PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM3 TNFAIP3 23105109 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 UBE2D4 21143188 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP GP G GP G G GP GP G TRIM3 CSNK1E 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 PDHA1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 UBE2U 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P GP TRIM3 TEAD2 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G TRIM3 UBE2K 11513855 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 HECW2 24163370 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G P GP GP G GP GP GP GP GP G GP GP TRIM3 UBE2G2 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G HGS TRIM3 15772161 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G KIF21B TRIM3 24086586 biogrid exp P P G G GP GP P P G P P P GP P GP P P P P P P G P P TRIM3 CUL3 25011449 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 TRIM3 11331580 hprd,biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G ACTN4 TRIM3 15772161,10673389, 25402006, 21836163 hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 MYO5A 15772161,10391919, 21836163 hprd,biogrid exp, pred GP G G G GP GP G G GP G GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 YWHAZ ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 CDKN1A ortho GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G TRIM3 TRPM7 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP TRIM3 YWHAE ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 YWHAB 25402006 ortho, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 MYO5B 25402006 ortho, pred GP GP G GP G GP GP G GP GP GP G G GP GP GP G GP GP GP GP G GP GP G TRIM3 LRSAM1 21836163 pred P GP G P GP G P GP G GP GP P GP P GP G GP G P GP P P P G P P G TRIM3 PHYHIP 23023127 pred G G G G G G G G G G G G G G G G G G G G TRIM3 COL17A1 25402006 pred P G G P P P G G P P TRIM3 CAMK2A 25402006 pred P P G GP G GP GP G GP P GP G G G P GP GP G G GP G TRIM3 NOS3 25402006 pred G P P G GP G TRIM3 FLNA 23023127 pred G G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP G G G G G GP GP G TRIM3 KIDINS220 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 CTNNB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 FEZF2 23023127 pred G G G TRIM3 RFFL 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP G TRIM3 PADI1 21836163 pred P G G G G G G G G G GP G G G G G G G G G G GP G TRIM3 CNTN6 23023127 pred GP G GP G P P G P GP P P GP P G P P P P P P TRIM3 RAB3B 23023127 pred P G G GP G GP G GP G GP GP GP P TRIM3 ACVR1B 23023127 pred G G G G G GP G G GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G TRIM3 RAB3A 23023127 pred GP G G G GP G G G G G G G GP G GP G G G G G G G TRIM3 MAPK8IP2 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PDLIM1 TRIM3 25402006 pred GP G G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP G GP GP G TRIM3 G3BP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 STAM 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 RABEP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 ARHGEF7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G TRIM3 GABARAPL1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G G G GP G GP GP GP G GP GP G TRIM3 RAB15 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP G GP GP G TRIM3 SHH 23023127 pred GP GP G G GP GP G P GP G GP G GP GP GP GP P G P GP P GP GP GP GP TRIM3 GCC2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G APBB1 TRIM3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP GP G TRIM3 TRIM10 16082366 pred G G G G G G G G G G G G G G GP G G G G G G G GP GP GP GP G TRIM3 NEURL1 23023127 pred GP G G G GP G G GP G G G G G GP G GP G G G G G G G G G TRIM3 ALPI 25402006 pred P P GP P P GP TRIM3 CRYBB3 25402006 pred P P P P P P P P P P P P P P TRIM3 KIAA0319 23023127 pred P P G GP G P P G P P P P P GP P G P P P P P P P TRIM3 RIMS1 23023127 pred P P G G G GP G GP G P P P GP G P G P GP GP GP GP GP GP G TRIM3 RPH3A 23023127 pred G G G G G GP G G G G G G GP G G G GP G G G G G G G G G G TRIM3 RAB4A 21836163 pred P P P P P P P P P P P P P P P P P P P P TRIM3 TJP1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 TRIM37 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 CAMK2B 25402006 pred G G G G GP G GP G G G G G GP G G G GP GP G G GP G TRIM3 CDH1 25402006 pred GP G G G GP GP GP GP G G GP G GP G GP GP GP GP G GP G TRIM3 VSTM2L 23023127 pred P G GP G GP GP G P P GP P P GP G G P P P P G GP P TRIM3 RAB11A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 TRIM9 23023127 pred G G G G G G G G G G G TRIM3 ANK3 23023127 pred GP G G GP G GP GP G GP G GP G G GP GP G GP G G GP GP G GP G GP GP G TRIM3 RAB5A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 AP2A2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 AMIGO1 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SNX3 TRIM3 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TRIM3 DOC2A 23023127 pred G G G G G G G G TRIM3 SH2D5 23023127 pred P P G G GP GP GP GP G P P P G GP GP P G GP P GP P P P GP TRIM3 RAB3C 23023127 pred P G GP G P G P GP P G P P P P TRIM3 ARHGAP26 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRIM3 MYOZ2 25402006 pred G GP GP G TRIM3 BSPRY 23023127 pred G GP G G G GP G G GP G G G GP G G G GP G G G GP G GP G G G GP G TRIM3 SNX13 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM3 RAB26 23023127 pred P G G G GP G G GP GP G GP G GP G G GP G G G G GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O75382 A8CDT9 in vivo 10391919 - X 2 O75382 A8CDT9 two hybrid 10391919 - X 2 O75382 O43707 in vivo 10673389 - X 2 O75382 O43707 two hybrid 10673389 - X 2 O75382 O43707 in vivo 10673389 - X 2 O75382 O43707 two hybrid 10673389 - X 2 O75382 A8CDT9 in vivo 10391919 - X 2 O75382 A8CDT9 two hybrid 10391919 - X 2 P61086-2 O75382 in vitro 11513855 - X 2 P61086-2 O75382 two hybrid 11513855 - X 2 P61086-2 O75382 in vivo 11513855 - X 2 P61086-2 O75382 in vitro 11513855 - X 2 P61086-2 O75382 two hybrid 11513855 - X 2 P61086-2 O75382 in vivo 11513855 - X 2 O75382 O75382 two hybrid 11331580 - X 2 P60604 O75382 two hybrid array 19690564 physical association X 2 O75382 Q5VVX9 two hybrid array 19690564 physical association X 2 O75382 Q7CH24 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ACTN4 TRIM3 MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 10673389,15772161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_216783|HPRD_13184|BIOGRID_105046|BIOGRID_105045 prey|-|prey|prey bait|-|bait|bait KIF21B TRIM3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24086586 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_294082|BIOGRID_294083 bait|bait prey|prey TRIM3 UBE2U MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123677|UniProt_102666 prey|prey bait|bait TRIM3 UBE2K MI:0492(in vitro) 11513855 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_11558 - - TRIM3 HECW2 MI:0004(affinity chromatography technology) 24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293835 prey bait HGS TRIM3 MI:0018(two hybrid) 15772161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_216781 bait prey TRIM3 MYO5A MI:0018(two hybrid)|MI:0493(in vivo) 10391919,15772161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_216784|HPRD_37853 bait|- prey|- TRIM3 UBE2D4 MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_194274 bait prey TRIM3 TNFAIP3 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248261 prey bait TRIM3 UBE2G2 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123582|UniProt_102571 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality ACTN4 TRIM3 10673389,10673389,15772161 0004,0018,0004 LC TRIM3 PDHA1 26344197 0401 HT TRIM3 CSNK1E 26496610,26496610 0007,0004 HT TRIM3 TEAD2 25609649,25609649 0676,0004 HT TRIM3 PDHA1 26344197 0401 HT TRIM3 CSNK1E 26496610,26496610 0007,0004 HT TRIM3 TEAD2 25609649,25609649 0676,0004 HT ACTN4 TRIM3 10673389,10673389,15772161 0004,0018,0004 LC A8CDT9 TRIM3 10391919 0018 LC ACTN4 TRIM3 10673389,10673389 0004,0018 LC KIF21B TRIM3 24086586,24086586 0018,0004 LC TRIM3 TRIM3 11331580 0018 LC TRIM3 PDHA1 26344197 0401 LC TRIM3 TNFAIP3 23105109 0018 LC TRIM3 CDKN1A 24393003 0415 LC TRIM3 UBE2G2 19690564,19690564 0397,0018 HT TRIM3 UBE2K 11513855 0018 LC TRIM3 UBE2U 19690564,19690564 0397,0018 HT TRIM3 UBE2D4 21143188 0018 LC TRIM3 MYO5A 10391919 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O75382 O14964 TRIM3 HGS 0.21 15772161 P60604 O75382 UBE2G2 TRIM3 0.286 19690564 Q5VVX9 O75382 UBE2U TRIM3 0.286 19690564 P08559 O75382 PDHA1 TRIM3 0.081 26344197 P38936 O75382 CDKN1A TRIM3 0.309 24393003 P51965 O75382 UBE2E1 TRIM3 0.309 24393003 P62837 O75382 UBE2D2 TRIM3 0.309 24393003 Q9Y2X8 O75382 UBE2D4 TRIM3 0.183 21143188 Q9Y4I1 O75382 MYO5A TRIM3 0.21 15772161 Q7CH24 O75382 CUTF TRIM3 0.126 20711500 Q96MP8 O75382 KCTD7 TRIM3 0.236 unassigned1304 Q8TBB1 O75382 LNX1 TRIM3 0.236 unassigned1304 Q15562 O75382 TEAD2 TRIM3 0.416 25609649,unassigned1304 Q9DC28 O75382 CSNK1D TRIM3 0.236 26496610 Q6NSJ5 O75382 LRRC8E TRIM3 0.236 unassigned1304 P49674 O75382 CSNK1E TRIM3 0.416 26496610,unassigned1304 O75382 A0A0G2JQ02 TRIM3 A0A0G2JQ02 0.236 unassigned1304 P04424 O75382 ASL TRIM3 0.236 unassigned1304 O75382 O75037 TRIM3 KIF21B 0.454 24086586 O75382 A0A0A0MR36 TRIM3 MYO5B {ECO:0000313|ENSEMBL:ENSP00000315531} 0.236 unassigned1304 P19474 O75382 TRIM21 TRIM3 0.236 unassigned1304 P28347 O75382 TEAD1 TRIM3 0.236 unassigned1304 P48730 O75382 CSNK1D TRIM3 0.236 unassigned1304 Q9HAT0 O75382 ROPN1 TRIM3 0.236 unassigned1304 Q8NHQ1 O75382 CEP70 TRIM3 0.236 unassigned1304 Q8NFA0 O75382 USP32 TRIM3 0.236 unassigned1304 Q9H832 O75382 UBE2Z TRIM3 0.236 unassigned1304 Q96LR5 O75382 UBE2E2 TRIM3 0.236 unassigned1304 Q9C040 O75382 TRIM2 TRIM3 0.236 unassigned1304 O75382 O75382 TRIM3 TRIM3 0.523 11331580,unassigned1304 O75382 O43707 TRIM3 ACTN4 0.569 10673389,15772161 P51668 O75382 UBE2D1 TRIM3 0.472 unassigned1304,24393003 Q9P2P5 O75382 HECW2 TRIM3 0.126 24163370 Q13618 O75382 CUL3 TRIM3 0.21 25011449 P21580 O75382 TNFAIP3 TRIM3 0.183 23105109

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HGS TRIM3 MI:0045 experimental interaction detection MI:0461 interaction database ACTN4 TRIM3 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TRIM3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBC MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 ACTN1 MI:0362 inference MI:0461 interaction database TRIM3 TNFAIP3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 YWHAQ MI:0362 inference MI:0461 interaction database TRIM3 YWHAB MI:0362 inference MI:0461 interaction database TRIM3 ACTN2 MI:0362 inference MI:0461 interaction database TRIM3 SNCA MI:0362 inference MI:0461 interaction database TRIM3 CDKN1A MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 CSNK1D MI:0362 inference MI:0461 interaction database TRIM3 CSNK1E MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBE2E1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBE2G2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 YWHAZ MI:0362 inference MI:0461 interaction database TRIM3 CUL3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 TEAD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 UBE2U MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 TRPM7 MI:0362 inference MI:0461 interaction database TRIM3 ZFYVE28 MI:0362 inference MI:0461 interaction database TRIM3 HECW2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 MYO5B MI:0362 inference MI:0461 interaction database TRIM3 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM3 MYO5A MI:0045 experimental interaction detection MI:0461 interaction database