PTM - CPLM Gene Name UniProt ID Type Position Code FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 262 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 96 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 156 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 263 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 480 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 173 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 320 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 475 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 429 K FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 Ubiquitination 336 K

PTM - dbPAF Gene Name UniProt ID Position Type Species FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 120 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 121 T Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 131 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 133 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 134 T Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 137 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 138 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 146 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 148 Y Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 149 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 151 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 154 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 163 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 30 T Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 300 T Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 32 T Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 343 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 346 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 35 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 36 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 39 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 40 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 42 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 5 Y Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 70 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 72 S Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 91 Y Homo sapiens(Human) FZR1; CDH1; FYR; FZR; KIAA1242 Q9UM11 92 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type FZR1; CDH1; FYR; FZR; KIAA1242 rs56007701 AGC->ATC S->I 151 S DVSPYSLSPVSNKSQ 151 Phosphorylation: CDK_group TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9UM11 S39-gl O-GlcNAc tPAssPVssPsKHGD Q9UM11 S40-gl O-GlcNAc PAssPVssPsKHGDR Q9UM11 S42-gl O-GlcNAc ssPVssPsKHGDRFI Q9UM11 Y5-p Phosphorylation ___MDQDyERRLLRQ Q9UM11 T30-p Phosphorylation RVTEMRRtLtPAssP Q9UM11 T32-p Phosphorylation TEMRRtLtPAssPVs Q9UM11 S35-p Phosphorylation RRtLtPAssPVssPs Q9UM11 S36-p Phosphorylation RtLtPAssPVssPsK Q9UM11 S39-p Phosphorylation tPAssPVssPsKHGD Q9UM11 S40-p Phosphorylation PAssPVssPsKHGDR Q9UM11 S42-p Phosphorylation ssPVssPsKHGDRFI Q9UM11 S70-p Phosphorylation RINENEKsPsQNRKA Q9UM11 S72-p Phosphorylation NENEKsPsQNRKAKD Q9UM11 Y91-p Phosphorylation NGKDGLAysALLkNE Q9UM11 S92-p Phosphorylation GKDGLAysALLkNEL Q9UM11 S120-p Phosphorylation EDRRLQPstPEKkGL Q9UM11 T121-p Phosphorylation DRRLQPstPEKkGLF Q9UM11 S131-p Phosphorylation KkGLFTYsLsTKRss Q9UM11 S133-p Phosphorylation GLFTYsLsTKRssPD Q9UM11 S137-p Phosphorylation YsLsTKRssPDDGND Q9UM11 S138-p Phosphorylation sLsTKRssPDDGNDV Q9UM11 S146-p Phosphorylation PDDGNDVsPYSLsPV Q9UM11 S151-p Phosphorylation DVsPYSLsPVsNkSQ Q9UM11 S154-p Phosphorylation PYSLsPVsNkSQKLL Q9UM11 S163-p Phosphorylation kSQKLLRsPRKPTRK Q9UM11 T300-p Phosphorylation ILQRDIRtPPLQSER Q9UM11 S343-p Phosphorylation KLLVWNHsSLsPVQQ Q9UM11 S346-p Phosphorylation VWNHsSLsPVQQYTE Q9UM11 K125-sm Sumoylation QPstPEKkGLFTYsL Q9UM11 K96-ub Ubiquitination LAysALLkNELLGAG Q9UM11 K156-ub Ubiquitination SLsPVsNkSQKLLRs Q9UM11 K262-ub Ubiquitination IWDAAAGkkLSMLEG Q9UM11 K263-ub Ubiquitination WDAAAGkkLSMLEGH

PTM - dbPTM UniProt ID Position Code Type Resources References Q9UM11 32 T Phosphorylation Swiss-Prot 1010711 18669648 Q9UM11 36 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q9UM11 39 S Phosphorylation Swiss-Prot 1010711 19413330 Q9UM11 40 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UM11 91 Y Phosphorylation Swiss-Prot 1010711 18187866 Q9UM11 92 S Phosphorylation Swiss-Prot 1010711 18187866 Q9UM11 137 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UM11 138 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UM11 146 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UM11 151 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q9UM11 36 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 40 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 70 S Phosphorylation PhosphoELM.10011 22067460 Q9UM11 72 S Phosphorylation PhosphoELM.10011 22067460 Q9UM11 137 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 138 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 146 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 154 S Phosphorylation PhosphoELM.10011 18669648 Q9UM11 151 S Phosphorylation PhosphoELM.10011 18669648;12560341 Q9UM11 163 S Phosphorylation PhosphoELM.10011 12560341 Q9UM11 32 T Phosphorylation PhosphoELM.10011 18669648 Q9UM11 156 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UM11 262 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UM11 263 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UM11 96 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UM11 138 S Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q9UM11 146 S Phosphorylation Phosphositeplus.1010730 18669648 Q9UM11 151 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20363803 Q9UM11 163 S Phosphorylation Phosphositeplus.1010730 18818692 Q9UM11 36 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;22115753 Q9UM11 40 S Phosphorylation Phosphositeplus.1010730 18669648;18818692;19690332;22115753 Q9UM11 42 S Phosphorylation Phosphositeplus.1010730 20068231 Q9UM11 70 S Phosphorylation Phosphositeplus.1010730 22067460 Q9UM11 72 S Phosphorylation Phosphositeplus.1010730 22067460 Q9UM11 92 S Phosphorylation Phosphositeplus.1010730 18187866 Q9UM11 121 T Phosphorylation Phosphositeplus.1010730 18818692 Q9UM11 32 T Phosphorylation Phosphositeplus.1010730 18669648;22115753 Q9UM11 91 Y Phosphorylation Phosphositeplus.1010730 18187866;21403953 Q9UM11 36 S Phosphorylation HPRD 9.0 18669648,19413330 Q9UM11 39 S Phosphorylation HPRD 9.0 19413330 Q9UM11 40 S Phosphorylation HPRD 9.0 18669648 Q9UM11 42 S Phosphorylation HPRD 9.0 20068231 Q9UM11 137 S Phosphorylation HPRD 9.0 18669648,20068231 Q9UM11 138 S Phosphorylation HPRD 9.0 18669648,20068231 Q9UM11 146 S Phosphorylation HPRD 9.0 18669648,20068231 Q9UM11 149 S Phosphorylation HPRD 9.0 20068231 Q9UM11 154 S Phosphorylation HPRD 9.0 18669648,20068231 Q9UM11 30 T Phosphorylation HPRD 9.0 20068231 Q9UM11 32 T Phosphorylation HPRD 9.0 18669648 Q9UM11 151 S Phosphorylation (CDK2) HPRD 9.0 12560341,18669648,20068231 Q9UM11 163 S Phosphorylation (CDK2) HPRD 9.0 12560341 Q9UM11 36 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 40 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 137 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 138 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 146 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 151 S Phosphorylation SysPTM 1.1 18669648 Q9UM11 32 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References FZR1 137 S Phosphorylation 18669648,20068231 FZR1 138 S Phosphorylation 18669648,20068231 FZR1 146 S Phosphorylation 18669648,20068231 FZR1 149 S Phosphorylation 20068231 FZR1 151 S Phosphorylation 12560341,18669648,20068231 FZR1 154 S Phosphorylation 18669648,20068231 FZR1 163 S Phosphorylation 12560341 FZR1 30 T Phosphorylation 20068231 FZR1 32 T Phosphorylation 18669648 FZR1 36 S Phosphorylation 18669648,19413330 FZR1 39 S Phosphorylation 19413330 FZR1 40 S Phosphorylation 18669648 FZR1 42 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9UM11 32 T 18669648 HTP Phosphorylation Q9UM11 163 S 12560341 CDK_group LTP Phosphorylation Q9UM11 36 S 18669648 HTP Phosphorylation Q9UM11 70 S 22067460 HTP Phosphorylation Q9UM11 40 S 18669648 HTP Phosphorylation Q9UM11 137 S 18669648 HTP Phosphorylation Q9UM11 138 S 18669648 HTP Phosphorylation Q9UM11 72 S 22067460 HTP Phosphorylation Q9UM11 146 S 18669648 HTP Phosphorylation Q9UM11 151 S 18669648 HTP Phosphorylation Q9UM11 151 S 12560341 CDK_group LTP Phosphorylation Q9UM11 154 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9UM11 32 Phosphothreonine 18669648 Q9UM11 36 Phosphoserine 18669648;19690332 Q9UM11 69 N6-acetyllysine 22014574 Q9UM11 133 Phosphoserine 23186163 Q9UM11 138 Phosphoserine 18669648;23186163 Q9UM11 146 Phosphoserine 18669648 Q9UM11 151 Phosphoserine 18669648;19690332;23186163 Q9UM11 159 N6-acetyllysine 22014574

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type FZR1 IPI00099464 S 151 VSPYSLpSPVSNKS phosphorylation FZR1 IPI00099464 S 154 YSLSPVpSNKSQKL phosphorylation FZR1 IPI00099464 S 42 SPVSSPpSKHGDRF phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 51343 119489 - K Ubiquitination 21963094 51343 119489 - K Ubiquitination 21139048 51343 119489 - K Ubiquitination 21890473 51343 119489 - K Ubiquitination 21906983 51343 119489 - K Ubiquitination 23972993

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID FZR1 Homo sapiens (Human) 156; 262; 263; 96; 480 "156,LSPVSNKSQKLLR; 262,WDAAAGKKLSMLE; 263,DAAAGKKLSMLEG; 96,AYSALLKNELLGA; 480,SKTRSTKESVSVL" "156:21906983; 262:21890473,21906983; 263:21906983; 96:21906983; 480:21906983" FZR1 Homo sapiens (Human) 156; 262; 263; 96 "156,LSPVSNKSQKLLR; 262,WDAAAGKKLSMLE; 263,DAAAGKKLSMLEG; 96,AYSALLKNELLGA" "156:21906983; 262:21890473,21906983; 263:21906983; 96:21906983" FZR1 Homo sapiens (Human) 174; 96; 173; 391 "174,DAAAGKKLSMLEG; 96,AYSALLKNELLGA; 173,WDAAAGKKLSMLE; 391,SKTRSTKESVSVL" "174:21906983; 96:21906983; 173:21890473,21906983; 391:21906983" CDH1 Homo sapiens (Human) 871; 738 "871,WGNRFKKLADMYG; 738,RRRAVVKEPLLPP" 871:21906983; 738:21906983 CDH1 Homo sapiens (Human) 677; 810 "677,RRRAVVKEPLLPP; 810,WGNRFKKLADMYG" 677:21906983; 810:21906983