PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NF2 CCNB1IP1 16532029 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1 CCNB1IP1 12612082 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G APP CCNB1IP1 21832049 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L3 CCNB1IP1 12612082 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KEAP1 CCNB1IP1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KRT15 CCNB1IP1 25416956 biogrid,intact exp G G G G G G EPM2AIP1 CCNB1IP1 25416956,21516116 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKAA2 CCNB1IP1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 CCNB1IP1 25416956,12612082,16189514 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST1H1D CCNB1IP1 26186194 biogrid exp G G G G G CDK1 CCNB1IP1 12612082, 21836163 biogrid exp, pred G G G G G G G G G G G G G G C10orf82 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G PENK CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G C20orf85 CCNB1IP1 ortho G G G KIAA1731NL CCNB1IP1 ortho CCNB1IP1 HOOK1 ortho G G G G G G G G G G G G G G G G G G G G G G G GGN CCNB1IP1 ortho G PHF12 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATOH8 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO2 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 OAZ3 ortho G G G G G G G CCNB1IP1 POMP ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MPC2 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 B9D1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G MIIP CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ENAH CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G POLR2B CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G INSL3 CCNB1IP1 ortho G G G G G G G FAM213A CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MRRF CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCDC181 CCNB1IP1 ortho G G G G G G G G G G G G G EMX1 CCNB1IP1 ortho G G EP400 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 OCIAD1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MSL1 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FHL5 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G MORN2 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPATA3 CCNB1IP1 ortho G GSG1 CCNB1IP1 ortho G YPEL2 CCNB1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM11 CCNB1IP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 FZR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZC3HC1 CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3A CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNB1IP1 ARIH1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRSAM1 CCNB1IP1 21836163 pred G G G G G G G G G G G G G G G G UBOX5 CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G BRAP CCNB1IP1 21836163 pred G G G G G G G G G G G RNF25 CCNB1IP1 21836163 pred G G CDC25C CCNB1IP1 25402006 pred G G G G G G G LNX1 CCNB1IP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G RNF144B CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PTCH1 CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DMC1 CCNB1IP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G MYLIP CCNB1IP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF144A CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GADD45A CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARIH2 CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7L775 Q9NPC3 two hybrid 25416956 direct interaction X 2 Q9NPC3 Q9NPC3 enzymatic study 12612082 direct interaction X 2 Q9NPC3 Q9NPC3 two hybrid 25416956 direct interaction X 2 Q9NPC3 B7Z3D6 enzymatic study 12612082 direct interaction X 2 Q9NPC3 Q9NPC3 two hybrid 16189514 direct interaction X 2 P54646 Q9NPC3 two hybrid 25416956 direct interaction X 2 P0CG48 Q9NPC3 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9NPC3 affinity chromatography technology 21906983 physical association X 2 A0A024R1A4 Q9NPC3 two hybrid 12612082 direct interaction X 2 A0A024R1A4 Q9NPC3 pull down 12612082 direct interaction X 2 Q9NPC3 A0A024R1F6 affinity chromatography technology 16532029 physical association X 2 Q9NPC3 A0A024R1F6 affinity chromatography technology 16532029 physical association X 2 Q9NPC3 A0A024R1F6 two hybrid 16532029 direct interaction X 2 Q9NPC3 P05067-7 pull down 21832049 direct interaction X 2 Q9NPC3 P14635 two hybrid 12612082 direct interaction X 2 A0A024R7C0 Q9NPC3 two hybrid 25416956 direct interaction X 2 Q9NPC3 two hybrid 25416956 direct interaction X 2 Q9NPC3 P68036-3 two hybrid 12612082 - X 2 Q9NPC3 Q9NPC3 two hybrid 16189514 - X 2 Q9NPC3 P68036-3 two hybrid 12612082 - X 2 Q9NPC3 P14635 two hybrid 12612082 - X 2 Q9NPC3 P14635 two hybrid 12612082 - X 2 Q9NPC3 protein kinase assay 12612082 phosphorylation reaction C 3 Q9NPC3 pull down 12612082 association C 3 Q7L775 Q9NPC3 two hybrid prey pooling approach 25416956 physical association X 2 Q7L775 Q9NPC3 two hybrid array 25416956 physical association X 2 Q7L775 Q9NPC3 validated two hybrid 25416956 physical association X 2 Q9NPC3 P62972 pull down 12612082 physical association X 2 Q9NPC3 Q9NPC3 two hybrid pooling approach 16189514 physical association X 2 Q9NPC3 Q7CHH7 two hybrid pooling approach 20711500 physical association X 2 Q9NPC3 Q9NPC3 two hybrid array 25416956 physical association X 2 Q9NPC3 P19012 two hybrid prey pooling approach 25416956 physical association X 2 Q9NPC3 P19012 two hybrid array 25416956 physical association X 2 Q9NPC3 P19012 validated two hybrid 25416956 physical association X 2 P54646 Q9NPC3 two hybrid prey pooling approach 25416956 physical association X 2 P54646 Q9NPC3 two hybrid array 25416956 physical association X 2 P54646 Q9NPC3 validated two hybrid 25416956 physical association X 2 A0A024R1A4 Q9NPC3 two hybrid 12612082 physical association X 2 Q9NPC3 P14635 two hybrid 12612082 physical association X 2 A0A024R7C0 Q9NPC3 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R7C0 Q9NPC3 two hybrid array 25416956 physical association X 2 A0A024R7C0 Q9NPC3 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality HIST1H1D CCNB1IP1 26186194 0004 HT HIST1H1D CCNB1IP1 26186194 0004 HT CDK1 CCNB1IP1 12612082 0415 LC CCNB1 CCNB1IP1 12612082,12612082 0424,0018 LC KRT15 CCNB1IP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT NF2 CCNB1IP1 16532029,16532029 0018,0004 LC PRKAA2 CCNB1IP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2L3 CCNB1IP1 12612082,12612082 0096,0018 LC KEAP1 CCNB1IP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT EPM2AIP1 CCNB1IP1 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT CCNB1IP1 CCNB1IP1 12612082,16189514,25416956,25416956,16189514 0415,0398,0397,0018,0018 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NPC3 P05067 CCNB1IP1 APP 0.183 21832049 Q9NPC3 P14635 CCNB1IP1 CCNB1 0.539 12612082 Q9NPC3 P16402 CCNB1IP1 HIST1H1D 0.126 26186194 Q9NPC3 P25375 CCNB1IP1 PRD1 0.332 27107014 Q9NPC3 P54646 CCNB1IP1 PRKAA2 0.454 25416956 Q9NPC3 Q7CHH7 CCNB1IP1 Q7CHH7 0.126 20711500 Q9NPC3 P06493 CCNB1IP1 CDK1 0.309 12612082 Q9NPC3 P19012 CCNB1IP1 KRT15 0.454 25416956 Q9NPC3 Q93034 CCNB1IP1 CUL5 0.236 unassigned1304 Q9NPC3 Q7L775 CCNB1IP1 EPM2AIP1 0.554 25416956,21516116 Q9NPC3 Q96HA8 CCNB1IP1 WDYHV1 0.236 unassigned1304 Q9NPC3 Q9BSW7 CCNB1IP1 SYT17 0.236 unassigned1304 Q9NPC3 P68036 CCNB1IP1 UBE2L3 0.74 12612082 Q9NPC3 Q14145 CCNB1IP1 KEAP1 0.454 25416956 Q9NPC3 Q9NPC3 CCNB1IP1 CCNB1IP1 0.702 25416956,12612082,16189514 Q9NPC3 P35240 CCNB1IP1 NF2 0.569 16532029 Q9NPC3 P46379 CCNB1IP1 BAG6 0.21 24981174 Q9NPC3 P62972 CCNB1IP1 P62972 0.376 12612082

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MPC2 CCNB1IP1 MI:0362 inference MI:0461 interaction database PENK CCNB1IP1 MI:0362 inference MI:0461 interaction database APP CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database CDK1 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database SRGN CCNB1IP1 MI:0362 inference MI:0461 interaction database CCNB1 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H1D CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database KRT15 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database POLR2B CCNB1IP1 MI:0362 inference MI:0461 interaction database NF2 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database INSL3 CCNB1IP1 MI:0362 inference MI:0461 interaction database THOP1 CCNB1IP1 MI:0362 inference MI:0461 interaction database PRKAA2 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 CCNB1IP1 MI:0362 inference MI:0461 interaction database SUMO1 CCNB1IP1 MI:0362 inference MI:0461 interaction database UBE2L3 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database H3F3A CCNB1IP1 MI:0362 inference MI:0461 interaction database EMX1 CCNB1IP1 MI:0362 inference MI:0461 interaction database EMX2 CCNB1IP1 MI:0362 inference MI:0461 interaction database KEAP1 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database GSG1 CCNB1IP1 MI:0362 inference MI:0461 interaction database MORN2 CCNB1IP1 MI:0362 inference MI:0461 interaction database MIIP CCNB1IP1 MI:0362 inference MI:0461 interaction database FHL5 CCNB1IP1 MI:0362 inference MI:0461 interaction database CCDC181 CCNB1IP1 MI:0362 inference MI:0461 interaction database SAMD13 CCNB1IP1 MI:0362 inference MI:0461 interaction database MSL1 CCNB1IP1 MI:0362 inference MI:0461 interaction database SUMO4 CCNB1IP1 MI:0362 inference MI:0461 interaction database EPM2AIP1 CCNB1IP1 MI:0045 experimental interaction detection MI:0461 interaction database GGN CCNB1IP1 MI:0362 inference MI:0461 interaction database ENAH CCNB1IP1 MI:0362 inference MI:0461 interaction database SPATA3 CCNB1IP1 MI:0362 inference MI:0461 interaction database C10orf82 CCNB1IP1 MI:0362 inference MI:0461 interaction database MRRF CCNB1IP1 MI:0362 inference MI:0461 interaction database EP400 CCNB1IP1 MI:0362 inference MI:0461 interaction database CEP295NL CCNB1IP1 MI:0362 inference MI:0461 interaction database YPEL2 CCNB1IP1 MI:0362 inference MI:0461 interaction database PHF12 CCNB1IP1 MI:0362 inference MI:0461 interaction database ATOH8 CCNB1IP1 MI:0362 inference MI:0461 interaction database AKAP9 CCNB1IP1 MI:0362 inference MI:0461 interaction database FAM213A CCNB1IP1 MI:0362 inference MI:0461 interaction database NLN CCNB1IP1 MI:0362 inference MI:0461 interaction database C20orf85 CCNB1IP1 MI:0362 inference MI:0461 interaction database CCNB1IP1 OCIAD1 MI:0362 inference MI:0461 interaction database CCNB1IP1 HOOK1 MI:0362 inference MI:0461 interaction database CCNB1IP1 OAZ3 MI:0362 inference MI:0461 interaction database CCNB1IP1 B9D1 MI:0362 inference MI:0461 interaction database CCNB1IP1 POMP MI:0362 inference MI:0461 interaction database