PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRPC1 TRPC4AP 20458742 biogrid exp GP GP G P GP G GP GP G GP P GP G G GP GP GP P G P G GP G GP GP GP GP G SKP2 TRPC4AP 26038816 biogrid exp GP GP G G GP GP G GP GP G G GP GP G G GP GP G GP G GP G G G GP GP GP GP G MYH7B TRPC4AP 26496610 biogrid,intact exp G G G G TAB1 TRPC4AP 21900206 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP G GP G GP GP GP GP G TRPC4AP CHMP4C 16730941 hprd,biogrid exp GP GP P GP GP GP GP GP G GP P GP G GP G GP GP GP GP P G MYC TRPC4AP 20551172,26038816 biogrid exp GP GP G GP P G GP GP GP GP GP G G GP P GP GP GP G GP G GP GP GP GP G TRPC4AP TRPC5 20458742 biogrid exp P P P P P P P TRPC4AP TRPC4 20458742 biogrid exp PPP1CA TRPC4AP 19389623 intact exp GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G GP G GP GP GP GP G PRG2 TRPC4AP 26186194 biogrid exp G GP G G GP G G SRPR TRPC4AP 26496610 biogrid,intact exp G G G G G G G G G G G G G G G GP G G G G G G G G GP G GP G G CHUK TRPC4AP 14585990, 25402006 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G CUL4A TRPC4AP 20551172,21145461,16964240, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRADD TRPC4AP 14585990, 25402006, 21836163 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP G GP G G GP GP GP G TRPC4AP DDA1 20551172, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP G GP GP GP P G GP G GP G GP GP GP GP G TRPC4AP IKBKG 14585990, 25402006 innatedb,hprd,biogrid,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBX1 TRPC4AP 20551172, 25402006 biogrid exp, pred G G G G G GP G GP G G G G GP G G G GP G GP G GP G G G G G G GP G IKBKB TRPC4AP 14585990, 25402006 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G G GP G GP G GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRAF2 TRPC4AP 16876162,14585990, 25402006 innatedb,hprd,biogrid,mint,intact,bci exp, pred P P P P P P P P P P P P P P P P GP GP P TRPC4AP COPS5 21145461, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G RIPK1 TRPC4AP 14585990, 25402006 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TNFRSF1A TRPC4AP 20458742,14585990, 25402006 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G DDB1 TRPC4AP 19966799,20551172,26038816,16964240, 25402006 biogrid,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G PPM1B TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G RPS3 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP GP GP GP G AKT1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G DCAF11 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP ABCB9 16082366 pred P P G G GP GP G GP P G GP P P G G P GP P P G P P P P GP GP TRPC4AP PHIP 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP G GP G GP G GP GP G TRPC4AP NT5DC2 25402006 pred GP GP G GP G GP GP G GP P GP G G GP GP G P G GP G GP GP P GP GP G B2M TRPC4AP 16082366 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TAP1 TRPC4AP 16082366 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G HSPA8 TRPC4AP 25402006 pred P P P P P P P P P P P P P P TRPC4AP DTL 25402006 pred P P G GP P G P P G P GP P P G G G GP FANCA TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G TRPC4AP DCAF13 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP GP GP GP G TRPC4AP DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G PPP2R1A TRPC4AP 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP STUB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G NFKB1 TRPC4AP 25402006 pred GP G G G GP G G G GP G G G GP G G GP G G G G GP G GP G GP GP G GP G CASP8 TRPC4AP 25402006 pred GP GP G GP P GP GP GP GP GP G G GP P GP P G GP G GP GP GP GP GP G IRAK1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G DCAF6 TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TUBA3C, TUBA3D TRPC4AP 25402006 pred P P P P P P P P P P P P P TRPC4AP CDT1 25402006 pred P P G GP P GP GP P P P GP P GP GP G P P GP P GP P G TUBB TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TLE2 TRPC4AP 25402006 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G HLA-B TRPC4AP 16082366 pred CDKN1A TRPC4AP 25402006 pred GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G TRAF3 TRPC4AP 25402006 pred G GP G G GP GP G G G G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G TNFRSF1B TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP GP G GP G GP GP GP P G TRPC4AP VPRBP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G PARP1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP MAD1L1 25402006 pred GP P G P GP G P P P GP GP G G GP GP P P G P G P G GP GP P GP TRPC4AP TBK1 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP G GP G GP GP GP GP G CUL4B TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP G GP G GP GP GP GP G HSPA5 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G NLRC5 TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRPC4AP DDB2 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP G GP GP G GP GP G EIF2AK2 TRPC4AP 25402006 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G NF2 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G CCAR2 TRPC4AP 25402006 pred P P G P GP P GP G GP P P GP P P G P GP G P P P GP MAP3K7 TRPC4AP 25402006 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP G G G G G GP GP G TRPC4AP EDARADD 25402006 pred P P G GP P GP P P P GP P P GP G GP P P P GP P HLA-G TRPC4AP 16082366 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G G G CTNNB1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G MAP3K1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G SLC25A6 TRPC4AP 25402006 pred G GP G G GP GP G G G G GP GP G G G GP GP G GP G G G GP G GP G GP GP G CDC37 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G EEF1A2 TRPC4AP 25402006 pred G G GP G GP G G P P G G GP GP G P G G G G GP G G TRPC4AP TNFRSF25 25402006 pred G G G G G G G G G G G G G G G G G G G G G G CRIP2 TRPC4AP 25402006 pred GP G G GP G G GP G GP G GP G G G GP G GP G GP G GP G G G GP G G TRPC4AP CRBN 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRIM38 TRPC4AP 25402006 pred GP GP G GP P G GP GP GP GP GP G G GP GP GP GP GP G GP G GP GP GP P G DCAF8 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP CUEDC2 25402006 pred G G G G GP GP G G G G GP G GP G G GP GP G G G G G G G GP G G G G TRPC4AP RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G MTOR TRPC4AP 25402006 pred G GP G G G GP G G G G G G GP G G G GP G G G G G G G G G GP G G RPL23 TRPC4AP 25402006 pred P P P P P P P P P P P P P P P P P P P SLC15A2 TRPC4AP 16082366 pred G G G G G G G G G G G G G G G G G G G G G TNFAIP3 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G DNAJA1 TRPC4AP 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G FADD TRPC4AP 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP GP GP GP G TRPC4AP STAP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP GP GP G NFKB2 TRPC4AP 25402006 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G GP G GP GP GP GP G TRIM27 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G PFKL TRPC4AP 25402006 pred GP G G G GP GP G G GP G GP GP G G G GP GP G G G GP G GP G GP G GP GP G TRPC4AP TSC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G MYO1D TRPC4AP 25402006 pred G GP P GP G P GP G GP GP G G G GP GP G GP G GP G G GP GP GP P G ACTG1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G MAP3K11 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G BIRC2 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP GP GP GP G ATP6V0C TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRPC4AP TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAP2 TRPC4AP 16082366 pred G GP G G GP GP G G G G GP G GP G G GP GP G G G GP G G G GP GP G GP G C1QBP TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP G GP G GP GP GP GP G SLC25A3 TRPC4AP 25402006 pred G G G G G GP G GP GP G GP GP G G G GP GP G GP G GP G GP G GP G GP G G TRPC4AP DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G TRPC4AP FAF2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K8 TRPC4AP 25402006 pred GP GP G GP P G GP GP GP GP GP G G P P GP P GP G P GP GP GP P G PRKDC TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G HSPA1L TRPC4AP 25402006 pred GP P G G G G G G G G G G G G GP G HSPA9 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G FAS TRPC4AP 25402006 pred GP GP G G G GP G G GP GP G GP G G GP GP G GP G GP G G G GP G GP GP G WDTC1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G TRPC4AP ATAD3A 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G HSPB1 TRPC4AP 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP GP G GP G GP G GP G GP GP G ZER1 TRPC4AP 25402006 pred GP G G G G GP G GP GP G GP G G G G GP GP G G G GP G G G GP G GP G G RPS27 TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SLC15A3 TRPC4AP 16082366 pred GP G G G GP P G GP GP G GP G G GP GP G G GP GP GP GP P G RELA TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G DCAF7 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G MAVS TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G BIRC3 TRPC4AP 25402006 pred GP G GP G G GP P GP G G G GP G GP P G GP GP GP GP GP POLR2E TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRPC4AP COPS7B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G SRC TRPC4AP 25402006 pred GP GP G GP GP G G GP G G G G GP GP G G G G GP G GP GP GP GP G PRKCQ TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CA11 TRPC4AP 25402006 pred GP G G G GP GP G G GP G GP G G G G GP GP G GP G GP G G G GP GP GP GP G NFKBIB TRPC4AP 25402006 pred GP P G GP GP G GP P G GP GP GP G G GP GP P GP G GP G GP G GP GP GP GP G TUBB4A TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G GP GP GP GP G GP GP G GP GP GP GP G TRPC4AP RNF216 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRPC4AP DDIT4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G SLC15A4 TRPC4AP 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G ERCC8 TRPC4AP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IKBKAP TRPC4AP 25402006 pred GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP GP GP GP G DCAF17 TRPC4AP 25402006 pred G GP G G G GP G GP G G P G G G GP GP DCAF12 TRPC4AP 25402006 pred G G G G GP GP G G GP G G G GP G G GP GP GP GP G G G GP G GP GP GP G G RFWD2 TRPC4AP 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G SLC25A5 TRPC4AP 25402006 pred G GP G G GP GP G G G G GP GP G G G GP GP G GP G G G GP G GP G GP GP G TRPC4AP PELI1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TICAM1 TRPC4AP 25402006 pred GP GP G P G GP GP GP GP GP G G GP P GP GP GP G GP G GP GP GP P G CLTC TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP GP GP GP G CALM1, CALM2, CALM3 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G CAD TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G G GP GP GP GP G TRAF1 TRPC4AP 25402006 pred G G G G GP GP G G GP G GP G G G G G GP G G G G G G G GP G G G TRPC4AP COPS7A 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP G GP G GP GP GP GP G TNF TRPC4AP 25402006 pred G G G G G GP G G GP G G G GP G GP GP G GP G G G G GP G GP G G TIMM50 TRPC4AP 25402006 pred GP GP G P GP G GP GP G GP GP GP G G GP GP GP P G P G GP G GP GP GP GP G HSP90AB1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G NFKBIA TRPC4AP 25402006 pred G GP G G GP GP G GP GP G G G GP G G GP GP G GP G GP G GP G GP GP GP GP G RCN2 TRPC4AP 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP GP G HSP90AA1 TRPC4AP 25402006 pred GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G LGALS3BP TRPC4AP 25402006 pred GP G G G G GP G G GP G GP G GP G G GP GP GP GP G GP G G G GP G GP GP G DCAF10 TRPC4AP 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G G G G GP G G TRPC4AP AMBRA1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP G GP G GP G GP GP G TRPC4AP MAP3K3 25402006 pred G G G G GP GP G GP G G GP G GP G G GP GP G G G GP G G G GP GP GP G G PKN1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G CFLAR TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G NAP1L1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G UBXN7 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TRPC4AP DCAF16 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G G G GP G G G GP GP G DET1 TRPC4AP 25402006 pred G G G G GP GP G G G G G GP GP G G GP GP G GP G GP G G G GP G GP G G TRPC4AP NCOA3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8TEL6 two hybrid 19966799 direct interaction X 2 Q8TEL6 tandem affinity purification 20360068 physical association C 32 A8K6K3 Q8TEL6 two hybrid 21900206 physical association X 2 P62136 Q8TEL6 pull down 19389623 direct interaction X 2 P62136 Q8TEL6 far western blotting 19389623 physical association X 2 Q81JF5 Q8TEL6 two hybrid pooling approach 20711500 physical association X 2 A0A024R8H5 Q8TEL6 anti bait coimmunoprecipitation 16876162 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRPC4AP IKBKG MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14585990 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_87683|HPRD_5448 bait|- prey|- CUL4A TRPC4AP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16964240,20551172,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_122507|BIOGRID_202930|BIOGRID_150536 bait|bait|prey prey|prey|bait IKBKB TRPC4AP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14585990 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_87682|HPRD_12203 prey|- bait|- COPS5 TRPC4AP MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205624 bait prey TRADD TRPC4AP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14585990 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_87681|HPRD_12428 prey|- bait|- DDB1 TRPC4AP MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16964240,19966799,20551172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(biogrid) DIP_55179|BIOGRID_150535|BIOGRID_122480 -|prey|bait -|bait|prey TRAF2 TRPC4AP MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 14585990,16876162 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) UniProt_86960|BIOGRID_87685|BIOGRID_213693|MINT_49972|HPRD_10003|MINT_82258 bait|prey|bait|bait|-|bait prey|bait|prey|prey|-|prey TRPC4AP DDA1 MI:0004(affinity chromatography technology) 20551172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_150537 bait prey TAB1 TRPC4AP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_179570|UniProt_158972|BIOGRID_158323 bait|bait|bait prey|prey|prey TNFRSF1A TRPC4AP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 14585990,20458742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_211823|BIOGRID_87680|HPRD_4626|BIOGRID_87679 prey|bait|-|bait bait|prey|-|prey TRPC1 TRPC4AP MI:0004(affinity chromatography technology) 20458742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211817 prey bait CHUK TRPC4AP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14585990 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_87684|HPRD_7513 prey|- bait|- TRPC4AP TRPC5 MI:0004(affinity chromatography technology) 20458742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211819 bait prey PPP1CA TRPC4AP MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0047(far western blotting) 19389623 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact) UniProt_98374|UniProt_167885|UniProt_98464 bait|bait|bait prey|prey|prey RIPK1 TRPC4AP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14585990 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_87686|HPRD_12378 prey|- bait|- TRPC4AP TRPC4 MI:0004(affinity chromatography technology) 20458742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211818 bait prey RBX1 TRPC4AP MI:0004(affinity chromatography technology) 20551172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_150538 prey bait UBC TRPC4AP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18781797,21139048,21890473,21906983,21963094,21987572,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_223868|BIOGRID_162229|BIOGRID_163182|BIOGRID_172584|BIOGRID_174020|BIOGRID_166238|BIOGRID_268821|BIOGRID_181677 bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey TRPC4AP CHMP4C MI:0018(two hybrid)|MI:0492(in vitro) 16730941 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_210930|HPRD_36249 prey|- bait|- MYC TRPC4AP MI:0004(affinity chromatography technology) 20551172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_150534 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MYH7B TRPC4AP 26496610 0004 HT MYC TRPC4AP 26038816,20551172 0004,0004 LC SRPRA TRPC4AP 26496610 0004 HT PRG2 TRPC4AP 26186194 0004 HT TNFRSF1A TRPC4AP 20458742,14585990,14585990 0004,0096,0004 LC TRAF2 TRPC4AP 14585990,14585990,16876162,14585990,16876162 0059,0004,0004,0007,0006 LC TRIM32 TRPC4AP 27173435 0676 HT CUL4A TRPC4AP 16964240,21145461,20551172 0004,0004,0004 LC,HT DDB1 TRPC4AP 16964240,26038816,20551172 0004,0004,0004 LC TRPC4AP COPS5 21145461 0004 HT MYH7B TRPC4AP 26496610 0004 HT SRPRA TRPC4AP 26496610 0004 HT PRG2 TRPC4AP 26186194 0004 HT TRIM32 TRPC4AP 27173435 0676 HT CUL4A TRPC4AP 21145461 0004 HT TRPC4AP COPS5 21145461 0004 HT MYC TRPC4AP 26038816,20551172 0004,0004 LC TNFRSF1A TRPC4AP 20458742,14585990,14585990 0004,0096,0004 LC TRAF2 TRPC4AP 14585990,14585990,16876162,14585990,16876162 0059,0004,0004,0007,0006 LC CUL4A TRPC4AP 16964240,20551172 0004,0004 LC DDB1 TRPC4AP 16964240,26038816,20551172 0004,0004,0004 LC MAP3K7IP1 TRPC4AP 21900206 0018 HT IKBKB TRPC4AP 14585990,14585990,14585990 0059,0004,0007 LC CHUK TRPC4AP 14585990,14585990,14585990 0059,0004,0007 LC CHMP2A TRPC4AP 16730941 0018 LC PPP1CA TRPC4AP 19389623,19389623 0096,0047 LC TRAF2 TRPC4AP 14585990,14585990,14585990 0059,0004,0007 LC RIPK1 TRPC4AP 14585990,14585990,14585990 0059,0004,0007 LC TRADD TRPC4AP 14585990,14585990,14585990 0059,0004,0007 LC TAB1 TRPC4AP 21900206 0018 HT DDB1 TRPC4AP 19966799 0018 LC CHMP1B TRPC4AP 16730941 0018 LC TRPC4AP CHMP4C 16730941 0018 LC TRPC4AP CHMP6 16730941 0018 LC TRPC4AP CHMP5 16730941 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8TEL6 P62139 TRPC4AP PPP1CA 0.126 19389623 Q8TEL6 O14920 TRPC4AP IKBKB 0.21 14585990 Q8TEL6 O15111 TRPC4AP CHUK 0.21 14585990 Q8TEL6 O43633 TRPC4AP CHMP2A 0.183 16730941 Q8TEL6 P01106 TRPC4AP MYC 0.376 20551172,26038816 Q8TEL6 P19438 TRPC4AP TNFRSF1A 0.569 14585990,20458742 Q8TEL6 P48995 TRPC4AP TRPC1 0.21 20458742 Q8TEL6 P62877 TRPC4AP RBX1 0.21 20551172 Q8TEL6 Q13546 TRPC4AP RIPK1 0.21 14585990 Q8TEL6 Q13619 TRPC4AP CUL4A 0.396 16964240,21145461,20551172 Q8TEL6 Q15628 TRPC4AP TRADD 0.21 14585990 Q8TEL6 Q81JF5 TRPC4AP Q81JF5 0.126 20711500 Q9BW61 Q8TEL6 DDA1 TRPC4AP 0.21 20551172 Q9UBN4 Q8TEL6 TRPC4 TRPC4AP 0.21 20458742 Q9UL62 Q8TEL6 TRPC5 TRPC4AP 0.21 20458742 Q9WH76 Q8TEL6 M TRPC4AP 0.309 25944354 Q9Y6K9 Q8TEL6 IKBKG TRPC4AP 0.21 14585990 Q9NZZ3 Q8TEL6 CHMP5 TRPC4AP 0.183 16730941 Q9Y6Y8 Q8TEL6 SEC23IP TRPC4AP 0.126 unassigned1312 Q8TEL6 P08240 TRPC4AP SRPR 0.126 26496610 Q8TEL6 Q7LBR1 TRPC4AP CHMP1B 0.183 16730941 Q8TEL6 P13727 TRPC4AP PRG2 0.126 26186194 Q96CF2 Q8TEL6 CHMP4C TRPC4AP 0.332 16730941 Q8TEL6 Q15750 TRPC4AP TAB1 0.332 21900206 Q8TEL6 Q3U1J4 TRPC4AP DDB1 0.236 20360068 Q92905 Q8TEL6 COPS5 TRPC4AP 0.126 21145461 Q96FZ7 Q8TEL6 CHMP6 TRPC4AP 0.183 16730941 Q8TEL6 Q13309 TRPC4AP SKP2 0.376 26038816 Q8TEL6 Q12933 TRPC4AP TRAF2 0.507 14585990,16876162 Q8TEL6 Q13509 TRPC4AP TUBB3 0.126 27291054 Q8TEL6 Q13049 TRPC4AP TRIM32 0.236 27173435,unassigned1312 Q8TEL6 A7E2Y1 TRPC4AP MYH7B 0.126 26496610 Q8TEL6 Q16531 TRPC4AP DDB1 0.623 16964240,19966799,20551172,26038816

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYH7B TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database IKBKB TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database CHUK TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database CHMP2A TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database MYC TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database SRPRA TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database UBC TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database PRG2 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF1A TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database HNF4A TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TRPC1 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database PPP1CA TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database RBX1 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TRIM32 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database SKP2 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TUBB3 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database RIPK1 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database CUL4A TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TRADD TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TAB1 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database DDB1 TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database CHMP1B TRPC4AP MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP COPS5 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP CHMP4C MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP CHMP6 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP DDA1 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP CHMP5 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP ONECUT1 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP TRPC4 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP TRPC5 MI:0045 experimental interaction detection MI:0461 interaction database TRPC4AP IKBKG MI:0045 experimental interaction detection MI:0461 interaction database