PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ATP5H FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 NUP205 23658844 biogrid exp G G G G G G G G G G G G GP G G G G G G G G G G G G GP G G G FBXW4 DCTN1 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 REST 18354482 biogrid exp G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 PDCL3 26186194 biogrid exp P P P P P P P RCAN1 FBXW4 18575781 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G DDX5 FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G HNRNPR FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 CCT6B 26186194 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 RNF32 21163940 biogrid,intact exp P P P P P G A2M FBXW4 21163940 biogrid exp G G G G G G G G G G G G G G G G G G G G GP G G G G G G G G FBXW4 PDCL 26186194 biogrid exp G G G G GP G G G G G G G GP G G GP G G P G GP G G GP G G G G PPP2R1B FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 RUVBL1 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G GP G G G G FBXW4 COPS7B 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 GPS1 23658844 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 CCT7 26186194,23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 NLK 18765672 biogrid exp G G G G GP G G G G G G G G G G G G G G G GP G G G G G G G G FBXW4 COPS2 23658844 biogrid exp G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 COPS4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G TXNDC9 FBXW4 26186194 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G CCT8 FBXW4 26186194,23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G CCT4 FBXW4 26186194,23658844 biogrid exp G G G G G G G G G G G G G G G G G G G G GP G G G G G G G G FBXW4 SLC25A11 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G CCT3 FBXW4 26186194,23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G TCP1 FBXW4 26186194,23658844 biogrid exp P P P P P P P FBXW4 COPS7A 23658844 biogrid exp G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G PPP2R1A FBXW4 23658844 biogrid exp G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 DHX9 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 COPS5 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G CCT6A FBXW4 26186194 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 YWHAH 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 COPS8 23658844 biogrid exp G G G G G G G G G G G G GP G G G G G G G G G G G G G G G G FBXW4 COPS6 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 MAST1 21163940 biogrid,intact exp G P G G G P P G P P P SEMG1 FBXW4 23658844 biogrid exp G FBXW4 COPS3 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G CCT5 FBXW4 26186194,23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G MCM4 FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 SKIV2L 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 ECSIT 21163940 biogrid,intact exp G G G G GP G G G G G G G GP G G GP G G GP G P G G G GP GP G G G PSMA2 FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 CDC37 21163940 biogrid,intact exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 PDRG1 26186194 biogrid exp G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 PFDN5 26186194 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 CCT2 26186194,23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 SLX4IP 19596235 biogrid,intact exp G P G G G G P G P P G P G P G G PFDN1 FBXW4 23658844 biogrid exp G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 CUL1 14603323,25515538,25143387,23658844 hprd,biogrid,mint,intact exp, ortho G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 SKP1 20596027,22632967,22388891,23658844, 23023127 biogrid,intact,dip exp, ortho, pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 NANOG ortho G P G G G DLL1 FBXW4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 DPCD 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 FBXO7 16082366 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP G G G G LRP6 FBXW4 23023127 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 FBXO6 16082366 pred G G G G GP G G G G G G G GP G G GP G G GP G P G G G GP GP G G G FBXW4 ZBTB16 23023127 pred G G G G G G G G G G G G GP G G GP G G GP G G G G G GP G G G G FBXW4 FBXW8 16082366 pred P P P P P P P FBXW4 SUFU 21836163 pred G G G G GP G G G G G G G GP G G P G G GP G GP G G G GP G G G G FBXW4 FBXO2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 JAG2 16082366 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 WWP1 21836163 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 GNAS 23023127 pred G G G G G G G G G G G G G G G GP G G GP G G G G G GP G G G G FBXW4 UBE4A 21836163 pred G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 GNA12 23023127 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 FBXW2 16082366 pred G G G G GP G G G G G G G GP G G GP G G GP G G G G G GP G G G G FBXW4 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 ZIC1 16082366 pred G P G G G P P G P P G P LHCGR FBXW4 16082366 pred G P G G P P FBXW4 RNF144B 21836163 pred G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 FBXO22 16082366 pred G G G G G G G G G G G G G G G G G G G G G WWP2 FBXW4 21836163 pred G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP G G G G GNAQ FBXW4 23023127 pred G G G G G G G G G G G G G G G GP G G GP G G G G G GP GP G G G FBXW4 FBXL5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIRA FBXW4 23023127 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G FBXW4 SHFM1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 TP63 21836163 pred G G G G G G G G G G G G G G G G G G G GP G G G G G G LBX1 FBXW4 21836163 pred P P P P P P P FBXW4 TINAG 16082366 pred G G G G GP G G G G G G G GP GP G GP G GP G G GP G G G BMPR1A FBXW4 23023127 pred G G G P G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 SMURF2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW4 BTRC 23023127, 16082366 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP G G G G FBXW4 FBXL6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSD17B3 FBXW4 16082366 pred G G G G G G G G G P G G GP G G G P G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants E7EQR6 P57775 affinity chromatography technology 23658844 physical association X 2 P50990 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024R471 P57775 affinity chromatography technology 23658844 physical association X 2 A8K7B7 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024R1K7 P57775 affinity chromatography technology 23658844 physical association X 2 P17844 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024RA52 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024QZ12 P57775 affinity chromatography technology 18765672 physical association X 2 Q9UBW8 P57775 affinity chromatography technology 23658844 physical association X 2 Q9Y265 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024R7W9 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024R7W9 P57775 affinity chromatography technology 23658844 physical association X 2 P57775 affinity chromatography technology 23658844 physical association X 2 P57775 Q9BQ95-2 two hybrid 21163940 direct interaction X 2 P57775 Q9Y2H9 two hybrid 21163940 direct interaction X 2 P57775 P78371 affinity chromatography technology 23658844 physical association X 2 P57775 P48643 affinity chromatography technology 23658844 physical association X 2 P57775 Q9BT78 affinity chromatography technology 23658844 physical association X 2 P57775 Q9UNS2 affinity chromatography technology 23658844 physical association X 2 P57775 Q7L5N1 affinity chromatography technology 23658844 physical association X 2 P57775 Q99627-2 affinity chromatography technology 23658844 physical association X 2 P57775 P33991 affinity chromatography technology 23658844 physical association X 2 P57775 O60925 affinity chromatography technology 23658844 physical association X 2 P57775 Q5VYV7 affinity chromatography technology 19596235 physical association X 2 P63208 P57775 affinity chromatography technology 22388891 physical association X 2 P63208 P57775 affinity chromatography technology 23658844 physical association X 2 P63208 P57775 affinity chromatography technology 23658844 physical association X 2 P01023 P57775 two hybrid 21163940 direct interaction X 2 P50991 P57775 affinity chromatography technology 23658844 physical association X 2 A0A090N7U0 P57775 affinity chromatography technology 14603323 physical association X 2 A0A090N7U0 P57775 affinity chromatography technology 23658844 physical association X 2 A0A090N7U0 P57775 affinity chromatography technology 25143387 physical association X 2 Q15477 P57775 affinity chromatography technology 23658844 physical association X 2 P0CG48 P57775 affinity chromatography technology 23658844 physical association X 2 P0CG48 P57775 affinity chromatography technology 23658844 physical association X 2 P57775 Q13127-3 affinity chromatography technology 18354482 physical association X 2 P57775 V9GYW9 affinity chromatography technology 18575781 physical association X 2 P57775 A0A024R7B7 two hybrid 21163940 direct interaction X 2 P57775 P61201-2 affinity chromatography technology 23658844 physical association X 2 P57775 Q99832-4 affinity chromatography technology 23658844 physical association X 2 P57775 Q13098-5 affinity chromatography technology 23658844 physical association X 2 P57775 Q59H77 affinity chromatography technology 23658844 physical association X 2 P57775 Q02978-2 affinity chromatography technology 23658844 physical association X 2 P57775 Q08211 affinity chromatography technology 23658844 physical association X 2 P57775 affinity chromatography technology 23658844 physical association X 2 P57775 affinity chromatography technology 23658844 physical association X 2 P57775 A0PJH2 affinity chromatography technology 23658844 physical association X 2 P57775 Q14203-4 affinity chromatography technology 23658844 physical association X 2 P57775 P61201-2 affinity chromatography technology 23658844 physical association X 2 P04279 P57775 affinity chromatography technology 23658844 physical association X 2 A0A024RD87 P57775 two hybrid 21163940 direct interaction X 2 P63208 P57775 anti tag coimmunoprecipitation 20596027 physical association X 2 A0A090N7U0 P57775 in vitro 14603323 - X 2 A0A090N7U0 P57775 in vitro 14603323 - X 2 P57775 anti tag coimmunoprecipitation 19596235 association C 17 P57775 Q9Y2H9 two hybrid array 21163940 physical association X 2 P63208 P57775 anti tag coimmunoprecipitation 22632967 physical association X 2 Q9BQ95 P57775 two hybrid array 21163940 physical association X 2 A0A090N7U0 P57775 coimmunoprecipitation 14603323 physical association X 2 P57775 A0A024R7B7 two hybrid array 21163940 physical association X 2 A0A024RD87 P57775 two hybrid array 21163940 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FBXW4 NUP205 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281195 bait prey RCAN1 FBXW4 MI:0004(affinity chromatography technology) 18575781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208133 bait prey FBXW4 ECSIT MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229772|UniProt_111089 prey|prey bait|bait FBXW4 COPS4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281164 bait prey PSMA2 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281193 prey bait PPP2R1B FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281194 prey bait FBXW4 COPS3 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281170 bait prey CCT5 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281161 prey bait PPP2R1A FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281198 prey bait FBXW4 SKP1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22388891,22632967,23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_122756|BIOGRID_281201|BIOGRID_197524|BIOGRID_281177 bait|bait|bait|bait prey|prey|prey|prey FBXW4 CCT7 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281165 bait prey FBXW4 COPS8 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281173 bait prey FBXW4 CDC37 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111062|BIOGRID_229745 prey|prey bait|bait SEMG1 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281192 prey bait FBXW4 DHX9 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281178 bait prey TCP1 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281175 prey bait FBXW4 RUVBL1 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281179 bait prey FBXW4 MAST1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111136|BIOGRID_229819 prey|prey bait|bait FBXW4 C20orf94 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19596235 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_120917|UniProt_100548 prey|prey bait|bait FBXW4 SKIV2L MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281191 bait prey FBXW4 COPS2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_281163|BIOGRID_281203 bait|bait prey|prey FBXW4 COPS6 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281171 bait prey ATP5H FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281196 prey bait FBXW4 DCTN1 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281200 bait prey CCT4 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281168 prey bait FBXW4 CUL1 MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation) 14603323,23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(intact) MINT_55234|BIOGRID_281159|MINT_57905|BIOGRID_256918|HPRD_12041|UniProt_74166 bait|bait|bait|bait|-|bait prey|prey|prey|prey|-|prey FBXW4 REST MI:0004(affinity chromatography technology) 18354482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201066 bait prey HNRNPR FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281181 prey bait UBC FBXW4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_281205|BIOGRID_281204 prey|bait bait|prey FBXW4 GPS1 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281167 bait prey FBXW4 RNF32 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111182|BIOGRID_229865 prey|prey bait|bait DDX5 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281180 prey bait A2M FBXW4 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229874 bait prey FBXW4 COPS7B MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281174 bait prey CCT3 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281169 prey bait FBXW4 NLK MI:0004(affinity chromatography technology) 18765672 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_116461 prey bait FBXW4 COPS7A MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281172 bait prey PFDN1 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281199 prey bait MCM4 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281182 prey bait CCT8 FBXW4 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281162 prey bait FBXW4 YWHAH MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281197 bait prey FBXW4 SLC25A11 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281176 bait prey FBXW4 CCT2 MI:0004(affinity chromatography technology) 23658844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281160 bait prey

PPI - HINT Gene A Gene B PMID Method Quality TXNDC9 FBXW4 26186194 0004 HT TCP1 FBXW4 23658844,26186194 0004,0004 LC,HT CCT6A FBXW4 26186194 0004 HT CCT8 FBXW4 23658844,26186194 0004,0004 LC,HT CCT4 FBXW4 23658844,26186194 0004,0004 LC,HT FBXW4 SKP1 22632967,22388891,20596027,23658844 0007,0004,0007,0004 LC FBXW4 PDCL 26186194 0004 HT FBXW4 CUL1 25515538,14603323,25143387,23658844,14603323 0004,0004,0004,0004,0019 LC FBXW4 Q59H77 23658844,26186194 0004,0004 LC,HT FBXW4 CCT6B 26186194 0004 HT FBXW4 PFDN5 26186194 0004 HT FBXW4 CCT7 23658844,26186194 0004,0004 LC,HT FBXW4 PDCL3 26186194 0004 HT FBXW4 PDRG1 26186194 0004 HT FBXW4 HEL-S-69 23658844,26186194 0004,0004 LC,HT FBXW4 HEL-S-100N 23658844,26186194 0004,0004 LC,HT TXNDC9 FBXW4 26186194 0004 HT TCP1 FBXW4 26186194 0004 HT CCT6A FBXW4 26186194 0004 HT CCT8 FBXW4 26186194 0004 HT CCT4 FBXW4 26186194 0004 HT FBXW4 PDCL 26186194 0004 HT FBXW4 Q59H77 26186194 0004 HT FBXW4 CCT6B 26186194 0004 HT FBXW4 PFDN5 26186194 0004 HT FBXW4 CCT7 26186194 0004 HT FBXW4 PDCL3 26186194 0004 HT FBXW4 PDRG1 26186194 0004 HT FBXW4 HEL-S-69 26186194 0004 HT FBXW4 HEL-S-100N 26186194 0004 HT TCP1 FBXW4 23658844 0004 LC CCT8 FBXW4 23658844 0004 LC CCT4 FBXW4 23658844 0004 LC FBXW4 SKP1 22632967,22388891,20596027,23658844 0007,0004,0007,0004 LC FBXW4 CUL1 25515538,14603323,25143387,23658844,14603323 0004,0004,0004,0004,0019 LC FBXW4 Q59H77 23658844 0004 LC FBXW4 CCT7 23658844 0004 LC FBXW4 HEL-S-69 23658844 0004 LC FBXW4 HEL-S-100N 23658844 0004 LC A2M FBXW4 21163940 0018 HT FBXW4 CUL1 14603323,14603323 0004,0019 LC FBXW4 CDC37 21163940,21163940 0397,0018 HT FBXW4 ECSIT 21163940,21163940 0397,0018 HT FBXW4 RNF32 21163940,21163940 0397,0018 HT FBXW4 MAST1 21163940,21163940 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P57775 O14530 FBXW4 TXNDC9 0.126 26186194 P57775 O43390 FBXW4 HNRNPR 0.21 23658844 P57775 O60925 FBXW4 PFDN1 0.21 23658844 P57775 O75947 FBXW4 ATP5H 0.21 23658844 P57775 P04279 FBXW4 SEMG1 0.21 23658844 P57775 P17844 FBXW4 DDX5 0.21 23658844 P57775 P25787 FBXW4 PSMA2 0.21 23658844 P57775 P30153 FBXW4 PPP2R1A 0.21 23658844 P57775 P30154 FBXW4 PPP2R1B 0.21 23658844 P57775 P33991 FBXW4 MCM4 0.21 23658844 P57775 P40227 FBXW4 CCT6A 0.126 26186194 P61201 P57775 COPS2 FBXW4 0.21 23658844 Q02978 P57775 SLC25A11 FBXW4 0.21 23658844 Q04917 P57775 YWHAH FBXW4 0.21 23658844 Q08211 P57775 DHX9 FBXW4 0.21 23658844 Q13098 P57775 GPS1 FBXW4 0.21 23658844 Q13127 P57775 REST FBXW4 0.21 18354482 Q13371 P57775 PDCL FBXW4 0.126 26186194 Q14203 P57775 DCTN1 FBXW4 0.21 23658844 Q15477 P57775 SKIV2L FBXW4 0.21 23658844 Q5VYV7 P57775 SLX4IP FBXW4 0.332 19596235 Q7L5N1 P57775 COPS6 FBXW4 0.21 23658844 Q92526 P57775 CCT6B FBXW4 0.126 26186194 Q92621 P57775 NUP205 FBXW4 0.21 23658844 Q92905 P57775 COPS5 FBXW4 0.21 23658844 Q99471 P57775 PFDN5 FBXW4 0.126 26186194 Q99627 P57775 COPS8 FBXW4 0.21 23658844 Q9BT78 P57775 COPS4 FBXW4 0.21 23658844 Q9H2J4 P57775 PDCL3 FBXW4 0.126 26186194 Q9H9Q2 P57775 COPS7B FBXW4 0.21 23658844 Q9NUG6 P57775 PDRG1 FBXW4 0.126 26186194 Q9UBW8 P57775 COPS7A FBXW4 0.21 23658844 Q9UNS2 P57775 COPS3 FBXW4 0.21 23658844 Q9Y265 P57775 RUVBL1 FBXW4 0.21 23658844 Q9Y2H9 P57775 MAST1 FBXW4 0.286 21163940 P57775 P53805 FBXW4 RCAN1 0.21 18575781 P57775 P01023 FBXW4 A2M 0.183 Q9H0A6 P57775 RNF32 FBXW4 0.286 21163940 Q16543 P57775 CDC37 FBXW4 0.286 21163940 P57775 P17987 FBXW4 TCP1 0.309 23658844,26186194 P78371 P57775 CCT2 FBXW4 0.309 23658844,26186194 P57775 P49368 FBXW4 CCT3 0.309 23658844,26186194 P57775 P48643 FBXW4 CCT5 0.309 23658844,26186194 P57775 P50990 FBXW4 CCT8 0.309 23658844,26186194 P57775 P50991 FBXW4 CCT4 0.309 23658844,26186194 Q99832 P57775 CCT7 FBXW4 0.309 23658844,26186194 Q13616 P57775 CUL1 FBXW4 0.659 14603323,25515538,23658844,25143387 Q9BQ95 P57775 ECSIT FBXW4 0.286 21163940 Q9UBE8 P57775 NLK FBXW4 0.21 18765672 P63208 P57775 SKP1 FBXW4 0.569 22632967,27705803,23658844,22388891

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TXNDC9 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXW4 MI:0362 inference MI:1106 pathways database HNRNPR FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database PFDN1 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database ATP5H FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXW4 MI:0362 inference MI:1106 pathways database A2M FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database SEMG1 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXW4 MI:0362 inference MI:1106 pathways database UBC FBXW4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DDX5 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database TCP1 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW4 MI:0362 inference MI:1106 pathways database TAF1 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database PSMA2 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1A FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1B FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database MCM4 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database CCT6A FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXW4 MI:0362 inference MI:1106 pathways database CCT5 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A FBXW4 MI:0362 inference MI:1106 pathways database CCT8 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database CCT4 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database RCAN1 FBXW4 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 COPS2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RBX1 MI:0362 inference MI:1106 pathways database FBXW4 RPS27A MI:0362 inference MI:1106 pathways database FBXW4 UBA52 MI:0362 inference MI:1106 pathways database FBXW4 SKP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXW4 CCT2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 SLC25A11 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 YWHAH MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 DHX9 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 GPS1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 REST MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 SKP2 MI:0362 inference MI:1106 pathways database FBXW4 PDCL MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 CUL1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXW4 DCTN1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 TRIP12 MI:0362 inference MI:1106 pathways database FBXW4 SKIV2L MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 CDC37 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 LONRF1 MI:0362 inference MI:1106 pathways database FBXW4 HECTD2 MI:0362 inference MI:1106 pathways database FBXW4 SLX4IP MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXO31 MI:0362 inference MI:1106 pathways database FBXW4 FBXW9 MI:0362 inference MI:1106 pathways database FBXW4 FBXW10 MI:0362 inference MI:1106 pathways database FBXW4 RNF213 MI:0362 inference MI:1106 pathways database FBXW4 FBXL22 MI:0362 inference MI:1106 pathways database FBXW4 FBXL19 MI:0362 inference MI:1106 pathways database FBXW4 FBXW12 MI:0362 inference MI:1106 pathways database FBXW4 RNF19B MI:0362 inference MI:1106 pathways database FBXW4 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RNF144B MI:0362 inference MI:1106 pathways database FBXW4 RBBP6 MI:0362 inference MI:1106 pathways database FBXW4 HUWE1 MI:0362 inference MI:1106 pathways database FBXW4 TRIM69 MI:0362 inference MI:1106 pathways database FBXW4 SIAH1 MI:0362 inference MI:1106 pathways database FBXW4 HERC6 MI:0362 inference MI:1106 pathways database FBXW4 UBR2 MI:0362 inference MI:1106 pathways database FBXW4 FBXL14 MI:0362 inference MI:1106 pathways database FBXW4 FBXW8 MI:0362 inference MI:1106 pathways database FBXW4 FBXL16 MI:0362 inference MI:1106 pathways database FBXW4 FBXO15 MI:0362 inference MI:1106 pathways database FBXW4 ZNRF1 MI:0362 inference MI:1106 pathways database FBXW4 FBXL13 MI:0362 inference MI:1106 pathways database FBXW4 FBXO22 MI:0362 inference MI:1106 pathways database FBXW4 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW4 FBXO27 MI:0362 inference MI:1106 pathways database FBXW4 FBXO30 MI:0362 inference MI:1106 pathways database FBXW4 RNF217 MI:0362 inference MI:1106 pathways database FBXW4 DTX3L MI:0362 inference MI:1106 pathways database FBXW4 FBXO41 MI:0362 inference MI:1106 pathways database FBXW4 LMO7 MI:0362 inference MI:1106 pathways database FBXW4 MYLIP MI:0362 inference MI:1106 pathways database FBXW4 CCT6B MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 NUP205 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXW7 MI:0362 inference MI:1106 pathways database FBXW4 FBXO32 MI:0362 inference MI:1106 pathways database FBXW4 FBXW5 MI:0362 inference MI:1106 pathways database FBXW4 MIB2 MI:0362 inference MI:1106 pathways database FBXW4 SPSB1 MI:0362 inference MI:1106 pathways database FBXW4 FBXL8 MI:0362 inference MI:1106 pathways database FBXW4 FBXO17 MI:0362 inference MI:1106 pathways database FBXW4 FBXL20 MI:0362 inference MI:1106 pathways database FBXW4 FBXL18 MI:0362 inference MI:1106 pathways database FBXW4 NEDD4L MI:0362 inference MI:1106 pathways database FBXW4 PFDN5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 COPS8 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 CCT7 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 ECSIT MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 COPS4 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RBCK1 MI:0362 inference MI:1106 pathways database FBXW4 RNF32 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 PDCL3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXL15 MI:0362 inference MI:1106 pathways database FBXW4 FBXO44 MI:0362 inference MI:1106 pathways database FBXW4 UNKL MI:0362 inference MI:1106 pathways database FBXW4 COPS7B MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 NANOG MI:0362 inference MI:0461 interaction database FBXW4 SMURF2 MI:0362 inference MI:1106 pathways database FBXW4 TRIM36 MI:0362 inference MI:1106 pathways database FBXW4 FBXO6 MI:0362 inference MI:1106 pathways database FBXW4 PDRG1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RNF19A MI:0362 inference MI:1106 pathways database FBXW4 RLIM MI:0362 inference MI:1106 pathways database FBXW4 FBXL12 MI:0362 inference MI:1106 pathways database FBXW4 NLK MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 COPS7A MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXO40 MI:0362 inference MI:1106 pathways database FBXW4 HERC5 MI:0362 inference MI:1106 pathways database FBXW4 FBXL7 MI:0362 inference MI:1106 pathways database FBXW4 FBXO2 MI:0362 inference MI:1106 pathways database FBXW4 FBXO10 MI:0362 inference MI:1106 pathways database FBXW4 FBXO9 MI:0362 inference MI:1106 pathways database FBXW4 FBXL5 MI:0362 inference MI:1106 pathways database FBXW4 FBXL4 MI:0362 inference MI:1106 pathways database FBXW4 FBXW11 MI:0362 inference MI:1106 pathways database FBXW4 FBXO4 MI:0362 inference MI:1106 pathways database FBXW4 FBXL21 MI:0362 inference MI:1106 pathways database FBXW4 FBXL3 MI:0362 inference MI:1106 pathways database FBXW4 FBXW2 MI:0362 inference MI:1106 pathways database FBXW4 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RUVBL1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 BTRC MI:0362 inference MI:1106 pathways database FBXW4 MAST1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXO7 MI:0362 inference MI:1106 pathways database FBXW4 RNF115 MI:0362 inference MI:1106 pathways database FBXW4 RNF114 MI:0362 inference MI:1106 pathways database FBXW4 WSB1 MI:0362 inference MI:1106 pathways database