PTM - CPLM Gene Name UniProt ID Type Position Code USP11; UHX1 P51784 Acetylation 245 K USP11; UHX1 P51784 Ubiquitination 107 K USP11; UHX1 P51784 Ubiquitination 245 K USP11; UHX1 P51784 Ubiquitination 355 K USP11; UHX1 P51784 Ubiquitination 367 K USP11; UHX1 P51784 Ubiquitination 531 K USP11; UHX1 P51784 Ubiquitination 714 K USP11; UHX1 P51784 Ubiquitination 806 K USP11; UHX1 P51784 Ubiquitination 835 K USP11; UHX1 P51784 Ubiquitination 840 K USP11; UHX1 P51784 Ubiquitination 920 K USP11; UHX1 P51784 Ubiquitination 447 K USP11; UHX1 P51784 Ubiquitination 766 K USP11; UHX1 P51784 Ubiquitination 896 K USP11; UHX1 P51784 Ubiquitination 813 K USP11; UHX1 P51784 Ubiquitination 776 K USP11; UHX1 P51784 Ubiquitination 385 K USP11; UHX1 P51784 Ubiquitination 493 K USP11; UHX1 P51784 Ubiquitination 753 K USP11; UHX1 P51784 Ubiquitination 519 K USP11; UHX1 P51784 Ubiquitination 521 K USP11; UHX1 P51784 Ubiquitination 182 K USP11; UHX1 P51784 Ubiquitination 191 K USP11; UHX1 P51784 Ubiquitination 383 K USP11; UHX1 P51784 Ubiquitination 752 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP11; UHX1 P51784 195 Y Homo sapiens(Human) USP11; UHX1 P51784 268 T Homo sapiens(Human) USP11; UHX1 P51784 276 T Homo sapiens(Human) USP11; UHX1 P51784 31 S Homo sapiens(Human) USP11; UHX1 P51784 33 S Homo sapiens(Human) USP11; UHX1 P51784 396 Y Homo sapiens(Human) USP11; UHX1 P51784 452 S Homo sapiens(Human) USP11; UHX1 P51784 584 S Homo sapiens(Human) USP11; UHX1 P51784 593 Y Homo sapiens(Human) USP11; UHX1 P51784 606 S Homo sapiens(Human) USP11; UHX1 P51784 607 Y Homo sapiens(Human) USP11; UHX1 P51784 608 Y Homo sapiens(Human) USP11; UHX1 P51784 642 Y Homo sapiens(Human) USP11; UHX1 P51784 644 T Homo sapiens(Human) USP11; UHX1 P51784 648 S Homo sapiens(Human) USP11; UHX1 P51784 671 S Homo sapiens(Human) USP11; UHX1 P51784 672 T Homo sapiens(Human) USP11; UHX1 P51784 675 S Homo sapiens(Human) USP11; UHX1 P51784 731 T Homo sapiens(Human) USP11; UHX1 P51784 733 S Homo sapiens(Human) USP11; UHX1 P51784 742 Y Homo sapiens(Human) USP11; UHX1 P51784 923 Y Homo sapiens(Human) USP11; UHX1 P51784 938 S Homo sapiens(Human) USP11; UHX1 P51784 942 S Homo sapiens(Human) USP11; UHX1 P51784 943 S Homo sapiens(Human) USP11; UHX1 P51784 948 S Homo sapiens(Human) USP11; UHX1 P51784 952 S Homo sapiens(Human) USP11; UHX1 P51784 953 S Homo sapiens(Human) USP11; UHX1 P51784 956 S Homo sapiens(Human) USP11; UHX1 P51784 957 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P51784 K245-ac Acetylation EDTrLWAkNSEGSLD P51784 R241-m1 Methylation VEPQEDTrLWAkNSE P51784 K383-m1 Methylation SIVPHVFkNKVGHFA P51784 R677-m1 Methylation PstGGsLrDPEPEQA P51784 S31-p Phosphorylation VEGRLPIsHsCVGCR P51784 S33-p Phosphorylation GRLPIsHsCVGCRRE P51784 Y195-p Phosphorylation NIQKVEVyPVELLLV P51784 T268-p Phosphorylation VLDAALEtGQLIIME P51784 T276-p Phosphorylation GQLIIMEtRKKDGTW P51784 Y396-p Phosphorylation FASQFLGyQQHDSQE P51784 S452-p Phosphorylation NHkRRNDsVIVDTFH P51784 S584-p Phosphorylation RIEAIEGsREDIVVP P51784 Y593-p Phosphorylation EDIVVPVyLRERTPA P51784 S606-p Phosphorylation PARDYNNsyyGLMLF P51784 Y607-p Phosphorylation ARDYNNsyyGLMLFG P51784 Y608-p Phosphorylation RDYNNsyyGLMLFGH P51784 S648-p Phosphorylation RYVTKPNsDDEDDGD P51784 S671-p Phosphorylation KDDVPGPstGGsLrD P51784 T672-p Phosphorylation DDVPGPstGGsLrDP P51784 S675-p Phosphorylation PGPstGGsLrDPEPE P51784 T731-p Phosphorylation SNGTSDRtTsPEEVH P51784 S733-p Phosphorylation GTSDRtTsPEEVHAQ P51784 Y742-p Phosphorylation EEVHAQPyIAIDWEP P51784 Y923-p Phosphorylation QIESKAAyVLFYQRQ P51784 S938-p Phosphorylation DVARRLLsPAGssGA P51784 S942-p Phosphorylation RLLsPAGssGAPAsP P51784 S943-p Phosphorylation LLsPAGssGAPAsPA P51784 S948-p Phosphorylation GssGAPAsPACssPP P51784 S952-p Phosphorylation APAsPACssPPssEF P51784 S953-p Phosphorylation PAsPACssPPssEFM P51784 S956-p Phosphorylation PACssPPssEFMDVN P51784 S957-p Phosphorylation ACssPPssEFMDVN_ P51784 K107-ub Ubiquitination ESWFLVEkHWYKQWE P51784 K245-ub Ubiquitination EDTrLWAkNSEGSLD P51784 K355-ub Ubiquitination FRNPLGMkGEIAEAY P51784 K367-ub Ubiquitination EAYADLVkQAWSGHH P51784 K447-ub Ubiquitination QEAWQNHkRRNDsVI P51784 K531-ub Ubiquitination DLCVALSkHTGISPE P51784 K714-ub Ubiquitination WPPRRRRkQLFTLQT P51784 K766-ub Ubiquitination VEAEGYVkHDCVGYV P51784 K835-ub Ubiquitination LKRFSYTkFSREkLD P51784 K840-ub Ubiquitination YTkFSREkLDTLVEF

PTM - dbPTM UniProt ID Position Code Type Resources References P51784 245 K Acetylation Swiss-Prot 1010711 19608861 P51784 948 S Phosphorylation Swiss-Prot 1010711 18669648 P51784 953 S Phosphorylation Swiss-Prot 1010711 18669648 P51784 948 S Phosphorylation PhosphoELM.10011 18669648 P51784 107 K Ubiquitylation Phosphositeplus.1010730 21890473 P51784 245 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P51784 355 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P51784 367 K Ubiquitylation Phosphositeplus.1010730 21890473 P51784 531 K Ubiquitylation Phosphositeplus.1010730 21890473 P51784 714 K Ubiquitylation Phosphositeplus.1010730 21890473 P51784 835 K Ubiquitylation Phosphositeplus.1010730 21890473 P51784 840 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P51784 245 K Acetylation Phosphositeplus.1010730 19608861 P51784 584 S Phosphorylation Phosphositeplus.1010730 21406692 P51784 648 S Phosphorylation Phosphositeplus.1010730 20068231;20164059;20363803;21406692;22115753 P51784 671 S Phosphorylation Phosphositeplus.1010730 21659604 P51784 675 S Phosphorylation Phosphositeplus.1010730 21659604 P51784 733 S Phosphorylation Phosphositeplus.1010730 19690332 P51784 948 S Phosphorylation Phosphositeplus.1010730 18669648;19664995 P51784 672 T Phosphorylation Phosphositeplus.1010730 21659604 P51784 195 Y Phosphorylation Phosphositeplus.1010730 18083107;20068231 P51784 245 K Acetylation HPRD 9.0 19608861 P51784 648 S Phosphorylation HPRD 9.0 19651622,18452278,20068231 P51784 948 S Phosphorylation HPRD 9.0 18669648,19664995,20068231 P51784 953 S Phosphorylation HPRD 9.0 18669648,20068231 P51784 644 T Phosphorylation HPRD 9.0 19651622 P51784 195 Y Phosphorylation HPRD 9.0 20068231

PTM - HPRD Symbol Position Code Type References USP11 195 Y Phosphorylation 20068231 USP11 245 K Acetylation 19608861 USP11 644 T Phosphorylation 19651622 USP11 648 S Phosphorylation 19651622,18452278,20068231 USP11 948 S Phosphorylation 18669648,19664995,20068231 USP11 953 S Phosphorylation 18669648,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P51784 905 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P51784 245 N6-acetyllysine 19608861 P51784 648 Phosphoserine 20068231;21406692 P51784 948 Phosphoserine 18669648;24275569

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP11 IPI00184533 K 245 DTRLWAaKNSEGSL acetylation USP11 IPI00184533 S 948 SSGAPApSPACSSP phosphorylation USP11 IPI00184533 Y 195 IQKVEVpYPVELLL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 8237 113866 - K Ubiquitination 22118674 8237 113866 - K Ubiquitination 21963094 8237 113866 - K Ubiquitination 21139048 8237 113866 - K Ubiquitination 21890473 8237 113866 - K Ubiquitination 21906983 8237 113866 - K Sumoylation 19471022 8237 113866 - K Ubiquitination 22505724 8237 113866 - K FAT10ylation 22797925 8237 113866 - K Ubiquitination 23000965 8237 113866 - K Sumoylation 24654937 8237 113866 - K Ubiquitination 24654937 8237 113866 - K Neddylation 24654937 8237 113866 - K Ubiquitination 24816145 8237 113866 - K Ubiquitination 25147182 8237 113866 - K Ubiquitination 12938929

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP11 Homo sapiens (Human) 258; 533; 567; 441; 562; 82; 94 "258,LCVALSKHTGISP; 533,WYCPSCKQHQLAT; 567,TKFSREKLDTLVE; 441,PPRRRRKQLFTLQ; 562,KRFSYTKFSREKL; 82,RNPLGMKGEIAEA; 94,AYADLVKQAWSGH" 258:21890473; 533:21890473; 567:21890473; 441:21890473; 562:21890473; 82:21890473; 94:21890473 USP11 Homo sapiens (Human) 258; 533; 567; 441; 562; 82; 94 "258,LCVALSKHTGISP; 533,WYCPSCKQHQLAT; 567,TKFSREKLDTLVE; 441,PPRRRRKQLFTLQ; 562,KRFSYTKFSREKL; 82,RNPLGMKGEIAEA; 94,AYADLVKQAWSGH" 258:21890473; 533:21890473; 567:21890473; 441:21890473; 562:21890473; 82:21890473; 94:21890473 USP11 Homo sapiens (Human) 258; 533; 567; 441; 562; 82; 94 "258,LCVALSKHTGISP; 533,WYCPSCKQHQLAT; 567,TKFSREKLDTLVE; 441,PPRRRRKQLFTLQ; 562,KRFSYTKFSREKL; 82,RNPLGMKGEIAEA; 94,AYADLVKQAWSGH" 258:21890473; 533:21890473; 567:21890473; 441:21890473; 562:21890473; 82:21890473; 94:21890473 USP11 Homo sapiens (Human) 835; 806; 714; 531; 355; 840; 245; 367; 107 "835,KRFSYTKFSREKL; 806,WYCPSCKQHQLAT; 714,PPRRRRKQLFTLQ; 531,LCVALSKHTGISP; 355,RNPLGMKGEIAEA; 840,TKFSREKLDTLVE; 245,DTRLWAKNSEGSL; 367,AYADLVKQAWSGH; 107,SWFLVEKHWYKQW" "835:21890473; 806:21890473; 714:21890473; 531:21890473; 355:21890473,21906983; 840:21890473,21906983; 245:21890473,21906983; 367:21890473; 107:21890473" USP11 Homo sapiens (Human) 835; 806; 714; 531; 355; 840; 245; 367; 107 "835,KRFSYTKFSREKL; 806,WYCPSCKQHQLAT; 714,PPRRRRKQLFTLQ; 531,LCVALSKHTGISP; 355,RNPLGMKGEIAEA; 840,TKFSREKLDTLVE; 245,DTRLWAKNSEGSL; 367,AYADLVKQAWSGH; 107,SWFLVEKHWYKQW" 835:21890473; 806:21890473; 714:21890473; 531:21890473; 355:21890473; 840:21890473; 245:21890473; 367:21890473; 107:21890473