DNA & RNA Element - UTRdb Gene Name Type ASPicDB UTRaspic Refseq ID Genome TLE6 3'UTR c0eb535587 BA109711 NM_001143986 chr19:2946004-2946176:+ TLE6 3'UTR 0affd4668c BA109712 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR 665d2dfa48 BA109713 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR b0fe0bd992 BA109714 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR 0ab7b8e92a BA109715 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR 2d5648cc79 BA109716 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR ecfaaf5f5e BA109717 NM_001143986 chr19:2946003-2946182:+ TLE6 3'UTR 466411d9c5 NM_001143986 chr19:2931185-2931404:+ TLE6 5'UTR c0eb535587 CA173081 NM_001143986 chr19:2928562-2938065:+ TLE6 5'UTR 0affd4668c CA173082 NM_001143986 chr19:2928444-2938064:+ TLE6 5'UTR 665d2dfa48 CA173083 NM_001143986 chr19:2928578-2938064:+ TLE6 5'UTR b0fe0bd992 CA173084 NM_001143986 chr19:2928568-2938064:+ TLE6 5'UTR 0ab7b8e92a CA173085 NM_001143986 chr19:2935146-2938064:+ TLE6 5'UTR 2d5648cc79 CA173086 NM_001143986 chr19:2938409-2939043:+ TLE6 5'UTR ecfaaf5f5e CA173087 NM_001143986 chr19:2939947-2939990:+

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0004597 hsa-miR-140-3p 79816 TLE6 ggcacCAAGAUGGGACACCAu | |||| :||||||| cgcacGAUCUAGUCUGUGGUg 2 17 111 131 [hg19:19:2995113-2995133:+] 0.5009 160 7 -22.75 -0.2424 MIMAT0002852 hsa-miR-517a 79816 TLE6 uguGAGAUUUCCCUA-CGUGCUa :||| : || || |||||| cucUUCU-GUGGCAUCGCACGAu 2 20 97 118 [hg19:19:2995099-2995120:+] 0.5009 121 6 -17.84 -0.1664 MIMAT0003248 hsa-miR-583 79816 TLE6 cauuacccuggaAGGAGAAAc |||||||| ucccacuccggcUCCUCUUUu 2 10 19 39 [hg19:19:2995021-2995041:+] 0.4781 145 7 -12.23 -0.2200 MIMAT0016846 hsa-miR-4297 79816 TLE6 gugUCUGUCCUUCCGu | :|:||||||| gggAAGCGGGAAGGCu 2 14 83 98 [hg19:19:2995085-2995100:+] 0.5009 149 7 -17.34 -0.1500 MIMAT0016863 hsa-miR-4311 79816 TLE6 guGUGA-GUCGA-GAGAAAg |||| |:||| |||||| ccCACUCCGGCUCCUCUUUu 2 17 20 39 [hg19:19:2995022-2995041:+] 0.4781 131 6 -19.79 -0.1395 MIMAT0000261 hsa-miR-183 79816 TLE6 ucACUUAAGAUGGUCA-CGGUAu ||: | ||::|| ||||| ugUGGUGUAGACUGGUCGCCAUc 2 21 125 147 [hg19:19:2995127-2995149:+] 0.5009 120 0 -17.88 -0.1567

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G035019 TLE6 Homo sapiens 79816

DNA & RNA Element - TargetScan Gene Name UTR Region Start UTR Region End AIR Total Normalized 3P-seq-tags & Pseudocounts Strand hg19_chromosome Genome Start Genome End TLE6 1 173 100 157.837 + chr19 2995002 2995175 TLE6 174 175 3.174 157.837 + chr19 2995175 2995177 TLE6 176 180 0.01 157.837 + chr19 2995177 2995182

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile TLE6 hsa-miR-583 beg:25 end:39 pic:3' CATTACCCTGGAAGGAGAAAC 5'& |.| |||||||| &5' -------GGC--TCCTCTTT- 3' TLE6 hsa-miR-140-3p beg:115 end:132 pic:3' GGCACCAAGATGGGACACCAT 5'& |||| .|||||||. &5' -------TCTAGTCTGTGGTG 3' TLE6 hsa-miR-4271 beg:40 end:58 pic:3' GGGGTGGAAAAGAAGGGGG 5'& |||| || |||||||| &5' CCCC-CCC---CTTCCCCC 3' TLE6 ebv-miR-BART17-5p beg:23 end:38 pic:3' GAACATACGGACGCAGGAGAAT 5'& || || ||||||| &5' --------CCGGC-TCCTCTT- 3' TLE6 kshv-miR-K12-6-5p beg:0 end:16 pic:3' GGCTACCTAATCCACGACGACC 5'& ||. ||||||| &5' -----GGGGCCTC-GCTGCTG- 3' TLE6 hsa-miR-4297 beg:85 end:98 pic:3' GTGTCTGTCCTTCCGT 5'& .|.||||||| &5' -----GCGGGAAGGC- 3' TLE6 hcmv-miR-UL148D beg:74 end:98 pic:3' GCCACT--TCTTC-CCCTCCTGCT 5'& ||||. .|||| |||| |.| &5' -GGTGGAGGGAAGCGGGAAGGC-- 3' TLE6 hcmv-miR-US25-2-5p beg:13 end:37 pic:3' AGTA-GGTGGACTTGTCTGGCGA 5'& |||| ||||. ..| || || &5' TCATCCCACTCCGGCT--CCTCT 3' TLE6 hsa-miR-103-2star beg:71 end:90 pic:3' GTTCCGTCGTGACATTTCTTCGA 5'& || || | |..||||| &5' CATGGTGG------AGGGAAGC- 3' TLE6 hsa-miR-1268 beg:40 end:57 pic:3' GGGGGTGGT-GGTGCGGGC 5'& ||||| || || | ||| &5' CCCCC-CCTTCC-C-CCC- 3' TLE6 hsa-miR-1470 beg:65 end:86 pic:3' GCCCCACGTGCCCGCCTCCCG 5'& |||| ||. ||.|||||| &5' -GGGGGACAT-GGTGGAGGG- 3' TLE6 hsa-miR-15astar beg:101 end:127 pic:3' ACTCCGT--CGTGTTATACCGGAC 5'& | |||| ||||.|| |.||| &5' -GTGGCATCGCACGATCTAGTCTG 3' TLE6 hsa-miR-204 beg:67 end:88 pic:3' TCCGTATCCT--ACTGTTTCCCTT 5'& || .||| ||. .|||||| &5' -GG---GGGACATGGTGGAGGGAA 3' TLE6 hsa-miR-211 beg:67 end:88 pic:3' TCCGCTTCCT--ACTGTTTCCCTT 5'& |..||| ||. .|||||| &5' ----GGGGGACATGGTGGAGGGAA 3' TLE6 hsa-miR-2277 beg:0 end:19 pic:3' CTCGGTCCGTCCCGCGACAGT 5'& |.||| || .||||||| &5' GGGCCTCGC----TGCTGTCA 3' TLE6 hsa-miR-28-3p beg:104 end:124 pic:3' AGGTCCTCGA---GTGTTAGATCAC 5'& .|| |||.||||||| &5' ------GGCATCGCACGATCTAGT- 3' TLE6 hsa-miR-28-5p beg:14 end:35 pic:3' GAGTTATCTGACACTCGAGGAA 5'& ||| ||| .|||||| &5' -TCATCCCACTCC-GGCTCCT- 3' TLE6 hsa-miR-296-5p beg:0 end:8 pic:3' TGTCCTAACTCCCCCCCGGGA 5'& ||||||. &5' -------------GGGGCCT- 3' TLE6 hsa-miR-3141 beg:33 end:53 pic:3' AGGAGGAGGTGGGCGGGAG 5'& |..|| ||| ||| ||||. &5' TTTTCATCC-CCC-CCCTT 3' TLE6 hsa-miR-3158 beg:85 end:102 pic:3' CAGGACGTCTCTCCTTCGGGAA 5'& ||.| || |.||.||| &5' -----GCGG-GA--AGGCTCTT 3' TLE6 hsa-miR-3179 beg:34 end:54 pic:3' TGCAAATTTAAAGT-----GGGGAAGA 5'& ||||| ||||||| &5' ---------TTTCATCCCCCCCCTTC- 3' TLE6 hsa-miR-3202 beg:30 end:55 pic:3' TAATTTCGAGAAGA--------GGGAAGGT 5'& |||||.| ||||||| &5' -------CTCTTTTCATCCCCCCCCTTCC- 3' TLE6 hsa-miR-412 beg:65 end:84 pic:3' TGCCGATCACCTGGTCCACTTCA 5'& || |||| ||||.|| &5' --GGG----GGACATGGTGGAG- 3' TLE6 hsa-miR-423-5p beg:16 end:36 pic:3' TTTCAGAGCGAGAGACGGGGAGT 5'& || | ||| | ||.|||| &5' ----TCCCACTC-CGGCTCCTC- 3' TLE6 hsa-miR-4252 beg:124 end:145 pic:3' ACCACGACTGAGTCACCGG 5'& |||||. |||| .|| ||| &5' TGGTGTAGACT-GGTCGCC 3' TLE6 hsa-miR-4281 beg:42 end:59 pic:3' GGGGGGAGGGGCCCTGGG 5'& |||||||.||| ||| &5' CCCCCCTTCCCC---CCC 3' TLE6 hsa-miR-4290 beg:78 end:98 pic:3' CTCCCTTCTTTCCTCCCGT 5'& |||||||| .||| ||| &5' GAGGGAAGC-GGGAAGGC- 3' TLE6 hsa-miR-4294 beg:5 end:23 pic:3' GGGACGACATCTGAGGG 5'& | ||||||| |||| &5' CGCTGCTGTCA--TCCC 3' TLE6 hsa-miR-4300 beg:22 end:35 pic:3' CTTCATCAGGTCGAGGGT 5'& |||.|||||. &5' -------TCCGGCTCCT- 3' TLE6 hsa-miR-4323 beg:115 end:133 pic:3' AGACTCCGACACCCCGAC 5'& ||| || |||||| |. &5' TCT-AGTCTGTGGTGT-- 3' TLE6 hsa-miR-516a-3p beg:76 end:90 pic:3' TGGGAGACTTTCCTTCGT 5'& ||.|.|||||| &5' ------TGGAGGGAAGC- 3' TLE6 hsa-miR-516bstar beg:76 end:90 pic:3' TGGGAGACTTTCCTTCGT 5'& ||.|.|||||| &5' ------TGGAGGGAAGC- 3' TLE6 hsa-miR-518e beg:71 end:91 pic:3' GTGAGACTTCCCTTCGCGAAA 5'& ||. ||.||||||||| &5' CATGGTGGAGGGAAGCG---- 3' TLE6 hsa-miR-542-3p beg:0 end:20 pic:3' AAAGTCAATAGTTA-GACAGTGT 5'& .| ||. ||||||. &5' ----GGGCCTCGCTGCTGTCAT- 3' TLE6 hsa-miR-609 beg:147 end:166 pic:3' TCTCTACTCTC-TTTGTGGGA 5'& .|| ||.||||| &5' ----GTGTAATAAAGCACCC- 3' TLE6 hsa-miR-625 beg:48 end:58 pic:3' CCTGATATCTTGAAAGGGGGA 5'& ||||||| &5' -------------TTCCCCC- 3' TLE6 hsa-miR-642 beg:67 end:87 pic:3' GTTCTGTGTAAACC-TCTCCCTG 5'& ..|||| ||| .|||||| &5' -GGGACA----TGGTGGAGGGA- 3' TLE6 hsa-miR-708 beg:17 end:35 pic:3' GGGTCGATCTAACATTCGAGGAA 5'& |||| || .|||||| &5' CCCA-CTCC------GGCTCCT- 3' TLE6 hsa-miR-920 beg:18 end:36 pic:3' ATGACGAAGGTG---TCGAGGGG 5'& |||| .|||||.| &5' --------CCACTCCGGCTCCTC 3' TLE6 hsv1-miR-H1 beg:22 end:44 pic:3' AGGTGAAGGGCAGGAAGGTAG 5'& |||. ||| ||.||.|||| &5' TCCGGCTCC--TCTTTTCATC 3' TLE6 hsv1-miR-H6-3p beg:74 end:96 pic:3' CCCTACCTTCC--TGCCCTTCAC 5'& |.||||.|| .||||||| &5' --GGTGGAGGGAAGCGGGAAG-- 3' TLE6 kshv-miR-K12-12star beg:36 end:58 pic:3' AGTTGGTCCCGTGGGAGGGGGT 5'& ||| || | ||.|||||| &5' TCATCCCCC-C-CCTTCCCCC- 3'

DNA & RNA Element - miRcode Gene Name Type microRNA Seed Position Seed Type Total Cons% Tr Region TLE6 High_conserved miR-503 chr19:2984062 7-mer-m8 0 ncRNA TLE6 High_conserved miR-503 chr19:2984168 7-mer-A1 4 ncRNA TLE6 High_conserved miR-503 chr19:2995017 7-mer-m8 9 3pUTR, ncRNA TLE6 High_conserved miR-7/7ab chr19:2987473 7-mer-m8 4 ncRNA TLE6 High_conserved miR-7/7ab chr19:2994940 7-mer-A1 13 3pUTR, CDS, ncRNA TLE6 High_conserved miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac chr19:2978281 7-mer-m8 7 CDS, ncRNA TLE6 High_conserved miR-135ab/135a-5p chr19:2980310 7-mer-m8 16 ncRNA TLE6 High_conserved miR-138/138ab chr19:2993514 7-mer-m8 9 CDS, ncRNA TLE6 High_conserved miR-145 chr19:2989152 8-mer 11 CDS, ncRNA TLE6 High_conserved miR-146ac/146b-5p chr19:2993573 7-mer-m8 42 CDS, ncRNA TLE6 High_conserved miR-155 chr19:2984210 7-mer-A1 31 ncRNA TLE6 High_conserved miR-155 chr19:2984233 7-mer-A1 36 ncRNA TLE6 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:2984168 7-mer-A1 4 ncRNA TLE6 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:2984278 7-mer-m8 11 ncRNA TLE6 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:2984281 7-mer-m8 11 ncRNA TLE6 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:2993474 7-mer-m8 24 CDS, ncRNA TLE6 High_conserved miR-193/193b/193a-3p chr19:2994023 7-mer-m8 31 CDS, ncRNA TLE6 High_conserved miR-205/205ab chr19:2987030 7-mer-A1 2 CDS, 5pUTR, ncRNA TLE6 High_conserved miR-205/205ab chr19:2989657 7-mer-A1 9 CDS, ncRNA TLE6 High_conserved miR-208ab/208ab-3p chr19:2986842 7-mer-m8 2 CDS, 5pUTR, ncRNA TLE6 High_conserved miR-214/761/3619-5p chr19:2986994 8-mer 9 CDS, 5pUTR, ncRNA TLE6 High_conserved miR-214/761/3619-5p chr19:2987312 7-mer-m8 11 ncRNA TLE6 High_conserved miR-214/761/3619-5p chr19:2989566 7-mer-m8 33 CDS, ncRNA TLE6 High_conserved miR-219-5p/508/508-3p/4782-3p chr19:2987117 8-mer 4 CDS, ncRNA TLE6 High_conserved miR-22/22-3p chr19:2987631 7-mer-m8 4 ncRNA TLE6 High_conserved miR-22/22-3p chr19:2988069 7-mer-m8 7 ncRNA TLE6 High_conserved miR-23abc/23b-3p chr19:2989654 7-mer-A1 9 CDS, ncRNA TLE6 High_conserved miR-33a-3p/365/365-3p chr19:2980155 7-mer-m8 9 CDS, 5pUTR, ncRNA TLE6 High_conserved miR-33ab/33-5p chr19:2987865 8-mer 4 ncRNA TLE6 High_conserved miR-34ac/34bc-5p/449abc/449c-5p chr19:2989687 7-mer-A1 13 CDS, ncRNA TLE6 High_conserved miR-125a-5p/125b-5p/351/670/4319 chr19:2987291 7-mer-m8 2 ncRNA TLE6 High_conserved miR-125a-5p/125b-5p/351/670/4319 chr19:2991843 7-mer-A1 40 CDS, ncRNA TLE6 High_conserved miR-455-5p chr19:2993531 7-mer-m8 9 CDS, ncRNA TLE6 High_conserved miR-129-5p/129ab-5p chr19:2993544 7-mer-m8 2 CDS, ncRNA TLE6 High_conserved miR-490-3p chr19:2981539 7-mer-m8 20 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-542-3p chr19:2994960 7-mer-A1 9 3pUTR, CDS, ncRNA TLE6 Medium_conserved miR-590-3p chr19:2980370 7-mer-A1 7 ncRNA TLE6 Medium_conserved miR-590-3p chr19:2980389 7-mer-m8 7 ncRNA TLE6 Medium_conserved miR-134/3118 chr19:2994921 7-mer-m8 4 3pUTR, CDS, ncRNA TLE6 Medium_conserved miR-873 chr19:2987458 7-mer-m8 11 ncRNA TLE6 Medium_conserved miR-874 chr19:2980153 7-mer-m8 9 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-874 chr19:2987446 7-mer-m8 4 ncRNA TLE6 Medium_conserved miR-876-5p/3167 chr19:2984304 8-mer 11 ncRNA TLE6 Medium_conserved miR-136 chr19:2980329 7-mer-A1 9 ncRNA TLE6 Medium_conserved miR-149 chr19:2980290 7-mer-m8 4 ncRNA TLE6 Medium_conserved miR-149 chr19:2983957 7-mer-A1 9 ncRNA TLE6 Medium_conserved miR-149 chr19:2993523 7-mer-m8 9 CDS, ncRNA TLE6 Medium_conserved miR-185/882/3473/4306/4644 chr19:2980244 7-mer-m8 11 ncRNA TLE6 Medium_conserved miR-320abcd/4429 chr19:2980355 7-mer-m8 13 ncRNA TLE6 Medium_conserved miR-326/330/330-5p chr19:2987231 8-mer 11 CDS, ncRNA TLE6 Medium_conserved miR-346 chr19:2987615 7-mer-A1 0 ncRNA TLE6 Medium_conserved miR-370 chr19:2982165 8-mer 11 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-370 chr19:2987024 7-mer-m8 4 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-370 chr19:2987360 7-mer-m8 13 CDS, ncRNA TLE6 Medium_conserved miR-370 chr19:2987696 7-mer-m8 2 ncRNA TLE6 Medium_conserved miR-370 chr19:2989581 8-mer 18 CDS, ncRNA TLE6 Medium_conserved miR-384/384-3p chr19:2986834 7-mer-A1 11 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-125a-3p/1554 chr19:2986991 7-mer-m8 7 CDS, 5pUTR, ncRNA TLE6 Medium_conserved miR-125a-3p/1554 chr19:2987911 7-mer-A1 7 CDS, ncRNA TLE6 Medium_conserved miR-125a-3p/1554 chr19:2989230 7-mer-m8 42 CDS, ncRNA TLE6 Medium_conserved miR-431 chr19:2987946 7-mer-A1 4 CDS, ncRNA TLE6 Medium_conserved miR-433 chr19:2991954 8-mer 11 CDS, ncRNA TLE6 Medium_conserved miR-488 chr19:2984102 7-mer-A1 7 ncRNA TLE6 Medium_conserved miR-491-5p chr19:2987893 7-mer-m8 2 ncRNA

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score TLE6 RAID01792167 hsa-miR-5187-5p miRNA MIMAT0021117 TLE6 mRNA 79816 Prediction 0.1828 TLE6 RAID02010745 hsa-miR-6887-5p miRNA MIMAT0027674 TLE6 mRNA 79816 Prediction 0.1828 TLE6 RAID02529614 hsa-miR-6795-5p miRNA MIMAT0027490 TLE6 mRNA 79816 Prediction 0.1828 TLE6 RAID02779784 hsa-miR-183-5p miRNA MIMAT0000261 TLE6 mRNA 79816 Prediction 0.1828