PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PEX12 PEX10 10562279,12096124,10837480, 25402006, 23023127, 21836163, 16082366 hprd,biogrid,i2d exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX14 21525035, 25402006, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX19 12096124,10704444,11390669, 25402006, 21836163 hprd,biogrid,i2d,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX5 10562279,22002062,12096124,12456682,10837480, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 UBE2D2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 TTC1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX2 23023127, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 COX4I2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX11A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G AGPS PEX12 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 ABCD3 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 GNPAT 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 ACADL 21836163 pred G G G G G G G G G G G G G G PEX12 ABCD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 RNF157 23023127 pred G G G G G G G G G G G G G G G G PEX12 ABCD2 25402006 pred G PEX12 CEP70 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX1 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 SSTR5 25402006 pred PEX12 PEX11B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX16 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX26 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 HAO2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX7 25402006, 23023127, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX6 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G PEX12 PPARGC1B 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX13 25402006, 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 PEX11G 21836163 pred G G G G G G G G G G G G G G G G G G G G PEX12 PEX3 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 SLC25A17 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX12 SLC27A2 21836163 pred G G G G G G G G G G G G G G PEX12 RING1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P50542-3 O00623 - 12096124 - X 2 O00623 P40855 - 12096124 - X 2 O00623 - 10562279 - X 2 O00623 - 10562279 - X 2 A0A024R068 O00623 - 10562279 - X 2 A0A024R068 O00623 - 10562279 - X 2 O00623 pull down 12456682 direct interaction X 2 O00623 two hybrid 12096124 direct interaction X 2 O00623 affinity chromatography technology 22002062 physical association X 2 O00623 pull down 10837480 direct interaction X 2 O00623 affinity chromatography technology 10562279 physical association X 2 O00623 two hybrid 10562279 direct interaction X 2 O00623 two hybrid 10837480 direct interaction X 2 O00623 P40855 two hybrid 12096124 direct interaction X 2 O00623 P40855 two hybrid 10704444 direct interaction X 2 O00623 P40855 pull down 10704444 direct interaction X 2 O00623 P40855 two hybrid 11390669 direct interaction X 2 O75381 O00623 biochemical 21525035 association X 2 A0A024R068 O00623 two hybrid 12096124 direct interaction X 2 A0A024R068 O00623 two hybrid 12096124 direct interaction X 2 A0A024R068 O00623 two hybrid 10562279 direct interaction X 2 A0A024R068 O00623 two hybrid 10837480 direct interaction X 2 A0A024R068 O00623 two hybrid 10837480 direct interaction X 2 A0A024R068 O00623 pull down 10837480 direct interaction X 2 A0A024R068 O00623 affinity chromatography technology 10837480 physical association X 2 A0A024R068 O00623 affinity chromatography technology 10562279 physical association X 2 P50542-2 O00623 two hybrid 10562279,10837480,12096124 - X 2 P50542-2 O00623 in vivo 10562279,10837480,12096124 - X 2 P50542-2 O00623 in vitro 10562279,10837480,12096124 - X 2 P50542-2 O00623 in vitro 10562279,10837480,12096124 - X 2 P50542-2 O00623 in vivo 10562279,10837480,12096124 - X 2 P50542-2 O00623 two hybrid 10562279,10837480,12096124 - X 2 O00623 P40855 two hybrid 10704444 - X 2 O00623 P40855 in vivo 10704444 - X 2 O00623 P40855 in vitro 10704444 - X 2 O00623 P40855 in vitro 10704444 - X 2 O00623 P40855 in vivo 10704444 - X 2 O00623 P40855 two hybrid 10704444 - X 2 A0A024R068 O00623 in vitro 10562279,10837480 - X 2 A0A024R068 O00623 two hybrid 10562279,10837480 - X 2 A0A024R068 O00623 in vivo 10562279,10837480 - X 2 A0A024R068 O00623 in vitro 10562279,10837480 - X 2 A0A024R068 O00623 two hybrid 10562279,10837480 - X 2 A0A024R068 O00623 in vivo 10562279,10837480 - X 2 O00623 anti tag coimmunoprecipitation 22002062 association C 21 O00623 P50542 two hybrid 10562279 physical association X 2 O00623 P50542 filter binding 10562279 physical association X 2 O00623 P50542 anti tag coimmunoprecipitation 10562279 physical association X 2 O00623 P50542 two hybrid 12096124 physical association X 2 O00623 P40855 far western blotting 10704444 direct interaction X 2 O00623 P40855 two hybrid 10704444 physical association X 2 O00623 P50542 two hybrid 10562279 - X 2 O00623 P50542 coimmunoprecipitation 10562279 - X 2 A0A024R068 O00623 two hybrid 10562279 - X 2 A0A024R068 O00623 coimmunoprecipitation 10562279 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PEX12 PEX14 MI:0401(biochemical) 21525035 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association) (biogrid) BIOGRID_257420 prey bait PEX12 PEX5 MI:0112(ubiquitin reconstruction)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0112(ubiquitin reconstruction)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0112(ubiquitin reconstruction) 10562279,10837480,12096124,12456682,22002062 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(biogrid)|MI:0471(mint) UniProt_70959|BIOGRID_255173|BIOGRID_110140|BIOGRID_211900|MINT_57247|BIOGRID_97613|UniProt_66145|BIOGRID_77709|HPRD_6941|UniProt_66144|UniProt_66143|BIOGRID_211488|BIOGRID_77710|MINT_77364 prey|prey|prey|bait|prey|bait|bait|bait|-|bait|bait|bait|bait|prey bait|bait|bait|prey|bait|prey|prey|prey|-|prey|prey|prey|prey|bait PEX12 PEX19 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10704444,11390669,12096124 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid) HPRD_6694|BIOGRID_211899|BIOGRID_109097|BIOGRID_104831|UniProt_66268|UniProt_66266|BIOGRID_104834 -|bait|prey|prey|prey|prey|prey -|prey|bait|bait|bait|bait|bait PEX12 PEX10 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10562279,10837480,12096124 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_211896|BIOGRID_97604|BIOGRID_211901|HPRD_9745|BIOGRID_97622|BIOGRID_77815|BIOGRID_77814|BIOGRID_110141|BIOGRID_97610 prey|prey|bait|-|prey|bait|bait|bait|bait bait|bait|prey|-|bait|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PEX12 PEX10 10562279,10562279,10562279,10837480,10837480,10837480 0019,0004,0018,0004,0018,0096 LC PEX12 PEX5 10562279,10562279,10562279,10837480,12456682,10837480,10562279,10562279,22002062 0019,0004,0018,0018,0096,0096,0007,0049,0004 LC PEX12 PEX10 10562279,10562279,10562279,10837480,10837480,10837480 0019,0004,0018,0004,0018,0096 LC PEX12 PEX5 10562279,10562279,10562279,10837480,12456682,10837480,10562279,10562279,22002062 0019,0004,0018,0018,0096,0096,0007,0049,0004 LC PEX12 PEX10 10562279,10562279,10562279,12096124,10837480,10837480,10837480 0019,0004,0018,0018,0004,0018,0096 LC PEX12 PEX14 21525035,21525035 0401,0096 LC PEX12 PEX19 12096124,10704444,10704444,11390669,10704444 0018,0018,0096,0018,0047 LC PEX12 PEX5 10562279,10562279,10562279,12096124,10837480,10837480,10562279,10562279 0019,0004,0018,0018,0018,0096,0007,0049 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PEX12 PEX10 MI:0045 experimental interaction detection MI:0461 interaction database PEX12 PEX14 MI:0045 experimental interaction detection MI:0461 interaction database PEX12 TAF1 MI:0045 experimental interaction detection MI:0461 interaction database PEX12 PEX19 MI:0045 experimental interaction detection MI:0461 interaction database PEX12 HNF4A MI:0045 experimental interaction detection MI:0461 interaction database PEX12 PEX5 MI:0045 experimental interaction detection MI:0461 interaction database PEX12 UBE2D1 MI:0362 inference MI:0461 interaction database PEX12 UBE2E1 MI:0362 inference MI:0461 interaction database PEX12 CLTCL1 MI:0362 inference MI:0461 interaction database PEX12 UBE2D2 MI:0362 inference MI:0461 interaction database PEX12 SKP1 MI:0362 inference MI:0461 interaction database PEX12 CLTC MI:0362 inference MI:0461 interaction database PEX12 PEX5L MI:0362 inference MI:0461 interaction database PEX12 PEX13 MI:0362 inference MI:0461 interaction database PEX12 UBE2E3 MI:0362 inference MI:0461 interaction database PEX12 UBE2E2 MI:0362 inference MI:0461 interaction database PEX12 UBQLN2 MI:0362 inference MI:0461 interaction database PEX12 UBE2D4 MI:0362 inference MI:0461 interaction database