PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NUP98 PARP11 17353931 biogrid exp G G G G G G G G G G G G G G G DCAF11 PARP11 19615732 biogrid,intact exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP MAPK12 PARP11 26186194 biogrid exp G GP G G P G P GP P GP P GP G P P G P GP G GP GP LYZ PARP11 19615732 biogrid,intact exp G G G G G G P P GP G P G G GP G GP RNF166 PARP11 26186194 biogrid exp G GP G G P G GP P G G P GP G G P GP G GP GP PARP11 RNF114 26186194,19615732 biogrid,intact exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP OTUD4 PARP11 19615732 biogrid exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP MDFI PARP11 25416956 biogrid,intact exp G G G P G P P G P G P P G GP P GTPBP3 PARP11 16189514 hprd,biogrid,mint,intact exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP TRIP13 PARP11 19060904, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G GP PARP15 PARP11 23023127 pred G G G PARP12 PARP11 23023127 pred G GP G G P G GP P P P GP G P GP G P P GP GP G GP GP ARL11 PARP11 25402006 pred P G G P P P P P P G P P P P P P P G P P PARP11 PARP11 23023127 pred G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP PARP9 PARP11 23023127 pred G G G G G G G G G G G G G G G DDAH2 PARP11 25402006 pred G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP P ZC3HAV1 PARP11 23023127 pred G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP TIPARP PARP11 23023127 pred G GP G G P G P GP P P P GP G P GP G P P GP GP G GP GP MPPED2 PARP11 25402006 pred GP G P GP P P G P G G GP GP FGF23 PARP11 21836163 pred LRRC61 PARP11 25402006 pred G GP G G P P GP P P P GP G P GP G P P P P P P GP MAD2L1BP PARP11 25402006 pred G G G G G G G G G G G G G G G GLYCTK PARP11 25402006 pred G GP G G P P GP P P P GP G P GP G P P GP P GP G GP P CRYBA2 PARP11 25402006 pred P P P P P P P P P P P P P P P TLDC1 PARP11 25402006 pred P P G P P P P P G G P P G P P GP P P G P P PARP14 PARP11 23023127 pred G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP PARP10 PARP11 23023127 pred G GP G G P G P GP GP G GP G P P G P G G GP GP C11orf54 PARP11 25402006 pred G GP G G G G P P G G G G P GP G G G G LOXL4 PARP11 25402006 pred G G G G P G P G P P G G GP G G G G G GP LASP1 PARP11 25402006 pred G G G G P G GP P P P GP G P GP G P P G GP G GP G HDHD3 PARP11 25402006 pred G GP G G P G P GP P P P GP G P GP G P P GP GP G GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NR21 Q15645 two hybrid array 19060904 physical association X 2 Q9NR21 Q15645 two hybrid pooling approach 19060904 physical association X 2 Q969Y2 Q9NR21 two hybrid pooling approach 16189514 physical association X 2 Q9NR21 anti tag coimmunoprecipitation 19615732 physical association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LYZ PARP11 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119570|UniProt_100647 prey|prey bait|bait DCAF11 PARP11 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120692|UniProt_100647 prey|prey bait|bait GTPBP3 PARP11 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_67684|MINT_38475 prey|prey bait|bait PARP11 RNF114 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120564|UniProt_100647 bait|bait prey|prey OTUD4 PARP11 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120591 bait prey TRIP13 PARP11 MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_97175|UniProt_99349|BIOGRID_262440 prey|prey|prey bait|bait|bait GTPBP3 PARP11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_80086|HPRD_23751|UniProt_152929 prey|-|unspecified role bait|-|unspecified role NUP98 PARP11 MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_83213 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NUP98 PARP11 17353931 0004 HT LYZ PARP11 19615732,19615732 0004,0007 HT OTUD4 PARP11 19615732 0004 HT DKFZP686M02159 PARP11 26186194 0004 HT DCAF11 PARP11 19615732,19615732 0004,0007 HT RNF166 PARP11 26186194 0004 HT PARP11 RNF114 26186194,19615732,19615732 0004,0004,0007 HT NUP98 PARP11 17353931 0004 HT LYZ PARP11 19615732,19615732 0004,0007 HT OTUD4 PARP11 19615732 0004 HT DKFZP686M02159 PARP11 26186194 0004 HT DCAF11 PARP11 19615732,19615732 0004,0007 HT RNF166 PARP11 26186194 0004 HT PARP11 RNF114 26186194,19615732,19615732 0004,0004,0007 HT B7Z563 PARP11 16189514 0018 HT TRIP13 PARP11 19060904,19060904,19060904 0018,0397,0398 HT GTPBP3 PARP11 16189514,16189514 0398,0018 HT MDFI PARP11 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PARP11 PARP11 25673562 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NR21 P53778 PARP11 MAPK12 0.126 26186194 Q9NR21 Q15645 PARP11 TRIP13 0.376 19060904 Q9NR21 Q96A37 PARP11 RNF166 0.126 26186194 Q9NR21 Q9NR21 PARP11 PARP11 0.332 25673562 Q9NR21 Q969G2 PARP11 LHX4 0.236 unassigned1304 Q9NR21 Q8TEB1 PARP11 DCAF11 0.236 19615732 Q9NR21 P61626 PARP11 LYZ 0.236 19615732 Q9NR21 Q8N9I9 PARP11 DTX3 0.236 unassigned1304 Q9UBR4 Q9NR21 LHX3 PARP11 0.236 unassigned1304 Q9NR21 Q96ED9 PARP11 HOOK2 0.236 unassigned1304 Q9Y508 Q9NR21 RNF114 PARP11 0.332 19615732,26186194 Q9NR21 Q969Y2 PARP11 GTPBP3 0.454 16189514,unassigned1304 Q9NR21 Q99750 PARP11 MDFI 0.183 25416956 Q9NR21 Q01804 PARP11 OTUD4 0.126 19615732 Q9NR21 P52948 PARP11 NUP98 0.126 17353931

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NUP98 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database MAPK12 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database LYZ PARP11 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database TRIP13 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database DCAF11 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database GTPBP3 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database RNF166 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database MDFI PARP11 MI:0045 experimental interaction detection MI:0461 interaction database PARP11 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database