PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SMAD1 TRIM35 15761153 i2d exp G G G G G G G G GP G G G G G G G G G G G G G G G G G GP G USP2 TRIM35 23105109 biogrid exp GP G P GP G GP P G GP GP GP GP P GP GP GP G GP P GP P GP P P GP G TRIM10 TRIM35 26186194 biogrid exp G G G G G G G G G G G G G G GP G GP G G G G G P GP GP GP G TSG101 TRIM35 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G UBE2D2 TRIM35 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G P G GP GP GP G TRIM5 TRIM35 16775307 biogrid exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G UBE2W TRIM35 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G UBE2D3 TRIM35 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G P G GP GP GP G TRIM11 TRIM35 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G TRIM35 UBE2D4 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G P G GP GP GP G UBE2U TRIM35 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P GP TRIM35 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G SMAD4 TRIM35 15761153 i2d exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP G SMAD2 TRIM35 15761153 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G UBE2K TRIM35 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G PAN2 TRIM35 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP49 TRIM35 23105109 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP P GP GP GP GP G UBE2D1 TRIM35 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G P G GP GP GP G SMAD3 TRIM35 15761153, 23023127 i2d exp, pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G IRF7 TRIM35 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G JARID2 TRIM35 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G TRIM35 MTF2 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G EZH2 TRIM35 25402006 ortho, pred GP P G GP GP P GP G GP G P P P GP GP GP GP EED TRIM35 25402006 ortho, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP P GP GP GP GP G MYCBP2 TRIM35 23023127 pred G GP G G G GP G GP GP G G G GP GP G GP GP G GP G G GP G GP G G GP G ILK TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G MED13 TRIM35 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL5 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G SOX17 TRIM35 21836163 pred GP GP G G GP P G GP GP GP GP GP GP G GP GP GP GP G GP GP P P GP GP GP GP G BTG3 TRIM35 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP G APP TRIM35 23023127 pred G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G GP G G GP G UBE2L3 TRIM35 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP P GP G GP GP G CGRRF1 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G P GP GP GP GP G DLG1 TRIM35 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP G CDKN2A TRIM35 23023127 pred G GP G G GP GP G G G G G G GP GP G G GP G GP G GP G G G GP GP G G APBB2 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G PABPN1 TRIM35 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G BMI1 TRIM35 23023127 pred P P P P P P P P P P P P P P P P P P P P P P CUL2 TRIM35 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G GP GP G CUL4A TRIM35 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G BARD1 TRIM35 23023127 pred P G GP P P GP P P P GP G GP P G P P GP P P P GP GP GP G TRIM35 MYO16 23023127 pred G GP P P P P GP P P P P P CUL1 TRIM35 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP P GP GP GP GP G TRIM24 TRIM35 21836163 pred G G G G G G G G GP G G G GP GP G GP G GP G G GP GP GP P GP G GP GP G UACA TRIM35 23023127 pred G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP GP G GP GP G DGKZ TRIM35 23023127 pred G G G G G GP G GP G G G G G GP G G GP G GP G G G GP G G GP GP G RPS9 TRIM35 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP G GP GP G CDKN2B TRIM35 23023127 pred GP P GP P P G G GP P G P GP G APBB1 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP P G GP GP GP G UBE2B TRIM35 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP GP GP GP G CGREF1 TRIM35 23023127 pred P P G P GP P P G P P P P GP GP GP P P GP P GP P GP P PSMD10 TRIM35 23023127 pred GP G G G G GP G G GP G G G GP GP G GP GP GP GP G GP GP GP GP G GP GP G MED13L TRIM35 21836163 pred GP GP G G G GP G G G G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP G UBE2C TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G PTPN3 TRIM35 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP P GP GP G TGFB1 TRIM35 23023127 pred G G G G GP G G G G G G G G G G GP G G G G GP G GP GP GP G G CDKN2D TRIM35 23023127 pred P P G G GP GP G P GP G P P GP GP P GP P P P P P P P GP P GP TRIM21 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G RPS8 TRIM35 21836163 pred P P P P P P P P P P SCRIB TRIM35 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G G GP G GP GP GP GP G GP GP G BTG4 TRIM35 23023127 pred G G TRIM35 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP GP GP GP GP G SMARCA4 TRIM35 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G HMX1 TRIM35 21836163 pred G G G G G G G G G G G G G G G G G G G G RFPL4A TRIM35 23023127 pred P P P P P P P P P P P P P P P P P P P P P P TRIM62 TRIM35 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UPQ4 O75604-2 two hybrid 23105109 direct interaction X 2 Q9UPQ4 Q70CQ1-2 two hybrid 23105109 direct interaction X 2 Q9UPQ4 Q504Q3-3 two hybrid 23105109 direct interaction X 2 Q9UPQ4 Q96F44 two hybrid 22493164 direct interaction X 2 Q9UPQ4 Q96FI0 two hybrid 19549727 direct interaction X 2 Q9UPQ4 Q99816 two hybrid 19549727 direct interaction X 2 Q9UPQ4 A0A087WW00 two hybrid 19549727 direct interaction X 2 Q9UPQ4 P61077-3 two hybrid 19549727 direct interaction X 2 Q9UPQ4 Q9C035 pull down 16775307 direct interaction X 2 Q9UPQ4 two hybrid 19690564 direct interaction X 2 Q9UPQ4 P62837 two hybrid 19549727 direct interaction X 2 Q9UPQ4 A0A024RA90 two hybrid 19549727 direct interaction X 2 P61086 Q9UPQ4 two hybrid 19549727 direct interaction X 2 A0A024QZJ2 Q9UPQ4 two hybrid array 19549727 physical association X 2 Q9UPQ4 Q99816 two hybrid array 19549727 physical association X 2 Q9UPQ4 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q9UPQ4 Q5VVX9 two hybrid array 19690564 physical association X 2 Q9UPQ4 Q96F44 two hybrid array 22493164 physical association X 2 Q96B02 Q9UPQ4 two hybrid array 19549727 physical association X 2 Q9UPQ4 P62837 two hybrid array 19549727 physical association X 2 Q9UPQ4 A0A024RA90 two hybrid array 19549727 physical association X 2 B3KSH4 Q9UPQ4 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP2 TRIM35 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248165 bait prey PAN2 TRIM35 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248236 bait prey TRIM5 TRIM35 MI:0096(pull down) 16775307 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_212746 prey bait TRIM35 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101452|BIOGRID_124553 prey|prey bait|bait TRIM11 TRIM35 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122582|BIOGRID_284001 bait|bait prey|prey UBE2U TRIM35 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123679|UniProt_102667 bait|bait prey|prey UBE2D3 TRIM35 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124552|UniProt_101282 bait|bait prey|prey UBE2D2 TRIM35 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124551|UniProt_101256 bait|bait prey|prey USP49 TRIM35 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248233 bait prey UBE2W TRIM35 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101173|BIOGRID_124221 bait|bait prey|prey TSG101 TRIM35 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_100988|BIOGRID_124222 bait|bait prey|prey UBE2D1 TRIM35 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101234|BIOGRID_124550 bait|bait prey|prey UBE2K TRIM35 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124220 bait prey TRIM35 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100977 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TRIM10 TRIM35 26186194 0004 HT TRIM10 TRIM35 26186194 0004 HT HIP2 TRIM35 19549727 0397 HT USP2 TRIM35 23105109 0018 LC UBE2D1 TRIM35 19549727,19549727 0397,0018 HT UBE2D3 TRIM35 19549727,19549727 0397,0018 HT UBE2K TRIM35 19549727 0018 HT UBE2D2 TRIM35 19549727,19549727 0397,0018 HT SMAD3 TRIM35 15761153 0019 HT SMAD4 TRIM35 15761153 0019 HT SMAD2 TRIM35 15761153 0019 HT SMAD1 TRIM35 15761153 0019 HT PAN2 TRIM35 23105109 0018 LC UBE2U TRIM35 19690564,19690564 0397,0018 HT USP49 TRIM35 23105109 0018 LC UBE2W TRIM35 19549727,19549727 0397,0018 HT TRIM11 TRIM35 22493164,22493164 0018,0397 HT TSG101 TRIM35 19549727,19549727 0397,0018 HT SMURF1 TRIM35 15761153 0019 HT TRIM35 UBE2D4 19549727,19549727 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UPQ4 B3KSH4 TRIM35 HIP2 0.126 19549727 Q9UPQ4 P61086 TRIM35 UBE2K 0.183 19549727 Q9UPQ4 O75604 TRIM35 USP2 0.183 23105109 Q9UPQ4 Q70CQ1 TRIM35 USP49 0.183 23105109 Q9UPQ4 Q96F44 TRIM35 TRIM11 0.286 22493164 Q9UPQ4 Q99816 TRIM35 TSG101 0.286 19549727 Q9UPQ4 Q5VVX9 TRIM35 UBE2U 0.286 19690564 Q9UPQ4 P61077 TRIM35 UBE2D3 0.286 19549727 Q9UPQ4 Q96B02 TRIM35 UBE2W 0.286 19549727 Q9UPQ4 Q9UDY6 TRIM35 TRIM10 0.126 26186194 Q9UPQ4 P14618 TRIM35 PKM 0.569 25263439 Q9UPQ4 P51668 TRIM35 UBE2D1 0.376 19549727 Q9UPQ4 P62837 TRIM35 UBE2D2 0.376 19549727 Q9UPQ4 Q9C035 TRIM35 TRIM5 0.309 16775307 Q9Y2X8 Q9UPQ4 UBE2D4 TRIM35 0.376 19549727 Q9UPQ4 Q504Q3 TRIM35 PAN2 0.183 23105109

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EED TRIM35 MI:0362 inference MI:0461 interaction database USP2 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database PKM TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database SMAD4 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database EZH2 TRIM35 MI:0362 inference MI:0461 interaction database PAN2 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database USP49 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database JARID2 TRIM35 MI:0362 inference MI:0461 interaction database IRF7 TRIM35 MI:0362 inference MI:0461 interaction database UBE2W TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database TRIM11 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database TSG101 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database TRIM5 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database SMURF1 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database TRIM10 TRIM35 MI:0045 experimental interaction detection MI:0461 interaction database TRIM35 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM35 MTF2 MI:0362 inference MI:0461 interaction database