PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CBLL1 RNF2 24457600 biogrid exp P P P P GP P P P P P P P P P P P KIAA1429 CBLL1 26344197 biogrid exp GP P G GP GP G G GP P P GP G GP GP GP P G GP GP G GP GP GP GP GP G KIF26B CBLL1 26496610 biogrid,intact exp P P GP P P P P P P P GP P P P P P P P P P CBLL1 DOK1 22252131 biogrid exp GP P G GP GP G G G P P GP G GP GP G P G GP G G GP GP G GP GP G DGCR6 CBLL1 24722188 biogrid exp P P P P P P P P P P P P P P P P SFPQ CBLL1 19535458 biogrid exp GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G WTAP CBLL1 26344197 biogrid exp GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G ESR1 CBLL1 20608937 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G YWHAQ CBLL1 15161933 biogrid exp GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP G GP GP GP GP G YWHAZ CBLL1 15161933 mint,intact exp GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G SRC CBLL1 21685945,18057010 biogrid,intact exp GP P GP GP G P G G GP GP G G GP GP G GP GP GP GP G CDC42 CBLL1 18057010 biogrid exp GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G CTTN CBLL1 22252131 biogrid exp, ortho GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G CDH1 CBLL1 22850631,16336960,19711372,22252131,21685945,18057010,11836526,22715382, 25402006, 21836163 hprd,biogrid,intact exp, ortho, pred GP G G G GP P P P G G GP G P G GP GP GP GP G GP G CBLL1 CBLL1 ortho GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G YWHAE CBLL1 ortho GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G CTNNB1 CBLL1 25402006 pred GP P G GP GP G GP GP P P P G G GP GP GP P G GP GP GP G GP G GP GP G CBLL1 NDRG1 25402006 pred GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP G GP GP GP GP G PTPRM CBLL1 25402006 pred GP P P GP G GP GP P P P G G GP GP GP P G GP GP G GP GP G GP GP G CDH3 CBLL1 25402006 pred GP P P P P P P G P G P P GP P P GP P P G CDON CBLL1 25402006 pred GP P G GP GP G GP GP P G G GP GP G G GP GP GP GP GP G GP GP G CBLL1 LIMA1 25402006 pred GP P G GP G G G GP P P G G GP G G P G GP GP GP GP GP G GP GP G FOXM1 CBLL1 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP VCL CBLL1 25402006 pred GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G JUP CBLL1 25402006 pred GP G G G G G GP P P G G GP G G P G GP GP GP G GP G GP G G CTNNA1 CBLL1 25402006 pred GP P G GP GP G GP GP P P P GP G GP GP GP P G GP GP GP GP GP GP GP GP G DSCAM CBLL1 23023127 pred G G GP G G GP P GP G P G G P G G G G G PLEKHA7 CBLL1 25402006 pred GP P P P G GP GP P P P P G GP GP G P GP P GP GP P GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P12931 Q75N03 affinity chromatography technology 21685945 physical association X 2 P12931 Q75N03 affinity chromatography technology 18057010 physical association X 2 P23246 Q75N03 affinity chromatography technology 19535458 physical association X 2 P0CG48 Q75N03 affinity chromatography technology 24654937 physical association X 2 Q75N03 P12830 affinity chromatography technology 19711372 physical association X 2 Q75N03 x-ray crystallography 22252131 association X 2 Q75N03 P12830 affinity chromatography technology 22252131 physical association X 2 Q75N03 Q14247 affinity chromatography technology 22252131 physical association X 2 Q75N03 P12830 affinity chromatography technology 22715382 physical association X 2 Q75N03 A0A024R3Z2 affinity chromatography technology 24654937 physical association X 2 Q75N03 P12830 fluorescent resonance energy transfer 22850631 direct interaction X 2 Q75N03 Q99496 affinity chromatography technology 24457600 physical association X 2 Q75N03 P12830 affinity chromatography technology 11836526 physical association X 2 Q75N03 P12830 affinity chromatography technology 16336960 physical association X 2 Q75N03 P12830 two hybrid 11836526 direct interaction X 2 Q75N03 P12830 affinity chromatography technology 21685945 physical association X 2 Q75N03 A0A024RAE4 pull down 18057010 direct interaction X 2 Q75N03 P12830 imaging technique 18057010 colocalization X 2 Q75N03 A0A024RAE4 imaging technique 18057010 colocalization X 2 P27348 Q75N03 pull down 15161933 direct interaction X 2 Q75N03 two hybrid 20608937 direct interaction X 2 Q75N03 affinity chromatography technology 20608937 physical association X 2 Q75N03 Q99704-3 affinity chromatography technology 22252131 physical association X 2 Q75N03 Q14129 two hybrid 24722188 direct interaction X 2 Q75N03 P12830-2 two hybrid 11836526 - X 2 Q75N03 P12830-2 two hybrid 11836526 - X 2 Q75N03 anti bait coimmunoprecipitation 21685945 association C 3 D0PNI1 Q75N03 pull down 15161933 physical association X 2 Q75N03 Q81KB5 two hybrid pooling approach 20711500 physical association X 2 Q75N03 P12830 anti bait coimmunoprecipitation 21685945 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CBLL1 RNF2 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_307057 prey bait SFPQ CBLL1 MI:0004(affinity chromatography technology) 19535458 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201628 bait prey YWHAZ CBLL1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 15161933 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint) MINT_83680|UniProt_77340|MINT_51336 bait|bait|bait prey|prey|prey CBLL1 DOK1 MI:0114(x-ray crystallography) 22252131 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_198794 bait prey CDC42 CBLL1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18057010 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_146990|BIOGRID_146984 bait|bait prey|prey SRC CBLL1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18057010,21685945 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_114145|BIOGRID_146987|BIOGRID_143318 bait|bait|bait prey|prey|prey CTTN CBLL1 MI:0114(x-ray crystallography) 22252131 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_198795 prey bait NRF1 CBLL1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296963 bait prey YWHAQ CBLL1 MI:0096(pull down) 15161933 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_291723 bait prey CDH1 CBLL1 MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11836526,16336960,18057010,19711372,21685945,22252131,22715382 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) HPRD_4760|UniProt_114146|BIOGRID_124934|BIOGRID_116710|BIOGRID_198793|BIOGRID_77561|BIOGRID_146989|BIOGRID_199794|BIOGRID_143319|BIOGRID_197488 -|bait|bait|bait|prey|bait|bait|bait|bait|bait -|prey|prey|prey|bait|prey|prey|prey|prey|prey ESR1 CBLL1 MI:0018(two hybrid)|MI:0018(two hybrid) 20608937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_198058|BIOGRID_198057 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CDH1 CBLL1 22252131,16336960,22715382,11836526,21685945,11836526,19711372,18057010,21685945 0004,0004,0004,0004,0006,0018,0004,0428,0004 LC SRC CBLL1 21685945,18057010,21685945 0006,0004,0004 LC WTAP CBLL1 26344197 0401 HT KIF26B CBLL1 26496610,26496610 0007,0004 HT KIAA1429 CBLL1 26344197 0401 HT CBLL1 Q9UII7 22252131,16336960,22715382,11836526,11836526,19711372,18057010,21685945 0004,0004,0004,0004,0018,0004,0428,0004 LC WTAP CBLL1 26344197 0401 HT KIF26B CBLL1 26496610,26496610 0007,0004 HT KIAA1429 CBLL1 26344197 0401 HT CDH1 CBLL1 22252131,16336960,22715382,11836526,21685945,11836526,19711372,18057010,21685945 0004,0004,0004,0004,0006,0018,0004,0428,0004 LC SRC CBLL1 21685945,18057010,21685945 0006,0004,0004 LC CBLL1 Q9UII7 22252131,16336960,22715382,11836526,11836526,19711372,18057010,21685945 0004,0004,0004,0004,0018,0004,0428,0004 LC ESR1 CBLL1 20608937,20608937 0018,0004 LC CDH1 CBLL1 11836526,11836526 0004,0018 LC DGCR6 CBLL1 24722188 0018 HT WTAP CBLL1 26344197 0401 LC KIAA1429 CBLL1 26344197 0401 LC CBLL1 Q9UBT1 20608937,20608937 0018,0004 LC CBLL1 Q9UII7 22850631,11836526,11836526 0055,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q75N03 P23246 CBLL1 SFPQ 0.21 19535458 Q75N03 P12830 CBLL1 CDH1 0.899 21685945,18057010,22850631,19711372,16336960,11836526,22252131,22715382 Q75N03 Q14247 CBLL1 CTTN 0.21 22252131 Q75N03 Q15007 CBLL1 WTAP 0.081 26344197 Q75N03 Q69YN4 CBLL1 KIAA1429 0.081 26344197 Q99704 Q75N03 DOK1 CBLL1 0.21 22252131 Q9JIY2 Q75N03 CBLL1 CBLL1 0.309 22252131 Q81KB5 Q75N03 Q81KB5 CBLL1 0.126 20711500 Q75N03 P03372 CBLL1 ESR1 0.454 20608937 Q75N03 P12931 CBLL1 SRC 0.376 21685945,18057010 Q75N03 Q2KJY2 CBLL1 KIF26B 0.236 26496610 Q75N03 P60953 CBLL1 CDC42 0.396 18057010 Q75N03 P27348 CBLL1 YWHAQ 0.183 15161933 Q99496 Q75N03 RNF2 CBLL1 0.126 24457600 Q75N03 Q14129 CBLL1 DGCR6 0.183 24722188 Q75N03 P63104 CBLL1 YWHAZ 0.126 15161933

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IRS4 CBLL1 MI:0362 inference MI:0461 interaction database PPP1R12A CBLL1 MI:0362 inference MI:0461 interaction database RNF40 CBLL1 MI:0362 inference MI:0461 interaction database PPM1B CBLL1 MI:0362 inference MI:0461 interaction database ESR1 CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database UBC CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database PRKAR1A CBLL1 MI:0362 inference MI:0461 interaction database CDH1 CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database SRC CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database HCLS1 CBLL1 MI:0362 inference MI:0461 interaction database SFPQ CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database JAK1 CBLL1 MI:0362 inference MI:0461 interaction database YWHAQ CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database PPM1A CBLL1 MI:0362 inference MI:0461 interaction database HNF4A CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database PRKCI CBLL1 MI:0362 inference MI:0461 interaction database PI4KA CBLL1 MI:0362 inference MI:0461 interaction database CSNK1D CBLL1 MI:0362 inference MI:0461 interaction database CSNK1E CBLL1 MI:0362 inference MI:0461 interaction database GDI2 CBLL1 MI:0362 inference MI:0461 interaction database IRAK1 CBLL1 MI:0362 inference MI:0461 interaction database EIF3E CBLL1 MI:0362 inference MI:0461 interaction database CDC42 CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database YWHAZ CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database PRKCD CBLL1 MI:0362 inference MI:0461 interaction database ILF2 CBLL1 MI:0362 inference MI:0461 interaction database DGCR6 CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database CTTN CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database KIF26B CBLL1 MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP21 CBLL1 MI:0362 inference MI:0461 interaction database RNF20 CBLL1 MI:0362 inference MI:0461 interaction database CBLL1 RNF2 MI:0045 experimental interaction detection MI:0461 interaction database CBLL1 PIK3R4 MI:0362 inference MI:0461 interaction database CBLL1 DOK1 MI:0045 experimental interaction detection MI:0461 interaction database CBLL1 LIMD1 MI:0362 inference MI:0461 interaction database CBLL1 NCKAP1 MI:0362 inference MI:0461 interaction database