PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBA1 POLI 25260751 intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G UBA52 POLI 16763556 hprd exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G APP POLI 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G G GP G GP G G G G G G G GP G POLI RNF11 15231748 hprd,biogrid,i2d,mint,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G ZBTB44 POLI 25416956 biogrid,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G UBE2N POLI 25260751 intact exp G GP G G GP GP G GP GP G GP GP G G G G GP G GP G G G G P G G GP GP G CALCOCO2 POLI 16189514 hprd,biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G TRIM23 POLI 19060904 biogrid,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G XRCC1 POLI 18923427 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G TRIM39 POLI 25416956,21516116 biogrid,mint,intact exp P P P P P P P P P POLI TRAF6 25416956 biogrid,intact exp G GP G G GP G G GP GP G GP GP G G G G G GP G G G G G G G GP GP G DVL2 POLI 16189514 hprd,biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G UBE2V1 POLI 25260751 intact exp DAZAP2 POLI 19060904,16189514 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMEM239 POLI 25416956 biogrid,intact exp G G G G G G G G G UBB POLI 16763556 hprd,biogrid exp G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G UBC POLI 23248005,16763556,20159559 biogrid,mint,intact exp, ortho G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G REV1 POLI 19170759,15189446, 25402006, 21836163 hprd,biogrid,i2d exp, ortho, pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G POLI POLH 23248005,12426396,12606586,16763556, 25402006, 21836163 hprd,biogrid exp, pred G G G G GP GP G GP GP G GP P G G GP GP G G G P G G GP GP PCNA POLI 23248005,11724965,18931444,15342632,16763556, 25402006 hprd,biogrid,mint,intact exp, pred G GP G G GP G G G GP G GP G G G G G G G GP G G G G G G GP GP G GNL3 POLI 21836163 pred GP P P P P P P G G P P GP G G P P P MINA POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G SHPRH POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G TRIM29 POLI 25402006 pred G G G G G GP G G G G G G G G G GP G GP G G G G G G G G G POLI RUVBL1 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G G GP GP G NOP56 POLI 21836163 pred P P P P P FBL POLI 21836163 pred G GP G G G GP G G GP G GP G G G G G GP GP GP G G G G P G G GP GP G POLI RUVBL2 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G UBE2B POLI 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LASP1 POLI 25402006 pred G G G G GP GP G G GP G GP GP G G G G GP GP GP G G G G G G GP G G BAAT POLI 21836163 pred P P P GP P P P POLI PUS1 21836163 pred G GP G G GP GP P GP G GP GP G G G G GP G P G G G P G G GP GP G PHAX POLI 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPP30 POLI 21836163 pred G GP G G GP GP G G GP G GP G G G G G GP G G G G G G G G GP GP G LEF1 POLI 25402006 pred G G G G GP GP G GP G GP G G G G GP G G G G G G G G G G SPP1 POLI 21836163 pred G GP G G GP G G G GP G GP G G G G G G GP GP G G G G P G GP G GEMIN2 POLI 21836163 pred G G G G GP GP G GP GP G G G G G G G GP GP GP G G G G G G GP GP G TCF7L2 POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G POLK POLI 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G DKC1 POLI 21836163 pred P P P P P P P P P P P P P ZC3H10 POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP G GP G G G G P G G GP GP G RAD18 POLI 25402006, 21836163 pred P P P P G P G G P POLQ POLI 25402006 pred G GP G GP GP G P GP G GP P G G G G GP GP P G G G P G G GP GP G ADARB1 POLI 21836163 pred G GP G G G GP G GP GP G GP GP G G G G GP GP P G G G P G G GP P G PLCD1 POLI 21836163 pred G GP G G G GP G G GP G GP GP G G G G GP GP GP G G G G G G GP GP G PHB POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G POP1 POLI 21836163 pred G G G G G G G G G G G G G G G G G G G RAD9A POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G G G GP GP G PSMA1 POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G RRP9 POLI 21836163 pred P P P P G G P P P P TCF7L1 POLI 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBTF POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G RPIA POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G CYTH1 POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G G G GP GP G GAR1 POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G RPP14 POLI 21836163 pred G GP G G G GP G GP GP G GP GP G G G G GP GP GP G G G G G G GP GP G TRIM31 POLI 25402006 pred P G GP P GP P P P P GP P P GP P TRIM31 POLI 25402006 pred P G GP P GP P P P P GP P P GP P GEM POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP G GP G G G G P G G GP GP G ASGR2 POLI 21836163 pred G G GP G NOLC1 POLI 21836163 pred G G G G G GP G G GP G G GP G G G G GP G G G G G G G G GP GP G TROAP POLI 25402006 pred G GP G G GP GP G GP GP G GP G G G G G GP GP GP G G G G P G G GP GP G DEPP POLI 25402006 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G P G G G GP G IGF2BP3 POLI 21836163 pred P P GP P P P P P P G P GP G FHL2 POLI 25402006 pred G GP G G GP GP G GP GP GP GP G G G G GP GP G G G G G P G G GP GP G EXOSC10 POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G DDX21 POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP G GP G G G G P G G GP GP G DDX20 POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G POLI NOP58 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G BATF2 POLI 25402006 pred G GP G G P G G GP GP GP G G G G P GP GP G G G P G G GP P G RPP40 POLI 21836163 pred G GP G G GP GP G G GP G GP G G G G G GP GP GP G G G G G G GP GP G MAD2L2 POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G G G GP GP G MPHOSPH10 POLI 21836163 pred G GP G G G GP G G GP G G G G G G G GP GP G G G G G G G GP GP NHP2 POLI 21836163 pred G GP G G G GP G G GP G GP G G G G G GP GP GP G G G G G G GP GP G NCL POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G FEN1 POLI 21836163 pred G GP G G GP GP G G GP G GP GP G G G G GP GP GP G G G G G G GP GP G ADAR POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G G G GP GP G FAM46B POLI 25402006 pred G G G G G G G G G G G G G G G G GEMIN4 POLI 21836163 pred G G G G G G G G G G G G G G G G G G G G G G COIL POLI 21836163 pred G GP G G G GP G GP GP G GP GP G G G G GP G GP G G G G P G G GP GP G ALKBH1 POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G ZFAND2B POLI 25402006 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q13137 Q9UNA4 two hybrid 16189514 direct interaction X 2 P18887 Q9UNA4 affinity chromatography technology 18923427 physical association X 2 P18887 Q9UNA4 affinity chromatography technology 18923427 physical association X 2 A0A024RD62 Q9UNA4 two hybrid 12606586 direct interaction X 2 A0A024RD62 Q9UNA4 far western blotting 12606586 direct interaction X 2 A0A024RD62 Q9UNA4 two hybrid 23248005 direct interaction X 2 A0A024RD62 Q9UNA4 far western blotting 23248005 direct interaction X 2 A0A024RD62 Q9UNA4 affinity chromatography technology 23248005 physical association X 2 Q9UNA4 two hybrid 15189446 direct interaction X 2 Q9UNA4 two hybrid 19170759 direct interaction X 2 Q9UNA4 pull down 19170759 direct interaction X 2 Q9UNA4 P05067-7 pull down 21832049 direct interaction X 2 Q9UNA4 P36406 two hybrid 19060904 direct interaction X 2 Q9UNA4 Q8NCP5 two hybrid 25416956 direct interaction X 2 O14641 Q9UNA4 two hybrid 16189514 direct interaction X 2 Q15038-2 Q9UNA4 two hybrid 19060904 direct interaction X 2 Q15038-2 Q9UNA4 two hybrid 16189514 direct interaction X 2 Q9UNA4 two hybrid 25416956 direct interaction X 2 Q9UNA4 Q9Y4K3 two hybrid 25416956 direct interaction X 2 Q9UNA4 A0A024RCP5 two hybrid 25416956 direct interaction X 2 P0CG48 Q9UNA4 two hybrid 16763556 direct interaction X 2 P0CG48 Q9UNA4 two hybrid 16763556 direct interaction X 2 P0CG48 Q9UNA4 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9UNA4 far western blotting 23248005 direct interaction X 2 P0CG48 Q9UNA4 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9UNA4 x-ray crystallography 20159559 association X 2 P0CG48 Q9UNA4 pull down 16763556 direct interaction X 2 P0CG48 Q9UNA4 far western blotting 23248005 direct interaction X 2 P0CG48 Q9UNA4 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9UNA4 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9UNA4 affinity chromatography technology 21906983 physical association X 2 Q9Y3C5 Q9UNA4 two hybrid 15231748 direct interaction X 2 P12004 Q9UNA4 two hybrid 16763556 direct interaction X 2 P12004 Q9UNA4 x-ray crystallography 18931444 association X 2 P12004 Q9UNA4 two hybrid 15342632 direct interaction X 2 P12004 Q9UNA4 affinity chromatography technology 15342632 physical association X 2 P12004 Q9UNA4 biochemical 11724965 colocalization X 2 P12004 Q9UNA4 far western blotting 23248005 direct interaction X 2 P12004 Q9UNA4 affinity chromatography technology 23248005 physical association X 2 P0CG47 Q9UNA4 two hybrid 16763556 direct interaction X 2 Q13137 Q9UNA4 two hybrid 16189514 - X 2 Q13137 Q9UNA4 two hybrid 16189514 - X 2 A0A024RD62 Q9UNA4 in vitro 12426396,12606586,16763556 - X 2 A0A024RD62 Q9UNA4 two hybrid 12426396,12606586,16763556 - X 2 A0A024RD62 Q9UNA4 in vivo 12426396,12606586,16763556 - X 2 A0A024RD62 Q9UNA4 in vivo 12426396,12606586,16763556 - X 2 A0A024RD62 Q9UNA4 in vitro 12426396,12606586,16763556 - X 2 A0A024RD62 Q9UNA4 two hybrid 12426396,12606586,16763556 - X 2 Q15038-3 Q9UNA4 two hybrid 16189514 - X 2 Q15038-3 Q9UNA4 two hybrid 16189514 - X 2 O14641 Q9UNA4 two hybrid 16189514 - X 2 O14641 Q9UNA4 two hybrid 16189514 - X 2 Q9UBZ9-2 Q9UNA4 two hybrid 15189446,19170759 - X 2 Q9UBZ9-2 Q9UNA4 two hybrid 15189446,19170759 - X 2 Q9UNA4 P62987 two hybrid 16763556 - X 2 Q9UNA4 P62987 two hybrid 16763556 - X 2 Q9Y3C5 Q9UNA4 two hybrid 15231748 - X 2 Q9Y3C5 Q9UNA4 two hybrid 15231748 - X 2 P12004 Q9UNA4 two hybrid 16763556 - X 2 P12004 Q9UNA4 in vitro 16763556 - X 2 P12004 Q9UNA4 two hybrid 16763556 - X 2 P12004 Q9UNA4 in vitro 16763556 - X 2 P0CG47 Q9UNA4 two hybrid 16763556 - X 2 P0CG47 Q9UNA4 two hybrid 16763556 - X 2 Q13137 Q9UNA4 two hybrid pooling approach 16189514 physical association X 2 P18887 Q9UNA4 anti tag coimmunoprecipitation 18923427 physical association X 2 P18887 Q9UNA4 anti tag coimmunoprecipitation 18923427 physical association X 2 A0A024R110 Q9UNA4 two hybrid pooling approach 16189514 physical association X 2 A0A024R110 Q9UNA4 two hybrid array 19060904 physical association X 2 A0A024R110 Q9UNA4 two hybrid pooling approach 19060904 physical association X 2 Q8WW34 Q9UNA4 two hybrid prey pooling approach 25416956 physical association X 2 Q8WW34 Q9UNA4 two hybrid array 25416956 physical association X 2 Q8WW34 Q9UNA4 validated two hybrid 25416956 physical association X 2 Q9UNA4 P36406 two hybrid array 19060904 physical association X 2 Q9UNA4 P36406 two hybrid pooling approach 19060904 physical association X 2 Q9UNA4 Q8NCP5 two hybrid prey pooling approach 25416956 physical association X 2 Q9UNA4 Q8NCP5 two hybrid array 25416956 physical association X 2 Q9UNA4 Q8NCP5 validated two hybrid 25416956 physical association X 2 Q9UNA4 ubiquitinase assay 25260751 ubiquitination reaction C 4 Q6FI35 Q9UNA4 pull down 16763556 direct interaction X 2 Q6FI35 Q9UNA4 two hybrid 16763556 physical association X 2 O14641 Q9UNA4 two hybrid pooling approach 16189514 physical association X 2 Q9UNA4 A0A024RCP5 two hybrid 21516116 physical association X 2 Q9UNA4 A0A024RCP5 two hybrid prey pooling approach 25416956 physical association X 2 Q9UNA4 Q9Y4K3 two hybrid prey pooling approach 25416956 physical association X 2 Q9UNA4 A0A024RCP5 two hybrid array 25416956 physical association X 2 Q9UNA4 Q9Y4K3 two hybrid array 25416956 physical association X 2 Q9UNA4 A0A024RCP5 validated two hybrid 25416956 physical association X 2 Q9UNA4 Q9Y4K3 validated two hybrid 25416956 physical association X 2 P0CG48 Q9UNA4 two hybrid 16763556 physical association X 2 P0CG48 Q9UNA4 two hybrid 16763556 physical association X 2 P0CG48 Q9UNA4 pull down 16763556 direct interaction X 2 P0CG48 Q9UNA4 two hybrid 16763556 physical association X 2 Q9Y3C5 Q9UNA4 two hybrid 15231748 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBB POLI MI:0018(two hybrid) 16763556 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_190106 prey bait POLI POLH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 12426396,12606586,23248005 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_192208|BIOGRID_192209|BIOGRID_247477|BIOGRID_247474|BIOGRID_247473|HPRD_30925 bait|bait|bait|bait|bait|- prey|prey|prey|prey|prey|- POLI RNF11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd) BIOGRID_259446|MINT_31445|MINT_60210|UniProt_78534|HPRD_37704 prey|prey|prey|prey|- bait|bait|bait|bait|- UBC POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 16763556,21139048,21890473,21906983,22505724,23000965,23248005 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid) BIOGRID_190109|BIOGRID_190107|MINT_49493|MINT_81718|MINT_81709|MINT_49494|BIOGRID_175851|UniProt_87277|UniProt_87287|BIOGRID_177690|UniProt_87290|MINT_81700|UniProt_87278|MINT_81699|BIOGRID_268779|BIOGRID_247475|BIOGRID_223396|MINT_49503|MINT_49510|BIOGRID_190114|BIOGRID_168305 bait|prey|prey|prey|prey|bait|bait|prey|prey|bait|prey|bait|bait|prey|bait|prey|bait|prey|prey|prey|bait prey|bait|bait|bait|bait|prey|prey|bait|bait|prey|bait|prey|prey|bait|prey|bait|prey|bait|bait|bait|prey TRIM23 POLI MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_99236|UniProt_97062|BIOGRID_262427 prey|prey|prey bait|bait|bait UBA52 POLI MI:0018(two hybrid) 16763556 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_32421 - - TRIM39 POLI MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114850 prey bait REV1 POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15189446,19170759 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_16231|BIOGRID_216658|BIOGRID_216662|BIOGRID_192203 -|bait|bait|prey -|prey|prey|bait XRCC1 POLI MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10,18923427 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) UniProt_98171|MINT_44095|UniProt_98170|BIOGRID_192194|BIOGRID_192193|MINT_74383|MINT_44097|MINT_74381 bait|prey|prey|bait|prey|bait|bait|prey prey|bait|bait|prey|bait|prey|prey|bait PCNA POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16763556 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_87280|MINT_49499|MINT_81704|MINT_81705|MINT_49498|UniProt_87289 prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait DVL2 POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint)|(biogrid) MINT_65993|HPRD_21924|UniProt_151628|MINT_36833|BIOGRID_78774 bait|-|unspecified role|bait|bait prey|-|unspecified role|prey|prey CALCOCO2 POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint) BIOGRID_80016|MINT_67452|UniProt_152860|HPRD_22882|MINT_38269 bait|bait|unspecified role|-|bait prey|prey|unspecified role|-|prey APP POLI MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228847 prey bait DAZAP2 POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array) 16189514,19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid)|(intact) MINT_66465|MINT_37284|UniProt_99237|UniProt_151914|BIOGRID_79064|HPRD_23178|BIOGRID_262372|UniProt_97063 bait|bait|prey|unspecified role|bait|-|prey|prey prey|prey|bait|unspecified role|prey|-|bait|bait NRF1 POLI MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295643 bait prey uniprotkb:(gene name) POLI MI:0018(two hybrid) 16763556 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_32422 - - PCNA POLI MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0401(biochemical) 11724965,15342632,16763556,18931444,23248005 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_190108|BIOGRID_192196|BIOGRID_192195|HPRD_32433|BIOGRID_192192|BIOGRID_247478|BIOGRID_247476|BIOGRID_192210 prey|bait|bait|-|bait|prey|prey|bait bait|prey|prey|-|prey|bait|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality UBC POLI 16763556,16763556,16763556 0096,0018,0004 LC PCNA POLI 16763556,15342632,15342632,23248005,23248005,16763556,11724965 0096,0018,0004,0047,0004,0018,0401 LC UBC POLI 16763556,16763556,16763556 0096,0018,0004 LC PCNA POLI 16763556,15342632,15342632,23248005,23248005,16763556,11724965 0096,0018,0004,0047,0004,0018,0401 LC DVL2 POLI 16189514,16189514 0398,0018 HT UBB POLI 24789524,16763556 0114,0018 LC UBC POLI 20159559,16763556,23248005,16763556,PDB_2KHW,16763556 0114,0096,0047,0018,0114,0004 LC PCNA POLI 16763556,15342632,15342632,23248005,23248005,16763556,11724965,18931444 0096,0018,0004,0047,0004,0018,0401,0114 LC UBA1 POLI 25260751 0997 LC TRIM23 POLI 19060904,19060904,19060904 0018,0397,0398 HT MTNR1B POLI 26514267 0112 LC UBE2N POLI 25260751 0997 LC RPS27A POLI 21049971 0114 LC UBA52 POLI 16763556 0018 LC CALCOCO2 POLI 16189514,16189514 0398,0018 HT UBE2V1 POLI 25260751 0997 LC DAZAP2 POLI 19060904,16189514,16189514,19060904,19060904 0018,0398,0018,0397,0398 HT Q7Z4P3 POLI 16763556 0018 LC ZBTB44 POLI 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TMEM239 POLI 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM39 POLI 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT REV1 POLI 19170759,15189446,19170759 0096,0018,0018 LC POLI POLI 15254543,19440206 0114,0114 LC POLI POLH 12606586,23248005,23248005,16763556,23248005,12606586,12426396 0018,0047,0004,0018,0018,0047,0018 LC POLI RNF11 15231748 0018 HT POLI TRAF6 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UNA4 Q9NSC5 POLI HOMER3 0.236 unassigned1304 Q9UNA4 Q15038 POLI DAZAP2 0.554 19060904,16189514 Q9UNA4 Q8NCP5 POLI ZBTB44 0.454 25416956 Q9UNA4 Q6FI35 POLI PCNA 0.523 16763556 Q9UNA4 P0CG48 POLI UBC 0.925 23248005,20159559,16763556 Q9UNA4 Q9HCM9 POLI TRIM39 0.636 21516116,25416956 Q9UNA4 P12004 POLI PCNA 0.876 23248005,15342632,18931444,11724965,16763556 Q9Y253 Q9UNA4 POLH POLI 0.82 23248005,12606586 Q9UNA4 O14641 POLI DVL2 0.286 16189514 Q9UNA4 P05067 POLI APP 0.183 21832049 Q9UNA4 P0CG47 POLI UBB 0.309 16763556 Q9UNA4 P22314 POLI UBA1 0.033 25260751 Q9UNA4 P36406 POLI TRIM23 0.376 19060904 Q9UNA4 P49286 POLI MTNR1B 0.126 26514267 Q9UNA4 P61088 POLI UBE2N 0.033 25260751 Q9UNA4 Q13137 POLI CALCOCO2 0.286 16189514 Q9UNA4 Q13404 POLI UBE2V1 0.033 25260751 Q9UNA4 Q8WW34 POLI TMEM239 0.454 25416956 Q9UNA4 Q9UBZ9 POLI REV1 0.671 15189446,19170759 Q9Y3C5 Q9UNA4 RNF11 POLI 0.332 15231748 Q9Y4K3 Q9UNA4 TRAF6 POLI 0.454 25416956 Q9UNA4 P18887 POLI XRCC1 0.507 18923427

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DVL2 POLI MI:0045 experimental interaction detection MI:0461 interaction database UBE2L6 POLI MI:0362 inference MI:1106 pathways database REV3L POLI MI:0362 inference MI:1106 pathways database APP POLI MI:0045 experimental interaction detection MI:0461 interaction database ISG15 POLI MI:0362 inference MI:1106 pathways database UBB POLI MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC POLI MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PCNA POLI MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPA2 POLI MI:0362 inference MI:1106 pathways database XRCC1 POLI MI:0045 experimental interaction detection MI:0461 interaction database TAF1 POLI MI:0045 experimental interaction detection MI:0461 interaction database UBA1 POLI MI:0045 experimental interaction detection MI:0461 interaction database RPA1 POLI MI:0362 inference MI:1106 pathways database RPA3 POLI MI:0362 inference MI:1106 pathways database RFC4 POLI MI:0362 inference MI:1106 pathways database RFC2 POLI MI:0362 inference MI:1106 pathways database RFC1 POLI MI:0362 inference MI:1106 pathways database TRIM23 POLI MI:0045 experimental interaction detection MI:0461 interaction database RFC5 POLI MI:0362 inference MI:1106 pathways database RFC3 POLI MI:0362 inference MI:1106 pathways database UBA7 POLI MI:0362 inference MI:1106 pathways database PXN POLI MI:0362 inference MI:0461 interaction database MTNR1B POLI MI:0045 experimental interaction detection MI:0461 interaction database UBE2N POLI MI:0045 experimental interaction detection MI:0461 interaction database RPS27A POLI MI:0362 inference MI:1106 pathways database UBA52 POLI MI:0362 inference MI:1106 pathways database CALCOCO2 POLI MI:0045 experimental interaction detection MI:0461 interaction database MAD2L1 POLI MI:0362 inference MI:0461 interaction database UBE2V1 POLI MI:0045 experimental interaction detection MI:0461 interaction database CUL3 POLI MI:0362 inference MI:0461 interaction database TRIM25 POLI MI:0362 inference MI:1106 pathways database USP10 POLI MI:0362 inference MI:1106 pathways database DAZAP2 POLI MI:0045 experimental interaction detection MI:0461 interaction database PPP2R5A POLI MI:0362 inference MI:0461 interaction database PPP2R5E POLI MI:0362 inference MI:0461 interaction database ZBTB44 POLI MI:0045 experimental interaction detection MI:0461 interaction database TMEM239 POLI MI:0045 experimental interaction detection MI:0461 interaction database TRAIP POLI MI:0362 inference MI:0461 interaction database TRIM39 POLI MI:0045 experimental interaction detection MI:0461 interaction database POLK POLI MI:0362 inference MI:1106 pathways database REV1 POLI MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MAD2L2 POLI MI:0362 inference MI:1106 pathways database POLI POLH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database POLI RNF11 MI:0045 experimental interaction detection MI:0461 interaction database POLI TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database