PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FBXO31 MRPS27 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G QSER1 FBXO31 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G G GP G G G GP GP G GP G G GP GP G MYH6 FBXO31 26496610 biogrid,intact exp G GP G GP G FBXO31 PARD6A 23469015 biogrid exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP G CCND1 FBXO31 24085301,24828503,19412162 biogrid,dip exp GP GP G P GP G G GP G GP G G G G GP GP G G G G G GP G GP GP GP P G FBXO31 DNAJC19 26496610 biogrid,intact exp G GP G P GP G GP G G GP G GP GP G G GP G GP G GP GP G G G GP GP GP G C18orf21 FBXO31 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G ATM FBXO31 19412162 dip exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 CEP170P1 26496610 intact exp EFR3A FBXO31 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G STX3 FBXO31 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP2K6 FBXO31 24936062 biogrid exp GP G G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP G G PRPS1 FBXO31 26496610 biogrid,intact exp GP GP G P G G G GP G GP G GP GP G GP G G G G GP GP GP GP GP GP GP GP G FBXO31 FAM58A 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G PDLIM1 FBXO31 26496610 biogrid,intact exp GP G G P GP G GP GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP GP G FBXO31 CDT1 24828503 biogrid exp P P P P GP GP P P P GP P G GP G P P P P GP P GP P G EDRF1 FBXO31 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 ZCCHC9 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G FBXO31 COPS5 21145461, 25402006 biogrid exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SKP1 FBXO31 16357137,22632967,19412162,23469015, 25402006, 23023127, 21836163 innatedb,biogrid,intact,dip exp, pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RBX1 FBXO31 16357137, 25402006, 21836163 innatedb,biogrid exp, pred G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G CUL1 FBXO31 16357137,26496610,23319600,19412162,23469015,21145461, 25402006, 21836163 innatedb,biogrid,intact,dip exp, pred GP G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP GP G ACVR1 FBXO31 21836163 pred GP GP G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP G FBXO31 BTRC 25402006, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SMAD4 FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G UBE2M FBXO31 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP G GP GP GP GP GP GP G FBXO31 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G APBB1 FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP G G G GP G GP G GP GP GP GP G GP GP GP G FBXO31 FBXO27 23023127 pred GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G CUL7 FBXO31 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM32 FBXO31 23023127 pred GP GP G GP G GP GP G GP G G GP G GP GP G GP G GP GP GP GP GP GP GP GP G MYCBP2 FBXO31 23023127 pred G GP G GP G GP GP G G G GP GP G GP GP G GP G G GP G G GP G G GP G SMAD7 FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G FBXO31 CGREF1 23023127 pred P P G P GP P P G P P P GP GP GP P P GP P GP P GP P FBXO31 FBXO11 21836163 pred G G G GP G G G G G G GP G G GP GP G G G GP G G G GP G G G G FBXO31 FBXO33 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G VHL FBXO31 25402006 pred G G G G G G G G GP G GP G G G G G P G G GP GP G G G G GP G RNF8 FBXO31 23023127 pred GP GP G GP G GP GP G GP G G G G GP GP G GP G G G GP G GP G GP GP G FBXO31 FBXO6 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP G DDB1 FBXO31 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 RCHY1 21836163 pred G GP G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G TCEB3 FBXO31 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G FBXO31 MPP5 23023127 pred GP G G GP G GP GP G GP G GP GP G GP GP G GP G G GP GP G GP G GP GP G FBXO31 UBQLN2 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 CAND1 25402006, 21836163 pred G GP G G G G GP G GP G G G G GP G G G G G G GP GP GP G G GP G FBXO31 FBXO44 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G P G GP GP GP GP GP GP GP GP G RNF103 FBXO31 23023127 pred G GP G P GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G BCL6 FBXO31 23023127 pred G G G P G G G G G G G G GP G G G G G G GP G G G G GP G G G FBXO31 RFWD3 23023127 pred G G G G G G G G G G G G G G G G FBXO31 FBXW5 25402006 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G TERF1 FBXO31 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO31 GCM1 21836163 pred P P GP P P FBXO31 FBXO2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G DGKZ FBXO31 23023127 pred G G G GP G GP G G G G G GP G G GP G GP G G G GP G G G GP GP G WNT9A FBXO31 23023127 pred GP GP P G G GP G P GP P G GP P G P G GP P G GP GP GP GP GP G FBXO31 FBXL3 25402006 pred G G G P G G G G G G G G G G G G G G G G G G G G GP G G G FBXO31 FBXO18 25402006, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CDKN1A FBXO31 23023127 pred GP GP G P G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G CUL4B FBXO31 25402006, 21836163 pred GP GP G P GP G GP GP G GP G G GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXW7 25402006, 23023127, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXO31 TERF2IP 23023127 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CUL3 FBXO31 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXO5 25402006 pred P P P P P GP P P P GP P G P P P P P GP GP P P FBXO31 FBXL2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXO31 TP63 23023127 pred GP G G G G G G G G G G G G G G G G GP GP G G G G G FBXO31 FBXW9 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXO31 FBXO46 25402006 pred GP G G GP G G GP G G G G G G GP GP G G G G G G GP GP G GP GP G RB1 FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FEM1B 25402006 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXO31 CUL5 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXO17 25402006 pred G G G G G G G G G G G FBXO31 TRIM63 23023127 pred G G G G FBXO31 FBXW11 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G NFKBIE FBXO31 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP GP GP GP GP GP GP GP GP G FBXO31 CACYBP 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G FBXO31 FBXL20 21836163 pred GP GP G P G G G GP G GP G GP GP G GP G G GP G GP GP GP G GP GP GP GP G FBXO31 TSPYL2 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G G GP GP GP GP GP GP GP G FBXO31 SENP8 21836163 pred P P G P GP G GP P G GP P P P P G P G P GP P GP GP P P GP FBXO31 COMMD1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NFKBIB FBXO31 25402006 pred GP P P GP G GP P G GP G GP GP G GP GP GP G GP GP GP GP GP GP GP GP G SKP2 FBXO31 25402006, 21836163 pred GP GP G P GP G GP GP G G G GP GP G GP GP G GP G GP G G GP GP GP GP GP G CUL2 FBXO31 25402006, 21836163 pred GP GP G GP G G GP G GP G GP GP G G GP G GP G GP GP GP G G G GP GP G NFKBIA FBXO31 25402006 pred G GP G P GP G GP GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXO7 25402006, 23023127, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G FBXO31 COPS6 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RAB3A FBXO31 23023127 pred GP G GP G G G G G G G GP G GP G G G G G G G FBXO31 ZC3HC1 25402006, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CUL4A FBXO31 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TP53 FBXO31 23023127 pred G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G FBXO31 FBXW2 25402006 pred G GP G P GP G GP GP G GP G GP G G GP GP G GP G G G GP GP GP G GP GP G FBXO31 NLK 21836163 pred GP GP G P GP G G GP G G G G G G G GP G G G GP GP G G G G G GP G CTNNB1 FBXO31 25402006 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G FBXO31 SUGT1 25402006 pred G G G G G GP GP G GP G G G G GP G G GP G G G G GP GP G GP GP G FBXO31 FBXL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HRAS FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 PPP1R13B 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXO4 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G FBXO31 FBXO34 25402006 pred G GP G G G G GP G G G G G G G G G G G GP G G GP G G GP GP G FBXO31 DCUN1D1 25402006 pred P G GP G P P G P P P GP G GP G GP GP P GP GP P P GP G DLG1 FBXO31 23023127 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TP73 FBXO31 23023127 pred G G G G G MDM2 FBXO31 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 FBXL8 25402006 pred P P P P P P P P P P P P P P P P TCEB2 FBXO31 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO31 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P FBXO31 CDCA3 25402006 pred G GP G P P G GP GP P GP GP G GP P G G G GP GP GP GP GP GP GP G FBXO31 FAF1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 ARL6 23023127 pred G GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP G GP GP GP GP GP GP CDC34 FBXO31 25402006, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 STUB1 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FBXO31 GML 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G IFI16 FBXO31 23023127 pred G G G P GP G G GP G GP G G GP G G GP G G G G G G G G GP G G G NEDD8 FBXO31 25402006, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G KITLG FBXO31 21836163 pred G G G P GP G G GP G GP G GP GP G GP GP G G G GP GP G GP GP GP GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5XUX0 A0A024R7W9 affinity chromatography technology 21145461 physical association X 2 Q5XUX0 Q9H211 affinity chromatography technology 24828503 physical association X 2 Q5XUX0 Q9H211 affinity chromatography technology 24828503 physical association X 2 Q5XUX0 Q9H211 pull down 24828503 direct interaction X 2 Q5XUX0 Q9H211 enzymatic study 24828503 direct interaction X 2 Q5XUX0 A0A090N7U0 affinity chromatography technology 21145461 physical association X 2 Q5XUX0 affinity chromatography technology 23469015 physical association X 2 Q5XUX0 affinity chromatography technology 23469015 physical association X 2 Q5XUX0 A0A090N7U0 affinity chromatography technology 23469015 physical association X 2 Q5XUX0 P24385 affinity chromatography technology 24085301 physical association X 2 Q5XUX0 A8K3Y2 affinity chromatography technology 24936062 physical association X 2 Q5XUX0 A8K3Y2 affinity chromatography technology 24936062 physical association X 2 Q5XUX0 A0A090N7U0 affinity chromatography technology 23319600 physical association X 2 Q5XUX0 P24385 pull down 24828503 direct interaction X 2 Q5XUX0 A0A090N7U0 affinity chromatography technology 16357137 physical association X 2 Q5XUX0 P62877 affinity chromatography technology 16357137 physical association X 2 Q5XUX0 P24385 affinity chromatography technology 19412162 physical association X 2 Q5XUX0 P24385 affinity chromatography technology 19412162 physical association X 2 Q5XUX0 P24385 enzymatic study 19412162 direct interaction X 2 P63208 Q5XUX0 affinity chromatography technology 23469015 physical association X 2 P63208 Q5XUX0 affinity chromatography technology 16357137 physical association X 2 P63208 Q5XUX0 affinity chromatography technology 16357137 physical association X 2 Q5XUX0 anti tag coimmunoprecipitation 16357137 association C 4 Q5XUX0 anti tag coimmunoprecipitation 19412162 - C 4 Q5XUX0 A0A024R3C7 anti bait coimmunoprecipitation 19412162 direct interaction X 2 Q5XUX0 A0A024R3C7 protein kinase assay 19412162 direct interaction X 2 Q5XUX0 P24385 anti bait coimmunoprecipitation 19412162 physical association X 2 Q5XUX0 P24385 anti tag coimmunoprecipitation 19412162 physical association X 2 Q5XUX0 P24385 anti tag coimmunoprecipitation 19412162 physical association X 2 Q5XUX0 P24385 anti tag coimmunoprecipitation 19412162 physical association X 2 Q5XUX0 A0A090N7U0 anti tag coimmunoprecipitation 19412162 physical association X 2 P63208 Q5XUX0 anti tag coimmunoprecipitation 19412162 physical association X 2 P63208 Q5XUX0 anti tag coimmunoprecipitation 22632967 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FBXO31 PARD6A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23469015 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_258175|BIOGRID_258176 bait|prey prey|bait SKP1 FBXO31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 16357137,22632967,23469015 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_124918|BIOGRID_124921|UniProt_122767|BIOGRID_258180 prey|bait|prey|prey bait|prey|bait|bait FBXO31 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205206 prey bait RBX1 FBXO31 MI:0004(affinity chromatography technology) 16357137 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124919 prey bait CCND1 FBXO31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19412162,24085301 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_144443|BIOGRID_144440|BIOGRID_144441|BIOGRID_294247 prey|prey|bait|prey bait|bait|prey|bait NRF1 FBXO31 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295871 bait prey CUL1 FBXO31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16357137,21145461,23469015 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_204517|BIOGRID_124917|BIOGRID_258179 bait|prey|prey prey|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PDLIM1 FBXO31 26496610 0007 HT MYH6 FBXO31 26496610,26496610 0007,0004 HT CCND1 FBXO31 19412162,19412162,19412162,19412162,24085301,24828503 0007,0006,0415,0004,0004,0096 LC PRPS1 FBXO31 26496610,26496610 0007,0004 HT SKP1 FBXO31 22632967,19412162,16357137,23469015,16357137 0007,0007,0004,0004,0007 LC STX3 FBXO31 26496610 0007 HT CUL1 FBXO31 23319600,26496610,26496610,19412162,21145461,23469015,26124108,16357137 0004,0004,0007,0007,0004,0004,0004,0004 LC,HT EFR3A FBXO31 26496610,26496610 0007,0004 HT QSER1 FBXO31 26496610,26496610 0007,0004 HT C18ORF21 FBXO31 26496610,26496610 0007,0004 HT EDRF1 FBXO31 26496610,26496610 0007,0004 HT STX3A FBXO31 26496610 0004 HT FBXO31 FAM58A 26496610,26496610 0007,0004 HT FBXO31 ZCCHC9 26496610,26496610 0007,0004 HT FBXO31 MRPS27 26496610,26496610 0007,0004 HT FBXO31 COPS5 21145461 0004 HT FBXO31 DNAJC19 26496610,26496610 0007,0004 HT FBXO31 CEP170P1 26496610 0007 HT FBXO31 HEL-S-112 26496610 0004 HT PDLIM1 FBXO31 26496610 0007 HT MYH6 FBXO31 26496610,26496610 0007,0004 HT PRPS1 FBXO31 26496610,26496610 0007,0004 HT STX3 FBXO31 26496610 0007 HT CUL1 FBXO31 26496610,26496610,21145461 0004,0007,0004 HT EFR3A FBXO31 26496610,26496610 0007,0004 HT QSER1 FBXO31 26496610,26496610 0007,0004 HT C18ORF21 FBXO31 26496610,26496610 0007,0004 HT EDRF1 FBXO31 26496610,26496610 0007,0004 HT STX3A FBXO31 26496610 0004 HT FBXO31 FAM58A 26496610,26496610 0007,0004 HT FBXO31 ZCCHC9 26496610,26496610 0007,0004 HT FBXO31 MRPS27 26496610,26496610 0007,0004 HT FBXO31 COPS5 21145461 0004 HT FBXO31 DNAJC19 26496610,26496610 0007,0004 HT FBXO31 CEP170P1 26496610 0007 HT FBXO31 HEL-S-112 26496610 0004 HT CCND1 FBXO31 19412162,19412162,19412162,19412162,24085301,24828503 0007,0006,0415,0004,0004,0096 LC SKP1 FBXO31 22632967,19412162,16357137,23469015,16357137 0007,0007,0004,0004,0007 LC CUL1 FBXO31 23319600,19412162,23469015,26124108,16357137 0004,0007,0004,0004,0004 LC CCND1 FBXO31 19412162,19412162,19412162,19412162 0007,0006,0415,0004 LC MDM2 FBXO31 26124108,26124108 0415,0004 LC ATM FBXO31 19412162,19412162 0006,0424 LC FBXO31 CDT1 24828503,24828503,24828503 0004,0415,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5XUX0 K7EM37 FBXO31 FAM58A {ECO:0000313|ENSEMBL:ENSP00000466345} 0.126 26496610 Q5XUX0 O00151 FBXO31 PDLIM1 0.126 26496610 Q5XUX0 P10912 FBXO31 GHR 0.309 25505247 Q5XUX0 P62877 FBXO31 RBX1 0.21 16357137 Q8N1B3 Q5XUX0 FAM58A FBXO31 0.126 26496610 Q92552 Q5XUX0 MRPS27 FBXO31 0.126 26496610 Q9NPB6 Q5XUX0 PARD6A FBXO31 0.376 23469015 Q5XUX0 P24385 FBXO31 CCND1 0.765 24085301,24828503,19412162 Q9H211 Q5XUX0 CDT1 FBXO31 0.702 24828503 Q9WTX5 Q5XUX0 SKP1 FBXO31 0.126 26496610 Q8VC57 Q5XUX0 KCTD5 FBXO31 0.236 26496610 Q5XUX0 P13533 FBXO31 MYH6 0.236 26496610 Q5XUX0 Q13277 FBXO31 STX3 0.236 26496610 Q5XUX0 P63208 FBXO31 SKP1 0.61 22632967,16357137,23469015 Q96DA6 Q5XUX0 DNAJC19 FBXO31 0.236 26496610 Q5XUX0 Q2KHR3 FBXO31 QSER1 0.236 26496610 Q5XUX0 Q14156 FBXO31 EFR3A 0.236 26496610 Q8N567 Q5XUX0 ZCCHC9 FBXO31 0.236 26496610 Q5XUX0 Q32NC0 FBXO31 C18ORF21 0.236 26496610 Q5XUX0 Q3B7T1 FBXO31 EDRF1 0.236 26496610 Q5XUX0 P60891 FBXO31 PRPS1 0.236 26496610 Q92905 Q5XUX0 COPS5 FBXO31 0.126 21145461 Q96L14 Q5XUX0 CEP170P1 FBXO31 0.126 26496610 Q5XUX0 Q13616 FBXO31 CUL1 0.702 26124108,21145461,16357137,26496610,23469015,23319600 Q5XUX0 Q00987 FBXO31 MDM2 0.569 26124108 Q5XUX0 P52564 FBXO31 MAP2K6 0.376 24936062

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PDLIM1 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXO31 MI:0362 inference MI:1106 pathways database FBXO21 FBXO31 MI:0362 inference MI:1106 pathways database UBB FBXO31 MI:0362 inference MI:1106 pathways database UBC FBXO31 MI:0362 inference MI:1106 pathways database GHR FBXO31 MI:0362 inference MI:0461 interaction database MYH6 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXO31 MI:0362 inference MI:1106 pathways database CCND1 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXO31 MI:0362 inference MI:1106 pathways database HNF4A FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A FBXO31 MI:0362 inference MI:1106 pathways database MAP2K6 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXO31 MI:0362 inference MI:1106 pathways database PRPS1 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 FBXO31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXO31 MI:0362 inference MI:1106 pathways database UBA52 FBXO31 MI:0362 inference MI:1106 pathways database SKP1 FBXO31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM2 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database STX3 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXO31 MI:0362 inference MI:1106 pathways database ATM FBXO31 MI:0362 inference MI:0461 interaction database CUL1 FBXO31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EFR3A FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXO31 MI:0362 inference MI:1106 pathways database LONRF1 FBXO31 MI:0362 inference MI:1106 pathways database QSER1 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database C18orf21 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database EDRF1 FBXO31 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 FBXO31 MI:0362 inference MI:1106 pathways database FBXO31 FBXW9 MI:0362 inference MI:1106 pathways database FBXO31 FBXW10 MI:0362 inference MI:1106 pathways database FBXO31 RNF213 MI:0362 inference MI:1106 pathways database FBXO31 FBXL22 MI:0362 inference MI:1106 pathways database FBXO31 FBXL19 MI:0362 inference MI:1106 pathways database FBXO31 FBXW12 MI:0362 inference MI:1106 pathways database FBXO31 RNF19B MI:0362 inference MI:1106 pathways database FBXO31 RNF144B MI:0362 inference MI:1106 pathways database FBXO31 RBBP6 MI:0362 inference MI:1106 pathways database FBXO31 HUWE1 MI:0362 inference MI:1106 pathways database FBXO31 TRIM69 MI:0362 inference MI:1106 pathways database FBXO31 SIAH1 MI:0362 inference MI:1106 pathways database FBXO31 HERC6 MI:0362 inference MI:1106 pathways database FBXO31 UBR2 MI:0362 inference MI:1106 pathways database FBXO31 FAM58A MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXL14 MI:0362 inference MI:1106 pathways database FBXO31 FBXW8 MI:0362 inference MI:1106 pathways database FBXO31 FBXL16 MI:0362 inference MI:1106 pathways database FBXO31 ZCCHC9 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXO15 MI:0362 inference MI:1106 pathways database FBXO31 ZNRF1 MI:0362 inference MI:1106 pathways database FBXO31 FBXL13 MI:0362 inference MI:1106 pathways database FBXO31 FBXO22 MI:0362 inference MI:1106 pathways database FBXO31 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO31 FBXO27 MI:0362 inference MI:1106 pathways database FBXO31 FBXO30 MI:0362 inference MI:1106 pathways database FBXO31 RNF217 MI:0362 inference MI:1106 pathways database FBXO31 DTX3L MI:0362 inference MI:1106 pathways database FBXO31 FBXO41 MI:0362 inference MI:1106 pathways database FBXO31 LMO7 MI:0362 inference MI:1106 pathways database FBXO31 MYLIP MI:0362 inference MI:1106 pathways database FBXO31 MRPS27 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXW7 MI:0362 inference MI:1106 pathways database FBXO31 FBXO32 MI:0362 inference MI:1106 pathways database FBXO31 FBXW5 MI:0362 inference MI:1106 pathways database FBXO31 MIB2 MI:0362 inference MI:1106 pathways database FBXO31 SPSB1 MI:0362 inference MI:1106 pathways database FBXO31 FBXL8 MI:0362 inference MI:1106 pathways database FBXO31 DNAJC19 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXO17 MI:0362 inference MI:1106 pathways database FBXO31 FBXL20 MI:0362 inference MI:1106 pathways database FBXO31 CEP170P1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXL18 MI:0362 inference MI:1106 pathways database FBXO31 NEDD4L MI:0362 inference MI:1106 pathways database FBXO31 RBCK1 MI:0362 inference MI:1106 pathways database FBXO31 CDT1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXL15 MI:0362 inference MI:1106 pathways database FBXO31 FBXO44 MI:0362 inference MI:1106 pathways database FBXO31 UNKL MI:0362 inference MI:1106 pathways database FBXO31 SMURF2 MI:0362 inference MI:1106 pathways database FBXO31 PARD6A MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 TRIM36 MI:0362 inference MI:1106 pathways database FBXO31 FBXO6 MI:0362 inference MI:1106 pathways database FBXO31 RNF19A MI:0362 inference MI:1106 pathways database FBXO31 RLIM MI:0362 inference MI:1106 pathways database FBXO31 FBXL12 MI:0362 inference MI:1106 pathways database FBXO31 KCTD5 MI:0362 inference MI:0461 interaction database FBXO31 FBXO40 MI:0362 inference MI:1106 pathways database FBXO31 HERC5 MI:0362 inference MI:1106 pathways database FBXO31 FBXL7 MI:0362 inference MI:1106 pathways database FBXO31 FBXO2 MI:0362 inference MI:1106 pathways database FBXO31 FBXO10 MI:0362 inference MI:1106 pathways database FBXO31 FBXO9 MI:0362 inference MI:1106 pathways database FBXO31 FBXL5 MI:0362 inference MI:1106 pathways database FBXO31 FBXL4 MI:0362 inference MI:1106 pathways database FBXO31 FBXW11 MI:0362 inference MI:1106 pathways database FBXO31 FBXO4 MI:0362 inference MI:1106 pathways database FBXO31 FBXL21 MI:0362 inference MI:1106 pathways database FBXO31 FBXL3 MI:0362 inference MI:1106 pathways database FBXO31 FBXW2 MI:0362 inference MI:1106 pathways database FBXO31 BTRC MI:0362 inference MI:1106 pathways database FBXO31 FBXO7 MI:0362 inference MI:1106 pathways database FBXO31 RNF115 MI:0362 inference MI:1106 pathways database FBXO31 RNF114 MI:0362 inference MI:1106 pathways database FBXO31 WSB1 MI:0362 inference MI:1106 pathways database