PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EXOSC2 FBXL4 26496610 biogrid,intact exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G ERLEC1 FBXL4 24035498 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G XPO1 FBXL4 26673895 biogrid exp GP GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP GP GP GP GP GP GP P G CCDC151 FBXL4 26186194 biogrid exp G G G GP GP G G GP G G G G GP G P GP G GP G G G G GP G GP G KDM4A FBXL4 21757720 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP G GP GP G GP GP GP GP P G SKP1 FBXL4 10531037 hprd,biogrid exp GP GP G GP GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP G GP GP GP P G CLGN FBXL4 24035498 biogrid exp P P P G GP P G P P P P P GP P GP P P RNF144B FBXL4 21836163 pred G GP G G GP G GP GP G GP GP GP G G GP GP GP GP GP G G G GP G G P G CUL1 FBXL4 25402006 pred GP G G G GP G GP GP G GP GP GP G G GP GP GP GP GP GP GP GP GP GP GP P G RNH1 FBXL4 23023127 pred GP GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP GP GP GP GP G GP P G RNASE2 FBXL4 23023127 pred G G GP G G G G P G P G G G G G G G G GP G WWP1 FBXL4 21836163 pred GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G WWP2 FBXL4 21836163 pred GP GP G G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP GP GP G GP P G FBXL4 FBXW11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SMURF2 FBXL4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CUL2 FBXL4 25402006 pred GP GP G G GP G G GP G GP GP GP GP G G GP GP GP GP GP GP G G G GP P G UBE4A FBXL4 21836163 pred GP GP G G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP G GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UKA2 O75164 affinity chromatography technology 21757720 physical association X 2 Q9UKA2 O75164 affinity chromatography technology 21757720 physical association X 2 Q9UKA2 Q96DZ1-2 affinity chromatography technology 24035498 physical association X 2 Q9UKA2 Q96DZ1-2 affinity chromatography technology 24035498 physical association X 2 P0CG48 Q9UKA2 affinity chromatography technology 21890473 physical association X 2 P63208 Q9UKA2 pull down 10531037 direct interaction X 2 O14967 Q9UKA2 affinity chromatography technology 24035498 physical association X 2 O14967 Q9UKA2 affinity chromatography technology 24035498 physical association X 2 P63208-2 Q9UKA2 in vitro 10531037 - X 2 P63208-2 Q9UKA2 in vitro 10531037 - X 2 Q7CKG1 Q9UKA2 two hybrid pooling approach 20711500 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UKA2 O14980 FBXL4 XPO1 0.126 26673895 Q9UKA2 Q7CKG1 FBXL4 NRDD 0.126 20711500 Q9UKA2 Q6P5F9 FBXL4 XPO1 0.126 26673895 Q9UKA2 P33215 FBXL4 NEDD1 0.236 26496610 Q9UKA2 A2APB8 FBXL4 TPX2 0.236 26496610 Q9UKA2 P63208 FBXL4 SKP1 0.396 10531037,27705803 Q9UKA2 Q96DZ1 FBXL4 ERLEC1 0.376 24035498 Q9UKA2 O14967 FBXL4 CLGN 0.376 24035498 Q9UKA2 O75164 FBXL4 KDM4A 0.376 21757720 Q9UKA2 Q13868 FBXL4 EXOSC2 0.126 26496610 Q9UKA2 A5D8V7 FBXL4 CCDC151 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CCDC151 FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database CLGN FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXL4 MI:0362 inference MI:1106 pathways database KDM4A FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXL4 MI:0362 inference MI:1106 pathways database UBB FBXL4 MI:0362 inference MI:1106 pathways database UBC FBXL4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 FBXL4 MI:0362 inference MI:1106 pathways database CCNF FBXL4 MI:0362 inference MI:1106 pathways database UBE2A FBXL4 MI:0362 inference MI:1106 pathways database FBXW4 FBXL4 MI:0362 inference MI:1106 pathways database RBX1 FBXL4 MI:0362 inference MI:1106 pathways database RPS27A FBXL4 MI:0362 inference MI:1106 pathways database UBA52 FBXL4 MI:0362 inference MI:1106 pathways database SKP1 FBXL4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXL4 MI:0362 inference MI:1106 pathways database CUL1 FBXL4 MI:0362 inference MI:1106 pathways database EXOSC2 FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXL4 MI:0362 inference MI:1106 pathways database LONRF1 FBXL4 MI:0362 inference MI:1106 pathways database HECTD2 FBXL4 MI:0362 inference MI:1106 pathways database FBXO31 FBXL4 MI:0362 inference MI:1106 pathways database FBXW9 FBXL4 MI:0362 inference MI:1106 pathways database FBXW10 FBXL4 MI:0362 inference MI:1106 pathways database RNF213 FBXL4 MI:0362 inference MI:1106 pathways database FBXL22 FBXL4 MI:0362 inference MI:1106 pathways database FBXL19 FBXL4 MI:0362 inference MI:1106 pathways database FBXW12 FBXL4 MI:0362 inference MI:1106 pathways database RNF19B FBXL4 MI:0362 inference MI:1106 pathways database RNF144B FBXL4 MI:0362 inference MI:1106 pathways database RBBP6 FBXL4 MI:0362 inference MI:1106 pathways database HUWE1 FBXL4 MI:0362 inference MI:1106 pathways database TRIM69 FBXL4 MI:0362 inference MI:1106 pathways database SIAH1 FBXL4 MI:0362 inference MI:1106 pathways database HERC6 FBXL4 MI:0362 inference MI:1106 pathways database UBR2 FBXL4 MI:0362 inference MI:1106 pathways database FBXL14 FBXL4 MI:0362 inference MI:1106 pathways database FBXW8 FBXL4 MI:0362 inference MI:1106 pathways database FBXL16 FBXL4 MI:0362 inference MI:1106 pathways database FBXO15 FBXL4 MI:0362 inference MI:1106 pathways database ZNRF1 FBXL4 MI:0362 inference MI:1106 pathways database FBXL13 FBXL4 MI:0362 inference MI:1106 pathways database FBXO22 FBXL4 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL4 MI:0362 inference MI:1106 pathways database NEDD1 FBXL4 MI:0362 inference MI:0461 interaction database FBXO27 FBXL4 MI:0362 inference MI:1106 pathways database FBXO30 FBXL4 MI:0362 inference MI:1106 pathways database RNF217 FBXL4 MI:0362 inference MI:1106 pathways database DTX3L FBXL4 MI:0362 inference MI:1106 pathways database FBXO41 FBXL4 MI:0362 inference MI:1106 pathways database LMO7 FBXL4 MI:0362 inference MI:1106 pathways database MYLIP FBXL4 MI:0362 inference MI:1106 pathways database FBXW7 FBXL4 MI:0362 inference MI:1106 pathways database FBXO32 FBXL4 MI:0362 inference MI:1106 pathways database FBXW5 FBXL4 MI:0362 inference MI:1106 pathways database MIB2 FBXL4 MI:0362 inference MI:1106 pathways database SPSB1 FBXL4 MI:0362 inference MI:1106 pathways database FBXL8 FBXL4 MI:0362 inference MI:1106 pathways database ERLEC1 FBXL4 MI:0045 experimental interaction detection MI:0461 interaction database FBXO17 FBXL4 MI:0362 inference MI:1106 pathways database FBXL20 FBXL4 MI:0362 inference MI:1106 pathways database FBXL18 FBXL4 MI:0362 inference MI:1106 pathways database NEDD4L FBXL4 MI:0362 inference MI:1106 pathways database RBCK1 FBXL4 MI:0362 inference MI:1106 pathways database FBXL15 FBXL4 MI:0362 inference MI:1106 pathways database FBXO44 FBXL4 MI:0362 inference MI:1106 pathways database UNKL FBXL4 MI:0362 inference MI:1106 pathways database SMURF2 FBXL4 MI:0362 inference MI:1106 pathways database TRIM36 FBXL4 MI:0362 inference MI:1106 pathways database FBXO6 FBXL4 MI:0362 inference MI:1106 pathways database RNF19A FBXL4 MI:0362 inference MI:1106 pathways database RLIM FBXL4 MI:0362 inference MI:1106 pathways database FBXL12 FBXL4 MI:0362 inference MI:1106 pathways database FBXO40 FBXL4 MI:0362 inference MI:1106 pathways database HERC5 FBXL4 MI:0362 inference MI:1106 pathways database FBXL7 FBXL4 MI:0362 inference MI:1106 pathways database FBXO2 FBXL4 MI:0362 inference MI:1106 pathways database FBXO10 FBXL4 MI:0362 inference MI:1106 pathways database FBXO9 FBXL4 MI:0362 inference MI:1106 pathways database FBXL5 FBXL4 MI:0362 inference MI:1106 pathways database FBXL4 FBXW11 MI:0362 inference MI:1106 pathways database FBXL4 FBXO4 MI:0362 inference MI:1106 pathways database FBXL4 FBXL21 MI:0362 inference MI:1106 pathways database FBXL4 FBXL3 MI:0362 inference MI:1106 pathways database FBXL4 FBXW2 MI:0362 inference MI:1106 pathways database FBXL4 TPX2 MI:0362 inference MI:0461 interaction database FBXL4 BTRC MI:0362 inference MI:1106 pathways database FBXL4 FBXO7 MI:0362 inference MI:1106 pathways database FBXL4 RNF115 MI:0362 inference MI:1106 pathways database FBXL4 RNF114 MI:0362 inference MI:1106 pathways database FBXL4 WSB1 MI:0362 inference MI:1106 pathways database