PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ATN1 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LIG4 TLE4 22990118 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G POLE2 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 WDR77 22169276 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAT1 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 FXYD6 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BRCA1 TLE4 22990118 biogrid exp G G G G TLE4 TSSC1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 RNF10 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 TBX20 26186194 biogrid exp PEX2 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 ZFP64 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUX1 TLE4 19332113 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SERPINB9 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCL18 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G TLE4 PCDHA13 16169070 i2d exp POU2F2 TLE4 16103132 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DLEU1 TLE4 16169070 i2d exp TLE4 CELF3 16169070 i2d exp G G G G G G G G G EIF2S2 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 QPRT 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNRPG TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HLA-DQA1 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G PFN1 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPM1B TLE4 22169276 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARL3 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 FUBP1 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GSTM4 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAX5 TLE4 10811620,12153506 biogrid,bci exp G G G G G G G G G G G G G G G G G G G G TK1 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G TLE4 CCDC183 26186194 biogrid exp G G G G G G G G G G G G G G PRMT5 TLE4 22169276 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 MPHOSPH6 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARL4D TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDKN2C TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 FOXB1 25609649 intact exp POLB TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 BTBD2 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD11 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 DAZAP2 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SRPK2 TLE4 23602568 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ERH TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPA2 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 PAFAH1B3 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G POU2F1 TLE4 bci exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MSX1 TLE4 bci exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G SIX3 TLE4 25402006 bci exp, ortho, pred G G G G G TLE1 TLE4 25402006 bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 HDAC1 11266540, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 TLE4 25402006 bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE3 TLE4 25402006 bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 TLE4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 AES 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAX3 TLE4 25402006 ortho, pred G G G G G G TLE4 LEF1 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G SIX6 TLE4 25402006 ortho, pred G G G G G G G G G G G OTX1 TLE4 25402006 ortho, pred G G G G G G G G G G OTX2 TLE4 25402006, 21836163 ortho, pred G G TLE4 RUNX3 25402006 pred G G G G G G G G G G G G G G G G G G G RUNX1 TLE4 25402006 pred FKBP4 TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IFIT2 TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HR TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRPPRC TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IFIT1 TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G KDM5C TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SGTA TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 RUNX2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G TLE4 HDAC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EN2 TLE4 21836163 pred G G TLE4 JMJD1C 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IFIT3 TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STRN TLE4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 CUX1 21836163 pred TLE4 FBXW11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 KDM5D 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G ETS1 TLE4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAX2 TLE4 21836163 pred G G G G G G G TLE4 IFIT5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE4 BTRC 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM5A TLE4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRP6 TLE4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R0H7 Q04727 affinity chromatography technology 22169276 physical association X 2 A0A024R0H7 Q04727 affinity chromatography technology 22169276 physical association X 2 Q04727 Q02548 pull down 10811620 direct interaction X 2 Q04727 Q02548 affinity chromatography technology 10811620 physical association X 2 Q04727 Q02548 pull down 12153506 direct interaction X 2 Q04727 Q02548 two hybrid 10811620 direct interaction X 2 Q04727 O75688-3 affinity chromatography technology 22169276 physical association X 2 Q04727 O75688-3 affinity chromatography technology 22169276 physical association X 2 A0A024RE06 Q04727 two hybrid 22990118 direct interaction X 2 A0A024RE06 Q04727 affinity chromatography technology 22990118 physical association X 2 P0CG48 Q04727 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q04727 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q04727 affinity chromatography technology 21890473 physical association X 2 Q04727 two hybrid 22990118 direct interaction X 2 Q04727 affinity chromatography technology 22990118 physical association X 2 Q04727 P09086-2 pull down 16103132 direct interaction X 2 Q04727 P09086-2 affinity chromatography technology 16103132 physical association X 2 Q04727 P78362-2 enzymatic study 23602568 direct interaction X 2 Q04727 Q13547 affinity chromatography technology 11266540 physical association X 2 Q04727 affinity chromatography technology 19332113 physical association X 2 Q04727 affinity chromatography technology 19332113 physical association X 2 Q04727 pull down 19332113 direct interaction X 2 Q04727 B4DV00 affinity chromatography technology 22169276 physical association X 2 Q04727 B4DV00 affinity chromatography technology 22169276 physical association X 2 Q04727 far western blotting 9334241 association C 7 Q04727 pull down 10559189 association C 7 Q04727 P09086 gst pull down 16103132 association X 2 Q04727 pull down 10559189 association C 11 Q04727 anti tag coimmunoprecipitation 10559189 association C 11 Q04727 P28360 in vitro 16002402 - X 2 Q04727 Q02548 in vitro 10811620,12153506 - X 2 Q04727 Q02548 two hybrid 10811620,12153506 - X 2 Q04727 Q02548 in vivo 10811620,12153506 - X 2 Q04727 Q02548 two hybrid 10811620,12153506 - X 2 Q04727 Q02548 in vivo 10811620,12153506 - X 2 Q04727 Q02548 in vitro 10811620,12153506 - X 2 Q04727 P28360 in vitro 16002402 - X 2 Q04727 P32243 in vivo 15105370 - X 2 Q04727 Q04727 in vitro 12153506 - X 2 Q04727 P32243 in vivo 15105370 - X 2 Q04727 P14859 in vitro 16002402 - X 2 Q04727 P32242 in vivo 15105370 - X 2 Q04727 P14859 in vitro 16002402 - X 2 Q04727 P32242 in vivo 15105370 - X 2 Q8D1P6 Q04727 two hybrid pooling approach 20711500 physical association X 2 Q04727 Q81VY7 two hybrid pooling approach 20711500 physical association X 2 Q04727 Q81T30 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B BRCA1 TLE4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_245633|BIOGRID_246466 bait|bait prey|prey POU2F2 TLE4 MI:0096(pull down)|MI:0096(pull down) 16103132 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_270570|BIOGRID_270569 prey|prey bait|bait TLE4 WDR77 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22169276 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_167129|BIOGRID_167132 bait|bait prey|prey UBC TLE4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_174541|BIOGRID_266785|BIOGRID_171185 bait|bait|bait prey|prey|prey PAX5 TLE4 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 10811620,12153506 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_77460|BIOGRID_108701|BIOGRID_99633|BIOGRID_99632 bait|prey|prey|prey prey|bait|bait|bait TLE4 HDAC1 MI:0018(two hybrid) 11266540 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_104127 bait prey TLE4 CUX1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19332113 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_123202|BIOGRID_123204|BIOGRID_123203 prey|bait|bait bait|prey|prey SRPK2 TLE4 MI:0004(affinity chromatography technology) 23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_291349 bait prey LIG4 TLE4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_246536|BIOGRID_245986 bait|bait prey|prey PPM1B TLE4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22169276 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_167128|BIOGRID_167131 prey|prey bait|bait PRMT5 TLE4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22169276 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_167127|BIOGRID_167130 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PAX5 TLE4 12153506,10811620,10811620,10811620,12153506 0018,0004,0018,0096,0096 LC TLE4 TSSC1 26186194 0004 HT TLE4 KIAA1984 26186194 0004 HT TLE4 FOXB1 25609649,25609649 0676,0004 HT TLE4 TBX20 26186194 0004 HT TLE4 HEL-S-90N 26186194 0004 HT TLE4 TSSC1 26186194 0004 HT TLE4 KIAA1984 26186194 0004 HT TLE4 FOXB1 25609649,25609649 0676,0004 HT TLE4 TBX20 26186194 0004 HT TLE4 HEL-S-90N 26186194 0004 HT PAX5 TLE4 12153506,10811620,10811620,10811620,12153506 0018,0004,0018,0096,0096 LC POU2F2 TLE4 16103132,16103132,16103132 0096,0059,0004 LC BRCA1 TLE4 22990118,22990118 0018,0004 LC LIG4 TLE4 22990118,22990118 0018,0004 LC SRPK2 TLE4 23602568 0415 LC PAX5 TLE4 12153506,10811620,10811620,10811620,12153506 0018,0004,0018,0096,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q53HC9 Q04727 TSSC1 TLE4 0.126 26186194 Q5T5S1 Q04727 CCDC183 TLE4 0.126 26186194 Q13547 Q04727 HDAC1 TLE4 0.21 11266540 Q04727 O14744 TLE4 PRMT5 0.21 22169276 Q04727 O75688 TLE4 PPM1B 0.21 22169276 Q81VY7 Q04727 MFD TLE4 0.126 20711500 Q81T30 Q04727 BRNQ3 TLE4 0.126 20711500 Q8D1P6 Q04727 TCAC1 TLE4 0.126 20711500 Q9BQA1 Q04727 WDR77 TLE4 0.21 22169276 Q99853 Q04727 FOXB1 TLE4 0.236 25609649 Q04727 P09086 TLE4 POU2F2 0.454 16103132 Q04727 P37198 TLE4 NUP62 0.236 unassigned1304 Q04727 P49917 TLE4 LIG4 0.286 22990118 Q04727 P38398 TLE4 BRCA1 0.286 22990118 Q04727 P39880 TLE4 CUX1 0.569 19332113 Q9UMR3 Q04727 TBX20 TLE4 0.126 26186194 Q04727 P78362 TLE4 SRPK2 0.183 23602568 Q13948 Q04727 CUX1 TLE4 0.569 19332113 Q15274 Q04727 QPRT TLE4 0.126 26186194 Q04727 Q02548 TLE4 PAX5 0.74 10811620,12153506

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PRMT5 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database SNAI2 TLE4 MI:0362 inference MI:0461 interaction database PPM1B TLE4 MI:0045 experimental interaction detection MI:0461 interaction database SIX3 TLE4 MI:0362 inference MI:0461 interaction database SIX6 TLE4 MI:0362 inference MI:0461 interaction database POU2F2 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database TPM1 TLE4 MI:0362 inference MI:0461 interaction database UBB TLE4 MI:0362 inference MI:1106 pathways database UBC TLE4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database POU2F1 TLE4 MI:0362 inference MI:0461 interaction database ELK1 TLE4 MI:0362 inference MI:0461 interaction database PAX3 TLE4 MI:0362 inference MI:0461 interaction database MSX1 TLE4 MI:0362 inference MI:0461 interaction database CTNNB1 TLE4 MI:0362 inference MI:1106 pathways database MSX2 TLE4 MI:0362 inference MI:0461 interaction database BRCA1 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database CUX1 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database DCT TLE4 MI:0362 inference MI:0461 interaction database LIG4 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A TLE4 MI:0362 inference MI:1106 pathways database UBA52 TLE4 MI:0362 inference MI:1106 pathways database SRPK2 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database XIAP TLE4 MI:0362 inference MI:1106 pathways database PAX5 TLE4 MI:0045 experimental interaction detection MI:0461 interaction database MECOM TLE4 MI:0362 inference MI:0461 interaction database TLE1 TLE4 MI:0362 inference MI:1106 pathways database TLE2 TLE4 MI:0362 inference MI:1106 pathways database TLE3 TLE4 MI:0362 inference MI:1106 pathways database TLE4 AES MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TLE4 FOXD4 MI:0362 inference MI:0461 interaction database TLE4 HDAC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TLE4 CUX1 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 HES1 MI:0362 inference MI:1106 pathways database TLE4 QPRT MI:0045 experimental interaction detection MI:0461 interaction database TLE4 FOXD4L6 MI:0362 inference MI:0461 interaction database TLE4 TSSC1 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 CCDC183 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 FOXD4L5 MI:0362 inference MI:0461 interaction database TLE4 FOXD4L3 MI:0362 inference MI:0461 interaction database TLE4 FOXD4L4 MI:0362 inference MI:0461 interaction database TLE4 HDAC2 MI:0362 inference MI:0461 interaction database TLE4 EYA1 MI:0362 inference MI:0461 interaction database TLE4 EIF3C MI:0362 inference MI:0461 interaction database TLE4 FOXB1 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 WDR77 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 TCF7L1 MI:0362 inference MI:0461 interaction database TLE4 TCF7L2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TLE4 FOXD4L1 MI:0362 inference MI:0461 interaction database TLE4 LEF1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TLE4 TBX20 MI:0045 experimental interaction detection MI:0461 interaction database TLE4 NR2E1 MI:0362 inference MI:0461 interaction database