PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GABARAPL2 KLHL5 21900206 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP GP G NKD1 KLHL5 19888210 i2d exp G G G G G P G G G G P GP MYC KLHL5 20195357 intact exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G TGFBR1 KLHL5 15761153 i2d exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G KLHL5 MAP1LC3B 21900206 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP G G G G GP GP G G G G G G GP GP G GP GP G FUS KLHL5 25192599 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TK1 KLHL5 21900206 biogrid,mint,intact exp GP GP G GP P G G GP G GP GP GP GP P G G G GP G G GP GP G KLHL5 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMN1, SMN2 KLHL5 21900206 biogrid,mint,intact exp P P P P P P P P P P P P P P P P P P P P CUL3 KLHL5 21988832,21145461 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BMPR1B KLHL5 15761153 i2d exp, ortho P GP G G GP GP G GP GP G GP P GP G GP GP GP GP G P GP P GP GP GP GP GP G NAGA KLHL5 ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96PQ7 P01106 display technology 20195357 physical association X 2 Q96PQ7 Q5NFN7 two hybrid pooling approach 20711500 physical association X 2 Q96PQ7 Q81RT0 two hybrid pooling approach 20711500 physical association X 2 Q96PQ7 Q8D0B2 two hybrid pooling approach 20711500 physical association X 2 Q96PQ7 P60520 two hybrid 21900206 physical association X 2 Q96PQ7 Q658J6 two hybrid 21900206 physical association X 2 Q96PQ7 Q16637 two hybrid 21900206 physical association X 2 Q96PQ7 P04183 two hybrid 21900206 physical association X 2 Q96PQ7 Q81NJ0 two hybrid pooling approach 20711500 physical association X 2 Q96PQ7 Q5NH70 two hybrid pooling approach 20711500 physical association X 2 Q96PQ7 Q7CIX7 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HDAC1 KLHL5 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_192728 bait prey CUL3 KLHL5 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21145461,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_288411|UniProt_119846|BIOGRID_201871 bait|unspecified role|bait prey|unspecified role|prey GABARAPL2 KLHL5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_158549|UniProt_179147|BIOGRID_156234 bait|bait|bait prey|prey|prey KLHL5 MAP1LC3B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_157749|UniProt_179506|UniProt_158908 prey|prey|prey bait|bait|bait TK1 KLHL5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_157530|BIOGRID_157291|UniProt_178128 bait|bait|bait prey|prey|prey MYC KLHL5 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_105281 bait prey SMN1 KLHL5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_157312|UniProt_177910|BIOGRID_158100 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CUL3 KLHL5 21145461 0004 HT CUL3 KLHL5 21145461 0004 HT MYC KLHL5 20195357 0034 LC TK1 KLHL5 21900206 0018 HT GABARAPL2 KLHL5 21900206 0018 HT CUL3 KLHL5 21988832 0018 HT SMN1|SMN2 KLHL5 21900206 0018 HT DKFZP762B153 KLHL5 21900206 0018 HT KLHL5 MAP1LC3B 21900206 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96PQ7 Q5NH70 KLHL5 Q5NH70 0.126 20711500 Q9GZQ8 Q96PQ7 MAP1LC3B KLHL5 0.183 21900206 Q96PQ7 Q7CIX7 KLHL5 AMPD3 0.126 20711500 Q96PQ7 Q81NJ0 KLHL5 HSCC 0.126 20711500 Q96PQ7 Q8D0B2 KLHL5 FLIH 0.126 20711500 Q96PQ7 Q81RT0 KLHL5 Q81RT0 0.126 20711500 Q96PQ7 P60520 KLHL5 GABARAPL2 0.332 21900206 Q96PQ7 P04183 KLHL5 TK1 0.332 21900206 Q96PQ7 P01106 KLHL5 MYC 0.126 20195357 Q96PQ7 Q5NFN7 KLHL5 Q5NFN7 0.126 20711500 Q96PQ7 Q16637 KLHL5 SMN2 0.332 21900206 Q96PQ7 Q13618 KLHL5 CUL3 0.416 21988832,21145461 Q96PQ7 P35637 KLHL5 FUS 0.126 25192599

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NPHP4 KLHL5 MI:0362 inference MI:0461 interaction database MYC KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database TK1 KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database NAGA KLHL5 MI:0362 inference MI:0461 interaction database FUS KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database GABARAPL2 KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 KLHL5 MI:0362 inference MI:1106 pathways database CUL3 KLHL5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SMN1 KLHL5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL5 MAP1LC3B MI:0045 experimental interaction detection MI:0461 interaction database