Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 16 2821480 2821480 + 3'UTR SNP C C A TCGA-FD-A3SP-01A-31D-A22Z-08 TCGA-FD-A3SP-10A-01D-A22Z-08 g.chr16:2821480C>A COAD 16 2821582 2821582 + 3'UTR SNP A A G TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr16:2821582A>G COADREAD 16 2821582 2821582 + 3'UTR SNP A A G TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr16:2821582A>G HNSC 16 2821598 2821598 + 3'UTR SNP C C T TCGA-QK-A6VB-01A-12D-A34J-08 TCGA-QK-A6VB-10B-01D-A34M-08 g.chr16:2821598C>T KIPAN 16 2825480 2825481 + Frame_Shift_Ins INS - - G TCGA-BP-4967-01A-01D-1462-08 TCGA-BP-4967-11A-01D-1462-08 g.chr16:2825480_2825481insG c.215_216insC c.(214-216)ccafs p.P72fs KIRC 16 2825480 2825481 + Frame_Shift_Ins INS - - G TCGA-BP-4967-01A-01D-1462-08 TCGA-BP-4967-11A-01D-1462-08 g.chr16:2825480_2825481insG c.215_216insC c.(214-216)ccafs p.P72fs LUAD 16 2821499 2821499 + 3'UTR SNP G G A TCGA-NJ-A4YP-01A-11D-A25L-08 TCGA-NJ-A4YP-10A-01D-A25L-08 g.chr16:2821499G>A PAAD 16 2822078 2822078 + Silent SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr16:2822078G>A c.270C>T c.(268-270)atC>atT p.I90I PRAD 16 2827129 2827129 + Splice_Site SNP C C T TCGA-CH-5753-01A-11D-1576-08 TCGA-CH-5753-10A-01D-1576-08 g.chr16:2827129C>T c.e2-1 SARC 16 2825483 2825483 + Silent SNP G G A TCGA-QC-A7B5-01A-11D-A33E-09 TCGA-QC-A7B5-11A-11D-A33H-09 g.chr16:2825483G>A c.213C>T c.(211-213)gcC>gcT p.A71A SKCM 16 2822061 2822061 + Frame_Shift_Del DEL G G - TCGA-EE-A3J5-06A-11D-A20D-08 TCGA-EE-A3J5-10A-01D-A20D-08 g.chr16:2822061delG c.287delC c.(286-288)ccgfs p.P97fs SKCM 16 2827033 2827033 + Silent SNP G G T TCGA-ER-A19P-06A-11D-A196-08 TCGA-ER-A19P-10A-01D-A198-08 g.chr16:2827033G>T c.99C>A c.(97-99)ggC>ggA p.G33G

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 16 2816588 2816588 single base substitution C T downstream_gene_variant BLCA-CN 16 2820386 2820386 single base substitution C G downstream_gene_variant BLCA-CN 16 2820396 2820396 single base substitution C T downstream_gene_variant BLCA-CN 16 2827075 2827075 single base substitution C T synonymous_variant K14K 42G>A BLCA-CN 16 2827075 2827075 single base substitution C T synonymous_variant K18K 54G>A BLCA-CN 16 2827075 2827075 single base substitution C T synonymous_variant K19K 57G>A BLCA-US 16 2817596 2817596 single base substitution G A downstream_gene_variant BLCA-US 16 2818133 2818133 single base substitution C G downstream_gene_variant BLCA-US 16 2818182 2818182 single base substitution G C downstream_gene_variant BLCA-US 16 2819183 2819183 single base substitution C G downstream_gene_variant BLCA-US 16 2820448 2820448 single base substitution C T downstream_gene_variant BOCA-FR 16 2822199 2822199 single base substitution T C intron_variant BOCA-FR 16 2827224 2827224 single base substitution C A intron_variant BOCA-FR 16 2827224 2827224 single base substitution C A upstream_gene_variant BRCA-EU 16 2817025 2817025 single base substitution G C downstream_gene_variant BRCA-EU 16 2817764 2817764 single base substitution C A downstream_gene_variant BRCA-EU 16 2819151 2819151 single base substitution C T downstream_gene_variant BRCA-EU 16 2820790 2820790 single base substitution G C downstream_gene_variant BRCA-EU 16 2821614 2821614 single base substitution G T 3_prime_UTR_variant BRCA-EU 16 2821614 2821614 single base substitution G T downstream_gene_variant BRCA-EU 16 2821614 2821614 single base substitution G T intron_variant BRCA-EU 16 2822726 2822726 single base substitution G A intron_variant BRCA-EU 16 2824337 2824337 single base substitution G A intron_variant BRCA-EU 16 2824668 2824668 insertion of <=200bp - GGTC intron_variant BRCA-EU 16 2824719 2824719 single base substitution G C intron_variant BRCA-EU 16 2825023 2825023 deletion of <=200bp C - intron_variant BRCA-EU 16 2825642 2825644 deletion of <=200bp GAG - intron_variant BRCA-EU 16 2826738 2826738 single base substitution T C intron_variant BRCA-EU 16 2826843 2826843 single base substitution C T intron_variant BRCA-EU 16 2827486 2827486 single base substitution G A upstream_gene_variant BRCA-EU 16 2827743 2827743 single base substitution G A upstream_gene_variant BRCA-EU 16 2827912 2827912 single base substitution G T upstream_gene_variant BRCA-EU 16 2827914 2827914 single base substitution T C upstream_gene_variant BRCA-EU 16 2828142 2828142 single base substitution G C upstream_gene_variant BRCA-EU 16 2828836 2828836 single base substitution G A upstream_gene_variant BRCA-EU 16 2828841 2828841 single base substitution C T upstream_gene_variant BRCA-EU 16 2829600 2829600 single base substitution G A upstream_gene_variant BRCA-EU 16 2829875 2829875 single base substitution C A upstream_gene_variant BRCA-EU 16 2831009 2831009 single base substitution G A upstream_gene_variant BRCA-EU 16 2831256 2831256 single base substitution C T upstream_gene_variant BRCA-EU 16 2831449 2831449 single base substitution C A upstream_gene_variant BRCA-EU 16 2831749 2831749 single base substitution G A upstream_gene_variant BRCA-FR 16 2819467 2819467 single base substitution G A downstream_gene_variant BRCA-FR 16 2824317 2824317 single base substitution C T intron_variant BRCA-FR 16 2826738 2826738 single base substitution T C intron_variant BRCA-FR 16 2826973 2826973 single base substitution C T intron_variant BRCA-FR 16 2829875 2829875 single base substitution C A upstream_gene_variant BRCA-FR 16 2830656 2830656 single base substitution G C upstream_gene_variant BRCA-FR 16 2831009 2831009 single base substitution G A upstream_gene_variant BRCA-FR 16 2831749 2831749 single base substitution G A upstream_gene_variant BRCA-KR 16 2816434 2816434 single base substitution C T downstream_gene_variant BRCA-UK 16 2820790 2820790 single base substitution G C downstream_gene_variant BRCA-US 16 2816501 2816501 single base substitution G A downstream_gene_variant BRCA-US 16 2816577 2816577 single base substitution C T downstream_gene_variant BRCA-US 16 2816674 2816674 single base substitution G C downstream_gene_variant BRCA-US 16 2816694 2816694 single base substitution A C downstream_gene_variant BRCA-US 16 2816852 2816852 single base substitution C A downstream_gene_variant BRCA-US 16 2816961 2816961 single base substitution A C downstream_gene_variant BRCA-US 16 2817327 2817327 single base substitution G A downstream_gene_variant BRCA-US 16 2818050 2818050 single base substitution G A downstream_gene_variant BRCA-US 16 2819269 2819269 deletion of <=200bp C - downstream_gene_variant BTCA-JP 16 2817016 2817016 single base substitution C T downstream_gene_variant BTCA-JP 16 2817704 2817704 single base substitution G A downstream_gene_variant BTCA-JP 16 2819148 2819148 single base substitution C T downstream_gene_variant CESC-US 16 2820872 2820872 single base substitution G A downstream_gene_variant COAD-US 16 2816591 2816591 single base substitution G A downstream_gene_variant COAD-US 16 2816615 2816615 single base substitution G A downstream_gene_variant COAD-US 16 2816874 2816874 single base substitution C T downstream_gene_variant COAD-US 16 2817553 2817553 single base substitution C T downstream_gene_variant COAD-US 16 2817980 2817980 single base substitution C T downstream_gene_variant COAD-US 16 2819119 2819121 deletion of <=200bp TCC - downstream_gene_variant COAD-US 16 2819178 2819178 single base substitution C T downstream_gene_variant COAD-US 16 2821525 2821525 single base substitution G A 3_prime_UTR_variant COAD-US 16 2821525 2821525 single base substitution G A downstream_gene_variant COAD-US 16 2821525 2821525 single base substitution G A missense_variant T145M 434C>T COAD-US 16 2821573 2821573 single base substitution C T 3_prime_UTR_variant COAD-US 16 2821573 2821573 single base substitution C T downstream_gene_variant COAD-US 16 2821573 2821573 single base substitution C T missense_variant S129N 386G>A COAD-US 16 2821582 2821582 single base substitution A G 3_prime_UTR_variant COAD-US 16 2821582 2821582 single base substitution A G downstream_gene_variant COAD-US 16 2821582 2821582 single base substitution A G missense_variant M126T 377T>C COCA-CN 16 2816651 2816651 single base substitution G A downstream_gene_variant COCA-CN 16 2819659 2819659 single base substitution T G downstream_gene_variant COCA-CN 16 2821091 2821091 single base substitution T G downstream_gene_variant ESAD-UK 16 2817774 2817774 single base substitution C A downstream_gene_variant ESAD-UK 16 2819161 2819163 deletion of <=200bp TCT - downstream_gene_variant ESAD-UK 16 2819172 2819172 single base substitution T C downstream_gene_variant ESAD-UK 16 2820205 2820205 single base substitution G A downstream_gene_variant ESAD-UK 16 2821307 2821307 single base substitution G C downstream_gene_variant ESAD-UK 16 2825884 2825884 insertion of <=200bp - T intron_variant ESAD-UK 16 2832176 2832176 single base substitution G A upstream_gene_variant GBM-US 16 2817214 2817214 single base substitution G C downstream_gene_variant KIRC-US 16 2817282 2817282 single base substitution A T downstream_gene_variant KIRC-US 16 2825480 2825480 insertion of <=200bp - G frameshift_variant P67P? KIRC-US 16 2825480 2825480 insertion of <=200bp - G frameshift_variant P72P? KIRC-US 16 2825480 2825480 insertion of <=200bp - G frameshift_variant P94P? KIRC-US 16 2825480 2825480 insertion of <=200bp - G intron_variant KIRP-US 16 2817459 2817459 single base substitution T C downstream_gene_variant KIRP-US 16 2818196 2818196 single base substitution C G downstream_gene_variant LGG-US 16 2819161 2819163 deletion of <=200bp TCT - downstream_gene_variant LGG-US 16 2820396 2820396 single base substitution C A downstream_gene_variant LICA-CN 16 2817255 2817255 single base substitution A T downstream_gene_variant LICA-CN 16 2819080 2819080 single base substitution C T downstream_gene_variant LICA-FR 16 2818665 2818665 single base substitution A T downstream_gene_variant LICA-FR 16 2822564 2822564 single base substitution A T intron_variant LICA-FR 16 2831360 2831360 single base substitution C G upstream_gene_variant LINC-JP 16 2816515 2816515 single base substitution T C downstream_gene_variant LINC-JP 16 2816989 2816989 single base substitution G A downstream_gene_variant LINC-JP 16 2817972 2817972 single base substitution A G downstream_gene_variant LINC-JP 16 2818911 2818911 insertion of <=200bp - C downstream_gene_variant LINC-JP 16 2827334 2827334 single base substitution G A upstream_gene_variant LIRI-JP 16 2817195 2817195 single base substitution C T downstream_gene_variant LIRI-JP 16 2820166 2820166 single base substitution G A downstream_gene_variant LIRI-JP 16 2821926 2821926 single base substitution A C 3_prime_UTR_variant LIRI-JP 16 2821926 2821926 single base substitution A C downstream_gene_variant LIRI-JP 16 2821926 2821926 single base substitution A C intron_variant LIRI-JP 16 2829521 2829521 single base substitution C T upstream_gene_variant LUSC-KR 16 2818056 2818056 single base substitution A C downstream_gene_variant LUSC-KR 16 2818395 2818395 single base substitution G A downstream_gene_variant LUSC-KR 16 2821525 2821525 single base substitution G A 3_prime_UTR_variant LUSC-KR 16 2821525 2821525 single base substitution G A downstream_gene_variant LUSC-KR 16 2821525 2821525 single base substitution G A missense_variant T145M 434C>T LUSC-KR 16 2828872 2828872 single base substitution G C upstream_gene_variant LUSC-US 16 2816580 2816580 single base substitution C T downstream_gene_variant LUSC-US 16 2817786 2817786 single base substitution G T downstream_gene_variant LUSC-US 16 2818169 2818169 single base substitution C G downstream_gene_variant LUSC-US 16 2819035 2819035 single base substitution C T downstream_gene_variant LUSC-US 16 2819118 2819118 single base substitution T C downstream_gene_variant MALY-DE 16 2824986 2824986 single base substitution G A intron_variant MALY-DE 16 2829264 2829264 single base substitution C T upstream_gene_variant MELA-AU 16 2816685 2816685 single base substitution C T downstream_gene_variant MELA-AU 16 2817295 2817295 single base substitution C T downstream_gene_variant MELA-AU 16 2817608 2817608 single base substitution C T downstream_gene_variant MELA-AU 16 2817727 2817727 single base substitution C T downstream_gene_variant MELA-AU 16 2817906 2817906 single base substitution C T downstream_gene_variant MELA-AU 16 2818913 2818913 single base substitution C T downstream_gene_variant MELA-AU 16 2819014 2819014 single base substitution C T downstream_gene_variant MELA-AU 16 2819159 2819159 single base substitution C T downstream_gene_variant MELA-AU 16 2819297 2819297 single base substitution C T downstream_gene_variant MELA-AU 16 2819364 2819364 single base substitution C T downstream_gene_variant MELA-AU 16 2820325 2820325 single base substitution T C downstream_gene_variant MELA-AU 16 2821793 2821793 single base substitution A G 3_prime_UTR_variant MELA-AU 16 2821793 2821793 single base substitution A G downstream_gene_variant MELA-AU 16 2821793 2821793 single base substitution A G intron_variant MELA-AU 16 2822324 2822324 single base substitution C T intron_variant MELA-AU 16 2822513 2822513 single base substitution G A intron_variant MELA-AU 16 2822765 2822766 multiple base substitution (>=2bp and <=200bp) GT AA intron_variant MELA-AU 16 2822938 2822938 single base substitution A C intron_variant MELA-AU 16 2823066 2823066 single base substitution G A intron_variant MELA-AU 16 2823993 2823993 single base substitution G A intron_variant MELA-AU 16 2824421 2824421 single base substitution G A intron_variant MELA-AU 16 2824448 2824448 single base substitution G A intron_variant MELA-AU 16 2824515 2824515 single base substitution G A intron_variant MELA-AU 16 2824766 2824766 single base substitution A G intron_variant MELA-AU 16 2824854 2824854 single base substitution C T intron_variant MELA-AU 16 2825271 2825271 deletion of <=200bp T - intron_variant MELA-AU 16 2826586 2826586 single base substitution G A intron_variant MELA-AU 16 2827497 2827497 single base substitution C T upstream_gene_variant MELA-AU 16 2827888 2827888 single base substitution G A upstream_gene_variant MELA-AU 16 2828406 2828406 single base substitution C T upstream_gene_variant MELA-AU 16 2828770 2828771 multiple base substitution (>=2bp and <=200bp) CC TT upstream_gene_variant MELA-AU 16 2828884 2828884 single base substitution C T upstream_gene_variant MELA-AU 16 2829625 2829625 single base substitution C T upstream_gene_variant MELA-AU 16 2829905 2829905 single base substitution G A upstream_gene_variant MELA-AU 16 2829947 2829947 single base substitution C T upstream_gene_variant MELA-AU 16 2830092 2830092 single base substitution C T upstream_gene_variant MELA-AU 16 2831373 2831373 single base substitution C T upstream_gene_variant MELA-AU 16 2831667 2831667 single base substitution C T upstream_gene_variant MELA-AU 16 2831711 2831711 single base substitution G A upstream_gene_variant MELA-AU 16 2831740 2831740 single base substitution C T upstream_gene_variant ORCA-IN 16 2817368 2817368 single base substitution C T downstream_gene_variant ORCA-IN 16 2818062 2818062 single base substitution C T downstream_gene_variant ORCA-IN 16 2820629 2820629 single base substitution G A downstream_gene_variant OV-AU 16 2817195 2817195 single base substitution C T downstream_gene_variant OV-AU 16 2821673 2821673 single base substitution C T 3_prime_UTR_variant OV-AU 16 2821673 2821673 single base substitution C T downstream_gene_variant OV-AU 16 2821673 2821673 single base substitution C T intron_variant OV-AU 16 2826429 2826429 single base substitution T C intron_variant PACA-AU 16 2816630 2816630 single base substitution C T downstream_gene_variant PACA-AU 16 2816789 2816789 single base substitution G T downstream_gene_variant PACA-AU 16 2818118 2818118 single base substitution G A downstream_gene_variant PACA-AU 16 2825283 2825283 single base substitution A G intron_variant PACA-AU 16 2825372 2825372 single base substitution G A intron_variant PACA-AU 16 2829347 2829347 single base substitution C A upstream_gene_variant PACA-CA 16 2816595 2816595 single base substitution A G downstream_gene_variant PACA-CA 16 2819072 2819072 single base substitution G A downstream_gene_variant PACA-CA 16 2819080 2819080 single base substitution C T downstream_gene_variant PACA-CA 16 2819139 2819139 single base substitution C T downstream_gene_variant PACA-CA 16 2821030 2821030 single base substitution T C downstream_gene_variant PACA-CA 16 2826661 2826661 single base substitution C T intron_variant PACA-CA 16 2826826 2826826 single base substitution G C intron_variant PACA-CA 16 2827994 2827994 deletion of <=200bp C - upstream_gene_variant PACA-CA 16 2828967 2828967 single base substitution G C upstream_gene_variant PACA-CA 16 2830282 2830284 deletion of <=200bp CTC - upstream_gene_variant PAEN-AU 16 2819283 2819283 single base substitution G A downstream_gene_variant PAEN-AU 16 2825271 2825271 deletion of <=200bp T - intron_variant PAEN-IT 16 2822636 2822636 single base substitution G A intron_variant PBCA-DE 16 2829979 2829979 single base substitution C A upstream_gene_variant PRAD-CA 16 2817523 2817523 single base substitution G A downstream_gene_variant PRAD-CA 16 2825276 2825276 single base substitution T A intron_variant PRAD-UK 16 2819481 2819481 single base substitution C A downstream_gene_variant PRAD-UK 16 2827106 2827106 single base substitution C T missense_variant R4H 11G>A PRAD-UK 16 2827106 2827106 single base substitution C T missense_variant R8H 23G>A PRAD-UK 16 2827106 2827106 single base substitution C T missense_variant R9H 26G>A PRAD-UK 16 2831791 2831791 single base substitution G C upstream_gene_variant PRAD-US 16 2817170 2817170 single base substitution C T downstream_gene_variant PRAD-US 16 2819185 2819187 deletion of <=200bp TCC - downstream_gene_variant PRAD-US 16 2827129 2827129 single base substitution C T 5_prime_UTR_variant PRAD-US 16 2827129 2827129 single base substitution C T splice_acceptor_variant PRAD-US 16 2827129 2827129 single base substitution C T upstream_gene_variant READ-US 16 2818173 2818173 single base substitution G A downstream_gene_variant RECA-EU 16 2826253 2826253 single base substitution A G intron_variant RECA-EU 16 2828760 2828760 single base substitution C T upstream_gene_variant RECA-EU 16 2830059 2830059 single base substitution G C upstream_gene_variant RECA-EU 16 2832160 2832160 single base substitution C T upstream_gene_variant SKCA-BR 16 2819611 2819611 single base substitution T C downstream_gene_variant SKCA-BR 16 2821573 2821573 single base substitution C T 3_prime_UTR_variant SKCA-BR 16 2821573 2821573 single base substitution C T downstream_gene_variant SKCA-BR 16 2821573 2821573 single base substitution C T missense_variant S129N 386G>A SKCA-BR 16 2825314 2825314 single base substitution G A intron_variant SKCA-BR 16 2827464 2827464 single base substitution T G upstream_gene_variant SKCA-BR 16 2831503 2831503 insertion of <=200bp - TTCTC upstream_gene_variant SKCA-BR 16 2831517 2831517 insertion of <=200bp - CTCTCTTT upstream_gene_variant SKCA-BR 16 2831958 2831958 single base substitution C T upstream_gene_variant SKCM-US 16 2816824 2816824 single base substitution C T downstream_gene_variant SKCM-US 16 2816884 2816884 single base substitution C T downstream_gene_variant SKCM-US 16 2817055 2817055 single base substitution C T downstream_gene_variant SKCM-US 16 2817115 2817115 single base substitution C T downstream_gene_variant SKCM-US 16 2817118 2817118 single base substitution C T downstream_gene_variant SKCM-US 16 2817437 2817437 single base substitution C A downstream_gene_variant SKCM-US 16 2817499 2817499 single base substitution C T downstream_gene_variant SKCM-US 16 2817587 2817587 single base substitution C T downstream_gene_variant SKCM-US 16 2817906 2817906 single base substitution C T downstream_gene_variant SKCM-US 16 2818193 2818193 single base substitution C T downstream_gene_variant SKCM-US 16 2819075 2819075 single base substitution A C downstream_gene_variant SKCM-US 16 2820365 2820365 single base substitution C T downstream_gene_variant SKCM-US 16 2820382 2820382 single base substitution C T downstream_gene_variant SKCM-US 16 2822061 2822061 deletion of <=200bp G - frameshift_variant P118 SKCM-US 16 2822061 2822061 deletion of <=200bp G - frameshift_variant P91 SKCM-US 16 2822061 2822061 deletion of <=200bp G - frameshift_variant P96 SKCM-US 16 2822061 2822061 deletion of <=200bp G - frameshift_variant R61 STAD-US 16 2816576 2816576 single base substitution G A downstream_gene_variant STAD-US 16 2816641 2816641 single base substitution C T downstream_gene_variant STAD-US 16 2816741 2816743 deletion of <=200bp CTC - downstream_gene_variant STAD-US 16 2817372 2817372 single base substitution T C downstream_gene_variant STAD-US 16 2817433 2817433 single base substitution A C downstream_gene_variant STAD-US 16 2817604 2817604 single base substitution G A downstream_gene_variant STAD-US 16 2817757 2817757 single base substitution C T downstream_gene_variant STAD-US 16 2818141 2818141 single base substitution T C downstream_gene_variant STAD-US 16 2818182 2818182 single base substitution G C downstream_gene_variant STAD-US 16 2822060 2822060 single base substitution C T missense_variant R61H 182G>A STAD-US 16 2822060 2822060 single base substitution C T synonymous_variant P118P 354G>A STAD-US 16 2822060 2822060 single base substitution C T synonymous_variant P91P 273G>A STAD-US 16 2822060 2822060 single base substitution C T synonymous_variant P96P 288G>A UCEC-US 16 2816494 2816494 single base substitution G A downstream_gene_variant UCEC-US 16 2816500 2816500 single base substitution C A downstream_gene_variant UCEC-US 16 2816501 2816501 single base substitution G A downstream_gene_variant UCEC-US 16 2816824 2816824 single base substitution C A downstream_gene_variant UCEC-US 16 2817541 2817541 single base substitution C A downstream_gene_variant UCEC-US 16 2817619 2817619 single base substitution G A downstream_gene_variant UCEC-US 16 2818134 2818134 single base substitution G C downstream_gene_variant UCEC-US 16 2818850 2818850 single base substitution T C downstream_gene_variant UCEC-US 16 2819124 2819124 single base substitution C A downstream_gene_variant UCEC-US 16 2819161 2819163 deletion of <=200bp TCT - downstream_gene_variant UCEC-US 16 2819228 2819228 single base substitution G T downstream_gene_variant UCEC-US 16 2821355 2821355 single base substitution T G downstream_gene_variant UCEC-US 16 2822013 2822013 single base substitution G A 3_prime_UTR_variant UCEC-US 16 2822013 2822013 single base substitution G A missense_variant A107V 320C>T UCEC-US 16 2822013 2822013 single base substitution G A missense_variant A112V 335C>T UCEC-US 16 2822013 2822013 single base substitution G A missense_variant A134V 401C>T UCEC-US 16 2822019 2822019 single base substitution C A 3_prime_UTR_variant UCEC-US 16 2822019 2822019 single base substitution C A missense_variant S105I 314G>T UCEC-US 16 2822019 2822019 single base substitution C A missense_variant S110I 329G>T UCEC-US 16 2822019 2822019 single base substitution C A missense_variant S132I 395G>T UCEC-US 16 2822078 2822078 single base substitution G A missense_variant S55L 164C>T UCEC-US 16 2822078 2822078 single base substitution G A synonymous_variant I112I 336C>T UCEC-US 16 2822078 2822078 single base substitution G A synonymous_variant I85I 255C>T UCEC-US 16 2822078 2822078 single base substitution G A synonymous_variant I90I 270C>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-AM-5821-01 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 - B110-Tumor COSM1749524 c.57G>A p.K19K Substitution - coding silent 16:2777074-2777074 - TCGA-D1-A103-01 COSM969449 c.335C>T p.A112V Substitution - Missense 16:2772012-2772012 - B110 COSM1749524 c.57G>A p.K19K Substitution - coding silent 16:2777074-2777074 - TCGA-06-0210 COSM2150688 c.211G>C p.A71P Substitution - Missense 16:2775484-2775484 - TCGA-AM-5820-01 COSM3754827 c.434C>T p.T145M Substitution - Missense 16:2771524-2771524 - TCGA-CH-5753-01 COSM1128994 c.4-1G>A p.? Unknown 16:2777128-2777128 - LS174T COSM3109593 c.239G>A p.R80Q Substitution - Missense 16:2775456-2775456 - LS180 COSM3109593 c.239G>A p.R80Q Substitution - Missense 16:2775456-2775456 - VLTS-2 COSM5702858 c.353+7A>C p.? Unknown 16:2771987-2771987 - SNUH_G26_S1 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 - DLD1 COSM3109588 c.442C>T p.P148S Substitution - Missense 16:2771516-2771516 - TCGA-AP-A0LM-01 COSM969450 c.329G>T p.S110I Substitution - Missense 16:2772018-2772018 - TCGA-CG-5733-01 COSM4059749 c.288G>A p.P96P Substitution - coding silent 16:2772059-2772059 - VLTS-2 COSM5702859 c.353+6G>A p.? Unknown 16:2771988-2771988 - SNUH_G10_S1 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 - TCGA-19-4068 COSM2157693 c.216_217insC p.A73fs*11 Insertion - Frameshift 16:2775478-2775479 - Pat_41_B COSM5850603 c.332G>A p.S111N Substitution - Missense 16:2772015-2772015 - TCGA-BS-A0TJ-01 COSM969451 c.270C>T p.I90I Substitution - coding silent 16:2772077-2772077 - HCT15 COSM3109588 c.442C>T p.P148S Substitution - Missense 16:2771516-2771516 - SNUH_G16_S1 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 - MedB-1 COSM5621978 c.424G>A p.A142T Substitution - Missense 16:2771534-2771534 - RKO COSM3109591 c.362T>C p.V121A Substitution - Missense 16:2771596-2771596 - Sample_1 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 - YUKAT COSM5384638 c.56A>G p.K19R Substitution - Missense 16:2777075-2777075 - HCT8 COSM3109588 c.442C>T p.P148S Substitution - Missense 16:2771516-2771516 - 0085_CRUK_PC_0085_T1_DNA COSM5421320 c.26G>A p.R9H Substitution - Missense 16:2777105-2777105 - TCGA-AA-3663-01 COSM1377056 c.377T>C p.M126T Substitution - Missense 16:2771581-2771581 - ESO-632 COSM1267527 c.423_424insAA p.A142fs*>21 Insertion - Frameshift 16:2771534-2771535 - QC2-32-T2 COSM3754828 c.386G>A p.S129N Substitution - Missense 16:2771572-2771572 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.172772 16p12.3 600787 2405816|CGAP|BC013306|C/G|non-coding||594|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer C T SpliceAcceptorSNV . c.4-1G>A 16 2827129 PRAD C T Synonymous p.P96P c.288G>A 16 2822060 STAD G A Synonymous p.F62F c.186C>T 16 2825510 THCA G A Synonymous p.I90I c.270C>T 16 2822078 UCEC - G Frameshift p.A73Sfs*11 c.215dupC 16 2825481 RCCC G - Frameshift p.P96Rfs*7 c.287delC 16 2822061 CM - TT Frameshift p.A142Kfs*72 c.423_424insAA 16 2821536 ESCA