PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FBXW7 DCLRE1C 19423708 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 BCAS3 25640309 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP FBXW7 MED29 23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 MED8 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 NOTCH4 11585921 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 HEMGN 24412244 intact exp G GP P YAP1 FBXW7 24884509 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CCDC6 FBXW7 23108047 biogrid,mint,intact exp G G G G GP GP G GP GP G G G G G G GP GP G GP G P G GP GP GP G GP GP IL24 FBXW7 25640309 biogrid,intact exp P P P P P P P P P P P P P P P P P G P P FBXW7 MED17 23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G EIF3E FBXW7 20890303 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP GNB2L1 FBXW7 21860413 biogrid exp P P P P P P P P P P P P P P P P P P FBXW7 EBNA1BP2 21220517 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CCNC FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP GATA3 FBXW7 24820417 biogrid exp G GP G G G G G G GP G GP GP GP G G GP G G G G P G G G GP G GP GP MAPKAPK3 FBXW7 24412244 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G BTG1 FBXW7 22975506 biogrid exp GP GP G G GP GP G GP G G GP GP GP G G GP GP G GP G P GP G GP GP G GP GP MED22 FBXW7 23322298 biogrid exp G G G G G GP G GP G G GP G GP G G G GP G GP G G GP GP G G GP G AKT1 FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXW7 22608923,23791182,17189384,21620836,21070969,17298674,24298052 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 STOML1 23082202 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP IGFBP3 FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P G G G GP G GP GP MYCN FBXW7 19111882 biogrid,intact exp G G G G G G G G G G FBXW7 TP63 20571051 biogrid exp GP G G G G G G G G G G G G G G G G G G P GP G G G G SMAD1 FBXW7 24412244 intact exp G G G G G G G G GP G G G G G G G G G G G G G G G G G GP MAP2K1 FBXW7 24412244 intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP SREBF2 FBXW7 i2d exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G P G GP GP GP GP GP GP FBXW7 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G MED14 FBXW7 23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G FBP2 FBXW7 24412244 intact exp P P P P P P P P P P P P P P P P GP GP P P P MAPK3 FBXW7 25753158 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MED16 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P G GP GP GP G GP GP MED21 FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP MMS22L FBXW7 16169070 hprd,biogrid,i2d,mint,intact exp MED13L FBXW7 26091241,23322298 biogrid exp GP GP G G G GP G G G G GP GP GP G G GP GP G GP G P GP GP G GP GP GP GP FBP1 FBXW7 24412244 intact exp G GP G G G G G G G G GP GP GP G G GP G G G G GP GP G GP G GP G MED19 FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP AURKA FBXW7 19111882,22513362 biogrid exp G GP P G G G G GP G P G P G G G G GP SEC61B FBXW7 24412244 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP RICTOR FBXW7 22285861 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MED30 23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G MED1 FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MED4 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 LINGO1 16169070 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G FBXW7 BEX1 25640309 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP G GP GP FBXW7 NCOA3 23514585 biogrid,i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 PPP3R2 24412244 intact exp P P G G G GP P P GP P P GP GP G P P GP P P GP REST FBXW7 18354482 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MED15 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP UBE2QL1 FBXW7 24000165 biogrid exp GP G G GP G G GP G GP G P G G GP GP G G G P G G GP GP FBXW7 CSF3R 23820376 biogrid exp G G G G GP GP G GP G G G G GP G G G GP G G P G G G G G G GP ARL6IP1 FBXW7 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP XPA FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP GALNT12 FBXW7 24412244 intact exp GP P P P GP GP GP G G GP P GP G GP GP GP GP GP CCNE2 FBXW7 19084516 biogrid exp G G GP GP P GP G P P P P G GP G GP P P GP P GP GP FBXW7 PPARGC1A 18198341 hprd,biogrid exp G G G G G G G G G G G G G CDK2 FBXW7 23082202 biogrid,intact exp GP GP G G GP GP G GP GP G GP G G GP G GP GP G G G P GP G G GP G GP GP FBXW7 MED9 23322298 biogrid exp G GP G G G GP G G GP G GP G G G G GP GP G GP G P G G G GP G GP GP FBXW7 KLF2 23507969 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP MED6 FBXW7 23322298 biogrid exp GP GP P P P GP GP GP GP GP G GP P G P G P G P G P GP GP GP HIF1A FBXW7 21964756 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P G GP G GP GP GP GP SREBF1 FBXW7 16054087,19126544,24298052 biogrid,i2d exp G GP G G G GP G G G G GP G GP GP G G GP G G G P GP G G G G G G DAB2IP FBXW7 24912918 biogrid exp G G G GP G G G G G G GP G G G GP G GP G GP G G G G G G SHPRH FBXW7 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 SCGB3A1 25640309 biogrid,intact exp G G G G G G G G G G TOP2A FBXW7 21254166 biogrid exp P P G GP GP P GP GP G P P GP GP GP GP FBXW7 MED31 23322298 biogrid exp GP G G G GP GP G GP P G GP GP GP GP G GP GP G GP G P GP GP G GP G GP GP NUDCD2 FBXW7 25036637 intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP MED27 FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP NFE2L1 FBXW7 21953459,23623971 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP FAM101A FBXW7 16169070 hprd,i2d exp MED12 FBXW7 23322298 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MED23 23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 MED20 23322298 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP G GP GP TRIM25 FBXW7 25640309 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP FBXW7 AURKB 23095493 biogrid exp P G GP P G GP P P P GP P G P P GP P GP P FBXW7 EYA1 24752894 biogrid exp G G G G FBXW7 MED28 23322298 biogrid exp GP G G G G GP G G GP G G G GP G G G GP G GP G P G GP G G G GP GP HSP90AB1 FBXW7 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 USP36 25775507 biogrid exp G G G G G GP G G GP G GP GP G GP G G GP G G G GP G GP G G G G GLMN FBXW7 22405651 biogrid exp GP P G G GP GP G GP GP G GP P P GP G GP GP G P P GP GP GP GP GP GP GP FBXW7 USP28 17558397 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP PTEN FBXW7 23514585 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P G GP G GP GP GP GP TGFB1 FBXW7 24412244 intact exp G G G G GP G G G G G G G G G G GP G G G G P G G GP GP GP G SHC1 FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CRY2 FBXW7 25855785 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G P GP G GP G P GP GP GP GP GP GP GP DVL1 FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP KLF5 FBXW7 24398687,20484041,20388706 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP TMOD1 FBXW7 24412244 intact exp G G G G G GP G GP GP G P GP G G G GP GP G GP G G GP GP GP MYB FBXW7 18765672 hprd,biogrid exp P P G GP P P GP P P GP GP G GP P G P P GP GP P GP P GP P KIAA1875 FBXW7 16169070 hprd,i2d,intact exp P P P P P P P P P FBXW7 ZNF510 24412244 intact exp G GP G G GP GP G G GP G G G G GP G GP GP G GP G P G GP G GP G GP GP FBXW7 MED10 23322298 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G GP GP GP GP ANP32B FBXW7 24412244 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 NANS 24412244 intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP MAP4K1 FBXW7 24362026 biogrid exp G G G GP G G G G G G GP GP G G G GP G GP G G FBXW7 MED11 23322298 biogrid exp G G G G G G G GP GP G G G G G G GP G G G G G G G GP G GP G MED24 FBXW7 23322298 biogrid exp GP G G G G GP G GP GP G G G G G G G GP G GP G G G G G G G GP FBXW7 ANGPTL4 25640309 biogrid,intact exp GP GP G G GP GP G GP G G P G GP G G G GP G GP P G GP GP G G G GP PSMA2 FBXW7 19193609 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP FBXW7 MED13 26091241,23322298 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FANCC FBXW7 24412244 intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP HSP90AA1 FBXW7 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G P G G G G G G GP MCL1 FBXW7 22608923 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP MTOR FBXW7 18787170 biogrid exp, ortho G GP G G G GP G G G G G G GP G G G GP G G G GP G G G G GP G PIN1 FBXW7 22608923 biogrid exp, ortho G GP G G GP GP G G GP G G G G GP G G GP G P G P GP G G G G GP GP SKP1 FBXW7 21205095,12628165,23791182,24811168,21620836,15070733,19412162,17434132,22632967,11585921,22388891,11565034,22524983, 25402006, 23023127, 21836163, 16082366 hprd,biogrid,mint,intact,dip exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP JUN FBXW7 16023596, 25402006 hprd,i2d exp, ortho, pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G P G GP G GP G GP G NOTCH1 FBXW7 11425854,17646408,20823234,17526737,24085301,11585921,22388891,21820430,26033182,23022380,17646409, 25402006, 21836163 hprd,biogrid,dip exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CUL1 FBXW7 21205095,14603323,23322298,22405651,23453757,25515538,25143387,11585921,22388891,11565034,23108047,22524983,21145461, 25402006, 21836163, 16082366 hprd,biogrid,mint,intact exp, ortho, pred GP G G G G GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP PSEN1 FBXW7 12354302, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP NFKB2 FBXW7 22864569,22388891,14743216, 25402006 biogrid,mint,intact,dip exp, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P G GP G GP GP GP GP CUL7 FBXW7 12904573, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CCNE1 FBXW7 16338364,17646408,11533444,21070969,24298052,15364936,17434132,14536078,22388891,11565034,11565033,16818231,17298674,18559665,15980150, 21836163 hprd,biogrid,i2d,mint,intact exp, pred P GP G G GP GP G GP GP G P P P GP GP GP P P P P P GP GP GP GP RBX1 FBXW7 21205095,22388891,11565034, 25402006 biogrid exp, pred G G G G G GP G GP G G G G GP G G G GP G GP G P GP G G G G G GP SNCA FBXW7 26033182, 25402006 biogrid exp, pred G G G G GP GP G GP GP G GP G G G G GP G G G G G G G GP G GP PARK2 FBXW7 12628165, 25402006, 21836163 hprd,biogrid exp, pred P GP G P GP G GP GP G GP P P G P GP G P G P GP GP GP P GP MDM2 FBXW7 20708156, 25402006 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 HIPK2 18765672, 25402006 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP SUMF2 FBXW7 16169070, 21836163 hprd,biogrid,i2d,mint,intact exp, pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G P GP GP G GP G GP GP GSK3B FBXW7 22513362, 25402006 biogrid exp, pred G G G G G GP G G GP G G G G G G G GP G G G P G G G G G G G HRAS FBXW7 24412244, 23023127 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CDC34 FBXW7 19084516, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 HEY1 11585921, 21836163 hprd exp, pred G G G G G GP G G G G G G G G G G GP G G G G G G G G G G MYC FBXW7 23791182,17157259,16023596,17646408,15150404,20848231,17873522,15498494,20970423,25716680,17314511,22524983,15103331, 21836163 hprd,biogrid,i2d,intact exp, pred GP GP G GP P G GP GP GP GP GP GP G GP P G GP P GP GP GP GP GP GP GP JAG1 FBXW7 21820430, 25402006 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP PRKCE FBXW7 ortho GP GP G G G GP G G GP G GP G G GP G GP GP G GP G P G GP G GP G GP GP PRKCZ FBXW7 ortho G GP G GP G GP GP G GP GP GP GP G GP GP GP G P GP GP P GP GP GP GP PRKCA FBXW7 ortho G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G P G G GP GP G GP GP PRKCD FBXW7 ortho GP GP G G GP GP G GP GP GP P GP GP G GP GP G GP P GP GP P GP GP GP GP PRKCB FBXW7 ortho GP GP G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G G GP GP GP NPM1 FBXW7 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP UBE2L3 FBXW7 25402006 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G GP GP GP G GP GP FBXW7 PTTG2 21836163 pred P P P P P P P P P P P P P P P P P P P FBXO18 FBXW7 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP PYDC1 FBXW7 21836163 pred G RPS5 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP UBE3C FBXW7 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP PPM1F FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P G GP GP GP GP GP P NEDD8 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CUL3 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP GTF2I FBXW7 25402006 pred G G G G G G G G G G G G G G G G G FBXW7 NLK 25402006, 21836163 pred GP GP G G GP GP G G GP G G G G G G G GP G G G P GP G G G G G GP FBXW7 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P G P G P GP P GP GP P P GP COMMD1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP PPP2CA FBXW7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 SPC25 21836163 pred P G GP P P P GP P GP P P P FBXW7 FBXO6 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 EXOC1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP REL FBXW7 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP MAML1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP KLHL26 FBXW7 23023127 pred GP P G P GP G P GP G GP P P GP G GP GP GP G P GP GP GP GP GP GP FBXW7 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 TUBGCP3 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP UBE2M FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P G GP GP GP GP GP GP PSMD2 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 ARL8B 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP G GP GP HNRNPU FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP KBTBD11 FBXW7 23023127 pred GP GP G G GP GP G P GP G GP GP GP GP G GP GP P G P GP P GP GP GP P P FBXW7 NDFIP1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP CHUK FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 SUGT1 25402006 pred G G G G G G G GP GP G GP G G G G GP G G GP G G G GP GP G GP GP CLTC FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP SMAD2 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MAN1B1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 TUBGCP2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP FBXW7 TBL1Y 21836163 pred P P P P P P GP P P P GP P G GP P GP GP P GP P P P SND1 FBXW7 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP CETN3 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP WEE1 FBXW7 21836163 pred GP GP G GP P G G GP G G GP GP G GP P G GP G P G G G GP GP GP GP NSF FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXO17 25402006 pred G G G G G G G G G G APBB1 FBXW7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G P GP GP GP G GP GP GP BCL6 FBXW7 23023127 pred G G G G GP G G G G G G G G GP G G G G G G P G G G G GP G G SMAD3 FBXW7 25402006 pred GP GP G G G GP G G G G G G GP GP G G GP G GP G P G G G G G G G SMARCA4 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP COPS5 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP USP9X FBXW7 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP HSPA1L FBXW7 25402006 pred GP P G G G G G G G G P G G G G GP EEF1A2 FBXW7 25402006 pred G G GP G GP G G P P G G GP GP G P GP G GP G GP G ACTG1 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP ZC3HC1 FBXW7 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP TCEB1 FBXW7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G MAF FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP PPP4R1 FBXW7 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP NDC80 FBXW7 21836163 pred G G G G G UBE2R2 FBXW7 25402006 pred G G G G GP G G G G G G G G GP G G G G G G G G G G GP GP G RPS3 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP PPARG FBXW7 25402006 pred GP P P P GP P GP G GP P G P P P P P GP P SKP2 FBXW7 25402006 pred GP GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G P G G GP GP GP GP GP RPL11 FBXW7 25402006 pred GP GP G G GP GP G G GP G G GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CDKN1A FBXW7 25402006 pred GP GP G G GP G G G GP G G G GP G G GP G G G G P G G G GP G G GP RNF123 FBXW7 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G P GP GP GP GP GP GP GP MAT1A FBXW7 25402006 pred P P P GP P P P P P NOTCH2 FBXW7 25402006 pred G GP G G G G G G GP G G G G G G G G G G G G G G G G GP G NFKBIB FBXW7 25402006 pred GP P G GP GP G GP P G GP GP GP GP G GP GP GP G P GP GP GP GP GP GP GP EP300 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP EFTUD2 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP BRCA1 FBXW7 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P GP FBXO31 FBXW7 25402006, 23023127, 21836163 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP PSMD9 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP GCK FBXW7 25402006 pred P P P P P GP G P GP P P GP P GP G P P P P P P P P FBXW7 FBXL20 21836163 pred GP GP G G GP G G G GP G GP GP GP GP G GP G G GP G P GP GP G GP GP GP GP NFKBIE FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP GP GP FBXW7 PLK3 21836163 pred GP GP P P G G P G P P GP GP G GP P G GP G P P GP G GP GP GP P ZFC3H1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G P G GP GP GP G GP GP UBE2D1 FBXW7 21836163 pred GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G P GP G GP G GP GP GP CTNNB1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP G GP G GP GP FBXW7 TRIM9 23023127 pred G G G G G G G G G G NFKBIA FBXW7 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G GP G P GP GP GP GP GP GP GP DDX3X FBXW7 25402006 pred G GP G G GP GP G G GP G G G GP GP G GP GP G GP G P GP GP G GP GP GP GP FBXW7 KLHL1 23023127 pred P G P G P P G P P P P P FBXW7 FBXO4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G TCEB3 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP FBXW7 TSPYL2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP RPL7A FBXW7 25402006 pred P P P P P P P P P P P UBXN1 FBXW7 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G P GP G GP GP GP GP GP FBXW7 CDC23 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 CWC25 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 MYBBP1A 25402006 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G GP G P GP GP GP GP GP GP GP HSPA9 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CDC25A FBXW7 25402006 pred P G GP P P P P P P P P P P P P P P P GP BCL3 FBXW7 25402006 pred G G G GP G GP GP G G G GP G GP G G P G G G GP G GP G FBXW7 BTBD3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP G GP GP GP GP FBXW7 FBXO2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ENC1 FBXW7 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP CDKN1B FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP RELA FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CUL5 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP RAD21 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXO5 25402006 pred P P G GP P P GP P P P P GP P G P P P P P GP GP P P ERC2 FBXW7 25402006 pred P P G P GP G P P G P P P P P GP P G P P P P P P P P LRPPRC FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP ZMYND11 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP EEF1G FBXW7 16082366 pred P P P P P P P P P P P P P P P P FOXM1 FBXW7 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P GP NRF1 FBXW7 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP G G GP GP GP GP CDK1 FBXW7 25402006 pred GP G GP G GP P P P GP G GP G P P GP GP GP GP CUL4B FBXW7 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G P GP GP GP GP GP GP GP CUL2 FBXW7 25402006, 16082366 pred GP GP G G G GP G G GP G GP GP GP GP G G GP G GP G P GP GP G G G GP GP FBXW7 ARHGAP35 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CUL4A FBXW7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 PINK1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW8 FBXW7 25402006 pred P P P P P P P P P P P P P P P P P P P P P ACVR1 FBXW7 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G P GP G GP GP GP GP GP NR1I2 FBXW7 25402006 pred G G G G G MAPRE1 FBXW7 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP RBL1 FBXW7 25402006 pred P P G GP P P GP P P P GP P P P P P GP GP GP GP P RBL2 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP RBPJ FBXW7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CREBBP FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP SPC24 FBXW7 21836163 pred P P G GP P P P GP P P P P P FBXO45 FBXW7 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G P GP GP GP GP G GP GP FBXW7 EXOC7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXW2 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP G GP GP FBXW7 RNF7 21836163 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G P GP G G GP GP GP GP HSPA1A, HSPA1B FBXW7 25402006 pred P P P P P P P P P P P P P P P P P P P P P FBXW7 FBXO7 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP CENPI FBXW7 21836163 pred P P G GP P P GP P P P P P G P P P P P P P P P NFKB1 FBXW7 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G G P GP GP G GP GP G GP HSPA8 FBXW7 25402006 pred P P P P P P P P P P P P P P P P FBXW7 FAF1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP CALM1, CALM2, CALM3 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP CDK9 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 MLXIPL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G FBXW7 MYOT 21836163 pred G G G G G G G G GP G G KLHL12 FBXW7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G MARS FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 CDC6 21836163 pred P P G GP P G P P P P P P GP P GP P P P P P P P GP FBXW7 GCM1 21836163 pred P P P P P PIAS2 FBXW7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G GP GP G G G FBXW7 STUB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXW11 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 FBXW7 21836163 pred GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G P GP G GP G GP GP GP FBXO11 FBXW7 21836163 pred G G G G G GP G G G G G GP GP G G GP GP G G G P G G G GP G G G FBXW7 MMS19 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP ESRRG FBXW7 25402006 pred G G G G GP G GP GP G GP P P G G GP G G G GP G GP G GP P NCL FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP YY1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP PPP2R1A FBXW7 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW7 FBXL3 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G GP G G HNF4A FBXW7 25402006 pred GP G G G GP GP GP GP G GP G G GP G GP GP P P FBXW7 UBQLN2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP MYCBP2 FBXW7 25402006 pred G GP G G G GP G GP GP G G G GP GP G GP GP G GP G GP G G GP G G GP CKAP5 FBXW7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP FBXW9 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP TUBA4A FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP HUWE1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP SNW1 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP ESRRA FBXW7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 BTRC 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP G GP GP RELB FBXW7 25402006 pred GP GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G GP GP GP GP CCAR2 FBXW7 25402006 pred P P G P GP P GP G GP P P P GP P G P P GP GP P P P GP TP73 FBXW7 25402006 pred G G G G G CETN1 FBXW7 21836163 pred GP GP G G GP GP G G GP G GP G GP G GP GP G GP G P GP GP GP GP GP GP GP MCM7 FBXW7 25402006 pred GP GP G G GP G G G GP G G G G GP G GP G G G G P GP GP G GP G GP GP FBXW7 FBXL2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P36956 Q969H0 - - - X 2 P36956-4 Q969H0 - - - X 2 A0A024R1Q0 Q969H0 - - - X 2 P24864 Q969H0 - 14999283 - X 2 Q969H0 tandem affinity purification 14743216 association C 10 Q969H0 coimmunoprecipitation 11565034 association C 4 Q969H0 coimmunoprecipitation 11585921 association C 4 Q00653 Q969H0 tandem affinity purification 14743216 physical association X 2 Q9Z0Z7 Q969H0 anti tag coimmunoprecipitation 22307056 physical association X 2 Q9Z0Z7 Q969H0 anti tag coimmunoprecipitation 22307056 physical association X 2 Q969H0 pull down 17909182 - C 3 Q969H0 P46531 pull down 25344755 direct interaction X 2 Q969H0 P46531 anti tag coimmunoprecipitation 20823234 direct interaction X 2 Q969H0 P46531 anti tag coimmunoprecipitation 25344755 direct interaction X 2 Q969H0 P46531 pull down 17909182 direct interaction X 2 Q969H0 P46531 anti tag coimmunoprecipitation 25344755 direct interaction X 2 Q969H0 P46531 anti tag coimmunoprecipitation 25344755 direct interaction X 2 Q969H0 P46531 anti bait coimmunoprecipitation 25344755 direct interaction X 2 Q969H0 P46531 anti tag coimmunoprecipitation 20823234 direct interaction X 2 Q969H0 P46531 pull down 17909182 direct interaction X 2 Q91LX9 Q969H0 anti tag coimmunoprecipitation 17909182 direct interaction X 2 Q91LX9 Q969H0 pull down 17909182 direct interaction X 2 Q91LX9 Q969H0 anti tag coimmunoprecipitation 17909182 direct interaction X 2 Q91LX9 Q969H0 pull down 17909182 direct interaction X 2 Q91LX9 Q969H0 anti bait coimmunoprecipitation 17909182 direct interaction X 2 P63208 Q969H0 anti tag coimmunoprecipitation 19412162 physical association X 2 P63208 Q969H0 anti tag coimmunoprecipitation 20596027 physical association X 2 P63208 Q969H0 anti tag coimmunoprecipitation 20596027 physical association X 2 P29353 Q969H0 two hybrid array 24412244 physical association X 2 Q9H6U6 Q969H0 two hybrid array 25640309 physical association X 2 Q969H0 anti tag coimmunoprecipitation 23791182 association C 4 Q969H0 anti tag coimmunoprecipitation 23791182 association C 4 Q969H0 anti tag coimmunoprecipitation 23791182 association C 4 Q969H0 anti tag coimmunoprecipitation 23791182 association C 4 Q969H0 tandem affinity purification 17314511 association C 222 Q969H0 anti bait coimmunoprecipitation 20890303 physical association C 3 Q969H0 anti tag coimmunoprecipitation 23108047 association C 3 Q969H0 anti tag coimmunoprecipitation 23108047 association C 3 Q969H0 anti tag coimmunoprecipitation 23791182 association C 3 Q969H0 anti tag coimmunoprecipitation 23791182 association C 3 O14640 Q969H0 two hybrid array 24412244 physical association X 2 Q96FE5 Q969H0 two hybrid pooling approach 16169070 physical association X 2 Q8NBJ7 Q969H0 two hybrid pooling approach 16169070 physical association X 2 Q14258 Q969H0 two hybrid array 25640309 physical association X 2 Q969H0 Q8IXK2 two hybrid array 24412244 physical association X 2 Q969H0 P28289 two hybrid array 24412244 physical association X 2 Q96QR1 Q969H0 two hybrid array 25640309 physical association X 2 P01106 Q969H0 anti bait coimmunoprecipitation 17157259 physical association X 2 Q96LZ3 Q969H0 two hybrid array 24412244 physical association X 2 P01137 Q969H0 two hybrid array 24412244 physical association X 2 Q16204 Q969H0 anti tag coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti tag coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti tag coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti tag coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti tag coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti bait coimmunoprecipitation 23108047 physical association X 2 Q16204 Q969H0 anti bait coimmunoprecipitation 23108047 physical association X 2 Q9BY76 Q969H0 two hybrid array 25640309 physical association X 2 B0LPE5 Q969H0 two hybrid array 24412244 physical association X 2 Q92688 Q969H0 two hybrid array 24412244 physical association X 2 A0A024R162 Q969H0 two hybrid array 24412244 physical association X 2 Q13007 Q969H0 two hybrid array 25640309 physical association X 2 Q9Y2H8 Q969H0 two hybrid array 24412244 physical association X 2 D3DR86 Q969H0 tandem affinity purification 14743216 physical association X 2 Q8WVJ2 Q969H0 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024R9N2 Q969H0 two hybrid array 24412244 physical association X 2 P60468 Q969H0 two hybrid array 24412244 physical association X 2 A4QPA9 Q969H0 two hybrid array 24412244 physical association X 2 Q969H0 Q969H0 anti tag coimmunoprecipitation 21620836 physical association X 2 Q969H0 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q969H0 P17936 two hybrid array 24412244 physical association X 2 Q969H0 A0A024R2W7 two hybrid array 24412244 physical association X 2 Q969H0 P23025 two hybrid array 24412244 physical association X 2 A0A090N7U0 Q969H0 coimmunoprecipitation 14603323 physical association X 2 P01112 Q969H0 two hybrid array 24412244 physical association X 2 Q9HBH7 Q969H0 two hybrid array 25640309 physical association X 2 Q15797 Q969H0 two hybrid array 24412244 physical association X 2 Q6ZRQ5 Q969H0 two hybrid pooling approach 16169070 physical association X 2 P24864 Q969H0 pull down 11533444 direct interaction X 2 P24864 Q969H0 coimmunoprecipitation 11533444 physical association X 2 P24864 Q969H0 experimental interaction detection 11533444 ubiquitination reaction X 2 Q149N8 Q969H0 two hybrid pooling approach 16169070 physical association X 2 A6NE52 Q969H0 two hybrid pooling approach 16169070 physical association X 2 A0A024QYV7 Q969H0 two hybrid pooling approach 16169070 physical association X 2 O00757 Q969H0 two hybrid array 24412244 physical association X 2 P04198 Q969H0 anti bait coimmunoprecipitation 19111882 physical association X 2 P63208 Q969H0 anti tag coimmunoprecipitation 15070733 physical association X 2 P63208 Q969H0 anti tag coimmunoprecipitation 21620836 physical association X 2 P63208 Q969H0 anti tag coimmunoprecipitation 22632967 physical association X 2 Q9NR45 Q969H0 two hybrid array 24412244 physical association X 2 P09467 Q969H0 two hybrid array 24412244 physical association X 2 P03070 Q969H0 anti tag coimmunoprecipitation 15611062 physical association X 2 P03070 Q969H0 anti bait coimmunoprecipitation 15611062 physical association X 2 P03070 Q969H0 anti bait coimmunoprecipitation 15611062 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PSMA2 FBXW7 MI:0004(affinity chromatography technology) 19193609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200352 bait prey FBXW7 STOML1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23082202 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_124220|BIOGRID_248409|UniProt_124221|UniProt_124219|BIOGRID_248404|BIOGRID_248403 null|bait|null|null|prey|bait bait|prey|prey|prey|bait|prey FBXW7 PPARGC1A MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18198341 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_33305|BIOGRID_117591|BIOGRID_117589|BIOGRID_117590 -|bait|bait|prey -|prey|prey|bait MED13L FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_247521|BIOGRID_247518|BIOGRID_247490 prey|prey|prey bait|bait|bait c-Jun FBXW7 MI:0492(in vitro) 16023596 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_3386 - - PSIP1 FBXW7 MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_29490 - - GSK3B FBXW7 MI:0004(affinity chromatography technology) 22513362 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208383 prey bait FBXW7 NFKB2 MI:0007(anti tag coimmunoprecipitation) 14743216 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_75940 prey bait PSEN1 FBXW7 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12354302 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36732|BIOGRID_101926 -|bait -|prey KLF5 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20388706,20484041 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_154413|BIOGRID_154429|BIOGRID_154414|BIOGRID_137118|BIOGRID_137119|BIOGRID_137117 prey|prey|bait|prey|bait|prey bait|bait|prey|bait|prey|bait SHPRH FBXW7 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint) BIOGRID_95384|UniProt_154914|HPRD_22681|MINT_63706|MINT_34736 bait|bait|-|bait|bait prey|prey|-|prey|prey NFE2L1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21953459,23623971 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272541|BIOGRID_153978 bait|bait prey|prey FBXW7 MED23 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247492 bait prey GLMN FBXW7 MI:0004(affinity chromatography technology) 22405651 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_212508 bait prey PIN1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22608923 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_187970|BIOGRID_187969 bait|bait prey|prey FBXW7 MED13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_247514|BIOGRID_247489|BIOGRID_247520 bait|bait|bait prey|prey|prey CREB3L2 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 8051045 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_285087|BIOGRID_285093|BIOGRID_285091 prey|prey|prey bait|bait|bait MED14 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247491|BIOGRID_247515 prey|prey bait|bait EIF3A FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12904573 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199276|BIOGRID_199280 bait|bait prey|prey HIF1A FBXW7 MI:0004(affinity chromatography technology) 21964756 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153453 bait prey CDC34 FBXW7 MI:0004(affinity chromatography technology)|MI:0096(pull down) 19084516,21098119 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_225948|BIOGRID_221524 prey|prey bait|bait FBXW7 NCOA3 MI:0004(affinity chromatography technology) 23514585 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272474 prey bait FBXW7 KLF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23507969 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272214|BIOGRID_272215 bait|bait prey|prey MED1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247516|BIOGRID_247488 prey|prey bait|bait FBXW7 HEY1 MI:0493(in vivo) 11585921 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25648 - - FBXW7 MED16 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247493 bait prey FBXW7 MED31 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247510 bait prey MMS22L FBXW7 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint) HPRD_29492|MINT_63888|BIOGRID_93418|UniProt_155982|MINT_34918 -|bait|bait|bait|bait -|prey|prey|prey|prey NFKB2 FBXW7 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 14743216,22388891,22864569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|MI:0465(dip)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0468(hprd) BIOGRID_197557|DIP_53364|BIOGRID_198835|BIOGRID_198834|MINT_86762|BIOGRID_83656|MINT_54018|MINT_53192|BIOGRID_197519|MINT_87632|BIOGRID_197529|HPRD_39502 prey|-|prey|bait|null|bait|null|null|prey|null|bait|- bait|-|bait|prey|prey|prey|prey|prey|bait|prey|prey|- PARK2 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12628165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_90134|BIOGRID_90133|BIOGRID_90132|HPRD_11037 prey|prey|bait|- bait|bait|prey|- SUMF2 FBXW7 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_64245|BIOGRID_94020|MINT_35243|UniProt_156594|HPRD_29518 bait|bait|bait|bait|- prey|prey|prey|prey|- FBXW7 MED10 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247501 bait prey RICTOR FBXW7 MI:0004(affinity chromatography technology) 22285861 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208883 bait prey TOP2A FBXW7 MI:0004(affinity chromatography technology) 21254166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199694 bait prey FBXW7 KIAA1875 MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_156261 prey bait FBXW7 UBE2QL1 MI:0004(affinity chromatography technology) 24000165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289225 prey bait EPHX1 FBXW7 MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_93691 bait prey FBXW7 EBNA1BP2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21220517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_198744|BIOGRID_198734|BIOGRID_198733 bait|bait|prey prey|prey|bait FBXW7 NOTCH4 MI:0493(in vivo) 11585921 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_157 - - FBXW7 CSF3R MI:0004(affinity chromatography technology) 23820376 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283252 prey bait HSP90AA1 FBXW7 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255391 bait prey CCNC FBXW7 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247512 prey bait CUL1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0055(fluorescent resonance energy transfer)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 11565034,11585921,14603323,21145461,21205095,22388891,22405651,23108047,23322298,23453757 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_197556|BIOGRID_197559|BIOGRID_221208|BIOGRID_204507|BIOGRID_200306|BIOGRID_197561|MINT_57907|BIOGRID_95855|UniProt_74168|HPRD_12037|MINT_55236|BIOGRID_247801|BIOGRID_258543|BIOGRID_185324|BIOGRID_247519|BIOGRID_256920|UniProt_126100|UniProt_126107 prey|prey|prey|bait|prey|prey|prey|prey|prey|-|prey|prey|bait|prey|prey|prey|prey|prey bait|bait|bait|prey|bait|bait|bait|bait|bait|-|bait|bait|prey|bait|bait|bait|bait|bait REST FBXW7 MI:0004(affinity chromatography technology) 18354482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201069 prey bait MED12 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247513|BIOGRID_247487 prey|prey bait|bait MED21 FBXW7 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247506 prey bait MTOR FBXW7 MI:0004(affinity chromatography technology) 18787170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_116441 prey bait MED27 FBXW7 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247500 prey bait CCDC6 FBXW7 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23108047 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_247800|UniProt_126102|UniProt_126104|UniProt_126106|UniProt_126108|UniProt_126101|UniProt_126103|BIOGRID_247799|UniProt_126105|UniProt_126100|UniProt_126107 prey|prey|prey|bait|prey|prey|prey|bait|prey|prey|prey bait|bait|bait|prey|bait|bait|bait|prey|bait|bait|bait FAM101A FBXW7 MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_29489 - - FBXW7 MED28 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247507 bait prey FBXW7 TP63 MI:0004(affinity chromatography technology) 20571051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196434 prey bait ARL6IP1 FBXW7 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) HPRD_29860|MINT_63346|MINT_34390|UniProt_155055|BIOGRID_94142 -|bait|bait|bait|bait -|prey|prey|prey|prey FBXW7 HIPK2 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18765672 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33201|BIOGRID_116459 -|prey -|bait PTEN FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23514585 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272473|BIOGRID_272472 bait|prey prey|bait GNB2L1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21860413 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_141617|BIOGRID_141614 prey|prey bait|bait HSP90AB1 FBXW7 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125006 prey bait FBXW7 MED20 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247498 bait prey MYB FBXW7 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18765672 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_33210|BIOGRID_116457|BIOGRID_116458 -|bait|prey -|prey|bait NOTCH1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11425854,11585921,17526737,17646408,17646409,17909182,21820430,22388891,23022380,24085301 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0465(dip)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_113128|BIOGRID_212579|BIOGRID_294246|BIOGRID_246669|BIOGRID_197555|HPRD_4286|DIP_54352|DIP_54350|BIOGRID_117992|BIOGRID_117993|BIOGRID_200616|BIOGRID_196639|BIOGRID_196640 bait|bait|prey|bait|prey|-|-|-|bait|prey|bait|bait|prey prey|prey|bait|prey|bait|-|-|-|prey|bait|prey|prey|bait CCNE1 FBXW7 MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0045(experimental interaction detection)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0045(experimental interaction detection)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method) 11533444,11565033,11565034,14536078,15364936,15980150,16338364,16818231,17298674,17434132,17646408,18559665,22388891,24298052 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) MINT_56798|MINT_56799|BIOGRID_127520|BIOGRID_197779|BIOGRID_207746|HPRD_26901|MINT_85537|MINT_56497|BIOGRID_307773|BIOGRID_123378|BIOGRID_307771|BIOGRID_221211|BIOGRID_117996|BIOGRID_221216|BIOGRID_197554|MINT_85895|BIOGRID_121793|BIOGRID_121794|BIOGRID_221187|BIOGRID_199288|MINT_85894|UniProt_69321|UniProt_69323|UniProt_69322|BIOGRID_87844|BIOGRID_209091|BIOGRID_197783 bait|bait|prey|bait|prey|-|neutral component|neutral component|prey|prey|prey|prey|prey|prey|prey|bait|prey|prey|bait|prey|bait|bait|bait|neutral component|prey|prey|prey prey|prey|bait|prey|bait|-|neutral component|neutral component|bait|bait|bait|bait|bait|bait|bait|prey|bait|bait|prey|bait|prey|prey|prey|neutral component|bait|bait|bait FBXW7 MED15 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247494 bait prey FBXW7 DCLRE1C MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19423708 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_146665|BIOGRID_146664 bait|prey prey|bait FBXW7 USP28 MI:0415(enzymatic study) 17558397 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199285 prey bait SKP1 FBXW7 MI:0402(chromatin immunoprecipitation assay)|MI:0402(chromatin immunoprecipitation assay)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0402(chromatin immunoprecipitation assay)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 11565034,11585921,12628165,15070733,17434132,21205095,21620836,22388891,22632967,23791182,8051045 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid) UniProt_130789|UniProt_130788|BIOGRID_221209|BIOGRID_197558|BIOGRID_285098|UniProt_130790|BIOGRID_200305|BIOGRID_153718|BIOGRID_95853|BIOGRID_197560|BIOGRID_95854|BIOGRID_95856|UniProt_122764|UniProt_77059|BIOGRID_90137|BIOGRID_121792|UniProt_115061|BIOGRID_219152|HPRD_9112|BIOGRID_197526 prey|prey|prey|prey|prey|bait|prey|prey|prey|prey|bait|prey|prey|prey|bait|bait|prey|prey|-|prey bait|bait|bait|bait|bait|prey|bait|bait|bait|bait|prey|bait|null|bait|prey|prey|bait|bait|-|bait MYCN FBXW7 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19111882 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_144404|UniProt_98677|BIOGRID_144402 bait|prey|prey prey|bait|bait MED6 FBXW7 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247511 prey bait MED24 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247497|BIOGRID_247517 prey|prey bait|bait FBXW7 CREB3L1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 8051045 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_285086|BIOGRID_285090|BIOGRID_285092 bait|bait|bait prey|prey|prey FBXW7 MED19 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247505 bait prey FBXW7 MED8 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247496 bait prey FBXW7 LINGO1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(intact)|(biogrid)|MI:0471(mint) MINT_34881|HPRD_29493|UniProt_156140|BIOGRID_93570|MINT_63851 prey|-|prey|prey|prey bait|-|bait|bait|bait FBXW7 MED30 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247509 bait prey FBXW7 AURKB MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23095493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247360|BIOGRID_247359 prey|bait bait|prey FBXW7 MED4 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247495 bait prey FBXW7 MED17 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247503 bait prey MDM2 FBXW7 MI:0007(anti tag coimmunoprecipitation) 20708156 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_108572 bait null EIF3E FBXW7 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20890303 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_108912|BIOGRID_153481 bait|bait prey|prey FBXW7 MED9 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247502 bait prey FBXW7 MED29 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247508 bait prey AURKA FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19111882,22513362 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_208382|BIOGRID_208381|BIOGRID_144403 prey|bait|prey bait|prey|bait JAG1 FBXW7 MI:0004(affinity chromatography technology) 21820430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_212581 bait prey MED22 FBXW7 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247499 prey bait BTG1 FBXW7 MI:0004(affinity chromatography technology) 22975506 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_217688 prey bait FBXW7 MED11 MI:0004(affinity chromatography technology) 23322298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247504 bait prey CCNE2 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19084516 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_142127|BIOGRID_142130 bait|prey prey|bait RBX1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 11565034,21205095,22388891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_200307|BIOGRID_197562|BIOGRID_221210 prey|prey|prey bait|bait|bait SREBF1 FBXW7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 16054087,19126544,24298052 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_126584|BIOGRID_126585|BIOGRID_307774|BIOGRID_148427 prey|prey|prey|bait bait|bait|bait|prey MYC FBXW7 MI:0402(chromatin immunoprecipitation assay)|MI:0402(chromatin immunoprecipitation assay)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15103331,15150404,15498494,16023596,17157259,17314511,17646408,17873522,20848231,20970423,23791182 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_130789|UniProt_130788|UniProt_89764|BIOGRID_150552|BIOGRID_199683|BIOGRID_130767|BIOGRID_130766|BIOGRID_130765|UniProt_87474|BIOGRID_144180|BIOGRID_214032|HPRD_3392|BIOGRID_164069|BIOGRID_117995|BIOGRID_130637|BIOGRID_129570 prey|prey|bait|bait|bait|bait|prey|bait|bait|bait|bait|-|prey|prey|prey|prey prey|bait|prey|prey|prey|prey|bait|prey|prey|prey|prey|-|bait|bait|bait|bait CDK2 FBXW7 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 23082202 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid) UniProt_124224|BIOGRID_248407|UniProt_124225|BIOGRID_248405 bait|bait|prey|prey null|prey|null|bait

PPI - HINT Gene A Gene B PMID Method Quality AURKA FBXW7 19111882,22513362 0004,0004 LC MED14 FBXW7 23322298,25720964 0004,0004 LC MED24 FBXW7 23322298,25720964 0004,0004 LC MED6 FBXW7 23322298,25720964 0004,0004 LC MYC FBXW7 20970423,20848231,17873522,17157259,15103331,15103331,17314511,25720964,17157259,22524983,17646408,25716680,23791182,15150404,17314511,15103331,15498494 0004,0096,0004,0006,0096,0004,0004,0004,0004,0004,0004,0004,0007,0004,0676,0415,0004 LC JUN FBXW7 16023596,14739463,14739463,16023596,14739463 0019,0415,0096,0004,0018 LC CCNE1 FBXW7 21070969,22388891,11533444,15364936,17646408,24298052,24298052,15980150,21070969,11565034,11533444,11565034,11533444,17434132,17434132,18559665,17298674,11565034 0096,0004,0045,0004,0004,0415,0004,0004,0415,0415,0096,0004,0019,0004,0114,0004,0004,0096 LC SREBF1 FBXW7 26759235,24298052,16054087,19126544,16054087 0004,0004,0019,0004,0004 LC NOTCH1 FBXW7 17526737,26108681,25344755,21820430,23022380,25344755,22388891,25344755,11425854,26033182,17646408,17909182,17646409,24085301,20823234 0004,0004,0096,0004,0004,0006,0004,0007,0004,0004,0004,0096,0004,0004,0007 LC RBX1 FBXW7 11565034,21205095,22388891 0004,0004,0401 LC SKP1 FBXW7 21620836,22388891,15070733,22632967,21205095,12628165,21620836,22524983,23791182,15070733,24811168,25720964,22388891,20596027,11585921,26087183,19412162,26474281,15070733,26540345,11585921,11565034 0007,0004,0007,0007,0004,0004,0004,0004,0007,0004,0004,0004,0401,0007,0004,0004,0007,0004,0019,0004,0096,0004 LC NFKB2 FBXW7 14743216,14743216,22388891,14743216,22864569,25720964 0004,0007,0004,0676,0004,0004 HT,LC MED21 FBXW7 23322298,25720964 0004,0004 LC PIN1 FBXW7 22608923,22608923,25720964 0004,0415,0004 LC CUL1 FBXW7 22388891,11565034,21145461,22388891,14603323,25143387,22524983,25515538,11585921,14603323,23108047,22405651,23322298,21205095,25720964,23108047 0401,0004,0004,0004,0004,0004,0004,0004,0096,0019,0004,0004,0004,0004,0004,0007 LC,HT KLF5 FBXW7 24398687,20388706,20484041,20388706,20484041 0004,0096,0004,0004,0415 LC MED1 FBXW7 23322298,25720964 0004,0004 LC CCDC6 FBXW7 23108047,23108047,25885523,23108047,25885523 0007,0006,0415,0004,0004 LC RICTOR FBXW7 25897075,22285861 0004,0004 LC MED13L FBXW7 23322298,23322298,25720964,26091241 0004,0415,0004,0004 LC FLJ00380 FBXW7 23623971,21953459 0004,0004 LC MED12 FBXW7 23322298,25720964 0004,0004 LC FBXW7 FBXW7 21620836,22608923,24298052,21620836,22608923,23791182,17298674,17189384,22608923 0007,0415,0004,0004,0004,0007,0004,0004,0096 LC FBXW7 MED8 23322298,25720964 0004,0004 LC FBXW7 MED4 23322298,25720964 0004,0004 LC FBXW7 MED17 23322298,25720964 0004,0004 LC FBXW7 MED11 23322298,25720964 0004,0004 LC FBXW7 MED13 23322298,23322298,25720964,26091241 0004,0415,0004,0004 LC FBXW7 MED16 23322298,25720964 0004,0004 LC NFKB2 FBXW7 14743216,14743216,14743216 0004,0007,0676 HT CUL1 FBXW7 21145461 0004 HT AURKA FBXW7 19111882,22513362 0004,0004 LC MED14 FBXW7 23322298,25720964 0004,0004 LC MED24 FBXW7 23322298,25720964 0004,0004 LC MED6 FBXW7 23322298,25720964 0004,0004 LC MYC FBXW7 20970423,20848231,17873522,17157259,15103331,15103331,17314511,25720964,17157259,22524983,17646408,25716680,23791182,15150404,17314511,15103331,15498494 0004,0096,0004,0006,0096,0004,0004,0004,0004,0004,0004,0004,0007,0004,0676,0415,0004 LC JUN FBXW7 16023596,14739463,14739463,16023596,14739463 0019,0415,0096,0004,0018 LC CCNE1 FBXW7 21070969,22388891,11533444,15364936,17646408,24298052,24298052,15980150,21070969,11565034,11533444,11565034,11533444,17434132,17434132,18559665,17298674,11565034 0096,0004,0045,0004,0004,0415,0004,0004,0415,0415,0096,0004,0019,0004,0114,0004,0004,0096 LC SREBF1 FBXW7 26759235,24298052,16054087,19126544,16054087 0004,0004,0019,0004,0004 LC NOTCH1 FBXW7 17526737,26108681,25344755,21820430,23022380,25344755,22388891,25344755,11425854,26033182,17646408,17909182,17646409,24085301,20823234 0004,0004,0096,0004,0004,0006,0004,0007,0004,0004,0004,0096,0004,0004,0007 LC RBX1 FBXW7 11565034,21205095,22388891 0004,0004,0401 LC SKP1 FBXW7 21620836,22388891,15070733,22632967,21205095,12628165,21620836,22524983,23791182,15070733,24811168,25720964,22388891,20596027,11585921,26087183,19412162,26474281,15070733,26540345,11585921,11565034 0007,0004,0007,0007,0004,0004,0004,0004,0007,0004,0004,0004,0401,0007,0004,0004,0007,0004,0019,0004,0096,0004 LC NFKB2 FBXW7 22388891,22864569,25720964 0004,0004,0004 LC MED21 FBXW7 23322298,25720964 0004,0004 LC PIN1 FBXW7 22608923,22608923,25720964 0004,0415,0004 LC CUL1 FBXW7 22388891,11565034,22388891,14603323,25143387,22524983,25515538,11585921,14603323,23108047,22405651,23322298,21205095,25720964,23108047 0401,0004,0004,0004,0004,0004,0004,0096,0019,0004,0004,0004,0004,0004,0007 LC KLF5 FBXW7 24398687,20388706,20484041,20388706,20484041 0004,0096,0004,0004,0415 LC MED1 FBXW7 23322298,25720964 0004,0004 LC CCDC6 FBXW7 23108047,23108047,25885523,23108047,25885523 0007,0006,0415,0004,0004 LC RICTOR FBXW7 25897075,22285861 0004,0004 LC MED13L FBXW7 23322298,23322298,25720964,26091241 0004,0415,0004,0004 LC FLJ00380 FBXW7 23623971,21953459 0004,0004 LC MED12 FBXW7 23322298,25720964 0004,0004 LC FBXW7 FBXW7 21620836,22608923,24298052,21620836,22608923,23791182,17298674,17189384,22608923 0007,0415,0004,0004,0004,0007,0004,0004,0096 LC FBXW7 MED8 23322298,25720964 0004,0004 LC FBXW7 MED4 23322298,25720964 0004,0004 LC FBXW7 MED17 23322298,25720964 0004,0004 LC FBXW7 MED11 23322298,25720964 0004,0004 LC FBXW7 MED13 23322298,23322298,25720964,26091241 0004,0415,0004,0004 LC FBXW7 MED16 23322298,25720964 0004,0004 LC WDR97 FBXW7 16169070,16169070 0018,0398 HT FBP2 FBXW7 24412244 0397 LC DVL1 FBXW7 24412244 0397 LC CCNE2 FBXW7 19084516,19084516 0004,0415 LC MYC FBXW7 15103331,15103331,15103331 0096,0004,0415 LC HRAS FBXW7 24412244 0397 LC TGFB1 FBXW7 24412244 0397 LC JUN FBXW7 16023596,14739463,14739463,16023596,14739463 0019,0415,0096,0004,0018 LC HSP90AB1 FBXW7 22939624 0729 HT FBP1 FBXW7 24412244 0397 LC MYB FBXW7 18765672,18765672 0415,0004 LC IGFBP3 FBXW7 24412244 0397 LC XPA FBXW7 24412244 0397 LC CCNE1 FBXW7 21070969,14536078,16818231,11533444,19956254,16338364,24298052,24298052,21070969,11565034,14999283,11533444,11565034,11533444,17434132,17434132,11565034 0096,0415,0415,0045,0415,0415,0415,0004,0415,0415,0019,0096,0004,0019,0004,0114,0096 LC MAPK3 FBXW7 25753158,25753158 0415,0004 LC TMOD1 FBXW7 24412244 0397 LC SHC1 FBXW7 24412244 0397 LC AKT1 FBXW7 24412244 0397 LC SREBF1 FBXW7 16054087,16054087 0019,0004 LC SEC61B FBXW7 24412244 0397 LC RBX1 FBXW7 22388891 0401 LC SKP1 FBXW7 22388891,15070733,15070733,22388891,15070733,17434132 0004,0007,0004,0401,0019,0114 LC FANCC FBXW7 24412244 0397 LC MAP2K1 FBXW7 24412244 0397 LC MCL1 FBXW7 22608923 0415 LC SREBF2 FBXW7 16054087,16054087 0004,0019 LC IL24 FBXW7 25640309,25640309 0018,0397 HT PIN1 FBXW7 22608923,22608923 0004,0415 LC CUL1 FBXW7 22388891,23453757,22388891,14603323,14603323 0401,0055,0004,0004,0019 LC KLF5 FBXW7 20484041,20484041 0004,0415 LC TRIM25 FBXW7 25640309,25640309 0018,0397 HT SHPRH FBXW7 16169070,16169070 0018,0398 HT ARL6IP1 FBXW7 16169070,16169070 0018,0398 HT SMAD1 FBXW7 24412244 0397 LC CCDC6 FBXW7 25885523,25885523 0415,0004 LC MAPKAPK3 FBXW7 24412244 0397 LC MMS22L FBXW7 16169070,16169070 0018,0398 HT FAM101A FBXW7 16169070 0018 HT MED13L FBXW7 23322298,23322298 0004,0415 LC GALNT12 FBXW7 24412244 0397 LC SUMF2 FBXW7 16169070,16169070 0018,0398 HT NUDCD2 FBXW7 25036637 0729 HT ANP32B FBXW7 24412244 0397 LC FBXW7 FBXW7 22608923,22608923,21070969,22608923 0415,0004,0415,0096 LC FBXW7 LINGO1 16169070,16169070 0018,0398 HT FBXW7 PPP3R2 24412244 0397 LC FBXW7 SCGB3A1 25640309,25640309 0018,0397 HT FBXW7 EBNA1BP2 21220517,21220517 0415,0004 LC FBXW7 HEMGN 24412244 0397 LC FBXW7 ANGPTL4 25640309,25640309 0018,0397 HT FBXW7 BCAS3 25640309,25640309 0018,0397 HT FBXW7 BEX1 25640309,25640309 0018,0397 HT FBXW7 NANS 24412244 0397 LC FBXW7 STOML1 23082202,23082202,23082202 0004,0007,0018 LC FBXW7 MED13 23322298,23322298 0004,0415 LC FBXW7 ZNF510 24412244 0397 LC FBXW7 KLF2 23507969,23507969 0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q969H0 O14640 FBXW7 DVL1 0.126 24412244 Q969H0 P60228 FBXW7 EIF3E 0.21 20890303 Q969H0 P60468 FBXW7 SEC61B 0.126 24412244 Q969H0 O14965 FBXW7 AURKA 0.507 19111882,22513362 Q969H0 Q5VWQ8 FBXW7 DAB2IP 0.21 24912918 Q969H0 Q8IXK2 FBXW7 GALNT12 0.126 24412244 Q9HBH7 Q969H0 BEX1 FBXW7 0.126 25640309 Q9HCE1 Q969H0 MOV10 FBXW7 0.126 22658674 Q969H0 O60260 FBXW7 PARK2 0.569 12628165 Q9NR45 Q969H0 NANS FBXW7 0.126 24412244 Q9H6U6 Q969H0 BCAS3 FBXW7 0.126 25640309 Q9H2X6 Q969H0 HIPK2 FBXW7 0.21 18765672 Q9H3D4 Q969H0 TP63 FBXW7 0.21 20571051 Q969H0 P25787 FBXW7 PSMA2 0.126 19193609 Q969H0 P07900 FBXW7 HSP90AA1 0.126 22939624 Q9Y6Q9 Q969H0 NCOA3 FBXW7 0.21 23514585 Q9Y4A8 Q969H0 NFE2L3 FBXW7 0.21 26306035 Q9Y2H8 Q969H0 ZNF510 FBXW7 0.126 24412244 Q969H0 Q7TS73 FBXW7 FAM101A 0.183 16169070 Q969H0 P01112 FBXW7 HRAS 0.126 24412244 Q969H0 P01137 FBXW7 TGFB1 0.126 24412244 Q969H0 P11388 FBXW7 TOP2A 0.21 21254166 Q969H0 P09467 FBXW7 FBP1 0.126 24412244 Q969H0 P04198 FBXW7 MYCN 0.507 19111882 Q969H0 Q13503 FBXW7 MED21 0.309 25720964,23322298 Q969H0 O75448 FBXW7 MED24 0.309 25720964,23322298 Q969H0 O60244 FBXW7 MED14 0.309 25720964,23322298 Q969H0 P03070 FBXW7 P03070 0.376 15611062 Q969H0 O75586 FBXW7 MED6 0.309 25720964,23322298 Q969H0 P63244 FBXW7 GNB2L1 0.454 21860413 Q969H0 P05412 FBXW7 JUN 0.772 14739463 Q969H0 Q15648 FBXW7 MED1 0.309 25720964,23322298 Q9P086 Q969H0 MED11 FBXW7 0.309 25720964,23322298 Q96G25 Q969H0 MED8 FBXW7 0.309 25720964,23322298 Q969H0 Q93074 FBXW7 MED12 0.309 25720964,23322298 Q9NVC6 Q969H0 MED17 FBXW7 0.309 25720964,23322298 Q9NPJ6 Q969H0 MED4 FBXW7 0.309 25720964,23322298 Q9Y2X0 Q969H0 MED16 FBXW7 0.309 25720964,23322298 Q9Y5W3 Q969H0 KLF2 FBXW7 0.454 23507969 Q969H0 Q13616 FBXW7 CUL1 0.973 21145461,22388891,11565034,23322298,23453757,25515538,25143387,23108047,22405651,22524983,14603323,25720964,21205095 Q969H0 Q14494 FBXW7 NFE2L1 0.376 23623971,21953459 Q969H0 P23771 FBXW7 GATA3 0.454 24820417 Q969H0 P36956 FBXW7 SREBF1 0.731 16054087,24298052,26759235,19126544 Q969H0 Q13887 FBXW7 KLF5 0.853 20388706,20484041,24398687 Q969H0 Q00653 FBXW7 NFKB2 0.712 25720964,22388891,14743216,22864569 Q969H0 P62877 FBXW7 RBX1 0.507 11565034,21205095,22388891 Q969H0 P24864 FBXW7 CCNE1 0.999 15364936,22388891,11565034,17646408,11533444,24298052,16338364,18559665,17298674,17434132,15980150,14536078,19956254,14739463,16818231,21070969 Q969H0 Q16204 FBXW7 CCDC6 0.895 23108047,25885523 Q969H0 Q91LX9 FBXW7 Q91LX9 0.659 17909182 Q969H0 Q71F56 FBXW7 MED13L 0.623 26091241,23322298,25720964 Q9UHV7 Q969H0 MED13 FBXW7 0.623 26091241,23322298,25720964 Q969H0 P46531 FBXW7 NOTCH1 0.964 26033182,17646409,22388891,23022380,17646408,17909182,21820430,11425854,24085301,26108681,17526737 Q969H0 P63208 FBXW7 SKP1 0.989 26540345,22388891,11565034,23791182,22632967,15070733,26474281,22524983,12628165,26087183,25720964,21620836,21205095,17434132,24811168 Q969H0 P01106 FBXW7 MYC 0.984 15498494,17157259,23791182,17314511,17646408,15150404,15103331,25716680,22524983,20970423,20848231,25720964,17873522 Q969H0 Q969H0 FBXW7 FBXW7 0.955 21070969,22608923,17298674,21620836,23791182,24298052,17189384 Q969H0 P29353 FBXW7 SHC1 0.126 24412244 Q969H0 Q92918 FBXW7 MAP4K1 0.21 24362026 Q969H0 Q92990 FBXW7 GLMN 0.309 22405651 Q969H0 Q8WVJ2 FBXW7 NUDCD2 0.126 25036637 Q969H0 A0JLT2 FBXW7 MED19 0.21 23322298 Q969H0 A6NE52 FBXW7 KIAA1875 0.286 16169070 Q969H0 D3DR86 FBXW7 NFKB2 0.126 14743216 Q969H0 O00148 FBXW7 DDX39A 0.126 25720964 Q969H0 O14617 FBXW7 AP3D1 0.126 25720964 Q969H0 O60762 FBXW7 DPM1 0.126 25720964 Q969H0 O75592 FBXW7 MYCBP2 0.126 25720964 Q969H0 O75934 FBXW7 BCAS2 0.126 25720964 Q969H0 O94808 FBXW7 GFPT2 0.126 25720964 Q969H0 O96020 FBXW7 CCNE2 0.454 19084516 Q969H0 P06733 FBXW7 ENO1 0.376 26097998 Q969H0 P08238 FBXW7 HSP90AB1 0.126 22939624 Q969H0 P0C2W1 FBXW7 FBXO45 0.126 25720964 Q969H0 P10242 FBXW7 MYB 0.454 18765672 Q969H0 P10412 FBXW7 HIST1H1E 0.126 25720964 Q969H0 P20671 FBXW7 HIST1H2AD 0.126 25720964 Q969H0 P23025 FBXW7 XPA 0.126 24412244 Q969H0 P23769 FBXW7 GATA2 0.569 25670854 Q969H0 P24863 FBXW7 CCNC 0.21 23322298 Q969H0 P24941 FBXW7 CDK2 0.376 23082202 Q969H0 P25789 FBXW7 PSMA4 0.126 25720964 Q969H0 P27361 FBXW7 MAPK3 0.569 25753158 Q969H0 P30419 FBXW7 NMT1 0.126 25720964 Q969H0 P31749 FBXW7 AKT1 0.126 24412244 Q969H0 P37840 FBXW7 SNCA 0.21 26033182 Q969H0 P40939 FBXW7 HADHA 0.126 25720964 Q969H0 P41219 FBXW7 PRPH 0.126 25720964 Q969H0 P41227 FBXW7 NAA10 0.126 25720964 Q969H0 P42345 FBXW7 MTOR 0.21 18787170 Q969H0 P46937 FBXW7 YAP1 0.376 24884509 Q969H0 P47914 FBXW7 RPL29 0.126 25720964 Q969H0 P49336 FBXW7 CDK8 0.126 25720964 Q969H0 P49368 FBXW7 CCT3 0.126 25720964 Q969H0 P49841 FBXW7 GSK3B 0.21 22513362 Q969H0 P53396 FBXW7 ACLY 0.126 25720964 Q969H0 P56693 FBXW7 SOX10 0.376 26461473 Q969H0 P60484 FBXW7 PTEN 0.376 23514585 Q969H0 P61160 FBXW7 ACTR2 0.126 25720964 Q969H0 P61244 FBXW7 MAX 0.126 25720964 Q969H0 P61587 FBXW7 RND3 0.21 26108681 Q969H0 P62140 FBXW7 PPP1CB 0.126 25720964 Q969H0 P62324 FBXW7 BTG1 0.21 22975506 Q969H0 P67809 FBXW7 YBX1 0.126 25720964 Q969H0 P78406 FBXW7 RAE1 0.126 25720964 Q969H0 Q00613 FBXW7 HSF1 0.126 25720964 Q969H0 Q00987 FBXW7 MDM2 0.21 20708156 Q969H0 Q03701 FBXW7 CEBPZ 0.126 25720964 Q969H0 Q06787 FBXW7 FMR1 0.126 25720964 Q969H0 Q07820 FBXW7 MCL1 0.309 22608923 Q969H0 Q08945 FBXW7 SSRP1 0.126 25720964 Q969H0 Q12874 FBXW7 SF3A3 0.126 25720964 Q969H0 Q13007 FBXW7 IL24 0.126 25640309 Q969H0 Q13127 FBXW7 REST 0.21 18354482 Q969H0 Q13451 FBXW7 FKBP5 0.126 25720964 Q969H0 Q13526 FBXW7 PIN1 0.309 22608923,25720964 Q969H0 Q13950 FBXW7 RUNX2 0.21 26542806 Q969H0 Q149N8 FBXW7 SHPRH 0.286 16169070 Q969H0 Q15014 FBXW7 MORF4L2 0.126 25720964 Q969H0 Q15041 FBXW7 ARL6IP1 0.286 16169070 Q969H0 Q15528 FBXW7 MED22 0.21 23322298 Q969H0 Q16594 FBXW7 TAF9 0.126 25720964 Q969H0 Q16644 FBXW7 MAPKAPK3 0.126 24412244 Q969H0 Q2TAY7 FBXW7 SMU1 0.126 25720964 Q969H0 Q3KQU3 FBXW7 MAP7D1 0.126 25720964 Q969H0 Q49AN0 FBXW7 CRY2 0.376 25855785 Q969H0 Q4LE39 FBXW7 ARID4B 0.126 25720964 Q969H0 Q6P2C8 FBXW7 MED27 0.21 23322298 Q969H0 Q6R327 FBXW7 RICTOR 0.507 22285861,25897075 Q969H0 Q6ZRQ5 FBXW7 MMS22L 0.286 16169070 Q969H0 Q70SY1 FBXW7 CREB3L2 0.126 25720964 Q969H0 Q7Z460 FBXW7 CLASP1 0.126 25720964 Q969H0 Q8N752 FBXW7 CSNK1A1L 0.126 25720964 Q969H0 Q8NAA4 FBXW7 ATG16L2 0.126 25720964 Q969H0 Q8NBJ7 FBXW7 SUMF2 0.286 16169070 Q969H0 Q8NC51 FBXW7 SERBP1 0.126 25720964 Q969H0 Q8NCJ5 FBXW7 SPRYD3 0.126 25720964 Q969H0 Q8TB45 FBXW7 DEPTOR 0.376 22017876 Q969H0 Q8TEX9 FBXW7 IPO4 0.126 25720964 Q969H0 Q8WUA4 FBXW7 GTF3C2 0.126 25720964 Q969H0 Q92841 FBXW7 DDX17 0.126 25720964 Q96FE5 Q969H0 LINGO1 FBXW7 0.286 16169070 Q96GD4 Q969H0 AURKB FBXW7 0.376 23095493 Q96HR3 Q969H0 MED30 FBXW7 0.21 23322298 Q96L21 Q969H0 RPL10L FBXW7 0.126 25720964 Q96L91 Q969H0 EP400 FBXW7 0.126 25720964 Q96LZ3 Q969H0 PPP3R2 FBXW7 0.126 24412244 Q96RN5 Q969H0 MED15 FBXW7 0.21 23322298 Q96SD1 Q969H0 DCLRE1C FBXW7 0.376 19423708 Q96ST3 Q969H0 SIN3A FBXW7 0.126 25720964 Q9BQE3 Q969H0 TUBA1C FBXW7 0.126 25720964 Q9BRS2 Q969H0 RIOK1 FBXW7 0.126 25720964 Q9BSV6 Q969H0 TSEN34 FBXW7 0.126 25720964 Q9BTT4 Q969H0 MED10 FBXW7 0.21 23322298 Q9BXL5 Q969H0 HEMGN FBXW7 0.126 24412244 Q9H204 Q969H0 MED28 FBXW7 0.21 23322298 Q9H4H8 Q969H0 FAM83D FBXW7 0.376 24344117 Q9H944 Q969H0 MED20 FBXW7 0.21 23322298 Q9HAY2 Q969H0 MAGEF1 FBXW7 0.126 25720964 Q9NP50 Q969H0 FAM60A FBXW7 0.126 25720964 Q9NW13 Q969H0 RBM28 FBXW7 0.126 25720964 Q9NWA0 Q969H0 MED9 FBXW7 0.21 23322298 Q9NX70 Q969H0 MED29 FBXW7 0.21 23322298 Q9NYL9 Q969H0 TMOD3 FBXW7 0.126 25720964 Q9P275 Q969H0 USP36 FBXW7 0.376 25775507 Q9UBF1 Q969H0 MAGEC2 FBXW7 0.21 26540345 Q9UKF6 Q969H0 CPSF3 FBXW7 0.126 25720964 Q9UKL0 Q969H0 RCOR1 FBXW7 0.126 25720964 Q9ULK4 Q969H0 MED23 FBXW7 0.21 23322298 Q9ULT8 Q969H0 HECTD1 FBXW7 0.126 25720964 Q9Y3C7 Q969H0 MED31 FBXW7 0.21 23322298 Q9Y4I1 Q969H0 MYO5A FBXW7 0.126 25720964 Q9Y5X2 Q969H0 SNX8 FBXW7 0.126 25720964 Q969H0 Q92688 FBXW7 ANP32B 0.126 24412244 Q99848 Q969H0 EBNA1BP2 FBXW7 0.569 21220517 Q96QR1 Q969H0 SCGB3A1 FBXW7 0.126 25640309 Q96RU2 Q969H0 USP28 FBXW7 0.21 17558397 Q9BY76 Q969H0 ANGPTL4 FBXW7 0.126 25640309 Q99062 Q969H0 CSF3R FBXW7 0.21 23820376 Q969H0 P28289 FBXW7 TMOD1 0.126 24412244 Q99502 Q969H0 EYA1 FBXW7 0.21 24752894 Q9UBI4 Q969H0 STOML1 FBXW7 0.569 23082202 Q9UBK2 Q969H0 PPARGC1A FBXW7 0.569 18198341 Q9UBU9 Q969H0 NXF1 FBXW7 0.126 22658674 Q9QR71 Q969H0 ORF73 FBXW7 0.21 17909182 Q969H0 P17936 FBXW7 IGFBP3 0.126 24412244 Q969H0 P78504 FBXW7 JAG1 0.21 21820430 Q969H0 A1L167 FBXW7 UBE2QL1 0.21 24000165 Q969H0 Q14258 FBXW7 TRIM25 0.126 25640309 Q969H0 P49768 FBXW7 PSEN1 0.21 12354302 Q969H0 Q14999 FBXW7 CUL7 0.21 12904573 Q969H0 Q00597 FBXW7 FANCC 0.126 24412244 Q969H0 P15056 FBXW7 BRAF 0.21 26898828 Q969H0 Q02750 FBXW7 MAP2K1 0.126 24412244 Q969H0 Q15797 FBXW7 SMAD1 0.126 24412244 Q969H0 O00757 FBXW7 FBP2 0.126 24412244 Q969H0 Q16665 FBXW7 HIF1A 0.21 21964756 Q969H0 Q08050 FBXW7 FOXM1 0.21 26912724

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MED19 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database UBE2QL1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database WDR97 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database DDX39A FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PSMD12 FBXW7 MI:0362 inference MI:0461 interaction database FBP2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database AP3D1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database DVL1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database AURKA FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database EIF3D FBXW7 MI:0362 inference MI:0461 interaction database SIAH2 FBXW7 MI:0362 inference MI:1106 pathways database MED14 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PARK2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAST3 FBXW7 MI:0362 inference MI:0461 interaction database DPM1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED24 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED6 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MYCBP2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database BCAS2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database GLRX3 FBXW7 MI:0362 inference MI:0461 interaction database GFPT2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXW7 MI:0362 inference MI:1106 pathways database CCNE2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MYC FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HRAS FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TGFB1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MYCN FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ATP1B1 FBXW7 MI:0362 inference MI:0461 interaction database RPLP0 FBXW7 MI:0362 inference MI:0461 interaction database JUN FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PRKCB FBXW7 MI:0362 inference MI:0461 interaction database ENO1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NPM1 FBXW7 MI:0362 inference MI:0461 interaction database HSP90AA1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RHOC FBXW7 MI:0362 inference MI:0461 interaction database HSP90AB1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database H2AFZ FBXW7 MI:0362 inference MI:0461 interaction database FBXO45 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXW7 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC FBXW7 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database HSPA1A FBXW7 MI:0362 inference MI:0461 interaction database HSPA1B FBXW7 MI:0362 inference MI:0461 interaction database MYB FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H1E FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HSPA8 FBXW7 MI:0362 inference MI:0461 interaction database TOP2A FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CDK4 FBXW7 MI:0362 inference MI:0461 interaction database BMP2 FBXW7 MI:0362 inference MI:0461 interaction database BMP4 FBXW7 MI:0362 inference MI:0461 interaction database ATP1A3 FBXW7 MI:0362 inference MI:0461 interaction database ETFA FBXW7 MI:0362 inference MI:0461 interaction database ATP1B2 FBXW7 MI:0362 inference MI:0461 interaction database BRAF FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ANPEP FBXW7 MI:0362 inference MI:0461 interaction database RPS2 FBXW7 MI:0362 inference MI:0461 interaction database HSPA6 FBXW7 MI:0362 inference MI:0461 interaction database PRKCA FBXW7 MI:0362 inference MI:0461 interaction database IGFBP3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW7 MI:0362 inference MI:1106 pathways database HIST1H2AD FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database XPA FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RPS3 FBXW7 MI:0362 inference MI:0461 interaction database RPS6KB1 FBXW7 MI:0362 inference MI:0461 interaction database GATA2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database GATA3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CCNC FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CCNE1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CDK2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PSMA2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PSMA4 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAPK3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TMOD1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SHC1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NMT1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAT2A FBXW7 MI:0362 inference MI:0461 interaction database AKT1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L FBXW7 MI:0362 inference MI:0461 interaction database SREBF1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SNCA FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HADHA FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXW7 MI:0362 inference MI:1106 pathways database PRPH FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NAA10 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MTOR FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 FBXW7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS5 FBXW7 MI:0362 inference MI:0461 interaction database YAP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RPL29 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CDK8 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CDC34 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A FBXW7 MI:0362 inference MI:1106 pathways database CEBPA FBXW7 MI:0362 inference MI:0461 interaction database PSEN1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database GSK3B FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PPP5C FBXW7 MI:0362 inference MI:0461 interaction database ACLY FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HSPA2 FBXW7 MI:0362 inference MI:0461 interaction database ATP1B3 FBXW7 MI:0362 inference MI:0461 interaction database RAD23B FBXW7 MI:0362 inference MI:0461 interaction database SOX10 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXW7 MI:0362 inference MI:1106 pathways database EIF3E FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SEC61B FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PTEN FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ACTR2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAX FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RHOA FBXW7 MI:0362 inference MI:0461 interaction database RND3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database WDR5 FBXW7 MI:0362 inference MI:0461 interaction database PPP1CB FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database BTG1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PSMC6 FBXW7 MI:0362 inference MI:0461 interaction database RPL7A FBXW7 MI:0362 inference MI:0461 interaction database RBX1 FBXW7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXW7 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 FBXW7 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SKP1 FBXW7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RACK1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database YBX1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database IGBP1 FBXW7 MI:0362 inference MI:0461 interaction database RAE1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database JAG1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ERH FBXW7 MI:0362 inference MI:0461 interaction database MAT1A FBXW7 MI:0362 inference MI:0461 interaction database CDK6 FBXW7 MI:0362 inference MI:0461 interaction database FANCC FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HSF1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NFKB2 FBXW7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PRKCE FBXW7 MI:0362 inference MI:0461 interaction database MAP2K1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CEBPZ FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2 FBXW7 MI:0362 inference MI:0461 interaction database PRKCZ FBXW7 MI:0362 inference MI:0461 interaction database PRKCD FBXW7 MI:0362 inference MI:0461 interaction database FMR1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MCL1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SSRP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SREBF2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SF3A3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database IL24 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database STK4 FBXW7 MI:0362 inference MI:0461 interaction database REST FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database STK3 FBXW7 MI:0362 inference MI:0461 interaction database SKP2 FBXW7 MI:0362 inference MI:1106 pathways database FKBP5 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED21 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PIN1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXW7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KLF5 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RUNX2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database EIF3A FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TRIM25 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NFE2L1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXW7 MI:0362 inference MI:1106 pathways database CUL7 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MORF4L2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ARL6IP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED22 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CCDC6 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database TAF9 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAPKAPK3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database HIF1A FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ATP2B3 FBXW7 MI:0362 inference MI:0461 interaction database LONRF1 FBXW7 MI:0362 inference MI:1106 pathways database SMU1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAP7D1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database CRY2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ARID4B FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FNDC3B FBXW7 MI:0362 inference MI:0461 interaction database TCP11X2 FBXW7 MI:0362 inference MI:0461 interaction database HECTD2 FBXW7 MI:0362 inference MI:1106 pathways database DAB2IP FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXW7 MI:0362 inference MI:1106 pathways database FBXW9 FBXW7 MI:0362 inference MI:1106 pathways database FBXW10 FBXW7 MI:0362 inference MI:1106 pathways database RNF213 FBXW7 MI:0362 inference MI:1106 pathways database FBXL22 FBXW7 MI:0362 inference MI:1106 pathways database MAST2 FBXW7 MI:0362 inference MI:0461 interaction database MED27 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXL19 FBXW7 MI:0362 inference MI:1106 pathways database RICTOR FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXW12 FBXW7 MI:0362 inference MI:1106 pathways database RNF19B FBXW7 MI:0362 inference MI:1106 pathways database MMS22L FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FAM101A FBXW7 MI:0362 inference MI:0461 interaction database PAXIP1 FBXW7 MI:0362 inference MI:0461 interaction database CREB3L2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED13L FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database H2AFV FBXW7 MI:0362 inference MI:0461 interaction database RNF144B FBXW7 MI:0362 inference MI:1106 pathways database CLASP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database RBBP6 FBXW7 MI:0362 inference MI:1106 pathways database HUWE1 FBXW7 MI:0362 inference MI:1106 pathways database WDR5B FBXW7 MI:0362 inference MI:0461 interaction database TRIM69 FBXW7 MI:0362 inference MI:1106 pathways database SIAH1 FBXW7 MI:0362 inference MI:1106 pathways database HERC6 FBXW7 MI:0362 inference MI:1106 pathways database UBR2 FBXW7 MI:0362 inference MI:1106 pathways database GALNT12 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 FBXW7 MI:0362 inference MI:1106 pathways database FBXW8 FBXW7 MI:0362 inference MI:1106 pathways database FBXL16 FBXW7 MI:0362 inference MI:1106 pathways database CSNK1A1L FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ATG16L2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SUMF2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SERBP1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SPRYD3 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO15 FBXW7 MI:0362 inference MI:1106 pathways database ZNRF1 FBXW7 MI:0362 inference MI:1106 pathways database FBXL13 FBXW7 MI:0362 inference MI:1106 pathways database FBXO22 FBXW7 MI:0362 inference MI:1106 pathways database ZNRF2 FBXW7 MI:0362 inference MI:1106 pathways database FBXO27 FBXW7 MI:0362 inference MI:1106 pathways database DEPTOR FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 FBXW7 MI:0362 inference MI:1106 pathways database RNF217 FBXW7 MI:0362 inference MI:1106 pathways database DTX3L FBXW7 MI:0362 inference MI:1106 pathways database IPO4 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO41 FBXW7 MI:0362 inference MI:1106 pathways database GTF3C2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database LMO7 FBXW7 MI:0362 inference MI:1106 pathways database TCP11 FBXW7 MI:0362 inference MI:0461 interaction database MYLIP FBXW7 MI:0362 inference MI:1106 pathways database ANP32B FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database DDX17 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MAP4K1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database GLMN FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database MED12 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO32 MI:0362 inference MI:1106 pathways database FBXW7 FBXW5 MI:0362 inference MI:1106 pathways database FBXW7 MIB2 MI:0362 inference MI:1106 pathways database FBXW7 CREB3L1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 SPSB1 MI:0362 inference MI:1106 pathways database FBXW7 FBXL8 MI:0362 inference MI:1106 pathways database FBXW7 FBXO17 MI:0362 inference MI:1106 pathways database FBXW7 LINGO1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 DYNLL2 MI:0362 inference MI:0461 interaction database FBXW7 MED8 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 AURKB MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED30 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXL20 MI:0362 inference MI:1106 pathways database FBXW7 FEM1C MI:0362 inference MI:0461 interaction database FBXW7 RPL10L MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 EP400 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 PPP3R2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXL18 MI:0362 inference MI:1106 pathways database FBXW7 NEDD4L MI:0362 inference MI:1106 pathways database FBXW7 SCGB3A1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED15 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 USP28 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 DCLRE1C MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 SIN3A MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 CSF3R MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 NOTCH4 MI:0362 inference MI:0461 interaction database FBXW7 EYA1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 EBNA1BP2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 TUBA1C MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RIOK1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FEM1A MI:0362 inference MI:0461 interaction database FBXW7 TSEN34 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED10 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 HEMGN MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 ANGPTL4 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RBCK1 MI:0362 inference MI:1106 pathways database FBXW7 MED28 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 HIPK2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 TP63 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXL15 MI:0362 inference MI:1106 pathways database FBXW7 FAM83D MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO44 MI:0362 inference MI:1106 pathways database FBXW7 BCAS3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED20 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 UNKL MI:0362 inference MI:1106 pathways database FBXW7 SMURF2 MI:0362 inference MI:1106 pathways database FBXW7 MAGEF1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 BEX1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FAM60A MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED4 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 TRIM36 MI:0362 inference MI:1106 pathways database FBXW7 NANS MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO6 MI:0362 inference MI:1106 pathways database FBXW7 TCP11L1 MI:0362 inference MI:0461 interaction database FBXW7 RNF19A MI:0362 inference MI:1106 pathways database FBXW7 MED17 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RLIM MI:0362 inference MI:1106 pathways database FBXW7 RBM28 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED9 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED29 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXL12 MI:0362 inference MI:1106 pathways database FBXW7 TMOD3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED11 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 USP36 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MAGEC2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 STOML1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 PPARGC1A MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RPS6KB2 MI:0362 inference MI:0461 interaction database FBXW7 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO40 MI:0362 inference MI:1106 pathways database FBXW7 MED13 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 HERC5 MI:0362 inference MI:1106 pathways database FBXW7 FBXL7 MI:0362 inference MI:1106 pathways database FBXW7 FBXO2 MI:0362 inference MI:1106 pathways database FBXW7 FEM1B MI:0362 inference MI:0461 interaction database FBXW7 FBXO10 MI:0362 inference MI:1106 pathways database FBXW7 FBXO9 MI:0362 inference MI:1106 pathways database FBXW7 FBXL5 MI:0362 inference MI:1106 pathways database FBXW7 FBXL4 MI:0362 inference MI:1106 pathways database FBXW7 FBXW11 MI:0362 inference MI:1106 pathways database FBXW7 CPSF3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RCOR1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO4 MI:0362 inference MI:1106 pathways database FBXW7 FBXL21 MI:0362 inference MI:1106 pathways database FBXW7 FBXL3 MI:0362 inference MI:1106 pathways database FBXW7 FBXW2 MI:0362 inference MI:1106 pathways database FBXW7 INO80 MI:0362 inference MI:0461 interaction database FBXW7 MED23 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 NOTCH3 MI:0362 inference MI:0461 interaction database FBXW7 ATP1B4 MI:0362 inference MI:0461 interaction database FBXW7 BTRC MI:0362 inference MI:1106 pathways database FBXW7 FNDC3A MI:0362 inference MI:0461 interaction database FBXW7 ZNF510 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MAST1 MI:0362 inference MI:0461 interaction database FBXW7 MED16 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MED31 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO7 MI:0362 inference MI:1106 pathways database FBXW7 NFE2L3 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 MYO5A MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 RNF115 MI:0362 inference MI:1106 pathways database FBXW7 RNF114 MI:0362 inference MI:1106 pathways database FBXW7 KLF2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 SNX8 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 WSB1 MI:0362 inference MI:1106 pathways database FBXW7 NCOA3 MI:0045 experimental interaction detection MI:0461 interaction database