PTM - CPLM Gene Name UniProt ID Type Position Code PRPF19; NMP200; PRP19; SNEV Q9UMS4 Acetylation 122 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Acetylation 261 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Acetylation 244 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 266 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 428 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 122 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 244 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 380 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 500 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 206 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 265 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 179 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 261 K PRPF19; NMP200; PRP19; SNEV Q9UMS4 Ubiquitination 200 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PRPF19; NMP200; PRP19; SNEV Q9UMS4 149 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 18 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 181 T Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 193 T Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 2 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 259 T Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 297 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 307 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 310 T Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 313 S Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 329 Y Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 342 T Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 405 Y Homo sapiens(Human) PRPF19; NMP200; PRP19; SNEV Q9UMS4 67 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9UMS4 K122-ac Acetylation RVIARLTkEVTAARE Q9UMS4 K179-ac Acetylation IIQKLQDkAtVLTTE Q9UMS4 K206-ac Acetylation VkPEELSkYRQVASH Q9UMS4 K244-ac Acetylation ILTGGADkNVVVFDK Q9UMS4 K261-ac Acetylation EQILAtLkGHTKkVT Q9UMS4 S2-p Phosphorylation ______MsLICSISN Q9UMS4 S18-p Phosphorylation VPEHPCVsPVSNHVY Q9UMS4 S149-p Phosphorylation VPQAVPSsQPSVVGA Q9UMS4 T181-p Phosphorylation QKLQDkAtVLTTERK Q9UMS4 T193-p Phosphorylation ERKKRGktVPEELVk Q9UMS4 T259-p Phosphorylation SSEQILAtLkGHTKk Q9UMS4 S281-p Phosphorylation PSQDLVFsAsPDATI Q9UMS4 S283-p Phosphorylation QDLVFsAsPDATIRI Q9UMS4 S297-p Phosphorylation IWSVPNAsCVQVVRA Q9UMS4 S307-p Phosphorylation QVVRAHEsAVtGLsL Q9UMS4 T310-p Phosphorylation RAHEsAVtGLsLHAT Q9UMS4 S313-p Phosphorylation EsAVtGLsLHATGDY Q9UMS4 Y329-p Phosphorylation LSSSDDQyWAFSDIQ Q9UMS4 T342-p Phosphorylation IQTGRVLtKVTDETS Q9UMS4 Y405-p Phosphorylation IAFSENGyYLATAAD Q9UMS4 S503-p Phosphorylation DRSLKFYsL______ Q9UMS4 K122-ub Ubiquitination RVIARLTkEVTAARE Q9UMS4 K179-ub Ubiquitination IIQKLQDkAtVLTTE Q9UMS4 K192-ub Ubiquitination TERKKRGktVPEELV Q9UMS4 K200-ub Ubiquitination tVPEELVkPEELSkY Q9UMS4 K206-ub Ubiquitination VkPEELSkYRQVASH Q9UMS4 K244-ub Ubiquitination ILTGGADkNVVVFDK Q9UMS4 K261-ub Ubiquitination EQILAtLkGHTKkVT Q9UMS4 K266-ub Ubiquitination tLkGHTKkVTSVVFH Q9UMS4 K380-ub Ubiquitination QIKIWDLkERTNVAN Q9UMS4 K428-ub Ubiquitination LRKLKNFkTLQLDNN

PTM - dbPTM UniProt ID Position Code Type Resources References Q9UMS4 2 S Phosphorylation Swiss-Prot 1010711 19413330 Q9UMS4 122 K Acetylation Swiss-Prot 1010711 19608861 Q9UMS4 261 K Acetylation Swiss-Prot 1010711 19608861 Q9UMS4 307 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UMS4 310 T Phosphorylation Swiss-Prot 1010711 18669648 Q9UMS4 313 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UMS4 329 Y Phosphorylation Swiss-Prot 1010711 18669648 Q9UMS4 342 T Phosphorylation Swiss-Prot 1010711 18669648 Q9UMS4 2 S Acetylation Swiss-Prot 1010711 - Q9UMS4 307 S Phosphorylation PhosphoELM.10011 18669648 Q9UMS4 313 S Phosphorylation PhosphoELM.10011 18669648 Q9UMS4 310 T Phosphorylation PhosphoELM.10011 18669648 Q9UMS4 342 T Phosphorylation PhosphoELM.10011 18669648 Q9UMS4 329 Y Phosphorylation PhosphoELM.10011 18669648 Q9UMS4 244 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UMS4 266 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9UMS4 380 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UMS4 428 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9UMS4 122 K Acetylation Phosphositeplus.1010730 19608861 Q9UMS4 261 K Acetylation Phosphositeplus.1010730 19608861 Q9UMS4 149 S Phosphorylation Phosphositeplus.1010730 22529335 Q9UMS4 307 S Phosphorylation Phosphositeplus.1010730 18669648 Q9UMS4 181 T Phosphorylation Phosphositeplus.1010730 21406692 Q9UMS4 193 T Phosphorylation Phosphositeplus.1010730 20629186 Q9UMS4 310 T Phosphorylation Phosphositeplus.1010730 18669648 Q9UMS4 342 T Phosphorylation Phosphositeplus.1010730 18669648 Q9UMS4 122 K Acetylation HPRD 9.0 19608861 Q9UMS4 261 K Acetylation HPRD 9.0 19608861 Q9UMS4 2 S Acetylation HPRD 9.0 19413330 Q9UMS4 67 S Phosphorylation HPRD 9.0 20068231 Q9UMS4 307 S Phosphorylation HPRD 9.0 18669648 Q9UMS4 313 S Phosphorylation HPRD 9.0 18669648 Q9UMS4 259 T Phosphorylation HPRD 9.0 18452278 Q9UMS4 310 T Phosphorylation HPRD 9.0 18669648 Q9UMS4 342 T Phosphorylation HPRD 9.0 18669648 Q9UMS4 329 Y Phosphorylation HPRD 9.0 18669648 Q9UMS4 307 S Phosphorylation SysPTM 1.1 18669648 Q9UMS4 313 S Phosphorylation SysPTM 1.1 18669648 Q9UMS4 310 T Phosphorylation SysPTM 1.1 18669648 Q9UMS4 342 T Phosphorylation SysPTM 1.1 18669648 Q9UMS4 329 Y Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References PRPF19 122 K Acetylation 19608861 PRPF19 2 S Acetylation 19413330 PRPF19 259 T Phosphorylation 18452278 PRPF19 261 K Acetylation 19608861 PRPF19 307 S Phosphorylation 18669648 PRPF19 310 T Phosphorylation 18669648 PRPF19 313 S Phosphorylation 18669648 PRPF19 329 Y Phosphorylation 18669648 PRPF19 342 T Phosphorylation 18669648 PRPF19 67 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9UMS4 307 S 18669648 HTP Phosphorylation Q9UMS4 310 T 18669648 HTP Phosphorylation Q9UMS4 329 Y 18669648 HTP Phosphorylation Q9UMS4 342 T 18669648 HTP Phosphorylation Q9UMS4 313 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9UMS4 2 N-acetylserine 19413330;22223895 Q9UMS4 122 N6-acetyllysine 19608861 Q9UMS4 261 N6-acetyllysine 19608861

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PRPF19 IPI00004968 K 122 VIARLTaKEVTAAR acetylation PRPF19 IPI00004968 K 261 QILATLaKGHTKKV acetylation PRPF19 IPI00004968 S 67 IRPKPPpSATSIPA phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 27339 118151 - K Ubiquitination 22178446 27339 118151 - K Ubiquitination 21139048 27339 118151 - K Ubiquitination 21890473 27339 118151 - K Ubiquitination 21906983 27339 118151 - K Ubiquitination 22053931 27339 118151 - K Ubiquitination 23000965 27339 118151 - K Ubiquitination 23220010 27339 118151 - K FAT10ylation 23862649 27339 118151 - K Ubiquitination 24654937 27339 118151 - K Neddylation 24654937 27339 118151 - K Sumoylation 24654937 27339 118151 - K Ubiquitination 24816145 27339 118151 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PRPF19 Homo sapiens (Human) 428; 266; 380; 244; 122 "428,RKLKNFKTLQLDN; 266,LKGHTKKVTSVVF; 380,IKIWDLKERTNVA; 244,LTGGADKNVVVFD; 122,VIARLTKEVTAAR" 428:21890473; 266:21890473; 380:21906983; 244:21906983; 122:22053931