PTM - CPLM Gene Name UniProt ID Type Position Code WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 Acetylation 779 K WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 Acetylation 781 K WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 Acetylation 1272 K WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 Acetylation 404 K

PTM - dbPAF Gene Name UniProt ID Position Type Species WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 102 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 11 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 110 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 114 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 115 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 121 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1213 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1214 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1238 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1316 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1332 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 1335 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 154 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 172 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 175 Y Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 177 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 190 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 193 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 194 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 196 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 220 Y Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 231 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 30 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 35 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 376 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 377 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 380 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 407 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 408 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 411 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 414 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 421 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 422 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 437 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 444 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 445 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 447 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 495 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 518 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 54 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 544 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 55 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 555 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 56 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 571 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 580 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 583 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 587 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 591 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 604 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 605 T Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 608 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 614 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 616 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 617 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 618 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 622 S Homo sapiens(Human) WHSC1; NSD2; KIAA1090; MMSET; TRX5 O96028 8 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O96028 K78-ac Acetylation LPFIPADkLKDLTSR O96028 K198-ac Acetylation KIssPsDkKIPAKKE O96028 K404-ac Acetylation MKRRRRAkLCssAEt O96028 K779-ac Acetylation PSNPRPSkGkMMRCV O96028 K781-ac Acetylation NPRPSkGkMMRCVRC O96028 K1231-ac Acetylation KTRRRRAkGEGKRQs O96028 K1272-ac Acetylation LSCLGLGkRPFGKWE O96028 K443-m3 Methylation GsPPGRKkttVsMPR O96028 K582-m1 Methylation MEAASsLksQAAtkN O96028 K588-m1 Methylation LksQAAtkNLsDACK O96028 K615-m1 Methylation sSALGFskSSSPSAS O96028 K1207-m1 Methylation GFLGDRPkTSTTLss O96028 S8-p Phosphorylation MEFSIKQsPLSVQSV O96028 S30-p Phosphorylation QAPEILGsANGKtPS O96028 T35-p Phosphorylation LGsANGKtPSCEVNR O96028 S56-p Phosphorylation SKAQLSSsLQEGVMQ O96028 S102-p Phosphorylation DAKLRFEsQEMKGIG O96028 T110-p Phosphorylation QEMKGIGtPPNttPI O96028 T114-p Phosphorylation GIGtPPNttPIKNGs O96028 T115-p Phosphorylation IGtPPNttPIKNGsP O96028 S121-p Phosphorylation ttPIKNGsPEIKLKI O96028 S154-p Phosphorylation SAADVSQsEENGQKP O96028 S172-p Phosphorylation ARRNRKRsIKyDsLL O96028 Y175-p Phosphorylation NRKRsIKyDsLLEQG O96028 S177-p Phosphorylation KRsIKyDsLLEQGLV O96028 S193-p Phosphorylation AALVSKIssPsDkKI O96028 S194-p Phosphorylation ALVSKIssPsDkKIP O96028 S196-p Phosphorylation VSKIssPsDkKIPAK O96028 Y220-p Phosphorylation DKDHLLKyNVGDLVW O96028 S231-p Phosphorylation DLVWSKVsGYPWWPC O96028 S376-p Phosphorylation SLGEMAEssGVsEEA O96028 S377-p Phosphorylation LGEMAEssGVsEEAA O96028 S380-p Phosphorylation MAEssGVsEEAAENP O96028 S389-p Phosphorylation EAAENPKsVREECIP O96028 S407-p Phosphorylation RRRAkLCssAEtLEs O96028 S408-p Phosphorylation RRAkLCssAEtLEsH O96028 T411-p Phosphorylation kLCssAEtLEsHPDI O96028 S414-p Phosphorylation ssAEtLEsHPDIGKs O96028 S421-p Phosphorylation sHPDIGKstPQKTAE O96028 T422-p Phosphorylation HPDIGKstPQKTAEA O96028 S437-p Phosphorylation DPRRGVGsPPGRKkt O96028 T444-p Phosphorylation sPPGRKkttVsMPRS O96028 T445-p Phosphorylation PPGRKkttVsMPRSR O96028 S447-p Phosphorylation GRKkttVsMPRSRKG O96028 S479-p Phosphorylation VAEHPDAsGEEIEEL O96028 S495-p Phosphorylation RSQWSLLsEKQRARY O96028 S518-p Phosphorylation PVQAEEDsGNVNGKK O96028 T544-p Phosphorylation EDAEAEDtPRKRLRT O96028 S555-p Phosphorylation RLRTDKHsLRKRDTI O96028 S580-p Phosphorylation KAMEAASsLksQAAt O96028 S583-p Phosphorylation EAASsLksQAAtkNL O96028 T587-p Phosphorylation sLksQAAtkNLsDAC O96028 S591-p Phosphorylation QAAtkNLsDACKPLK O96028 S604-p Phosphorylation LKKRNRAsTAAsSAL O96028 S608-p Phosphorylation NRAsTAAsSALGFsk O96028 S614-p Phosphorylation AsSALGFskSSSPSA O96028 S1213-p Phosphorylation PkTSTTLssEEKGKK O96028 S1214-p Phosphorylation kTSTTLssEEKGKKT O96028 S1238-p Phosphorylation kGEGKRQsEDECFRC O96028 T1316-p Phosphorylation DGTAFSCtPDGRSYC O96028 S1332-p Phosphorylation EHDLGAAsVRsTKTE O96028 S1335-p Phosphorylation LGAAsVRsTKTEKPP O96028 K912-sm Sumoylation PPNIQKMkHEIGEFP O96028 K1069-sm Sumoylation YPETKIIkTDGKGWG O96028 K292-ub Ubiquitination EGEGQFEkLCQESAK

PTM - dbPTM UniProt ID Position Code Type Resources References O96028 102 S Phosphorylation Swiss-Prot 1010711 17525332 O96028 110 T Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O96028 114 T Phosphorylation Swiss-Prot 1010711 19413330;19690332 O96028 115 T Phosphorylation Swiss-Prot 1010711 18669648;19413330 O96028 121 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O96028 376 S Phosphorylation Swiss-Prot 1010711 19690332 O96028 437 S Phosphorylation Swiss-Prot 1010711 19007248 O96028 544 T Phosphorylation Swiss-Prot 1010711 17081983;18669648;19007248;19413330;19690332 O96028 779 K Acetylation Swiss-Prot 1010711 19608861 O96028 781 K Acetylation Swiss-Prot 1010711 19608861 O96028 102 S Phosphorylation PhosphoELM.10011 17525332 O96028 121 S Phosphorylation PhosphoELM.10011 18669648 O96028 172 S Phosphorylation PhosphoELM.10011 18669648 O96028 177 S Phosphorylation PhosphoELM.10011 18669648 O96028 110 T Phosphorylation PhosphoELM.10011 18669648 O96028 115 T Phosphorylation PhosphoELM.10011 18669648 O96028 544 T Phosphorylation PhosphoELM.10011 18669648;17081983 O96028 175 Y Phosphorylation PhosphoELM.10011 18669648 O96028 779 K Acetylation Phosphositeplus.1010730 19608861 O96028 781 K Acetylation Phosphositeplus.1010730 19608861 O96028 102 S Phosphorylation Phosphositeplus.1010730 17525332;20068231;21293379 O96028 121 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19690332;20068231;20363803 O96028 172 S Phosphorylation Phosphositeplus.1010730 19690332 O96028 376 S Phosphorylation Phosphositeplus.1010730 19690332;20068231 O96028 377 S Phosphorylation Phosphositeplus.1010730 19690332;20068231 O96028 380 S Phosphorylation Phosphositeplus.1010730 20068231 O96028 407 S Phosphorylation Phosphositeplus.1010730 19276368 O96028 437 S Phosphorylation Phosphositeplus.1010730 19691289;20363803 O96028 495 S Phosphorylation Phosphositeplus.1010730 20068231 O96028 56 S Phosphorylation Phosphositeplus.1010730 19691289 O96028 110 T Phosphorylation Phosphositeplus.1010730 18669648;19276368;19690332;20068231;20164059;20363803;22115753 O96028 114 T Phosphorylation Phosphositeplus.1010730 19690332 O96028 115 T Phosphorylation Phosphositeplus.1010730 19276368;20068231;20363803;22115753 O96028 544 T Phosphorylation Phosphositeplus.1010730 18669648;19690332;19691289;20068231;21659604 O96028 779 K Acetylation HPRD 9.0 19608861 O96028 781 K Acetylation HPRD 9.0 19608861 O96028 56 S Phosphorylation HPRD 9.0 19691289 O96028 102 S Phosphorylation HPRD 9.0 17525332,20068231 O96028 121 S Phosphorylation HPRD 9.0 18669648,19413330,20068231 O96028 172 S Phosphorylation HPRD 9.0 18669648,20068231 O96028 177 S Phosphorylation HPRD 9.0 18669648 O96028 376 S Phosphorylation HPRD 9.0 20068231 O96028 377 S Phosphorylation HPRD 9.0 20068231 O96028 380 S Phosphorylation HPRD 9.0 20068231 O96028 437 S Phosphorylation HPRD 9.0 19007248,19691289 O96028 495 S Phosphorylation HPRD 9.0 20068231 O96028 580 S Phosphorylation HPRD 9.0 19413330 O96028 583 S Phosphorylation HPRD 9.0 19413330 O96028 110 T Phosphorylation HPRD 9.0 18669648,19413330,19651622,20068231 O96028 114 T Phosphorylation HPRD 9.0 19413330,20068231 O96028 115 T Phosphorylation HPRD 9.0 18669648,19413330,19651622,20068231 O96028 422 T Phosphorylation HPRD 9.0 19413330 O96028 544 T Phosphorylation HPRD 9.0 17081983,18669648,19413330,19007248,19691289,18452278,20068231 O96028 587 T Phosphorylation HPRD 9.0 19413330 O96028 175 Y Phosphorylation HPRD 9.0 18669648,20068231 O96028 121 S Phosphorylation SysPTM 1.1 18669648 O96028 110 T Phosphorylation SysPTM 1.1 18669648 O96028 115 T Phosphorylation SysPTM 1.1 18669648 O96028 544 T Phosphorylation SysPTM 1.1 17081983;18669648

PTM - HPRD Symbol Position Code Type References WHSC1 102 S Phosphorylation 17525332,20068231 WHSC1 110 T Phosphorylation 18669648,19413330,19651622,20068231 WHSC1 114 T Phosphorylation 19413330,20068231 WHSC1 115 T Phosphorylation 18669648,19413330,19651622,20068231 WHSC1 121 S Phosphorylation 18669648,19413330,20068231 WHSC1 172 S Phosphorylation 18669648,20068231 WHSC1 175 Y Phosphorylation 18669648,20068231 WHSC1 177 S Phosphorylation 18669648 WHSC1 376 S Phosphorylation 20068231 WHSC1 377 S Phosphorylation 20068231 WHSC1 380 S Phosphorylation 20068231 WHSC1 422 T Phosphorylation 19413330 WHSC1 437 S Phosphorylation 19007248,19691289 WHSC1 495 S Phosphorylation 20068231 WHSC1 544 T Phosphorylation 17081983,18669648,19413330,19007248,19691289,18452278,20068231 WHSC1 56 S Phosphorylation 19691289 WHSC1 580 S Phosphorylation 19413330 WHSC1 583 S Phosphorylation 19413330 WHSC1 587 T Phosphorylation 19413330 WHSC1 779 K Acetylation 19608861 WHSC1 781 K Acetylation 19608861

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O96028 115 T 18669648 HTP Phosphorylation O96028 121 S 18669648 HTP Phosphorylation O96028 102 S 17525332 HTP Phosphorylation O96028 177 S 18669648 HTP Phosphorylation O96028 544 T 18669648 HTP Phosphorylation O96028 544 T 17081983 HTP Phosphorylation O96028 175 Y 18669648 HTP Phosphorylation O96028 110 T 18669648 HTP Phosphorylation O96028 172 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O96028 110 Phosphothreonine 19690332;23186163 O96028 114 Phosphothreonine 19690332 O96028 121 Phosphoserine 18669648;19690332;23186163 O96028 172 Phosphoserine 23186163 O96028 376 Phosphoserine 19690332 O96028 422 Phosphothreonine 23186163 O96028 544 Phosphothreonine 17081983;18669648;19690332;20068231;23186163 O96028 614 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type WHSC1 IPI00107486 S 571 KTARTSpSYKAMEA phosphorylation WHSC1 IPI00107486 S 580 AMEAASpSLKSQAA phosphorylation WHSC1 IPI00218240 K 781 SNPRPSaKGKMMRC acetylation WHSC1 IPI00218240 K 783 PRPSKGaKMMRCVR acetylation WHSC1 IPI00334604 T 544 DAEAEDpTPRKRLR phosphorylation WHSC1 IPI00790144 S 481 LCFMLApSFRI___ phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7468 113306 - K Ubiquitination 21139048 7468 113306 - K Ubiquitination 24816145