PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SMURF1 PAK1IP1 15761153 hprd,i2d exp G GP G P GP G G GP G GP G GP G G G GP GP P G G G GP G GP RPL10 PAK1IP1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P ZC3H3 PAK1IP1 26186194 biogrid exp GP GP G GP G GP GP G GP GP GP G G GP GP GP GP P GP GP G G GP PAK1 PAK1IP1 11371639 hprd,biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PRR11 PAK1IP1 26186194 biogrid exp GP GP G GP G GP GP G GP G GP G G GP GP G P GP P GP GP G GP GP PAK1IP1 RRP15 26344197 biogrid exp GP GP P P G GP GP GP P GP GP G GP P GP P P GP P GP GP G GP GP MNDA PAK1IP1 25665578 intact exp G G G P G G G G GP GP G G G GP G RPL11 PAK1IP1 26344197 biogrid exp GP GP G P GP G G GP G G GP GP GP G GP GP G P P GP P GP GP GP GP GP IFI16 PAK1IP1 25693804 biogrid exp G G G P GP G G GP G GP G G GP G G GP GP G G G GP G G RPL14 PAK1IP1 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PAK1IP1 AGO1 17932509 intact exp G G G G G G G G G G G G G G G G G G G G G G CUL3 PAK1IP1 25011449 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PAK1IP1 NOL12 26186194 biogrid exp G G G G G G G G G G G G G G G G TINF2 PAK1IP1 15316005 biogrid exp G G G G G G G G G G G G G G G G G G G G G G NIFK PAK1IP1 26186194 biogrid exp GP G G P GP G G GP G GP G G GP G GP GP GP P P G GP GP GP GP GP NPM1 PAK1IP1 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP MDM2 PAK1IP1 21097889 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP XPO1 PAK1IP1 ortho GP GP G P GP G GP GP G GP G GP GP G GP GP GP P P GP P GP GP GP GP GP PAK1IP1 MRTO4 ortho GP GP G GP G GP GP G GP G GP G G G GP GP P P G G G G GP GP DDX31 PAK1IP1 ortho G G G G G G GP G GP G G GP G P G GP G G G FBL PAK1IP1 ortho GP GP G GP G G GP G GP G G GP G GP GP GP P P GP P GP GP GP GP GP PAK1IP1 DDX56 ortho GP GP G GP G GP GP G GP GP GP GP G GP GP GP P GP P GP GP G GP GP DKC1 PAK1IP1 ortho P P P P P P P P P P P P P P P P P P P P P P NOC3L PAK1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G NOP56 PAK1IP1 ortho P P P P P RPF2 PAK1IP1 ortho GP GP G GP G GP GP G GP G G GP G GP GP G P P G GP GP G GP GP NOL6 PAK1IP1 ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP UPF2 PAK1IP1 ortho G G G G G G G G G G G G G G G G G G G G G G BRIX1 PAK1IP1 ortho GP G P GP GP GP P P GP G GP GP G P P G P GP GP GP GP GP PAK1IP1 PAK1IP1 ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP MAK16 PAK1IP1 ortho GP GP G GP G GP GP G GP G G GP G GP GP GP P P GP P GP GP G GP GP PAK1IP1 DDX52 ortho G G G G G G G G G G G G G G G G G G G G G G PAK1IP1 NIP7 ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP DDX55 PAK1IP1 ortho GP GP G P GP G GP GP G GP G GP GP G GP GP GP P P GP P GP GP GP GP GP XRN1 PAK1IP1 ortho GP GP G P GP G GP GP G GP GP GP G G GP GP GP P P GP P GP GP G GP GP PAK1IP1 NOC2L ortho GP G G P GP G G GP G GP G G GP G G GP GP P GP P GP G G G GP WDR12 PAK1IP1 25402006 ortho, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P P GP P GP GP GP GP GP BOP1 PAK1IP1 16082366 ortho, pred G G G G G G G G G G G G G G G G G G G EIF6 PAK1IP1 16082366 ortho, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P G GP GP GP GP RPF1 PAK1IP1 21836163 ortho, pred GP GP G GP G G GP G GP G G G G G GP GP P P G G G G GP GP PES1 PAK1IP1 21836163, 16082366 ortho, pred GP G G GP G GP GP G GP G GP G G GP GP G P P GP GP G GP GP PAK1IP1 RSL24D1 21836163 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP GP G P P GP P GP GP G GP GP DDX18 PAK1IP1 25402006 ortho, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P P G P G GP GP GP GP GTPBP4 PAK1IP1 25402006 ortho, pred GP GP G P GP G GP GP G GP G GP GP G GP GP G P P GP P GP GP GP GP GP NOP2 PAK1IP1 16082366 pred GP G G GP G GP GP G GP GP GP GP G GP GP G P P G G GP G GP GP GNB2L1 PAK1IP1 23023127 pred P P P P P P P P P P P P P P P P P P PAK1IP1 DDX49 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PPP2R1A PAK1IP1 23023127 pred GP GP G GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP CRIPAK PAK1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G H3F3A, H3F3B PAK1IP1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP EBNA1BP2 PAK1IP1 21836163 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP NLE1 PAK1IP1 21836163 pred GP P G P P GP P P GP G GP P GP P P P P GP P PAK1IP1 GAR1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PGM1 PAK1IP1 25402006 pred GP GP G P GP G GP GP G GP GP G G G GP GP G P P G P GP GP G GP GP PAK1IP1 DDX19B 23023127 pred P P P P P P P P P P P P P P P P P P P P P P ARHGEF6 PAK1IP1 25402006 pred G GP G P GP G G GP G GP GP GP GP G GP GP G P G G GP G GP G ELF3 PAK1IP1 25402006 pred GP G G G G G GP G GP G G G G GP G G P P G P G GP G GP G NCF1B PAK1IP1 25402006 pred GIT2 PAK1IP1 25402006 pred GP GP G P GP G G GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP PPP2CB PAK1IP1 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP BMX PAK1IP1 25402006 pred GP P P P G GP GP P P P G GP P P P P P GP P P ARPC1B PAK1IP1 25402006 pred G G G P GP G G GP G GP G GP GP G G GP G P G G G GP GP GP RGS9 PAK1IP1 23023127 pred G G G G G WDR18 PAK1IP1 23023127 pred GP P G P P P GP GP GP P P P P GP P G GP P GP SPEN PAK1IP1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP GNAI3 PAK1IP1 23023127 pred G GP G GP G GP GP G G G GP G G GP GP G P G G GP G GP GP RHOU PAK1IP1 25402006 pred GP GP G GP G GP GP G GP G GP GP G GP GP GP P P GP P GP GP G GP GP PAK1IP1 CDK11A 25402006 pred P P P P P P P P P P P P P P P P P P P P P P CDK11B PAK1IP1 25402006 pred YWHAG PAK1IP1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P P GP P GP GP GP GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NWT1 P61956-2 affinity chromatography technology 25027693 physical association X 2 A0A024R5P0 Q9NWT1 two hybrid 11371639 direct interaction X 2 A0A024R5P0 Q9NWT1 affinity chromatography technology 11371639 physical association X 2 A0A024R5P0 Q9NWT1 pull down 11371639 direct interaction X 2 Q9NWT1 A0A024R475 affinity chromatography technology 25011449 physical association X 2 Q9NWT1 two hybrid 15316005 direct interaction X 2 Q00987 Q9NWT1 affinity chromatography technology 21097889 physical association X 2 Q00987 Q9NWT1 affinity chromatography technology 21097889 physical association X 2 P0CG48 Q9NWT1 affinity chromatography technology 24654937 physical association X 2 P0CG48 Q9NWT1 affinity chromatography technology 24816145 physical association X 2 A0A024R3Z2 Q9NWT1 affinity chromatography technology 24654937 physical association X 2 A0A024R5P0 Q9NWT1 in vivo 11371639 - X 2 A0A024R5P0 Q9NWT1 in vitro 11371639 - X 2 A0A024R5P0 Q9NWT1 in vivo 11371639 - X 2 A0A024R5P0 Q9NWT1 in vitro 11371639 - X 2 Q9HCE7-2 Q9NWT1 in vivo 15761153 - X 2 Q9HCE7-2 Q9NWT1 in vivo 15761153 - X 2 Q9NWT1 anti tag coimmunoprecipitation 17932509 association C 116

PPI - HINT Gene A Gene B PMID Method Quality NPM1 PAK1IP1 26186194 0004 HT RPL10 PAK1IP1 26496610,26496610 0007,0004 HT RPL14 PAK1IP1 26186194 0004 HT RPL11 PAK1IP1 26344197 0401 HT ZC3H3 PAK1IP1 26186194 0004 HT PRR11 PAK1IP1 26186194 0004 HT NIFK PAK1IP1 26186194 0004 HT PAK1IP1 NOL12 26186194 0004 HT PAK1IP1 RRP15 26344197 0401 HT NPM1 PAK1IP1 26186194 0004 HT RPL10 PAK1IP1 26496610,26496610 0007,0004 HT RPL14 PAK1IP1 26186194 0004 HT RPL11 PAK1IP1 26344197 0401 HT ZC3H3 PAK1IP1 26186194 0004 HT PRR11 PAK1IP1 26186194 0004 HT NIFK PAK1IP1 26186194 0004 HT PAK1IP1 NOL12 26186194 0004 HT PAK1IP1 RRP15 26344197 0401 HT RPL11 PAK1IP1 26344197 0401 LC PAK1 PAK1IP1 11371639,11371639,11371639 0004,0018,0096 LC TINF2 PAK1IP1 15316005 0018 LC SMURF1 PAK1IP1 15761153 0019 HT PAK1IP1 RRP15 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NWT1 Q8IXZ2 PAK1IP1 ZC3H3 0.126 26186194 Q9NWT1 Q13153 PAK1IP1 PAK1 0.623 11371639 Q9Y3B9 Q9NWT1 RRP15 PAK1IP1 0.081 26344197 Q9NWT1 P06748 PAK1IP1 NPM1 0.126 26186194 Q9NWT1 A4D127 PAK1IP1 MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.236 unassigned1304 Q9NWT1 P60122 PAK1IP1 RUVBL1 0.236 26496610 Q9NWT1 Q96HE9 PAK1IP1 PRR11 0.126 26186194 Q9NWT1 Q9BSI4 PAK1IP1 TINF2 0.309 15316005 Q9NWT1 Q9BYG3 PAK1IP1 NIFK 0.126 26186194 Q9P258 Q9NWT1 RCC2 PAK1IP1 0.21 25074804 Q9NWT1 P27635 PAK1IP1 RPL10 0.126 26496610 Q9UGY1 Q9NWT1 NOL12 PAK1IP1 0.126 26186194 Q9UL18 Q9NWT1 AGO1 PAK1IP1 0.126 17932509 Q9NWT1 P41218 PAK1IP1 MNDA 0.126 25665578 Q9NWT1 Q13618 PAK1IP1 CUL3 0.21 25011449 Q9NWT1 P62913 PAK1IP1 RPL11 0.081 26344197 Q9NWT1 F8VQC1 PAK1IP1 F8VQC1 0.126 26496610 Q9NWT1 Q00987 PAK1IP1 MDM2 0.376 21097889 Q9NWT1 P50914 PAK1IP1 RPL14 0.126 26186194 Q9NWT1 Q16666 PAK1IP1 IFI16 0.126 25693804

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PES1 PAK1IP1 MI:0362 inference MI:0461 interaction database NOP56 PAK1IP1 MI:0362 inference MI:0461 interaction database XPO1 PAK1IP1 MI:0362 inference MI:0461 interaction database DKC1 PAK1IP1 MI:0362 inference MI:0461 interaction database SRP72 PAK1IP1 MI:0362 inference MI:0461 interaction database NPM1 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B PAK1IP1 MI:0362 inference MI:0461 interaction database HSPA8 PAK1IP1 MI:0362 inference MI:0461 interaction database HSPA6 PAK1IP1 MI:0362 inference MI:0461 interaction database RCC1 PAK1IP1 MI:0362 inference MI:0461 interaction database FBL PAK1IP1 MI:0362 inference MI:0461 interaction database RPL10 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L PAK1IP1 MI:0362 inference MI:0461 interaction database RPL4 PAK1IP1 MI:0362 inference MI:0461 interaction database MNDA PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database NAA10 PAK1IP1 MI:0362 inference MI:0461 interaction database HNF4A PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database RBM34 PAK1IP1 MI:0362 inference MI:0461 interaction database NOP2 PAK1IP1 MI:0362 inference MI:0461 interaction database RPL14 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA2 PAK1IP1 MI:0362 inference MI:0461 interaction database RRP1 PAK1IP1 MI:0362 inference MI:0461 interaction database EIF6 PAK1IP1 MI:0362 inference MI:0461 interaction database SUMO2 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database RPL10A PAK1IP1 MI:0362 inference MI:0461 interaction database SUMO1 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database EEF1A1 PAK1IP1 MI:0362 inference MI:0461 interaction database RPL24 PAK1IP1 MI:0362 inference MI:0461 interaction database MDM2 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database EEF1A2 PAK1IP1 MI:0362 inference MI:0461 interaction database PAK1 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 PAK1IP1 MI:0362 inference MI:0461 interaction database CUL3 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database BOP1 PAK1IP1 MI:0362 inference MI:0461 interaction database RRP1B PAK1IP1 MI:0362 inference MI:0461 interaction database PDCD11 PAK1IP1 MI:0362 inference MI:0461 interaction database UBE3C PAK1IP1 MI:0362 inference MI:0461 interaction database PUM3 PAK1IP1 MI:0362 inference MI:0461 interaction database DDB1 PAK1IP1 MI:0362 inference MI:0461 interaction database IFI16 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database HID1 PAK1IP1 MI:0362 inference MI:0461 interaction database ZC3H3 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database XRN1 PAK1IP1 MI:0362 inference MI:0461 interaction database DDX55 PAK1IP1 MI:0362 inference MI:0461 interaction database BRIX1 PAK1IP1 MI:0362 inference MI:0461 interaction database NOC3L PAK1IP1 MI:0362 inference MI:0461 interaction database DDX27 PAK1IP1 MI:0362 inference MI:0461 interaction database PRR11 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database TINF2 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database NAA11 PAK1IP1 MI:0362 inference MI:0461 interaction database MAK16 PAK1IP1 MI:0362 inference MI:0461 interaction database NIFK PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database GTPBP4 PAK1IP1 MI:0362 inference MI:0461 interaction database WDR12 PAK1IP1 MI:0362 inference MI:0461 interaction database DDX24 PAK1IP1 MI:0362 inference MI:0461 interaction database NOL6 PAK1IP1 MI:0362 inference MI:0461 interaction database RPF2 PAK1IP1 MI:0362 inference MI:0461 interaction database DDX31 PAK1IP1 MI:0362 inference MI:0461 interaction database RPF1 PAK1IP1 MI:0362 inference MI:0461 interaction database UPF2 PAK1IP1 MI:0362 inference MI:0461 interaction database SMURF1 PAK1IP1 MI:0045 experimental interaction detection MI:0461 interaction database PPAN PAK1IP1 MI:0362 inference MI:0461 interaction database DDX18 PAK1IP1 MI:0362 inference MI:0461 interaction database PAK1IP1 DDX56 MI:0362 inference MI:0461 interaction database PAK1IP1 RCC2 MI:0045 experimental interaction detection MI:0461 interaction database PAK1IP1 NOL12 MI:0045 experimental interaction detection MI:0461 interaction database PAK1IP1 RSL24D1 MI:0362 inference MI:0461 interaction database PAK1IP1 MRTO4 MI:0362 inference MI:0461 interaction database PAK1IP1 AGO1 MI:0045 experimental interaction detection MI:0461 interaction database PAK1IP1 NIP7 MI:0362 inference MI:0461 interaction database PAK1IP1 RUVBL1 MI:0362 inference MI:0461 interaction database PAK1IP1 DDX52 MI:0362 inference MI:0461 interaction database PAK1IP1 NOC2L MI:0362 inference MI:0461 interaction database