PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC42 FBXO9 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS5 FBXO9 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPTOR FBXO9 23263282 dip exp G G G G G G G G G G G G G G G G G G RICTOR FBXO9 23263282 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AB1 FBXO9 22939624 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 FBXO9 21145461 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CALM1, CALM2, CALM3 FBXO9 15840729 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AA1 FBXO9 22939624 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MTOR FBXO9 23263282 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 FBXO9 26673895 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TTI1 FBXO9 23263282 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO9 TELO2 23263282 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GFOD1 FBXO9 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKP1 FBXO9 20596027,10531035,22632967,17463251, 23023127 hprd,biogrid,intact,dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO45 FBXO9 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HUWE1 FBXO9 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MBNL1 FBXO9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD12 FBXO9 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 FBXO9 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPG11 FBXO9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYCBP2 FBXO9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UFL1 FBXO9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UK97 anti tag coimmunoprecipitation 23263282 - C 4 Q8N122 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 Q8N122 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 P63208 Q9UK97 anti tag coimmunoprecipitation 20596027 physical association X 2 Q9UK97 anti tag coimmunoprecipitation 23263282 - C 4 Q9UK97 anti tag coimmunoprecipitation 23263282 - C 4 Q9UK97 anti tag coimmunoprecipitation 23263282 - C 3 Q9UK97 tandem affinity purification 23263282 - C 3 Q9Y4R8 Q9UK97 tandem affinity purification 23263282 physical association X 2 Q9Y4R8 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 Q9Y4R8 Q9UK97 pull down 23263282 physical association X 2 Q9Y4R8 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 Q9Y4R8 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 O43156 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 O43156 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 O43156 Q9UK97 tandem affinity purification 23263282 physical association X 2 O43156 Q9UK97 anti tag coimmunoprecipitation 23263282 physical association X 2 O43156 Q9UK97 pull down 23263282 physical association X 2 Q9UK97 Q6R327 anti tag coimmunoprecipitation 23263282 physical association X 2 Q9UK97 Q6R327 anti tag coimmunoprecipitation 23263282 physical association X 2 Q9UK97 P42345 anti tag coimmunoprecipitation 23263282 physical association X 2 P63208 Q9UK97 anti tag coimmunoprecipitation 22632967 physical association X 2 Q9UK97 Q8D0D4 two hybrid pooling approach 20711500 physical association X 2 Q9UK97 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q9UK97 Q8ZJG9 two hybrid pooling approach 20711500 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UK97 O14980 FBXO9 XPO1 0.126 26673895 Q9UK97 P62158 FBXO9 CALM3 0.183 15840729 Q9UK97 Q9NXC2 FBXO9 GFOD1 0.126 26186194 Q9UK97 P07900 FBXO9 HSP90AA1 0.126 22939624 Q9UK97 P08238 FBXO9 HSP90AB1 0.126 22939624 Q9UK97 Q6P5F9 FBXO9 XPO1 0.126 26673895 Q9WTX5 Q9UK97 SKP1 FBXO9 0.236 26496610 Q9UK97 P63208 FBXO9 SKP1 0.583 22632967,27705803,17463251,unassigned1304 Q9UK97 Q92905 FBXO9 COPS5 0.126 21145461 Q9UK97 Q8ZJG9 FBXO9 PCKA 0.126 20711500 Q9UK97 Q8D0D4 FBXO9 HMSH 0.126 20711500 Q9UK97 Q13616 FBXO9 CUL1 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMD14 FBXO9 MI:0362 inference MI:0461 interaction database PPP6C FBXO9 MI:0362 inference MI:0461 interaction database XPO1 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database TTI1 FBXO9 MI:0362 inference MI:0461 interaction database SIAH2 FBXO9 MI:0362 inference MI:1106 pathways database IDH3B FBXO9 MI:0362 inference MI:0461 interaction database DNAJB5 FBXO9 MI:0362 inference MI:0461 interaction database FBXO21 FBXO9 MI:0362 inference MI:1106 pathways database HSPA4L FBXO9 MI:0362 inference MI:0461 interaction database HSP90AA1 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXO9 MI:0362 inference MI:1106 pathways database UBC FBXO9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HSPA1B FBXO9 MI:0362 inference MI:0461 interaction database HSPD1 FBXO9 MI:0362 inference MI:0461 interaction database HSPA8 FBXO9 MI:0362 inference MI:0461 interaction database HSPA6 FBXO9 MI:0362 inference MI:0461 interaction database RCC1 FBXO9 MI:0362 inference MI:0461 interaction database TRIM21 FBXO9 MI:0362 inference MI:1106 pathways database SDS FBXO9 MI:0362 inference MI:0461 interaction database DNAJB1 FBXO9 MI:0362 inference MI:0461 interaction database RPL12 FBXO9 MI:0362 inference MI:0461 interaction database POLR2B FBXO9 MI:0362 inference MI:0461 interaction database HSPA1L FBXO9 MI:0362 inference MI:0461 interaction database HSPA4 FBXO9 MI:0362 inference MI:0461 interaction database CCNF FBXO9 MI:0362 inference MI:1106 pathways database GARS FBXO9 MI:0362 inference MI:0461 interaction database MTOR FBXO9 MI:0362 inference MI:0461 interaction database UBE2A FBXO9 MI:0362 inference MI:1106 pathways database CCT8 FBXO9 MI:0362 inference MI:0461 interaction database IDH3G FBXO9 MI:0362 inference MI:0461 interaction database HSPA2 FBXO9 MI:0362 inference MI:0461 interaction database VCP FBXO9 MI:0362 inference MI:0461 interaction database FBXW4 FBXO9 MI:0362 inference MI:1106 pathways database DNAJB13 FBXO9 MI:0362 inference MI:0461 interaction database VBP1 FBXO9 MI:0362 inference MI:0461 interaction database CALM1 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database CNBP FBXO9 MI:0362 inference MI:0461 interaction database RBX1 FBXO9 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database RPS27A FBXO9 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 FBXO9 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SKP1 FBXO9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXO9 MI:0362 inference MI:1106 pathways database CUL1 FBXO9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL2 FBXO9 MI:0362 inference MI:0461 interaction database TRIP12 FBXO9 MI:0362 inference MI:1106 pathways database LONRF1 FBXO9 MI:0362 inference MI:1106 pathways database HECTD2 FBXO9 MI:0362 inference MI:1106 pathways database FBXO31 FBXO9 MI:0362 inference MI:1106 pathways database FBXW9 FBXO9 MI:0362 inference MI:1106 pathways database FBXW10 FBXO9 MI:0362 inference MI:1106 pathways database RNF213 FBXO9 MI:0362 inference MI:1106 pathways database FBXL22 FBXO9 MI:0362 inference MI:1106 pathways database FBXL19 FBXO9 MI:0362 inference MI:1106 pathways database RICTOR FBXO9 MI:0362 inference MI:0461 interaction database FBXW12 FBXO9 MI:0362 inference MI:1106 pathways database RNF19B FBXO9 MI:0362 inference MI:1106 pathways database RNF144B FBXO9 MI:0362 inference MI:1106 pathways database RBBP6 FBXO9 MI:0362 inference MI:1106 pathways database HUWE1 FBXO9 MI:0362 inference MI:1106 pathways database TRIM69 FBXO9 MI:0362 inference MI:1106 pathways database SIAH1 FBXO9 MI:0362 inference MI:1106 pathways database HERC6 FBXO9 MI:0362 inference MI:1106 pathways database UBR2 FBXO9 MI:0362 inference MI:1106 pathways database RPTOR FBXO9 MI:0362 inference MI:0461 interaction database FBXL14 FBXO9 MI:0362 inference MI:1106 pathways database FBXW8 FBXO9 MI:0362 inference MI:1106 pathways database GUF1 FBXO9 MI:0362 inference MI:0461 interaction database FBXL16 FBXO9 MI:0362 inference MI:1106 pathways database D2HGDH FBXO9 MI:0362 inference MI:0461 interaction database FBXO15 FBXO9 MI:0362 inference MI:1106 pathways database ZNRF1 FBXO9 MI:0362 inference MI:1106 pathways database FBXL13 FBXO9 MI:0362 inference MI:1106 pathways database FBXO22 FBXO9 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO9 MI:0362 inference MI:1106 pathways database FBXO27 FBXO9 MI:0362 inference MI:1106 pathways database FBXO30 FBXO9 MI:0362 inference MI:1106 pathways database RNF217 FBXO9 MI:0362 inference MI:1106 pathways database DTX3L FBXO9 MI:0362 inference MI:1106 pathways database FBXO41 FBXO9 MI:0362 inference MI:1106 pathways database ZCCHC13 FBXO9 MI:0362 inference MI:0461 interaction database LMO7 FBXO9 MI:0362 inference MI:1106 pathways database MYLIP FBXO9 MI:0362 inference MI:1106 pathways database HSPH1 FBXO9 MI:0362 inference MI:0461 interaction database COPS5 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO9 MI:0362 inference MI:1106 pathways database FBXO32 FBXO9 MI:0362 inference MI:1106 pathways database FBXW5 FBXO9 MI:0362 inference MI:1106 pathways database MIB2 FBXO9 MI:0362 inference MI:1106 pathways database SPSB1 FBXO9 MI:0362 inference MI:1106 pathways database FBXL8 FBXO9 MI:0362 inference MI:1106 pathways database FBXO17 FBXO9 MI:0362 inference MI:1106 pathways database SDSL FBXO9 MI:0362 inference MI:0461 interaction database FBXL20 FBXO9 MI:0362 inference MI:1106 pathways database FBXL18 FBXO9 MI:0362 inference MI:1106 pathways database NEDD4L FBXO9 MI:0362 inference MI:1106 pathways database RBCK1 FBXO9 MI:0362 inference MI:1106 pathways database FBXL15 FBXO9 MI:0362 inference MI:1106 pathways database FBXO44 FBXO9 MI:0362 inference MI:1106 pathways database UNKL FBXO9 MI:0362 inference MI:1106 pathways database SMURF2 FBXO9 MI:0362 inference MI:1106 pathways database TRIM36 FBXO9 MI:0362 inference MI:1106 pathways database PFDN4 FBXO9 MI:0362 inference MI:0461 interaction database FBXO6 FBXO9 MI:0362 inference MI:1106 pathways database RNF19A FBXO9 MI:0362 inference MI:1106 pathways database RLIM FBXO9 MI:0362 inference MI:1106 pathways database GFOD1 FBXO9 MI:0045 experimental interaction detection MI:0461 interaction database FBXL12 FBXO9 MI:0362 inference MI:1106 pathways database DNAJB4 FBXO9 MI:0362 inference MI:0461 interaction database FBXO40 FBXO9 MI:0362 inference MI:1106 pathways database HERC5 FBXO9 MI:0362 inference MI:1106 pathways database FBXL7 FBXO9 MI:0362 inference MI:1106 pathways database FBXO2 FBXO9 MI:0362 inference MI:1106 pathways database FBXO10 FBXO9 MI:0362 inference MI:1106 pathways database FBXO9 FBXL5 MI:0362 inference MI:1106 pathways database FBXO9 FBXL4 MI:0362 inference MI:1106 pathways database FBXO9 FBXW11 MI:0362 inference MI:1106 pathways database FBXO9 FBXO4 MI:0362 inference MI:1106 pathways database FBXO9 FBXL21 MI:0362 inference MI:1106 pathways database FBXO9 FBXL3 MI:0362 inference MI:1106 pathways database FBXO9 FBXW2 MI:0362 inference MI:1106 pathways database FBXO9 BTRC MI:0362 inference MI:1106 pathways database FBXO9 FAM96B MI:0362 inference MI:0461 interaction database FBXO9 FBXO7 MI:0362 inference MI:1106 pathways database FBXO9 RNF115 MI:0362 inference MI:1106 pathways database FBXO9 TELO2 MI:0362 inference MI:0461 interaction database FBXO9 RNF114 MI:0362 inference MI:1106 pathways database FBXO9 GMPPB MI:0362 inference MI:0461 interaction database FBXO9 WSB1 MI:0362 inference MI:1106 pathways database