PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus COPS8 NOD1 17337451 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NUDCD3 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATG16L1 NOD1 19898471,23300079 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G PTGES3 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC37 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FKBP5 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NOD1 MAGED1 17353931 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF34 NOD1 25012219 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GABRB1 NOD1 21988832 biogrid,intact exp G G G G G G G G G G G MLF2 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NOD1 NOD1 10880512,23300079,18186648,10329646 innatedb,hprd,biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XIAP NOD1 19667203 innatedb,biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP5C NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC NOD1 23300079 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CACYBP NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FKBPL NOD1 25036637 intact exp G G G G G G G G PSMA7 NOD1 23839082 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHMT2 NOD1 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSPA8 NOD1 25036637 intact exp MOV10 NOD1 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G TRIP6 NOD1 15657077 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRAF4 NOD1 21097508 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G PSMD2 NOD1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX8 NOD1 21988832 biogrid,intact exp G G G G G G G G G HSP90AA1 NOD1 17435760,16083881,25036637,17420470 innatedb,biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AB1 NOD1 25036637 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G OLFM4 NOD1 20534456 dip exp, ortho G G G G G G G G G G CASP4 NOD1 10329646, 25402006, 23023127, 16082366 hprd,biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G NOD1 SUGT1 17435760,23935490,25036637,17420470, 25402006 innatedb,biogrid,intact,dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NOD2 NOD1 19898471, 25402006, 23023127, 16082366 biogrid exp, pred G G G G NLRC4 NOD1 15107016, 25402006, 23023127, 16082366 innatedb,biogrid,i2d exp, pred G G G G CASP8 NOD1 10329646, 23023127, 16082366 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G COPS5 NOD1 17337451, 25402006 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP9 NOD1 10329646, 23023127, 21836163, 16082366 hprd,biogrid,i2d,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BID NOD1 21552281, 25402006 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G ACAP1 NOD1 17005562, 25402006, 21836163 innatedb exp, pred G G G G G G G HSPA1A, HSPA1B NOD1 16083881,25036637, 21836163 mint,intact exp, pred CFLAR NOD1 10329646, 23023127, 16082366 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSPA6 NOD1 25036637, 25402006 intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G GPS1 NOD1 17337451, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP1 NOD1 12459189,10329646, 25402006, 16082366 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS6 NOD1 17337451, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP2 NOD1 10329646, 23023127, 21836163, 16082366 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS7A NOD1 17337451, 25402006 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RIPK2 NOD1 19337385,17054981,23300079,10329646,10224040,24958724,12459189,16517750,19667203, 25402006, 23023127, 21836163, 16082366 innatedb,hprd,biogrid,i2d,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS3 NOD1 17337451, 25402006 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP1 NOD1 11113115, 25402006, 23023127 hprd exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CARD6 NOD1 12775719, 23023127, 16082366 innatedb,hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G CHORDC1 NOD1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM38 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G TFG NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP12 NOD1 25402006 pred NOD1 LY96 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G CD86 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G EREG NOD1 23023127 pred G G G IL10 NOD1 23023127 pred G CARD11 NOD1 25402006 pred G G G G G ZAK NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLR7 NOD1 23023127 pred DPEP1 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G PYCARD NOD1 25402006, 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G COL18A1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CRTAM NOD1 23023127 pred G G G G HSPA1L NOD1 25402006 pred G G G G G G G G G G G G G G G NPM1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NGFR NOD1 25402006, 23023127 pred G G G G G G G G G G G G FADD NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCC NOD1 23023127 pred G G G BMPER NOD1 23023127 pred G IL6 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G C3 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4A NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G S100A4 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CD276 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TFRC NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARAF NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCOR1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BIRC3 NOD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G C5AR1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G RNASE3 NOD1 23023127 pred G G G G G G G G G G G TLR5 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TIRAP NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CARD18 NOD1 25402006, 23023127, 16082366 pred G G G G G PGLYRP2 NOD1 21836163 pred G G GFER NOD1 25402006 pred G G G G G G G G G G G G G G G G G BCL10 NOD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARHGEF2 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PLA2G2A NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G GRB10 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFB1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G MID1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G NOD1 NCOA3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VWF NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERPUD1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FLNA NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NAIP NOD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G TNNT3 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP5 NOD1 23023127, 16082366 pred NLRP8 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G TLR9 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G DEDD NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP4 NOD1 25402006, 21836163 pred G PGLYRP3 NOD1 21836163 pred G COPS2 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PLCE1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G CARD16 NOD1 25402006, 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G IL27RA NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP14 NOD1 16082366 pred G G G TRADD NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BCL3 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G CLTC NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDR NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SLC2A4 NOD1 25402006 pred ELANE NOD1 23023127 pred G G G G NOL3 NOD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CIDEA NOD1 23023127 pred G G G G G G G G TFEC NOD1 23023127 pred G G G G G G G G SLC22A18 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFB2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FAS NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G DNAJB6 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP12 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G HSP90B1 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ADORA2B NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G CARD9 NOD1 23023127, 16082366 pred G G G G CASP12 NOD1 25402006 pred IGF1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP10 NOD1 21836163 pred G LBP NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G COPS4 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLR4 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G CASP7 NOD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PGLYRP4 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APOA2 NOD1 23023127 pred G G TLR1 NOD1 23023127 pred G G G G G G G G G G G G G G TLR2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G TAB2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EDA2R NOD1 23023127 pred G G G G G G G G TLR3 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G NLRP13 NOD1 25402006 pred G G G CRADD NOD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX7 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G MALT1 NOD1 25402006, 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G NOD1 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAT5A NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF10A NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CD1D NOD1 23023127 pred G G G G G G G G G IL19 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP6 NOD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G DEDD2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EPB41L5 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K7 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASP10 NOD1 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PYDC1 NOD1 23023127 pred G IRAK1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATN1 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRAF5 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPG7 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CARD17 NOD1 25402006, 23023127, 21836163 pred IRAK2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G NLRP2 NOD1 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G CDH1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G MNDA NOD1 23023127 pred G G G G G G G G G G G G G G G G G SQSTM1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BMP4 NOD1 23023127 pred G G G G G G G G G G G G G APAF1 NOD1 23023127, 21836163, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PGLYRP1 NOD1 21836163 pred G G NOD1 IRAK3 23023127 pred G G G G G G G G G G G G G G ITGB1 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP100 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G CD74 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RIPK1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFKB1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G S100A6 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEBPB NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CARD14 NOD1 16082366 pred G G G G G G G G G G G G G G G G G G TNFRSF8 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP3 NOD1 25402006, 23023127, 16082366 pred G G NOD1 TLR6 23023127 pred G G G G G G G G LIF NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G DLG5 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G INS NOD1 23023127 pred G G G ICAM1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF25 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G NLRP11 NOD1 25402006 pred G CTGF NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BIRC2 NOD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NOD1 CARD8 25402006, 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CD14 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IFI16 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFAM1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G BIRC5 NOD1 23023127 pred G G G G G G G G G RP1 NOD1 23023127 pred AXIN1 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF1A NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EIF3E NOD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRC3 NOD1 23023127 pred G G G G G G G G G G G G G G IL12A NOD1 23023127 pred G CASP3 NOD1 25402006, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP73 NOD1 23023127 pred G G G G G TCF7L2 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP7 NOD1 25402006 pred G G G G G CARD10 NOD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IL6R NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TICAM1 NOD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G TLR8 NOD1 23023127 pred G G G G G G G G G G G G CNKSR3 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G MYD88 NOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AGER NOD1 23023127 pred G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NOD1 SUGT1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17420470,17435760 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_270552|BIOGRID_197693|BIOGRID_270550 prey|bait|bait bait|prey|prey NOD1 MAGED1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_145041 prey bait PSMA7 NOD1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23839082 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_283866|BIOGRID_283865 bait|prey prey|bait COPS6 NOD1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17337451 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_207562|BIOGRID_207564 bait|prey prey|bait XIAP NOD1 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 19667203 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|MI:0465(dip)|MI:0465(dip) BIOGRID_214407|DIP_55514|DIP_55505 bait|-|- prey|-|- CASP4 NOD1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_11260|BIOGRID_104901 -|prey -|bait HSP90AA1 NOD1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 16083881,17420470,17435760 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0468(hprd) UniProt_82861|BIOGRID_197690|MINT_32857|MINT_61766|BIOGRID_270551|HPRD_39847 prey|prey|prey|prey|prey|- bait|bait|bait|bait|bait|- SOX8 NOD1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118212|BIOGRID_288591 unspecified role|prey unspecified role|bait CASP8 NOD1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_104902|HPRD_9797 prey|- bait|- GPS1 NOD1 MI:0004(affinity chromatography technology) 17337451 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_207563 bait prey TRAF4 NOD1 MI:0004(affinity chromatography technology) 21097508 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_212989 bait prey CARD6 NOD1 MI:0004(affinity chromatography technology)|MI:0492(in vitro) 12775719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_89218|HPRD_13861 bait|- prey|- NLRC4 NOD1 MI:0004(affinity chromatography technology) 15107016 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_86621 bait prey UBC NOD1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23300079,23839082 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_248597|BIOGRID_283867|BIOGRID_248595 bait|prey|prey prey|bait|bait CASP9 NOD1 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(intact) MINT_85549|MINT_56509|BIOGRID_104903|HPRD_10520|UniProt_66604 bait|bait|prey|-|bait prey|prey|bait|-|prey GABRB1 NOD1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_287970|UniProt_117599 bait|unspecified role prey|unspecified role CFLAR NOD1 MI:0004(affinity chromatography technology) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_104905 prey bait CASP2 NOD1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_7451|BIOGRID_104900 -|prey -|bait HSPA1A NOD1 MI:0007(anti tag coimmunoprecipitation)|MI:0397(two hybrid array)|MI:0397(two hybrid array) 16083881 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_82862|MINT_32858|MINT_61767 prey|prey|prey bait|bait|bait ATG16L1 NOD1 MI:0004(affinity chromatography technology) 23300079 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248594 prey bait NLRP1 NOD1 MI:0493(in vivo) 11113115 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_13860 - - CASP1 NOD1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10329646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36540|BIOGRID_104899 -|prey -|bait RIPK2 NOD1 MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 10329646,16517750,17054981,19667203,23300079 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_86000|HPRD_12385|BIOGRID_104904|UniProt_87378|BIOGRID_271972|MINT_56887|UniProt_66605|BIOGRID_248593|DIP_55505 prey|-|prey|bait|bait|prey|prey|prey|- bait|-|bait|prey|prey|bait|bait|bait|-

PPI - HINT Gene A Gene B PMID Method Quality RIPK2 NOD1 23300079,10329646,16517750,17054981,10329646,10329646 0096,0004,0004,0007,0018,0019 LC HSP90AA1 NOD1 16083881,17420470 0007,0007 LC UBC NOD1 23300079,23300079 0096,0114 LC ATG16L1 NOD1 19898471,23300079,19898471 0004,0096,0007 LC Q86SX1 NOD1 17420470,17435760 0004,0004 LC NOD1 NOD1 23300079,10329646,10329646,10329646 0096,0004,0019,0045 LC NOD1 SUGT1 17420470,17435760,17435760,17420470,23935490 0004,0004,0007,0007,0007 LC NOD1 MAGED1 17353931 0006 HT NOD1 MAGED1 17353931 0006 HT RIPK2 NOD1 23300079,10329646,16517750,17054981,10329646,10329646 0096,0004,0004,0007,0018,0019 LC HSP90AA1 NOD1 16083881,17420470 0007,0007 LC UBC NOD1 23300079,23300079 0096,0114 LC ATG16L1 NOD1 19898471,23300079,19898471 0004,0096,0007 LC Q86SX1 NOD1 17420470,17435760 0004,0004 LC NOD1 NOD1 23300079,10329646,10329646,10329646 0096,0004,0019,0045 LC NOD1 SUGT1 17420470,17435760,17435760,17420470,23935490 0004,0004,0007,0007,0007 LC A8K1F4 NOD1 25036637 0729 HT B3KTT5 NOD1 25036637 0729 HT B4DYC6 NOD1 25036637 0729 HT RIPK2 NOD1 10329646,10224040,12459189,10329646,10329646,19337385 0004,0018,0018,0018,0019,0018 LC HSP90AA1 NOD1 25036637 0729 HT HSP90AB1 NOD1 25036637 0729 HT UBC NOD1 25127239,23300079,23300079 0114,0096,0114 LC GABRB1 NOD1 21988832,21988832 0397,0018 HT PPP5C NOD1 25036637 0729 HT CASP9 NOD1 10329646,10329646,10329646 0004,0019,0045 LC SOX8 NOD1 21988832,21988832 0397,0018 HT PSMD2 NOD1 25036637 0729 HT FKBP5 NOD1 25036637 0729 HT PTGES3 NOD1 25036637 0729 HT CDC37 NOD1 25036637 0729 HT Q53FC7 NOD1 25036637 0729 HT NUDCD3 NOD1 25036637 0729 HT RNF34 NOD1 25012219,25012219,25012219 0096,0018,0004 LC Q96BE0 NOD1 25036637 0729 HT CACYBP NOD1 25036637 0729 HT NLRC4 NOD1 15107016,15107016,15107016 0019,0004,0007 LC FKBPL NOD1 25036637 0729 HT COPS3 NOD1 17337451,17337451 0007,0018 LC NOD1 NOD1 10329646,10880512,18186648,10880512,10329646,18186648,10329646 0004,0019,0114,0045,0019,0071,0045 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y239 O14818 NOD1 PSMA7 0.376 23839082 Q9Y239 A1A4Y4 NOD1 IRGM 0.21 25891078 Q9Y239 O43353 NOD1 RIPK2 0.659 16517750,10329646,23300079 Q9Y239 Q8K2C9 NOD1 PTPLAD1 0.126 25036637 Q9Y239 Q9HC29 NOD1 NOD2 0.376 19898471 Q9Y239 Q9HCE1 NOD1 MOV10 0.126 22658674 Q9Y239 Q9NPP4 NOD1 NLRC4 0.21 15107016 Q9Y239 Q8IVD9 NOD1 NUDCD3 0.126 25036637 Q9Y5V3 Q9Y239 MAGED1 NOD1 0.236 17353931 Q9Y239 Q9HB71 NOD1 CACYBP 0.126 25036637 Q9Y239 Q9BPW0 NOD1 PPP5C 0.126 25036637 Q9Y239 Q9UIM3 NOD1 FKBPL 0.126 25036637 Q9Y239 Q3UJD6 NOD1 USP19 0.126 25036637 Q9Y239 Q14790 NOD1 CASP8 0.21 10329646 Q9Y239 Q15185 NOD1 PTGES3 0.126 25036637 Q9Y239 Q7L5N1 NOD1 COPS6 0.376 17337451 Q9Y239 P49662 NOD1 CASP4 0.21 10329646 Q9Y239 P42575 NOD1 CASP2 0.21 10329646 Q9Y239 O15519 NOD1 CFLAR 0.21 10329646 Q9Y239 P08107 NOD1 HSPA1B 0.21 16083881 Q9Y239 P29466 NOD1 CASP1 0.21 10329646 Q9Y239 P0CG48 NOD1 UBC 0.523 23300079 Q9Y239 A8K1F4 NOD1 A8K1F4 0.126 25036637 Q9Y239 B4DYC6 NOD1 B4DYC6 0.126 25036637 Q9Y239 B3KTT5 NOD1 B3KTT5 0.126 25036637 Q9Y239 Q13200 NOD1 PSMD2 0.126 25036637 Q9Y239 Q53FC7 NOD1 Q53FC7 0.126 25036637 Q9Y2Z0 Q9Y239 SUGT1 NOD1 0.507 17435760,17420470 Q9Y239 Q6PK50 NOD1 HSP90AB1 0.126 25036637 Q9Y239 Q676U5 NOD1 ATG16L1 0.569 23300079,19898471 Q9Y239 P55211 NOD1 CASP9 0.376 10329646 Q9Y239 P57073 NOD1 SOX8 0.286 21988832 Q9Y239 Q9Y239 NOD1 NOD1 0.49 23300079,10329646 Q9Y239 P18505 NOD1 GABRB1 0.286 21988832 Q9Y239 P98170 NOD1 XIAP 0.454 19667203 Q9Y239 P07900 NOD1 HSP90AA1 0.569 17435760,16083881,25036637,17420470 Q9Y239 Q969K3 NOD1 RNF34 0.623 25012219 Q9Y239 Q96BE0 NOD1 Q96BE0 0.126 25036637 Q9Y239 Q9BUZ4 NOD1 TRAF4 0.21 21097508 Q9Y239 Q9BX69 NOD1 CARD6 0.21 12775719 Q9Y239 Q9D1P4 NOD1 CHORDC1 0.21 16083881 Q9Y239 P34897 NOD1 SHMT2 0.126 22658674 Q9Y239 Q13451 NOD1 FKBP5 0.126 25036637 Q9Y239 Q13098 NOD1 GPS1 0.21 17337451 Q9Y239 Q16543 NOD1 CDC37 0.126 25036637

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IRGM NOD1 MI:0045 experimental interaction detection MI:0461 interaction database MAP2K7 NOD1 MI:0362 inference MI:1106 pathways database PSMA7 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database IKBKB NOD1 MI:0362 inference MI:1106 pathways database CHUK NOD1 MI:0362 inference MI:1106 pathways database CFLAR NOD1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 NOD1 MI:0362 inference MI:1106 pathways database RIPK2 NOD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP19 NOD1 MI:0362 inference MI:0461 interaction database HSP90AA1 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 NOD1 MI:0362 inference MI:0461 interaction database UBC NOD1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A NOD1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B NOD1 MI:0045 experimental interaction detection MI:0461 interaction database GABRB1 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database HNF1A NOD1 MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 NOD1 MI:0362 inference MI:1106 pathways database CASP1 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database SHMT2 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database CASP2 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database MAP2K4 NOD1 MI:0362 inference MI:1106 pathways database MAP2K3 NOD1 MI:0362 inference MI:1106 pathways database CASP4 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database MAP2K6 NOD1 MI:0362 inference MI:1106 pathways database CASP9 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database SOX8 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N NOD1 MI:0362 inference MI:1106 pathways database XIAP NOD1 MI:0045 experimental interaction detection MI:0461 interaction database GPS1 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database PSMD2 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 NOD1 MI:0362 inference MI:1106 pathways database FKBP5 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database CASP8 NOD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PTGES3 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database TAB1 NOD1 MI:0362 inference MI:1106 pathways database CDC37 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database HACD4 NOD1 MI:0362 inference MI:0461 interaction database ATG16L1 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database OLFM4 NOD1 MI:0362 inference MI:0461 interaction database COPS6 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database TAB3 NOD1 MI:0362 inference MI:1106 pathways database RNF34 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database ITCH NOD1 MI:0362 inference MI:1106 pathways database TRAF4 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database CARD6 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database CARD9 NOD1 MI:0362 inference MI:1106 pathways database CACYBP NOD1 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database MOV10 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database NLRC4 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database CYLD NOD1 MI:0362 inference MI:1106 pathways database TAB2 NOD1 MI:0362 inference MI:1106 pathways database HACD3 NOD1 MI:0362 inference MI:0461 interaction database CHORDC1 NOD1 MI:0362 inference MI:0461 interaction database FKBPL NOD1 MI:0045 experimental interaction detection MI:0461 interaction database NOD1 SUGT1 MI:0045 experimental interaction detection MI:0461 interaction database NOD1 TRAF6 MI:0362 inference MI:1106 pathways database NOD1 MAGED1 MI:0045 experimental interaction detection MI:0461 interaction database NOD1 IKBKG MI:0362 inference MI:1106 pathways database