PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus JOSD1 TRIM63 22626734 biogrid exp G G G G JOSD1 NOTCH2NL 25416956 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 PJA1 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 TRIM54 22626734 biogrid exp P P GP P P P G P GP GP P CALM1, CALM2, CALM3 JOSD1 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 MID2 25416956 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP G GP GP GP G GP G G JOSD1 STUB1 23625928 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 KRT40 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P EIF3F JOSD1 26186194 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 KRTAP9-2 25416956 biogrid,intact exp P P P P P P P P P KRTAP10-8 JOSD1 25416956 biogrid,intact exp TRIM27 JOSD1 25416956,21516116 biogrid,mint,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP G G TIMM8A JOSD1 19615732 biogrid,intact exp P P G G G GP GP GP GP G G P GP G GP G P GP GP G GP GP G KRTAP10-3 JOSD1 25416956 biogrid exp KRTAP10-4 JOSD1 25416956 intact exp JOSD1 USP15 22626734 biogrid exp G GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 ELAVL1 19322201 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 KRT31 25416956 biogrid,intact exp G G G GP G P P G P GP G P P GP G GP P G JOSD1 JOSD1 25416956 intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G TRAF1 JOSD1 25416956 biogrid,intact exp G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G KRTAP5-9 JOSD1 25416956 biogrid,intact exp JOSD1 USP28 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 LNX1 22889411 biogrid exp GP G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP G UBC JOSD1 19382171,21118805,23625928 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G TRIM23 JOSD1 25416956 innatedb,biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G SUMO1 JOSD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 FAF1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 UBQLN1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G ARAF JOSD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP14 JOSD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G UBXN8 JOSD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC JOSD1 23023127 pred DCLK1 JOSD1 23023127 pred G G G GP G G GP G G G GP GP GP GP G P G G G GP G GP G RAD23B JOSD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 UBLCP1 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 EPB41L3 23023127 pred G GP G GP G G GP G GP G G G GP GP GP GP G GP G GP G G JOSD1 CIDEC 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G CIDEA JOSD1 23023127 pred G G G G G G G G RGS14 JOSD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP G G PRKCI JOSD1 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP G G JOSD1 UBQLN2 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 TLN1 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G JOSD1 UBL7 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP G G PARK2 JOSD1 23023127 pred P GP G GP G GP GP G GP P G P GP GP P G P GP GP GP P G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UNE7 Q15040 enzymatic study 23625928 direct interaction X 2 Q6A162 Q15040 two hybrid 25416956 direct interaction X 2 Q9UJV3 Q15040 two hybrid 25416956 direct interaction X 2 Q8NG27 Q15040 enzymatic study 22626734 direct interaction X 2 Q15040 Q9BYV2 enzymatic study 22626734 direct interaction X 2 Q15040 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q15040 Q15323 two hybrid 25416956 direct interaction X 2 Q15040 O60220 affinity chromatography technology 19615732 physical association X 2 Q9BYQ4 Q15040 two hybrid 25416956 direct interaction X 2 P60369 Q15040 two hybrid 25416956 direct interaction X 2 Q7Z3S9 Q15040 two hybrid 25416956 direct interaction X 2 Q969Q1 Q15040 enzymatic study 22626734 direct interaction X 2 Q96RU2 Q15040 enzymatic study 22626734 direct interaction X 2 Q15040 two hybrid 25416956 direct interaction X 2 P60410 Q15040 two hybrid 25416956 direct interaction X 2 P14373 Q15040 two hybrid 25416956 direct interaction X 2 P0CG48 Q15040 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q15040 pull down 19382171 direct interaction X 2 P0CG48 Q15040 x-ray crystallography 19382171 association X 2 P0CG48 Q15040 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q15040 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q15040 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q15040 enzymatic study 23625928 direct interaction X 2 P0CG48 Q15040 affinity chromatography technology 23625928 physical association X 2 P0CG48 Q15040 affinity chromatography technology 25015289 physical association X 2 P0CG48 Q15040 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q15040 enzymatic study 21118805 direct interaction X 2 P0CG48 Q15040 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q15040 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q15040 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q15040 affinity chromatography technology 21906983 physical association X 2 Q15040 Q8TBB1 two hybrid 22889411 direct interaction X 2 Q15040 Q9Y4E8-2 enzymatic study 22626734 direct interaction X 2 Q15040 P36406 two hybrid 25416956 direct interaction X 2 Q15040 B4DJ51 affinity chromatography technology 19615732 physical association X 2 Q13077-2 Q15040 two hybrid 25416956 direct interaction X 2 P26371 Q15040 two hybrid 25416956 direct interaction X 2 Q15040 anti tag coimmunoprecipitation 19615732 physical association C 3 Q6A162 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 Q6A162 Q15040 two hybrid array 25416956 physical association X 2 Q6A162 Q15040 validated two hybrid 25416956 physical association X 2 Q15040 Q15323 two hybrid prey pooling approach 25416956 physical association X 2 Q15040 Q15323 two hybrid array 25416956 physical association X 2 Q15040 Q15323 validated two hybrid 25416956 physical association X 2 Q13077 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 Q13077 Q15040 two hybrid array 25416956 physical association X 2 Q13077 Q15040 validated two hybrid 25416956 physical association X 2 Q9BYQ4 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 Q9BYQ4 Q15040 two hybrid array 25416956 physical association X 2 Q9BYQ4 Q15040 validated two hybrid 25416956 physical association X 2 Q7Z3S9 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 Q7Z3S9 Q15040 two hybrid array 25416956 physical association X 2 Q7Z3S9 Q15040 validated two hybrid 25416956 physical association X 2 Q9UJV3-2 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 Q9UJV3-2 Q15040 two hybrid array 25416956 physical association X 2 Q9UJV3-2 Q15040 validated two hybrid 25416956 physical association X 2 P60410 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 P60410 Q15040 two hybrid array 25416956 physical association X 2 P60410 Q15040 validated two hybrid 25416956 physical association X 2 P14373 Q15040 two hybrid 21516116 physical association X 2 P14373 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 P14373 Q15040 two hybrid array 25416956 physical association X 2 P14373 Q15040 validated two hybrid 25416956 physical association X 2 Q15040 P36406 two hybrid prey pooling approach 25416956 physical association X 2 Q15040 P36406 two hybrid array 25416956 physical association X 2 Q15040 P36406 validated two hybrid 25416956 physical association X 2 P26371 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 P26371 Q15040 two hybrid array 25416956 physical association X 2 P26371 Q15040 validated two hybrid 25416956 physical association X 2 P60372 Q15040 two hybrid prey pooling approach 25416956 physical association X 2 P60372 Q15040 two hybrid array 25416956 physical association X 2 P60372 Q15040 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B JOSD1 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186984 prey bait TRIM27 JOSD1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114754 prey bait TIMM8A JOSD1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100637|BIOGRID_119436 prey|prey bait|bait JOSD1 LNX1 MI:0018(two hybrid) 22889411 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_208601 prey bait JOSD1 TRIM63 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223001 prey bait JOSD1 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223116 prey bait CALM1 JOSD1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119371|UniProt_100637 prey|prey bait|bait JOSD1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223074 prey bait JOSD1 TRIM54 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223043 prey bait JOSD1 STUB1 MI:0415(enzymatic study) 23625928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_309270 prey bait JOSD1 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222987 prey bait UBC JOSD1 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19382171,21139048,21890473,21906983,21963094,21987572,22053931,22505724,23000965,23625928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_222842|BIOGRID_222841|BIOGRID_168345|BIOGRID_222248|BIOGRID_163588|BIOGRID_309272|BIOGRID_225620|BIOGRID_309268|BIOGRID_264253|BIOGRID_267921|BIOGRID_177727|BIOGRID_174213 prey|prey|bait|bait|bait|prey|bait|prey|bait|bait|bait|bait bait|bait|prey|prey|prey|bait|prey|bait|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality HEL-S-72 JOSD1 19615732 0004 HT EIF3F JOSD1 26186194 0004 HT TIMM8A JOSD1 19615732,19615732 0004,0007 HT CALM1|CALM2|CALM3 JOSD1 19615732,19615732 0004,0007 HT HEL-S-72 JOSD1 19615732 0004 HT EIF3F JOSD1 26186194 0004 HT TIMM8A JOSD1 19615732,19615732 0004,0007 HT CALM1|CALM2|CALM3 JOSD1 19615732,19615732 0004,0007 HT UBC JOSD1 21118805,19382171,19382171,23625928 0415,0096,0114,0415 LC TRIM27 JOSD1 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT KRTAP5-9 JOSD1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM23 JOSD1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KRTAP10-3 JOSD1 25416956 0018 HT KRTAP10-4 JOSD1 25416956,25416956,25416956 1112,0397,1356 HT KRTAP10-8 JOSD1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRAF1 JOSD1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 KRT31 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 KRT40 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 NOTCH2NL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 PJA1 22626734 0415 HT JOSD1 LNX1 22889411 0018 LC JOSD1 TRIM63 22626734 0415 HT JOSD1 USP28 22626734 0415 HT JOSD1 KRTAP9-2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 TRIM54 22626734 0415 HT JOSD1 MID2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT JOSD1 USP21 22626734 0415 HT JOSD1 STUB1 23625928 0415 LC JOSD1 USP15 22626734 0415 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q15040 P60372 JOSD1 KRTAP10-4 0.332 25416956 Q8NG27 Q15040 PJA1 JOSD1 0.183 22626734 Q8TBB1 Q15040 LNX1 JOSD1 0.183 22889411 Q9Y4E8 Q15040 USP15 JOSD1 0.183 22626734 Q15040 P0C7H8 JOSD1 KRTAP2-3 0.236 unassigned1304 Q9BWT7 Q15040 CARD10 JOSD1 0.236 unassigned1304 Q9BYQ3 Q15040 KRTAP9-3 JOSD1 0.236 unassigned1304 Q15040 P98095 JOSD1 FBLN2 0.236 unassigned1304 Q15040 P62158 JOSD1 CALM3 0.236 19615732 Q15040 B8A4K4 JOSD1 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q15040 O76011 JOSD1 KRT34 0.236 unassigned1304 Q15040 O43790 JOSD1 KRT86 0.236 unassigned1304 Q15040 O60220 JOSD1 TIMM8A 0.236 19615732 Q15040 P26371 JOSD1 KRTAP5-9 0.454 25416956 Q15040 P22735 JOSD1 TGM1 0.236 unassigned1304 Q15040 P36406 JOSD1 TRIM23 0.454 25416956 Q15040 P60328 JOSD1 KRTAP12-3 0.236 unassigned1304 Q7Z3Y8 Q15040 KRT27 JOSD1 0.236 unassigned1304 Q99750 Q15040 MDFI JOSD1 0.236 unassigned1304 Q15040 Q07627 JOSD1 KRTAP1-1 0.236 unassigned1304 Q6A162 Q15040 KRT40 JOSD1 0.583 25416956,unassigned1304 Q5JR59 Q15040 MTUS2 JOSD1 0.236 unassigned1304 Q6UY14 Q15040 ADAMTSL4 JOSD1 0.236 unassigned1304 Q7Z3S9 Q15040 NOTCH2NL JOSD1 0.583 25416956,unassigned1304 Q15040 P60410 JOSD1 KRTAP10-8 0.583 25416956,unassigned1304 Q9BYQ4 Q15040 KRTAP9-2 JOSD1 0.583 25416956,unassigned1304 Q15040 Q13077 JOSD1 TRAF1 0.454 25416956 Q15040 P0CG48 JOSD1 UBC 0.772 23625928,21118805,19382171 Q969Q1 Q15040 TRIM63 JOSD1 0.183 22626734 Q96RU2 Q15040 USP28 JOSD1 0.183 22626734 Q9BYV2 Q15040 TRIM54 JOSD1 0.183 22626734 Q9UJV3 Q15040 MID2 JOSD1 0.454 25416956 Q9UK80 Q15040 USP21 JOSD1 0.183 22626734 Q9UNE7 Q15040 STUB1 JOSD1 0.309 23625928 Q15040 P14373 JOSD1 TRIM27 0.636 21516116,25416956 Q15040 P60369 JOSD1 KRTAP10-3 0.183 25416956 Q15323 Q15040 KRT31 JOSD1 0.454 25416956 Q15717 Q15040 ELAVL1 JOSD1 0.126 19322201 Q15040 O00303 JOSD1 EIF3F 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EIF3F JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database TIMM8A JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database UBB JOSD1 MI:0362 inference MI:1106 pathways database UBC JOSD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM27 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP5-9 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-3 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-4 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-8 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database CALM1 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A JOSD1 MI:0362 inference MI:1106 pathways database UBA52 JOSD1 MI:0362 inference MI:1106 pathways database TRAF1 JOSD1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 KRT31 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 KRT40 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 NOTCH2NL MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 LNX1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 TRIM63 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 USP28 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 KRTAP9-2 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 TRIM54 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 MID2 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 STUB1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 USP15 MI:0045 experimental interaction detection MI:0461 interaction database