Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 10 104184263 104184263 + Missense_Mutation SNP C C A TCGA-GV-A6ZA-01A-12D-A339-08 TCGA-GV-A6ZA-10A-01D-A339-08 g.chr10:104184263C>A c.273G>T c.(271-273)agG>agT p.R91S BLCA 10 104184490 104184490 + Missense_Mutation SNP G G A TCGA-CF-A9FH-01A-11D-A38G-08 TCGA-CF-A9FH-10A-01D-A38J-08 g.chr10:104184490G>A c.134C>T c.(133-135)tCg>tTg p.S45L BLCA 10 104184490 104184490 + Missense_Mutation SNP G G A TCGA-DK-A6B6-01A-11D-A30E-08 TCGA-DK-A6B6-10A-01D-A30H-08 g.chr10:104184490G>A c.134C>T c.(133-135)tCg>tTg p.S45L BRCA 10 104184498 104184498 + Silent SNP C C A TCGA-A7-A5ZV-01A-11D-A28B-09 TCGA-A7-A5ZV-10A-01D-A28E-09 g.chr10:104184498C>A c.126G>T c.(124-126)ctG>ctT p.L42L CESC 10 104184033 104184033 + Missense_Mutation SNP G G T TCGA-EA-A439-01A-11D-A243-09 TCGA-EA-A439-10A-01D-A243-09 g.chr10:104184033G>T c.399C>A c.(397-399)gaC>gaA p.D133E CESC 10 104184490 104184490 + Missense_Mutation SNP G G A TCGA-UC-A7PF-01A-11D-A351-09 TCGA-UC-A7PF-11A-31D-A351-09 g.chr10:104184490G>A c.134C>T c.(133-135)tCg>tTg p.S45L COAD 10 104183292 104183292 + Missense_Mutation SNP A A G TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr10:104183292A>G c.755T>C c.(754-756)gTa>gCa p.V252A COAD 10 104184052 104184052 + Missense_Mutation SNP G G A TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr10:104184052G>A c.380C>T c.(379-381)tCg>tTg p.S127L COAD 10 104184086 104184086 + Missense_Mutation SNP G G A TCGA-CM-5860-01A-01D-1650-10 TCGA-CM-5860-10A-01D-1650-10 g.chr10:104184086G>A c.346C>T c.(346-348)Cgg>Tgg p.R116W COAD 10 104184467 104184467 + Missense_Mutation SNP C C T TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr10:104184467C>T c.157G>A c.(157-159)Gat>Aat p.D53N COADREAD 10 104183292 104183292 + Missense_Mutation SNP A A G TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr10:104183292A>G c.755T>C c.(754-756)gTa>gCa p.V252A COADREAD 10 104184052 104184052 + Missense_Mutation SNP G G A TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr10:104184052G>A c.380C>T c.(379-381)tCg>tTg p.S127L COADREAD 10 104184086 104184086 + Missense_Mutation SNP G G A TCGA-CM-5860-01A-01D-1650-10 TCGA-CM-5860-10A-01D-1650-10 g.chr10:104184086G>A c.346C>T c.(346-348)Cgg>Tgg p.R116W COADREAD 10 104184467 104184467 + Missense_Mutation SNP C C T TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr10:104184467C>T c.157G>A c.(157-159)Gat>Aat p.D53N GBMLGG 10 104184302 104184302 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr10:104184302G>A c.234C>T c.(232-234)gaC>gaT p.D78D GBMLGG 10 104184887 104184887 + Missense_Mutation SNP G G A TCGA-FG-7637-01A-11D-2086-08 TCGA-FG-7637-10A-01D-2086-08 g.chr10:104184887G>A c.59C>T c.(58-60)cCg>cTg p.P20L HNSC 10 104184420 104184420 + Silent SNP G G A TCGA-CN-6013-01A-11D-1683-08 TCGA-CN-6013-10A-01D-1683-08 g.chr10:104184420G>A c.204C>T c.(202-204)ttC>ttT p.F68F HNSC 10 104184490 104184490 + Missense_Mutation SNP G G C TCGA-CR-7365-01A-11D-2012-08 TCGA-CR-7365-10A-01D-2013-08 g.chr10:104184490G>C c.134C>G c.(133-135)tCg>tGg p.S45W KIPAN 10 104184284 104184284 + Silent SNP T T A TCGA-AK-3436-01A-02D-1386-10 TCGA-AK-3436-10A-01D-1251-10 g.chr10:104184284T>A c.252A>T c.(250-252)tcA>tcT p.S84S KIPAN 10 104184514 104184514 + Missense_Mutation SNP C C T TCGA-AL-3473-01A-01D-1252-08 TCGA-AL-3473-10A-01D-1252-08 g.chr10:104184514C>T c.110G>A c.(109-111)gGg>gAg p.G37E KIPAN 10 104184908 104184908 + Missense_Mutation SNP G G A TCGA-GL-A9DE-01A-11D-A36X-10 TCGA-GL-A9DE-10A-01D-A370-10 g.chr10:104184908G>A c.38C>T c.(37-39)gCc>gTc p.A13V KIRC 10 104184284 104184284 + Silent SNP T T A TCGA-AK-3436-01A-02D-1386-10 TCGA-AK-3436-10A-01D-1251-10 g.chr10:104184284T>A c.252A>T c.(250-252)tcA>tcT p.S84S KIRP 10 104184514 104184514 + Missense_Mutation SNP C C T TCGA-AL-3473-01A-01D-1252-08 TCGA-AL-3473-10A-01D-1252-08 g.chr10:104184514C>T c.110G>A c.(109-111)gGg>gAg p.G37E KIRP 10 104184908 104184908 + Missense_Mutation SNP G G A TCGA-GL-A9DE-01A-11D-A36X-10 TCGA-GL-A9DE-10A-01D-A370-10 g.chr10:104184908G>A c.38C>T c.(37-39)gCc>gTc p.A13V LGG 10 104184302 104184302 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr10:104184302G>A c.234C>T c.(232-234)gaC>gaT p.D78D LGG 10 104184887 104184887 + Missense_Mutation SNP G G A TCGA-FG-7637-01A-11D-2086-08 TCGA-FG-7637-10A-01D-2086-08 g.chr10:104184887G>A c.59C>T c.(58-60)cCg>cTg p.P20L LUAD 10 104183901 104183901 + Missense_Mutation SNP A A T TCGA-78-7220-01A-11D-2036-08 TCGA-78-7220-10A-01D-2036-08 g.chr10:104183901A>T c.446T>A c.(445-447)gTg>gAg p.V149E LUAD 10 104184914 104184915 + Frame_Shift_Ins INS - - G TCGA-95-7947-01A-11D-2184-08 TCGA-95-7947-10A-01D-2184-08 g.chr10:104184914_104184915insG c.31_32insC c.(31-33)ctcfs p.L11fs PAAD 10 104183780 104183780 + Silent SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr10:104183780C>T c.567G>A c.(565-567)ggG>ggA p.G189G SKCM 10 104183554 104183554 + Splice_Site SNP C C T TCGA-EE-A29V-06A-12D-A197-08 TCGA-EE-A29V-10A-01D-A199-08 g.chr10:104183554C>T c.e7+1 SKCM 10 104184490 104184490 + Missense_Mutation SNP G G A TCGA-EE-A29A-06A-12D-A196-08 TCGA-EE-A29A-10A-01D-A198-08 g.chr10:104184490G>A c.134C>T c.(133-135)tCg>tTg p.S45L

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 10 104184872 104184872 single base substitution C T intron_variant BLCA-CN 10 104184872 104184872 single base substitution C T missense_variant S25N 74G>A BLCA-CN 10 104184872 104184872 single base substitution C T splice_region_variant BLCA-CN 10 104184872 104184872 single base substitution C T upstream_gene_variant BRCA-EU 10 104179676 104179676 single base substitution T A downstream_gene_variant BRCA-EU 10 104180133 104180133 single base substitution C T downstream_gene_variant BRCA-EU 10 104182875 104182875 single base substitution T G downstream_gene_variant BRCA-EU 10 104183351 104183351 single base substitution G A downstream_gene_variant BRCA-EU 10 104183351 104183351 single base substitution G A intron_variant BRCA-EU 10 104183411 104183411 single base substitution C T downstream_gene_variant BRCA-EU 10 104183411 104183411 single base substitution C T splice_region_variant BRCA-EU 10 104184020 104184020 single base substitution C T exon_variant BRCA-EU 10 104184020 104184020 single base substitution C T splice_donor_variant BRCA-EU 10 104185515 104185515 single base substitution C T intron_variant BRCA-EU 10 104185515 104185515 single base substitution C T upstream_gene_variant BRCA-EU 10 104186821 104186821 deletion of <=200bp A - intron_variant BRCA-EU 10 104186821 104186821 deletion of <=200bp A - upstream_gene_variant BRCA-EU 10 104186830 104186830 insertion of <=200bp - G intron_variant BRCA-EU 10 104186830 104186830 insertion of <=200bp - G upstream_gene_variant BRCA-EU 10 104187202 104187202 single base substitution G A intron_variant BRCA-EU 10 104187202 104187202 single base substitution G A upstream_gene_variant BRCA-EU 10 104187924 104187924 single base substitution C G intron_variant BRCA-EU 10 104187924 104187924 single base substitution C G upstream_gene_variant BRCA-EU 10 104187952 104187952 single base substitution C A intron_variant BRCA-EU 10 104187952 104187952 single base substitution C A upstream_gene_variant BRCA-EU 10 104191027 104191027 single base substitution G C intron_variant BRCA-EU 10 104191753 104191753 single base substitution C G intron_variant BRCA-EU 10 104191789 104191789 single base substitution C T intron_variant BRCA-EU 10 104193069 104193069 single base substitution C T upstream_gene_variant BRCA-EU 10 104193791 104193791 single base substitution G C upstream_gene_variant BRCA-EU 10 104194180 104194180 single base substitution G T upstream_gene_variant BRCA-EU 10 104194421 104194421 single base substitution G C upstream_gene_variant BRCA-EU 10 104195787 104195787 single base substitution G C upstream_gene_variant BRCA-FR 10 104182669 104182669 single base substitution C T downstream_gene_variant BRCA-FR 10 104183351 104183351 single base substitution G A downstream_gene_variant BRCA-FR 10 104183351 104183351 single base substitution G A intron_variant BRCA-FR 10 104183411 104183411 single base substitution C T downstream_gene_variant BRCA-FR 10 104183411 104183411 single base substitution C T splice_region_variant BRCA-FR 10 104187952 104187952 single base substitution C A intron_variant BRCA-FR 10 104187952 104187952 single base substitution C A upstream_gene_variant BRCA-FR 10 104191753 104191753 single base substitution C G intron_variant BRCA-FR 10 104192538 104192538 single base substitution G C upstream_gene_variant BRCA-FR 10 104194421 104194421 single base substitution G C upstream_gene_variant BRCA-UK 10 104181253 104181253 single base substitution G A downstream_gene_variant BRCA-US 10 104184498 104184498 single base substitution C A exon_variant BRCA-US 10 104184498 104184498 single base substitution C A synonymous_variant L42L 126G>T BRCA-US 10 104184498 104184498 single base substitution C A upstream_gene_variant BTCA-JP 10 104179375 104179375 single base substitution G C downstream_gene_variant BTCA-JP 10 104180855 104180855 single base substitution A C downstream_gene_variant BTCA-JP 10 104184953 104184953 single base substitution C G intron_variant BTCA-JP 10 104184953 104184953 single base substitution C G splice_region_variant BTCA-JP 10 104184953 104184953 single base substitution C G upstream_gene_variant CESC-US 10 104180693 104180693 single base substitution G A downstream_gene_variant CESC-US 10 104182625 104182625 single base substitution G A downstream_gene_variant CESC-US 10 104183034 104183034 single base substitution G A 3_prime_UTR_variant CESC-US 10 104183034 104183034 single base substitution G A downstream_gene_variant CESC-US 10 104183034 104183034 single base substitution G A exon_variant CESC-US 10 104184033 104184033 single base substitution G T exon_variant CESC-US 10 104184033 104184033 single base substitution G T missense_variant D133E 399C>A CESC-US 10 104184490 104184490 single base substitution G A exon_variant CESC-US 10 104184490 104184490 single base substitution G A missense_variant S45L 134C>T CESC-US 10 104184490 104184490 single base substitution G A upstream_gene_variant CESC-US 10 104196339 104196339 single base substitution C T upstream_gene_variant COAD-US 10 104179968 104179968 deletion of <=200bp C - downstream_gene_variant COAD-US 10 104181620 104181620 single base substitution C T downstream_gene_variant COAD-US 10 104182667 104182667 single base substitution G A downstream_gene_variant COAD-US 10 104183229 104183229 single base substitution G A downstream_gene_variant COAD-US 10 104183229 104183229 single base substitution G A exon_variant COAD-US 10 104183229 104183229 single base substitution G A missense_variant A273V 818C>T COAD-US 10 104184052 104184052 single base substitution G A exon_variant COAD-US 10 104184052 104184052 single base substitution G A missense_variant S127L 380C>T COAD-US 10 104184081 104184081 single base substitution G A exon_variant COAD-US 10 104184081 104184081 single base substitution G A synonymous_variant P117P 351C>T COAD-US 10 104184081 104184081 single base substitution G A upstream_gene_variant COAD-US 10 104184086 104184086 single base substitution G A exon_variant COAD-US 10 104184086 104184086 single base substitution G A missense_variant R116W 346C>T COAD-US 10 104184086 104184086 single base substitution G A upstream_gene_variant COAD-US 10 104184467 104184467 single base substitution C T exon_variant COAD-US 10 104184467 104184467 single base substitution C T missense_variant D53N 157G>A COAD-US 10 104184467 104184467 single base substitution C T upstream_gene_variant COCA-CN 10 104180031 104180031 single base substitution T C downstream_gene_variant COCA-CN 10 104183385 104183385 single base substitution G A downstream_gene_variant COCA-CN 10 104183385 104183385 single base substitution G A intron_variant COCA-CN 10 104184080 104184080 single base substitution C T exon_variant COCA-CN 10 104184080 104184080 single base substitution C T missense_variant E118K 352G>A COCA-CN 10 104184080 104184080 single base substitution C T upstream_gene_variant COCA-CN 10 104185186 104185186 single base substitution A C intron_variant COCA-CN 10 104185186 104185186 single base substitution A C upstream_gene_variant ESAD-UK 10 104178071 104178071 single base substitution T C downstream_gene_variant ESAD-UK 10 104178092 104178092 single base substitution G C downstream_gene_variant ESAD-UK 10 104178909 104178909 single base substitution G A downstream_gene_variant ESAD-UK 10 104179471 104179471 single base substitution C A downstream_gene_variant ESAD-UK 10 104180785 104180785 single base substitution G A downstream_gene_variant ESAD-UK 10 104182613 104182613 single base substitution C T downstream_gene_variant ESAD-UK 10 104187351 104187351 single base substitution G A intron_variant ESAD-UK 10 104187351 104187351 single base substitution G A upstream_gene_variant ESAD-UK 10 104189231 104189231 single base substitution G A intron_variant ESAD-UK 10 104191079 104191079 single base substitution T G intron_variant ESAD-UK 10 104192420 104192420 single base substitution A C upstream_gene_variant ESAD-UK 10 104192450 104192450 single base substitution C G upstream_gene_variant ESAD-UK 10 104193969 104193969 single base substitution T A upstream_gene_variant ESAD-UK 10 104194770 104194770 single base substitution G T upstream_gene_variant KIRC-US 10 104184284 104184284 single base substitution T A exon_variant KIRC-US 10 104184284 104184284 single base substitution T A synonymous_variant S84S 252A>T KIRC-US 10 104184284 104184284 single base substitution T A upstream_gene_variant KIRP-US 10 104182716 104182716 insertion of <=200bp - G downstream_gene_variant KIRP-US 10 104184514 104184514 single base substitution C T exon_variant KIRP-US 10 104184514 104184514 single base substitution C T missense_variant G37E 110G>A KIRP-US 10 104184514 104184514 single base substitution C T upstream_gene_variant LAML-KR 10 104184953 104184953 single base substitution C G intron_variant LAML-KR 10 104184953 104184953 single base substitution C G splice_region_variant LAML-KR 10 104184953 104184953 single base substitution C G upstream_gene_variant LGG-US 10 104184887 104184887 single base substitution G A exon_variant LGG-US 10 104184887 104184887 single base substitution G A intron_variant LGG-US 10 104184887 104184887 single base substitution G A missense_variant P20L 59C>T LGG-US 10 104184887 104184887 single base substitution G A upstream_gene_variant LICA-FR 10 104181185 104181185 single base substitution G A downstream_gene_variant LICA-FR 10 104194132 104194139 deletion of <=200bp AAAAAAAA - upstream_gene_variant LINC-JP 10 104181128 104181128 single base substitution G A downstream_gene_variant LINC-JP 10 104183025 104183025 single base substitution T C 3_prime_UTR_variant LINC-JP 10 104183025 104183025 single base substitution T C downstream_gene_variant LINC-JP 10 104183025 104183025 single base substitution T C exon_variant LINC-JP 10 104185491 104185491 single base substitution G A intron_variant LINC-JP 10 104185491 104185491 single base substitution G A upstream_gene_variant LINC-JP 10 104194327 104194327 single base substitution T A upstream_gene_variant LIRI-JP 10 104179106 104179106 single base substitution G A downstream_gene_variant LIRI-JP 10 104183827 104183827 insertion of <=200bp - C exon_variant LIRI-JP 10 104183827 104183827 insertion of <=200bp - C frameshift_variant D174G? LIRI-JP 10 104186885 104186885 single base substitution T C intron_variant LIRI-JP 10 104186885 104186885 single base substitution T C upstream_gene_variant LIRI-JP 10 104186908 104186908 single base substitution C T intron_variant LIRI-JP 10 104186908 104186908 single base substitution C T upstream_gene_variant LIRI-JP 10 104189843 104189843 single base substitution C T intron_variant LIRI-JP 10 104190622 104190622 single base substitution T C intron_variant LIRI-JP 10 104191594 104191594 single base substitution T A intron_variant LIRI-JP 10 104192106 104192106 single base substitution A G intron_variant LUSC-KR 10 104178050 104178050 single base substitution A T downstream_gene_variant LUSC-KR 10 104178153 104178153 single base substitution C A downstream_gene_variant LUSC-KR 10 104181308 104181308 single base substitution C T downstream_gene_variant LUSC-KR 10 104194033 104194033 single base substitution G C upstream_gene_variant MALY-DE 10 104178067 104178067 single base substitution T A downstream_gene_variant MALY-DE 10 104181018 104181018 single base substitution C T downstream_gene_variant MALY-DE 10 104187154 104187154 single base substitution C T intron_variant MALY-DE 10 104187154 104187154 single base substitution C T upstream_gene_variant MALY-DE 10 104189610 104189610 single base substitution C A intron_variant MALY-DE 10 104192060 104192060 single base substitution G A intron_variant MALY-DE 10 104195279 104195279 single base substitution G A upstream_gene_variant MALY-DE 10 104196751 104196751 insertion of <=200bp - T upstream_gene_variant MALY-DE 10 104196891 104196891 deletion of <=200bp G - upstream_gene_variant MELA-AU 10 104178226 104178226 single base substitution G A downstream_gene_variant MELA-AU 10 104178259 104178259 single base substitution C T downstream_gene_variant MELA-AU 10 104178810 104178810 single base substitution C T downstream_gene_variant MELA-AU 10 104179099 104179099 single base substitution G A downstream_gene_variant MELA-AU 10 104179345 104179345 single base substitution G A downstream_gene_variant MELA-AU 10 104179348 104179348 single base substitution G A downstream_gene_variant MELA-AU 10 104179431 104179432 multiple base substitution (>=2bp and <=200bp) GG AA downstream_gene_variant MELA-AU 10 104179452 104179452 single base substitution G A downstream_gene_variant MELA-AU 10 104179853 104179853 single base substitution G A downstream_gene_variant MELA-AU 10 104180735 104180735 single base substitution G A downstream_gene_variant MELA-AU 10 104180769 104180769 single base substitution C T downstream_gene_variant MELA-AU 10 104180912 104180912 single base substitution G A downstream_gene_variant MELA-AU 10 104180956 104180956 single base substitution G A downstream_gene_variant MELA-AU 10 104181463 104181463 single base substitution G A downstream_gene_variant MELA-AU 10 104182344 104182344 single base substitution C T downstream_gene_variant MELA-AU 10 104182469 104182469 single base substitution C T downstream_gene_variant MELA-AU 10 104182931 104182931 single base substitution G A downstream_gene_variant MELA-AU 10 104183444 104183444 single base substitution C T downstream_gene_variant MELA-AU 10 104183444 104183444 single base substitution C T exon_variant MELA-AU 10 104183444 104183444 single base substitution C T synonymous_variant Q229Q 687G>A MELA-AU 10 104183644 104183644 single base substitution C T downstream_gene_variant MELA-AU 10 104183644 104183644 single base substitution C T exon_variant MELA-AU 10 104183644 104183644 single base substitution C T intron_variant MELA-AU 10 104184969 104184969 single base substitution G A intron_variant MELA-AU 10 104184969 104184969 single base substitution G A upstream_gene_variant MELA-AU 10 104185958 104185958 single base substitution C G intron_variant MELA-AU 10 104185958 104185958 single base substitution C G upstream_gene_variant MELA-AU 10 104186639 104186639 single base substitution G A intron_variant MELA-AU 10 104186639 104186639 single base substitution G A upstream_gene_variant MELA-AU 10 104186829 104186829 single base substitution A G intron_variant MELA-AU 10 104186829 104186829 single base substitution A G upstream_gene_variant MELA-AU 10 104187084 104187084 single base substitution C G intron_variant MELA-AU 10 104187084 104187084 single base substitution C G upstream_gene_variant MELA-AU 10 104187350 104187350 single base substitution C T intron_variant MELA-AU 10 104187350 104187350 single base substitution C T upstream_gene_variant MELA-AU 10 104189348 104189348 single base substitution A T intron_variant MELA-AU 10 104189357 104189357 single base substitution C T intron_variant MELA-AU 10 104189795 104189795 single base substitution G A intron_variant MELA-AU 10 104191004 104191004 single base substitution C A intron_variant MELA-AU 10 104191035 104191035 single base substitution T A intron_variant MELA-AU 10 104191170 104191171 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 10 104192933 104192933 single base substitution C T upstream_gene_variant MELA-AU 10 104193605 104193605 single base substitution T A upstream_gene_variant MELA-AU 10 104193609 104193610 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 10 104193717 104193717 single base substitution T A upstream_gene_variant MELA-AU 10 104194583 104194583 single base substitution G A upstream_gene_variant MELA-AU 10 104194671 104194671 single base substitution C T upstream_gene_variant MELA-AU 10 104194677 104194677 single base substitution C T upstream_gene_variant MELA-AU 10 104194680 104194680 single base substitution C T upstream_gene_variant MELA-AU 10 104195434 104195434 single base substitution C T upstream_gene_variant MELA-AU 10 104195714 104195714 single base substitution G A upstream_gene_variant MELA-AU 10 104195994 104195994 single base substitution G A upstream_gene_variant MELA-AU 10 104196163 104196163 single base substitution C T upstream_gene_variant MELA-AU 10 104196203 104196203 single base substitution G A upstream_gene_variant MELA-AU 10 104196214 104196214 single base substitution G A upstream_gene_variant MELA-AU 10 104196670 104196670 single base substitution C T upstream_gene_variant MELA-AU 10 104196864 104196864 single base substitution C T upstream_gene_variant MELA-AU 10 104197007 104197007 single base substitution C T upstream_gene_variant ORCA-IN 10 104181853 104181853 single base substitution C A downstream_gene_variant ORCA-IN 10 104183570 104183570 single base substitution G A downstream_gene_variant ORCA-IN 10 104183570 104183570 single base substitution G A exon_variant ORCA-IN 10 104183570 104183570 single base substitution G A missense_variant S214F 641C>T ORCA-IN 10 104184147 104184147 single base substitution G T exon_variant ORCA-IN 10 104184147 104184147 single base substitution G T missense_variant N95K 285C>A ORCA-IN 10 104184147 104184147 single base substitution G T upstream_gene_variant OV-AU 10 104182086 104182086 single base substitution C T downstream_gene_variant OV-AU 10 104190339 104190339 single base substitution A G intron_variant PACA-AU 10 104178660 104178660 single base substitution C T downstream_gene_variant PACA-AU 10 104183173 104183173 single base substitution G A 3_prime_UTR_variant PACA-AU 10 104183173 104183173 single base substitution G A downstream_gene_variant PACA-AU 10 104183173 104183173 single base substitution G A exon_variant PACA-AU 10 104183213 104183213 single base substitution G A downstream_gene_variant PACA-AU 10 104183213 104183213 single base substitution G A exon_variant PACA-AU 10 104183213 104183213 single base substitution G A synonymous_variant L278L 834C>T PACA-AU 10 104183553 104183553 insertion of <=200bp - A downstream_gene_variant PACA-AU 10 104183553 104183553 insertion of <=200bp - A splice_donor_variant PACA-AU 10 104194813 104194813 single base substitution C A upstream_gene_variant PACA-AU 10 104197319 104197319 single base substitution C T upstream_gene_variant PACA-CA 10 104180169 104180169 single base substitution T C downstream_gene_variant PACA-CA 10 104181279 104181279 single base substitution G A downstream_gene_variant PACA-CA 10 104186829 104186829 single base substitution A G intron_variant PACA-CA 10 104186829 104186829 single base substitution A G upstream_gene_variant PACA-CA 10 104189092 104189092 single base substitution G A intron_variant PACA-CA 10 104192115 104192115 single base substitution G A intron_variant PACA-CA 10 104192700 104192700 single base substitution T G upstream_gene_variant PACA-CA 10 104193975 104193975 single base substitution A C upstream_gene_variant PACA-CA 10 104195670 104195670 single base substitution C T upstream_gene_variant PBCA-DE 10 104188317 104188317 single base substitution T C intron_variant PBCA-DE 10 104188317 104188317 single base substitution T C upstream_gene_variant PBCA-DE 10 104193229 104193229 deletion of <=200bp G - upstream_gene_variant READ-US 10 104180897 104180897 single base substitution C T downstream_gene_variant READ-US 10 104183302 104183302 single base substitution C T downstream_gene_variant READ-US 10 104183302 104183302 single base substitution C T exon_variant READ-US 10 104183302 104183302 single base substitution C T missense_variant D249N 745G>A RECA-EU 10 104180322 104180322 single base substitution C T downstream_gene_variant RECA-EU 10 104183288 104183288 single base substitution C T downstream_gene_variant RECA-EU 10 104183288 104183288 single base substitution C T exon_variant RECA-EU 10 104183288 104183288 single base substitution C T synonymous_variant V253V 759G>A RECA-EU 10 104191244 104191244 single base substitution G C intron_variant RECA-EU 10 104193482 104193482 single base substitution G A upstream_gene_variant RECA-EU 10 104194153 104194153 single base substitution A G upstream_gene_variant RECA-EU 10 104194672 104194672 single base substitution C A upstream_gene_variant SKCA-BR 10 104184213 104184213 single base substitution G A intron_variant SKCA-BR 10 104184213 104184213 single base substitution G A upstream_gene_variant SKCA-BR 10 104188004 104188004 single base substitution G C intron_variant SKCA-BR 10 104188004 104188004 single base substitution G C upstream_gene_variant SKCA-BR 10 104191769 104191769 single base substitution G T intron_variant SKCA-BR 10 104192882 104192882 single base substitution C T upstream_gene_variant SKCA-BR 10 104193205 104193207 deletion of <=200bp ATT - upstream_gene_variant SKCA-BR 10 104195304 104195304 single base substitution G A upstream_gene_variant SKCA-BR 10 104195847 104195847 single base substitution C T upstream_gene_variant SKCA-BR 10 104196908 104196909 deletion of <=200bp AT - upstream_gene_variant SKCM-US 10 104181773 104181773 single base substitution C T downstream_gene_variant SKCM-US 10 104182012 104182012 single base substitution C T downstream_gene_variant SKCM-US 10 104183554 104183554 single base substitution C T downstream_gene_variant SKCM-US 10 104183554 104183554 single base substitution C T splice_donor_variant SKCM-US 10 104184490 104184490 single base substitution G A exon_variant SKCM-US 10 104184490 104184490 single base substitution G A missense_variant S45L 134C>T SKCM-US 10 104184490 104184490 single base substitution G A upstream_gene_variant STAD-US 10 104181683 104181683 single base substitution T C downstream_gene_variant STAD-US 10 104182697 104182697 single base substitution G T downstream_gene_variant STAD-US 10 104183602 104183602 single base substitution G A downstream_gene_variant STAD-US 10 104183602 104183602 single base substitution G A exon_variant STAD-US 10 104183602 104183602 single base substitution G A synonymous_variant R203R 609C>T STAD-US 10 104184490 104184490 single base substitution G A exon_variant STAD-US 10 104184490 104184490 single base substitution G A missense_variant S45L 134C>T STAD-US 10 104184490 104184490 single base substitution G A upstream_gene_variant STAD-US 10 104184490 104184490 single base substitution G T exon_variant STAD-US 10 104184490 104184490 single base substitution G T stop_gained S45* 134C>A STAD-US 10 104184490 104184490 single base substitution G T upstream_gene_variant UCEC-US 10 104183215 104183215 single base substitution G T downstream_gene_variant UCEC-US 10 104183215 104183215 single base substitution G T exon_variant UCEC-US 10 104183215 104183215 single base substitution G T missense_variant L278I 832C>A UCEC-US 10 104183256 104183256 single base substitution C A downstream_gene_variant UCEC-US 10 104183256 104183256 single base substitution C A exon_variant UCEC-US 10 104183256 104183256 single base substitution C A missense_variant R264L 791G>T UCEC-US 10 104183283 104183283 single base substitution G A downstream_gene_variant UCEC-US 10 104183283 104183283 single base substitution G A exon_variant UCEC-US 10 104183283 104183283 single base substitution G A missense_variant T255I 764C>T UCEC-US 10 104183288 104183288 single base substitution C G downstream_gene_variant UCEC-US 10 104183288 104183288 single base substitution C G exon_variant UCEC-US 10 104183288 104183288 single base substitution C G synonymous_variant V253V 759G>C UCEC-US 10 104183303 104183303 single base substitution G T downstream_gene_variant UCEC-US 10 104183303 104183303 single base substitution G T exon_variant UCEC-US 10 104183303 104183303 single base substitution G T synonymous_variant I248I 744C>A UCEC-US 10 104183425 104183425 single base substitution C T downstream_gene_variant UCEC-US 10 104183425 104183425 single base substitution C T exon_variant UCEC-US 10 104183425 104183425 single base substitution C T missense_variant A236T 706G>A UCEC-US 10 104183456 104183456 single base substitution G A downstream_gene_variant UCEC-US 10 104183456 104183456 single base substitution G A exon_variant UCEC-US 10 104183456 104183456 single base substitution G A synonymous_variant S225S 675C>T UCEC-US 10 104184080 104184080 single base substitution C T exon_variant UCEC-US 10 104184080 104184080 single base substitution C T missense_variant E118K 352G>A UCEC-US 10 104184080 104184080 single base substitution C T upstream_gene_variant UCEC-US 10 104184459 104184459 single base substitution C A exon_variant UCEC-US 10 104184459 104184459 single base substitution C A missense_variant E55D 165G>T UCEC-US 10 104184459 104184459 single base substitution C A upstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-AP-A059-01 COSM914225 c.764C>T p.T255I Substitution - Missense 10:102423526-102423526 - T36 COSM4675555 c.520_521insG p.D174fs*38 Insertion - Frameshift 10:102424069-102424070 - TCGA-BG-A0LX-01 COSM914227 c.744C>A p.I248I Substitution - coding silent 10:102423546-102423546 - TCGA-AK-3436-01 COSM1134961 c.252A>T p.S84S Substitution - coding silent 10:102424527-102424527 - TCGA-AX-A0J1-01 COSM914229 c.675C>T p.S225S Substitution - coding silent 10:102423699-102423699 - B110-Tumor COSM1745593 c.74G>A p.S25N Substitution - Missense 10:102425115-102425115 - N600T COSM236401 c.660C>A p.Y220* Substitution - Nonsense 10:102423714-102423714 - TCGA-D1-A0ZO-01 COSM914224 c.791G>T p.R264L Substitution - Missense 10:102423499-102423499 - T2940 COSM4675556 c.406G>T p.D136Y Substitution - Missense 10:102424269-102424269 - CSCC-16-T COSM4498115 c.512C>T p.A171V Substitution - Missense 10:102424078-102424078 - TCGA-EA-A439-01 COSM4843670 c.399C>A p.D133E Substitution - Missense 10:102424276-102424276 - ESCC_66 COSM5633667 c.636_637insCAGCT p.K213fs*11 Insertion - Frameshift 10:102423817-102423818 - 15T COSM3709812 c.285C>A p.N95K Substitution - Missense 10:102424390-102424390 - TCGA-D1-A17H-01 COSM914226 c.759G>C p.V253V Substitution - coding silent 10:102423531-102423531 - TCGA-AP-A051-01 COSM914223 c.832C>A p.L278I Substitution - Missense 10:102423458-102423458 - TCGA-AZ-6601-01 COSM122428 c.157G>A p.D53N Substitution - Missense 10:102424710-102424710 - 587332 COSM914224 c.791G>T p.R264L Substitution - Missense 10:102423499-102423499 - TCGA-EE-A29A-06 COSM2059322 c.134C>T p.S45L Substitution - Missense 10:102424733-102424733 - PASFXA COSM5005846 c.816G>T p.K272N Substitution - Missense 10:102423474-102423474 - TCGA-EE-A29V-06 COSM3433775 c.656+1G>A p.? Unknown 10:102423797-102423797 - TCGA-B7-5816-01 COSM2059322 c.134C>T p.S45L Substitution - Missense 10:102424733-102424733 - TCGA-AM-5820-01 COSM3686483 c.818C>T p.A273V Substitution - Missense 10:102423472-102423472 - TCGA-D1-A103-01 COSM914228 c.706G>A p.A236T Substitution - Missense 10:102423668-102423668 - 4_RESISTANT COSM1723931 c.188C>T p.A63V Substitution - Missense 10:102424679-102424679 - LUAD-S01331 COSM396353 c.685C>T p.Q229* Substitution - Nonsense 10:102423689-102423689 - TCGA-D7-6524-01 COSM4011268 c.134C>A p.S45* Substitution - Nonsense 10:102424733-102424733 - TCGA-BS-A0TC-01 COSM914230 c.352G>A p.E118K Substitution - Missense 10:102424323-102424323 - TCGA-UC-A7PF-01 COSM2059322 c.134C>T p.S45L Substitution - Missense 10:102424733-102424733 - TCGA-CH-5739-01 COSM3670422 c.219G>T p.R73S Substitution - Missense 10:102424560-102424560 - OSCC-GB_00150111 COSM3709812 c.285C>A p.N95K Substitution - Missense 10:102424390-102424390 - OSCC-GB_00110111 COSM3709811 c.641C>T p.S214F Substitution - Missense 10:102423813-102423813 - SNUH_G26_S1 COSM147036 c.351C>T p.P117P Substitution - coding silent 10:102424324-102424324 - TCGA-AM-5820-01 COSM147036 c.351C>T p.P117P Substitution - coding silent 10:102424324-102424324 - Sample_1 COSM5021681 c.513T>C p.A171A Substitution - coding silent 10:102424077-102424077 - TCGA-AL-3473-01 COSM3985389 c.110G>A p.G37E Substitution - Missense 10:102424757-102424757 - CSCC-5-T COSM4536608 c.231G>A p.G77G Substitution - coding silent 10:102424548-102424548 - TCGA-EI-6917-01 COSM3414640 c.745G>A p.D249N Substitution - Missense 10:102423545-102423545 - 8047575 COSM3382652 c.834C>T p.L278L Substitution - coding silent 10:102423456-102423456 - 465 COSM4437083 c.228A>G p.I76M Substitution - Missense 10:102424551-102424551 - 16 COSM3735403 c.214C>T p.P72S Substitution - Missense 10:102424653-102424653 - Pat_41_A COSM5836155 c.59C>A p.P20Q Substitution - Missense 10:102425130-102425130 - 4_PRE-TREATMENT COSM1723931 c.188C>T p.A63V Substitution - Missense 10:102424679-102424679 - TCGA-A7-A5ZV-01 COSM3806351 c.126G>T p.L42L Substitution - coding silent 10:102424741-102424741 - GC8_T COSM147036 c.351C>T p.P117P Substitution - coding silent 10:102424324-102424324 - CSCC-32-T COSM4558692 c.776G>A p.R259Q Substitution - Missense 10:102423514-102423514 - HN_62469 COSM122428 c.157G>A p.D53N Substitution - Missense 10:102424710-102424710 - TCGA-AP-A059-01 COSM914231 c.165G>T p.E55D Substitution - Missense 10:102424702-102424702 - 11T COSM3709811 c.641C>T p.S214F Substitution - Missense 10:102423813-102423813 - SJRHB027 COSM3737620 c.788T>C p.V263A Substitution - Missense 10:102423502-102423502 - TCGA-FG-7637-01 COSM3966850 c.59C>T p.P20L Substitution - Missense 10:102425130-102425130 - TCGA-CM-5860-01 COSM1345484 c.346C>T p.R116W Substitution - Missense 10:102424329-102424329 - TCGA-CG-5721-01 COSM4011267 c.609C>T p.R203R Substitution - coding silent 10:102423845-102423845 - B110 COSM1745593 c.74G>A p.S25N Substitution - Missense 10:102425115-102425115 - T3094 COSM4675557 c.191A>G p.Y64C Substitution - Missense 10:102424676-102424676 - PD6719a COSM5800246 c.411+1G>A p.? Unknown 10:102424263-102424263 - TCGA-AZ-4315-01 COSM1345483 c.380C>T p.S127L Substitution - Missense 10:102424295-102424295 - C0021T COSM4165376 c.759G>A p.V253V Substitution - coding silent 10:102423531-102423531 - SNU-C4 COSM3966850 c.59C>T p.P20L Substitution - Missense 10:102425130-102425130 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.500874 10q24.32 614142 2434553|CGAP|BC000262|C/T|non-coding||973|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer C A Missense p.R264L c.791G>T 10 104183256 UCEC C A Nonsense p.E184* c.550G>T 10 104183797 STAD C G Synonymous p.V253V c.759G>C 10 104183288 UCEC C T Missense p.D53N c.157G>A 10 104184467 HNSC C T Missense p.E118K c.352G>A 10 104184080 UCEC C T SpliceDonorSNV . c.656+1G>A 10 104183554 CM G A Missense p.P20L c.59C>T 10 104184887 LGG G A Missense p.S45L c.134C>T 10 104184490 CM G A Missense p.S45L c.134C>T 10 104184490 STAD G A Synonymous p.F68F c.204C>T 10 104184420 HNSC G C Missense p.S45W c.134C>G 10 104184490 HNSC G T Nonsense p.S45* c.134C>A 10 104184490 STAD G T Synonymous p.I248I c.744C>A 10 104183303 UCEC T A Synonymous p.S84S c.252A>T 10 104184284 RCCC