950392,22170068 innatedb,biogrid,intact exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DHX15 GGA1 26344197 biogrid exp G GP G G G GP G G GP G GP G G G G G GP GP GP G GP G G G G G GP GP G NECAP2 GGA1 14665628 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP G G G GP G GP GP G GGA1 GGA1 17506864,11821067 hprd,biogrid,i2d exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SMAD3 GGA1 15231748 hprd,biogrid,i2d,mint,intact exp GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G VCP GGA1 23383273 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CDKL3 GGA1 21988832 biogrid,intact exp P P G P GP G P G P G P P GP GP GP P G P G G G GP P P GP G TOLLIP GGA1 15047686 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G UBB GGA1 15143060 intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G JUN GGA1 14973137 biogrid exp GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G GIPC1 GGA1 26344197 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G BAG3 GGA1 23824909 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DTNB GGA1 25416956 biogrid,intact exp P P G GP G P GP G P P G P GP P P GP GP G P P GP G TMEM17 GGA1 26638075 biogrid,intact exp P GP G P GP G P P G GP P G G P GP P GP G P GP GP P P P GP UBC GGA1 19285159,17494868,14660606,15143060 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RABEPK GGA1 26344197 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TSG101 GGA1 15143060 hprd,biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G C1orf216 GGA1 25416956 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP GP G G GP G GP G GP G GP GP G VPS18 GGA1 16996030 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G EIF4EBP1 GGA1 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G CSNK2A1 GGA1 12060753 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G AP1AR GGA1 15775984 hprd,i2d exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP GP GP GP G GP GP GP GP G DNM2 GGA1 26344197 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G F8 GGA1 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G LIX1L GGA1 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDKN2A GGA1 11792819 biogrid exp G GP G G GP GP G G G G G G GP GP G G GP G GP G GP G G G G GP GP G G APP GGA1 17151287 biogrid exp, ortho G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G ARF3 GGA1 10749927,12221117,11950392,14690499, 25402006, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G M6PR GGA1 11387475,15044437, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SORL1 GGA1 11821067,20015111,17855360, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP GP GP GP G CLTC GGA1 17506864,17052248,11301005,17344219, 16082366 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G GGA2 GGA1 14638859, 25402006, 21836163 biogrid exp, pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GGA1 BACE2 12135764, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G STAM GGA1 26344197, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G GGA1 RNF11 25195858,15231748,20676133, 25402006 hprd,biogrid,i2d,mint,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MON2 GGA1 18418388, 25402006 biogrid,mint,intact exp, pred G G G G G GP G GP GP G GP G G G G G GP G GP G G G G G G G GP GP G RABGEF1 GGA1 12505986,15143060, 25402006 hprd,biogrid exp, pred P P P P P GP G GP P P GP P P GP G P P GP P GP P P RABGEF1 GGA1 12505986,15143060, 25402006 hprd,biogrid exp, pred P P P P P GP G GP P P GP P P GP G P P GP P GP P P CCDC91 GGA1 12808037,12858163,17596511, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GGA1 SYNRG 17506864,10747088,12858163,10814529, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAB1 GGA1 15345724, 21836163 biogrid exp, pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RABEP1 GGA1 14637142,14636058,12505986,14665628,17506864,10747088,15457209,16473621,15143060, 25402006, 21836163 hprd,biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CLINT1 GGA1 17506864, 25402006, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SORT1 GGA1 11821067,11390366,20676133,20015111,11859376, 25402006 hprd,biogrid,i2d,mint,intact exp, pred G G G G GP GP G GP GP G GP G GP G G G GP G GP G GP G G G G G G GP G IGF2R GGA1 11859375,12060753,14567678,15117318,11387475,11390366,20676133,11859376, 25402006, 21836163, 16082366 hprd,biogrid,i2d,mint,intact exp, pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ARF5 GGA1 11950392, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GGA3 GGA1 14638859, 25402006, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP GP GP GP G BACE1 GGA1 15886016,15466887,14567678,15117318, 21836163 biogrid exp, pred G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G ARF1 GGA1 11950392,10747089,15143060,12636914, 25402006, 21836163 hprd,biogrid,intact exp, pred GP GP G G GP GP GP GP G GP G GP GP G GP GP G P G GP GP GP P GP GP GP G HGS GGA1 15611048, 23023127 mint,intact exp, pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G SCG2 GGA1 ortho P GP G P GP G P GP G P P GP GP GP GP GP G P GP P GP P GP P YWHAE GGA1 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CNST GGA1 25402006 ortho, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G GLTSCR2 GGA1 21836163 pred P P P P P P P P GP P P P P P P GP P P P P SEC24C GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CLTCL1 GGA1 21836163 pred ARFIP2 GGA1 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G GGA1 PACSIN2 23023127, 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RIN2 GGA1 23023127, 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP P G AP1G2 GGA1 25402006, 23023127 pred GP GP G G GP GP GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP G RPS15 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TOM1L1 GGA1 23023127 pred GP GP P P G GP GP GP G GP GP G GP P GP GP G P GP GP GP P GP GP G SEC23B GGA1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G GGA1 TRAK1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G STX6 GGA1 23023127 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SEC24B GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SEC23A GGA1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CORO7 GGA1 21836163 pred P P G G GP GP P GP G P GP GP GP GP P GP P P GP GP P GP CORO7 GGA1 21836163 pred P P G G GP GP P GP G P GP GP GP GP P GP P P GP GP P GP PACS1 GGA1 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G LYST GGA1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VPS41 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZNF749 GGA1 21836163 pred P P P P P P P P P P P P P P P P P P P ITSN1 GGA1 16082366 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G G G GP G GP G GP G GP GP G TMUB2 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TG GGA1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ENTHD1 GGA1 23023127 pred P P P P P P P P P P P P P P P P P P P GP AP3B1 GGA1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G TMF1 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GGA1 NSFL1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G VAC14 GGA1 21836163 pred GP G GP G P P G GP G GP GP G GP GP GP P G P GP GP G GP G GP GP MAP4K3 GGA1 21836163 pred G G G P GP G G GP G GP G GP GP G GP GP G GP G GP G G G GP G GP GP G STX11 GGA1 23023127 pred GP P G GP P P GP P GP P G P P P P GP P P P GP GP P SNF8 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SNX18 GGA1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP G GP G GP GP G PIK3C3 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G P GP GP GP G GP GP GP G GP GP GP GP G GOLPH3 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G G GP G GP GP GP GP G GP GP GP G GP G GP GP G FLNA GGA1 23023127 pred G G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP G G G G G GP GP G ARHGAP17 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP GP GP GP G STAM2 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SAR1A GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CHSY1 GGA1 21836163 pred G GP G G GP G G GP G G GP G G GP G GP G G G G G G G G GP GP G G G EEA1 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G RIT2 GGA1 21836163 pred G G G G G VPS26A GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GGA1 VPS4A 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GBF1 GGA1 21836163 pred GP GP G G G GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP G GP G G GP G SNAP29 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RHOA GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G AP1S1 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NGF GGA1 25402006 pred G G G G G G ITSN2 GGA1 16082366 pred G G G G G GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G XPO1 GGA1 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G HIP1R GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RFWD2 GGA1 21836163 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G SMURF1 GGA1 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G LRPAP1 GGA1 25402006 pred GP G G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CHMP4B GGA1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G LONP1 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G STX10 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RAB27A GGA1 23023127 pred G GP G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP G GP GP GP GP G RAB1B GGA1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SQSTM1 GGA1 23023127 pred GP GP G G GP G G G GP G GP G GP GP G GP G GP GP G GP GP GP G GP GP GP GP G AP2M1 GGA1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G G G GP G GP GP G AP2A1 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PLIN3 GGA1 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G EPN2 GGA1 23023127 pred P P P P P P P SYT11 GGA1 21836163 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G G G G GP G G G G AMPH GGA1 21836163 pred G G G G GP G G GP G G G G G GP G GP G G G G G G G G G GGA1 AP4E1 25402006 pred GP GP G G G G GP G G GP G GP G G GP G G P G G G GP G GP G GP GP G RABEP2 GGA1 25402006 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP GP G GP GP GP G GP GP GP GP G SCAMP1 GGA1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AP1B1 GGA1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CHMP5 GGA1 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G GGA1 SNX9 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RAB24 GGA1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPB1 GGA1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GGA1 EPN1 25402006 pred GP GP G G G GP G G GP G GP G G GP G GP GP G GP G GP GP GP G GP G GP GP G ARFIP1 GGA1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G STAB2 GGA1 21836163 pred GP GP G G G GP G GP GP G G GP G G P GP G G GP GP G P G GP G G TCF7L2 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ARFGAP1 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP GP G AP1G1 GGA1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RAB5A GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TOM1 GGA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ARHGAP24 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NUP210L GGA1 21836163 pred G G RAB11A GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SEC24D GGA1 21836163 pred GP GP G GP P G GP GP GP G GP GP G GP P GP GP G G GP GP GP GP GP GP G TIMM23B GGA1 23023127 pred P RIN3 GGA1 21836163 pred G GP G G G GP G GP GP G G G GP GP G G GP G G G G G G G G GP G GP G SNX2 GGA1 23023127, 21836163 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G NTS GGA1 25402006 pred G G G G G G G GP G G G GP P LYPLA2 GGA1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GGA1 UNC13A 21836163 pred P P G P GP G P G P P GP P G P P P P P TOM1L2 GGA1 23023127 pred G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP GP G GP G GP GP G SEC24A GGA1 21836163 pred G GP G G G G G G GP G GP G GP GP G GP G G GP G GP GP GP G GP GP GP GP G GGA1 FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G USO1 GGA1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G EPS15L1 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CLTCL1 GGA1 16082366 pred G G G G G G G G G G G G G G G G G GGA1 CHMP3 21836163 pred P P P P P P P P P P P P P P P P P P P P VPS29 GGA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UJY5 Q15276 - 15457209 - X 2 Q9UJY5 - 15775984 - X 2 Q9UJY5 Q15276 - 15457209 - X 2 Q9UJY5 Q13563 - 15692563 - X 2 Q9UJY5 Q9UJY5 - 12858163 - X 2 Q9UJY5 Q9UJY5 - 12808037 - X 2 Q9UJY5 - 11859376 - X 2 Q9UJY5 - 11859376 - X 2 Q9UJY5 P49951 pull down 11301005 direct interaction X 2 Q9UJY5 Q99523 pull down 11390366 direct interaction X 2 Q9UJY5 Q99523 two hybrid 11390366 physical association X 2 Q9UJY5 Q15276 two hybrid 12505986 physical association X 2 Q9UJY5 Q15276 two hybrid 12505986 physical association X 2 Q9UJY5 O18973 pull down 12505986 physical association X 2 Q9UJY5 Q15276 anti tag coimmunoprecipitation 12505986 physical association X 2 Q9UJY5 Q15276 affinity chromatography technology 12505986 physical association X 2 Q9UJY5 O18973 immunodepleted coimmunoprecipitation 12505986 physical association X 2 Q9UJY5 Q8BSL7 x-ray crystallography 12679809 direct interaction X 2 Q9UJY5 Q15276 x-ray crystallography 14637142 direct interaction X 2 Q9UJY5 Q15276 two hybrid 15143060 physical association X 2 Q9UJY5 Q99816 two hybrid 15143060 physical association X 2 Q9UJY5 Q9Y3C5 two hybrid 15231748 physical association X 2 Q9UJY5 A0A024R5Z3 two hybrid 15231748 physical association X 2 Q9UJY5 Q15276 x-ray crystallography 15457209 direct interaction X 2 Q9UJY5 Q15276 pull down 15457209 physical association X 2 Q9UJY5 Q7Z3U7 pull down 18418388 physical association X 2 Q9UJY5 Q7Z3U7 anti tag coimmunoprecipitation 18418388 physical association X 2 Q9UJY5 Q9Y3C5 far western blotting 20676133 direct interaction X 2 Q9UJY5 Q9Y3C5 pull down 20676133 direct interaction X 2 Q9UJY5 Q99523 far western blotting 20676133 direct interaction X 2 Q9UJY5 P62331 pull down 22522702 physical association X 2 Q9UJY5 P62331 pull down 22522702 physical association X 2 Q9UJY5 Q8TAB5 two hybrid prey pooling approach 25416956 physical association X 2 Q9UJY5 Q8TAB5 two hybrid array 25416956 physical association X 2 Q9UJY5 Q8TAB5 validated two hybrid 25416956 physical association X 2 O60941 Q9UJY5 mammalian protein protein interaction trap 25416956 physical association X 2 O60941 Q9UJY5 two hybrid prey pooling approach 25416956 physical association X 2 O60941 Q9UJY5 two hybrid array 25416956 physical association X 2 O60941 Q9UJY5 validated two hybrid 25416956 physical association X 2 Q9UJY5 Q9UMZ2 pull down 10747088 direct interaction X 2 Q9UJY5 P84080 two hybrid 10747089 physical association X 2 Q9UJY5 P84080 pull down 10747089 direct interaction X 2 Q9UJY5 P11717 pull down 11387475 direct interaction X 2 Q9UJY5 P20645 two hybrid 11387475 physical association X 2 Q9UJY5 P11717 two hybrid 11387475 physical association X 2 Q9UJY5 O75074 two hybrid 11390366 physical association X 2 Q9UJY5 P11717 two hybrid 11390366 physical association X 2 Q9UJY5 Q92673 two hybrid 11821067 physical association X 2 Q9UJY5 Q92673 pull down 11821067 direct interaction X 2 Q9UJY5 A0A024R3Q3 two hybrid 15143060 physical association X 2 Q9UJY5 P0CG47 affinity chromatography technology 15143060 physical association X 2 Q9UJY5 P0CG47 pull down 15143060 physical association X 2 Q9UJY5 P0CG47 two hybrid 15143060 physical association X 2 Q9UJY5 O14964 two hybrid 15611048 physical association X 2 Q9UJY5 P48563 pull down 18418388 direct interaction X 2 Q9UJY5 P11717 far western blotting 20676133 direct interaction X 2 Q9UJY5 Q5NFR9 two hybrid pooling approach 20711500 physical association X 2 Q9UJY5 P00451 two hybrid array 21988832 physical association X 2 Q9UJY5 Q8IVW4 two hybrid array 21988832 physical association X 2 Q9UJY5 P62330 pull down 23603394 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B VPS18 GGA1 MI:0096(pull down)|MI:0096(pull down) 16996030 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_122358|BIOGRID_122355 prey|prey bait|bait CDKL3 GGA1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286714|UniProt_118365 bait|unspecified role prey|unspecified role HGS GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15611048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_81031|MINT_31203|MINT_59799 bait|bait|bait prey|prey|prey UBB GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_76492|UniProt_76494|UniProt_76496 bait|bait|prey prey|prey|bait ARF6 GGA1 MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy) 19327867,23603394 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_194476|UniProt_129963 prey|prey bait|bait CLTC GGA1 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0686(unspecified method)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 11301005,17052248,17344219,17506864 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_195586|BIOGRID_98849|BIOGRID_210707|BIOGRID_195386|BIOGRID_195588|BIOGRID_195587|HPRD_20139 bait|prey|prey|prey|prey|prey|- prey|bait|bait|bait|bait|bait|- SORL1 GGA1 MI:0018(two hybrid)|MI:0686(unspecified method)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0686(unspecified method)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11821067,20015111 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(biogrid)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint) UniProt_71430|BIOGRID_207822|MINT_48967|MINT_48966|HPRD_10153|BIOGRID_114425|BIOGRID_207820|MINT_80731|UniProt_71433|BIOGRID_114413|MINT_80732 bait|prey|bait|bait|-|bait|prey|bait|bait|bait|bait prey|bait|prey|prey|-|prey|bait|prey|prey|prey|prey UBC GGA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14660606,15143060,17494868,19285159,21139048,21890473,21906983,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_192413|BIOGRID_194092|BIOGRID_176995|BIOGRID_167553|BIOGRID_200642|BIOGRID_132823|BIOGRID_265949|BIOGRID_192417|BIOGRID_223864|BIOGRID_269859|BIOGRID_174531 bait|prey|bait|bait|bait|prey|bait|prey|bait|bait|bait prey|bait|prey|prey|prey|bait|prey|bait|prey|prey|prey CSNK2A1 GGA1 MI:0415(enzymatic study) 12060753 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_195775 bait prey MON2 GGA1 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18418388 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact) MINT_38226|MINT_38227|BIOGRID_251736|UniProt_200687|MINT_67409|UniProt_95624|MINT_67410|UniProt_95621 prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait GGA1 RNF11 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0047(far western blotting)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0047(far western blotting)|MI:0018(two hybrid) 15231748,20676133 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0218(physical interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0218(physical interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_47509|MINT_47508|BIOGRID_146535|BIOGRID_259426|UniProt_108985|HPRD_37706|MINT_79382|MINT_79383|UniProt_108992|UniProt_78536 prey|prey|prey|prey|bait|-|prey|prey|prey|prey bait|bait|bait|bait|prey|-|bait|bait|bait|bait MAP1A GGA1 MI:0004(affinity chromatography technology) 10747088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_259716 prey bait CLINT1 GGA1 MI:0686(unspecified method) 17506864 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_210703 prey bait ARF3 GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 10749927,12221117,14690499 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_116989|BIOGRID_81452|BIOGRID_195842|BIOGRID_116991 bait|bait|prey|prey prey|prey|bait|bait BACE1 GGA1 MI:0055(fluorescent resonance energy transfer)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0055(fluorescent resonance energy transfer)|MI:0004(affinity chromatography technology) 14567678,15117318,15466887,15886016 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_194093|BIOGRID_195687|BIOGRID_195686|BIOGRID_195599|BIOGRID_195046|BIOGRID_195600|BIOGRID_195685|BIOGRID_195044|BIOGRID_194094|BIOGRID_195596 bait|bait|bait|bait|prey|bait|prey|prey|prey|bait prey|prey|prey|prey|bait|prey|bait|bait|bait|prey CCDC91 GGA1 MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0055(fluorescent resonance energy transfer)|MI:0114(x-ray crystallography) 12808037,12858163,17596511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) HPRD_15917|BIOGRID_194102|BIOGRID_195635|BIOGRID_216607|BIOGRID_195636 -|prey|prey|bait|prey -|bait|bait|prey|bait ARF1 GGA1 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 12636914,15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid)|(biogrid) HPRD_35071|UniProt_76489|BIOGRID_192416|BIOGRID_90054 -|bait|prey|prey -|prey|bait|bait GGA1 BACE2 MI:0686(unspecified method)|MI:0686(unspecified method) 12135764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_110571|BIOGRID_110573 bait|bait prey|prey BAG3 GGA1 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282977 bait prey GGA2 GGA1 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique) 14638859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_210738|BIOGRID_210742|BIOGRID_210740 prey|bait|prey bait|prey|bait IGF2R GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0047(far western blotting)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 11387475,11390366,11859375,11859376,12060753,14567678,15117318,20676133 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint) BIOGRID_195024|MINT_86269|UniProt_69480|BIOGRID_195022|BIOGRID_195776|MINT_57130|UniProt_108986|BIOGRID_195593|UniProt_68803|BIOGRID_195045|BIOGRID_215603|UniProt_68800|HPRD_36261|BIOGRID_215600|BIOGRID_216496|MINT_48969|MINT_48968|MINT_80733|BIOGRID_215608|MINT_80734 prey|prey|prey|prey|bait|prey|prey|bait|bait|prey|prey|bait|-|prey|bait|bait|bait|bait|bait|bait bait|bait|bait|bait|prey|bait|bait|prey|prey|bait|bait|prey|-|bait|prey|prey|prey|prey|prey|prey F8 GGA1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285517|UniProt_117787 bait|unspecified role prey|unspecified role AP1AR GGA1 MI:0492(in vitro) 15775984 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26270 - - TOLLIP GGA1 MI:0004(affinity chromatography technology) 15047686 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195242 prey bait GGA3 GGA1 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique) 14638859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_210739|BIOGRID_210744|BIOGRID_210741 prey|bait|prey bait|prey|bait AFTPH GGA1 MI:0018(two hybrid) 14665628 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_15636 - - RAB5A GGA1 MI:0004(affinity chromatography technology) 14665628 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_87277 bait prey c-Jun GGA1 MI:0004(affinity chromatography technology) 14973137 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_194096 bait prey M6PR GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 11387475,15044437 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) MINT_78208|MINT_48757|BIOGRID_97681|UniProt_68802|BIOGRID_194368|BIOGRID_97683|HPRD_37389|BIOGRID_194367 bait|bait|bait|bait|prey|bait|-|bait prey|prey|prey|prey|bait|prey|-|prey STAB1 GGA1 MI:0096(pull down) 15345724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_207843 bait prey NECAP2 GGA1 MI:0004(affinity chromatography technology) 14665628 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_87275 prey bait RABGEF1 GGA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0492(in vitro) 12505986,15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_192415|BIOGRID_192411|BIOGRID_105054|HPRD_15729 prey|bait|prey|- bait|prey|bait|- RABGEF1 GGA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0492(in vitro) 12505986,15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_192415|BIOGRID_192411|BIOGRID_105054|HPRD_15729 prey|bait|prey|- bait|prey|bait|- CDKN2A GGA1 MI:0018(two hybrid) 11792819 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_195804 bait prey SORT1 GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0047(far western blotting)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0686(unspecified method)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology) 11390366,11821067,11859376,20015111,20676133 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_195023|UniProt_69484|UniProt_69478|BIOGRID_114415|UniProt_108987|MINT_77326|MINT_77327|MINT_57211|BIOGRID_207821|MINT_57210|BIOGRID_114423|HPRD_10881|BIOGRID_215604|BIOGRID_207823|BIOGRID_215596|BIOGRID_207819|BIOGRID_215598 prey|bait|bait|bait|prey|bait|bait|bait|prey|bait|bait|-|bait|prey|prey|prey|prey bait|prey|prey|prey|bait|prey|prey|prey|bait|prey|prey|-|prey|bait|bait|bait|bait TSG101 GGA1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_76491|BIOGRID_192418|HPRD_9040 bait|prey|- prey|bait|- RABEP1 GGA1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0686(unspecified method)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 10747088,12505986,14636058,14637142,15143060,15457209,16473621,17506864 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association) (intact)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid) UniProt_76490|HPRD_12556|BIOGRID_259719|UniProt_72152|BIOGRID_207642|UniProt_72165|BIOGRID_207639|BIOGRID_210704|UniProt_74044|UniProt_72149|UniProt_72158|BIOGRID_194100|BIOGRID_105055|BIOGRID_105053|BIOGRID_305543|UniProt_78309|BIOGRID_105057|UniProt_78308|BIOGRID_194095 prey|-|prey|prey|prey|bait|prey|prey|neutral component|prey|bait|prey|prey|prey|prey|prey|bait|neutral component|prey bait|-|bait|bait|bait|prey|bait|bait|neutral component|bait|prey|bait|bait|bait|bait|bait|prey|neutral component|bait SMAD3 GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_38364|UniProt_78714|BIOGRID_259058 -|bait|bait -|prey|prey LRP3 GGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 11390366 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd) MINT_78128|MINT_48696|UniProt_69479|BIOGRID_215595|BIOGRID_215597|HPRD_26400 bait|bait|bait|prey|prey|- prey|prey|prey|bait|bait|- VCP GGA1 MI:0004(affinity chromatography technology) 23383273 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249717 bait prey RPS27A GGA1 MI:0492(in vitro) 15143060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_4737 - - APP GGA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17151287 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_207232|BIOGRID_207233 prey|prey bait|bait GGA1 SYNRG MI:0096(pull down)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0686(unspecified method) 10747088,10814529,12858163,17506864 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid) MINT_85656|BIOGRID_102080|BIOGRID_259723|MINT_56596|HPRD_14237|BIOGRID_195637|UniProt_67468|BIOGRID_210702 bait|bait|bait|bait|-|bait|bait|bait prey|prey|prey|prey|-|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality GIPC1 GGA1 26344197 0401 HT DHX15 GGA1 26344197 0401 HT FLNB GGA1 26344197 0401 HT UBC GGA1 17494868,15143060,19285159,14660606,15143060 0096,0004,0096,0096,0018 LC IGF2R GGA1 11387475,11387475,12060753,11390366,11390366,15117318,14567678 0018,0096,0004,0018,0004,0096,0004 LC M6PR GGA1 11387475,15044437,11387475 0096,0004,0018 LC AKT2 GGA1 26344197 0401 HT ARF3 GGA1 10749927,11950392,14690499,10749927 0018,0096,0096,0096 LC ARF6 GGA1 22170068,22170068,23603394,11950392 0007,0096,0096,0096 LC ARF1 GGA1 11950392,12636914,12636914 0096,0096,0018 LC CLTC GGA1 11301005,17344219,17052248,17506864,17052248,17052248 0096,0096,0018,0096,0004,0114 LC EIF4EBP1 GGA1 26344197 0401 HT RABEP1 GGA1 10747088,12505986,12505986,12505986,15457209,15457209,12505986,14636058,16473621,15457209,16473621 0004,0004,0018,0007,0096,0018,0096,0004,0114,0114,0096 LC KIAA1149 GGA1 15886016,14567678,15117318,14567678,15117318,14567678,15886016 0096,0096,0114,0114,0096,0004,0004 LC CCDC91 GGA1 12808037 0004 LC RABEPK GGA1 26344197 0401 HT TMEM17 GGA1 26638075,26638075 1314,1313 HT LIX1L GGA1 26344197 0401 HT Q8N1K8 GGA1 26344197 0401 HT SORL1 GGA1 11821067,20015111,20015111,17855360,11821067 0096,0096,0114,0004,0018 LC STAM GGA1 26344197 0401 HT SORT1 GGA1 11390366,20015111,11821067,20015111,11390366,11390366,20015111,11821067 0004,0018,0096,0096,0018,0096,0114,0018 LC RABGEF1 GGA1 15143060,15143060,12505986 0004,0018,0096 LC GGA1 RNF11 20676133,25195858,20676133,20676133,25195858 0047,0096,0096,0081,0004 LC GIPC1 GGA1 26344197 0401 HT DHX15 GGA1 26344197 0401 HT FLNB GGA1 26344197 0401 HT AKT2 GGA1 26344197 0401 HT EIF4EBP1 GGA1 26344197 0401 HT RABEPK GGA1 26344197 0401 HT TMEM17 GGA1 26638075,26638075 1314,1313 HT LIX1L GGA1 26344197 0401 HT Q8N1K8 GGA1 26344197 0401 HT STAM GGA1 26344197 0401 HT UBC GGA1 17494868,15143060,19285159,14660606,15143060 0096,0004,0096,0096,0018 LC IGF2R GGA1 11387475,11387475,12060753,11390366,11390366,15117318,14567678 0018,0096,0004,0018,0004,0096,0004 LC M6PR GGA1 11387475,15044437,11387475 0096,0004,0018 LC ARF3 GGA1 10749927,11950392,14690499,10749927 0018,0096,0096,0096 LC ARF6 GGA1 22170068,22170068,23603394,11950392 0007,0096,0096,0096 LC ARF1 GGA1 11950392,12636914,12636914 0096,0096,0018 LC CLTC GGA1 11301005,17344219,17052248,17506864,17052248,17052248 0096,0096,0018,0096,0004,0114 LC RABEP1 GGA1 10747088,12505986,12505986,12505986,15457209,15457209,12505986,14636058,16473621,15457209,16473621 0004,0004,0018,0007,0096,0018,0096,0004,0114,0114,0096 LC KIAA1149 GGA1 15886016,14567678,15117318,14567678,15117318,14567678,15886016 0096,0096,0114,0114,0096,0004,0004 LC CCDC91 GGA1 12808037 0004 LC SORL1 GGA1 11821067,20015111,20015111,17855360,11821067 0096,0096,0114,0004,0018 LC SORT1 GGA1 11390366,20015111,11821067,20015111,11390366,11390366,20015111,11821067 0004,0018,0096,0096,0018,0096,0114,0018 LC RABGEF1 GGA1 15143060,15143060,12505986 0004,0018,0096 LC GGA1 RNF11 20676133,25195858,20676133,20676133,25195858 0047,0096,0096,0081,0004 LC GIPC1 GGA1 26344197 0401 LC HGS GGA1 15611048 0018 LC DHX15 GGA1 26344197 0401 LC DTNB GGA1 25416956,25416956,25416956,25416956,25416956 1112,0397,0018,0231,1356 HT LRP3 GGA1 11390366,11390366 0018,0004 LC FLNB GGA1 26344197 0401 LC F8 GGA1 21988832,21988832 0397,0018 HT UBB GGA1 15143060,15143060,15143060 0004,0018,0096 LC UBC GGA1 15143060,15143060 0004,0018 LC IGF2R GGA1 11859375,11387475,11387475,11390366,11390366,11859376,11859376,20676133 0018,0018,0096,0018,0004,0018,0114,0047 LC M6PR GGA1 11387475,11387475 0096,0018 LC AKT2 GGA1 26344197 0401 LC CDKN2A GGA1 11792819 0018 LC BACE1 GGA1 15117318 0114 LC ARF3 GGA1 10749927,12221117,10749927 0018,0018,0096 LC CSNK2A1 GGA1 12060753 0415 LC SMAD3 GGA1 15231748 0018 HT ARF1 GGA1 12636914,10747089,12636914,15143060 0096,0018,0018,0018 LC CLTC GGA1 17052248,17052248,17052248 0018,0004,0114 LC EIF4EBP1 GGA1 26344197 0401 LC RABEP1 GGA1 12505986,12505986,12505986,14665628,15457209,15457209,15143060,12505986,14637142,16473621,15457209,16473621 0004,0018,0007,0018,0096,0018,0018,0096,0114,0114,0114,0096 LC KIAA1149 GGA1 14567678,15117318,15466887,14567678,15117318,14567678 0096,0114,0055,0114,0096,0004 LC AFTPH GGA1 14665628 0018 LC CCDC91 GGA1 12858163,17596511 0114,0055 LC RABEPK GGA1 26344197 0401 LC LIX1L GGA1 26344197 0401 LC CDKL3 GGA1 21988832,21988832 0397,0018 HT Q8N1K8 GGA1 26344197 0401 LC C1ORF216 GGA1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SORL1 GGA1 11821067,20015111,20015111,11821067 0096,0096,0114,0018 LC STAM GGA1 26344197 0401 LC SORT1 GGA1 11390366,20015111,11821067,20015111,11390366,11390366,20015111,20676133,11859376,11821067 0004,0018,0096,0096,0018,0096,0114,0047,0018,0018 LC TSG101 GGA1 15143060 0018 LC Q9P0T0 GGA1 15231748 0018 HT RABGEF1 GGA1 15143060,15143060 0004,0018 LC GGA1 GGA1 20015111,17506864,15117318,12858163,12808037,11859376,11821067 0114,0114,0114,0114,0114,0114,0018 LC GGA1 SYNRG 10747088,10814529,10747088,10747088 0004,0018,0096,0018 LC GGA1 RNF11 20676133,20676133,20676133,15231748 0047,0096,0081,0018 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UJY5 Q5NFR9 GGA1 PILQ 0.126 20711500 Q9UJY5 O14964 GGA1 HGS 0.309 15611048 Q9UJY5 Q5SQN1 GGA1 SNAP47 0.126 unassigned1312 Q9UJY5 P61204 GGA1 ARF3 0.772 10749927,14690499,11950392 Q9UJY5 O43747 GGA1 AP1G1 0.21 14973137 Q9UJY5 Q8N726 GGA1 CDKN2A 0.309 11792819 Q9UJY5 Q9NTX5 GGA1 ECHDC1 0.126 unassigned1312 Q9UJY5 Q9NY15 GGA1 STAB1 0.309 15345724 Q9UJY5 Q9NZ52 GGA1 GGA3 0.583 14638859 Q9UJY5 O75074 GGA1 LRP3 0.623 11390366 Q9UJY5 O75369 GGA1 FLNB 0.081 26344197 Q9UJY5 P08169 GGA1 IGF2R 0.309 12578827 Q9UJY5 P0CG47 GGA1 UBB 0.569 15143060 Q9UJY5 Q7Z3U7 GGA1 MON2 0.507 18418388 Q9UJY5 Q7Z6B0 GGA1 CCDC91 0.74 12808037,12858163,17596511 Q9UJY5 P14335 GGA1 P14335 0.126 22014111 Q9UJY5 O95817 GGA1 BAG3 0.126 23824909 Q9UJY5 H0Y8A2 GGA1 ATXN7L1 {ECO:0000313|ENSEMBL:ENSP00000418900} 0.236 unassigned1304 Q9UJY5 P05067 GGA1 APP 0.454 17151287 Q9UJY5 P20645 GGA1 M6PR 0.82 11387475,15044437 Q9UJY5 P0CG48 GGA1 UBC 0.74 17494868,15143060,19285159 Q9UJY5 Q9P253 GGA1 VPS18 0.454 16996030 Q9UJY5 Q9UJY5 GGA1 GGA1 0.554 17506864 Q9Y5Z0 Q9UJY5 BACE2 GGA1 0.523 12135764 Q9UJY5 Q8WYH8 GGA1 ING5 0.236 unassigned1304 Q9UJY5 P00451 GGA1 F8 0.286 21988832 Q9UJY5 Q9BY27 GGA1 DGCR6L 0.236 unassigned1304 Q9UJY5 P84022 GGA1 SMAD3 0.332 15231748 Q9UJY5 O18973 GGA1 RABGEF1 0.376 12505986 Q9UJY5 Q86X19 GGA1 TMEM17 0.236 26638075 Q9UJY5 Q8IVW4 GGA1 CDKL3 0.286 21988832 Q9UJY5 O60941 GGA1 DTNB 0.636 25416956,unassigned1304 Q9UJY5 Q92673 GGA1 SORL1 0.902 11821067,17855360,26053850,20015111 Q9UJY5 Q99523 GGA1 SORT1 0.978 11821067,11859376,11390366,20015111 Q9Y3C5 Q9UJY5 RNF11 GGA1 0.826 15231748,25195858,20676133 Q9UJY5 P56817 GGA1 BACE1 0.98 14567678,15466887,15117318,15886016,26053850 Q9UJY5 P11717 GGA1 IGF2R 0.98 11859376,14567678,12060753,15117318,11390366,11387475,11859375 Q9UJY5 Q15276 GGA1 RABEP1 0.997 14637142,16473621,10747088,15143060,17506864,14665628,12505986,14636058,15457209 Q9UJY5 Q92783 GGA1 STAM 0.081 26344197 Q9UJY5 P31751 GGA1 AKT2 0.081 26344197 Q9UJY5 Q9E7P0 GGA1 Q9E7P0 0.126 22014111 Q9UJY5 Q99816 GGA1 TSG101 0.523 15143060 Q9UJY5 Q9UJ41 GGA1 RABGEF1 0.623 12505986,15143060 Q9UJY5 Q9UJ41 GGA1 RABGEF1 0.623 12505986,15143060 Q9UJY5 Q9UJY4 GGA1 GGA2 0.583 14638859 Q9UJY5 O14908 GGA1 GIPC1 0.081 26344197 Q9UJY5 O43143 GGA1 DHX15 0.081 26344197 Q9UJY5 P48563 GGA1 MON2 0.454 18418388 Q9UJY5 P62330 GGA1 ARF6 0.454 23603394,11950392 Q9UJY5 P62331 GGA1 ARF6 0.21 22522702 Q9UJY5 P78559 GGA1 MAP1A 0.21 10747088 Q9UJY5 P84078 GGA1 ARF1 0.309 12679809 Q9UJY5 P84080 GGA1 ARF1 0.523 10747089 Q9UJY5 P84085 GGA1 ARF5 0.309 11950392 Q9UJY5 Q13541 GGA1 EIF4EBP1 0.081 26344197 Q9UJY5 Q14677 GGA1 CLINT1 0.309 17506864 Q9UJY5 Q60994 GGA1 ADIPOQ 0.309 16407204 Q9UJY5 Q7Z6M1 GGA1 RABEPK 0.081 26344197 Q9UJY5 Q8BSL7 GGA1 ARF2 0.309 12679809 Q9UJY5 Q8IVB5 GGA1 LIX1L 0.081 26344197 Q9UJY5 Q8TAB5 GGA1 C1ORF216 0.583 25416956,unassigned1304 Q9UJY5 Q9NVZ3 GGA1 NECAP2 0.21 14665628 Q9UMZ2 Q9UJY5 SYNRG GGA1 0.82 12858163,10814529,17506864,10747088 Q9UJY5 P42771 GGA1 CDKN2A 0.309 11792819 Q9UJY5 P84077 GGA1 ARF1 0.772 12636914,15143060,11950392 Q9UJY5 Q00610 GGA1 CLTC 0.876 17506864,11301005,17344219,17052248 Q9UJY5 P49951 GGA1 CLTC 0.309 11301005 Q9UJY5 P50570 GGA1 DNM2 0.081 26344197 Q9UJY5 P68400 GGA1 CSNK2A1 0.309 12060753 Q9UJY5 P67774 GGA1 PPP2CA 0.309 12578827 Q9UJY5 P55072 GGA1 VCP 0.126 23383273

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HGS GGA1 MI:0045 experimental interaction detection MI:0461 interaction database AP1G1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database DTNB GGA1 MI:0045 experimental interaction detection MI:0461 interaction database LRP3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database BAG3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database F8 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database APP GGA1 MI:0045 experimental interaction detection MI:0461 interaction database JUN GGA1 MI:0045 experimental interaction detection MI:0461 interaction database UBB GGA1 MI:0045 experimental interaction detection MI:0461 interaction database UBC GGA1 MI:0045 experimental interaction detection MI:0461 interaction database IGF2R GGA1 MI:0045 experimental interaction detection MI:0461 interaction database SLC2A4 GGA1 MI:0362 inference MI:0461 interaction database RAB5A GGA1 MI:0045 experimental interaction detection MI:0461 interaction database M6PR GGA1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CDKN2A GGA1 MI:0045 experimental interaction detection MI:0461 interaction database VCP GGA1 MI:0045 experimental interaction detection MI:0461 interaction database BACE1 GGA1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ARF3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database ARF6 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database PPP2CA GGA1 MI:0362 inference MI:0461 interaction database CSNK2A1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database MAP1A GGA1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database ARF1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database ARF5 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CLTC GGA1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 GGA1 MI:0362 inference MI:0461 interaction database CLINT1 GGA1 MI:0362 inference MI:0461 interaction database RABEP1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database ADIPOQ GGA1 MI:0362 inference MI:0461 interaction database AP1AR GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CNST GGA1 MI:0362 inference MI:0461 interaction database MON2 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CCDC91 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database TMEM17 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CDKL3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database CDKN2A GGA1 MI:0045 experimental interaction detection MI:0461 interaction database C1orf216 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database SORL1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database SORT1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database TSG101 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database TOLLIP GGA1 MI:0045 experimental interaction detection MI:0461 interaction database NECAP2 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database STAB1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database GGA3 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database VPS18 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database RABGEF1 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database GGA2 GGA1 MI:0045 experimental interaction detection MI:0461 interaction database GGA1 SYNRG MI:0045 experimental interaction detection MI:0461 interaction database GGA1 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database GGA1 BACE2 MI:0045 experimental interaction detection MI:0461 interaction database