Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 6 25967015 25967015 + Missense_Mutation SNP C C G TCGA-OR-A5K2-01A-11D-A29I-10 TCGA-OR-A5K2-10B-01D-A29L-10 g.chr6:25967015C>G c.265C>G c.(265-267)Caa>Gaa p.Q89E BLCA 6 25966926 25966926 + Missense_Mutation SNP G G C TCGA-XF-A9SY-01A-21D-A42E-08 TCGA-XF-A9SY-10A-01D-A42H-08 g.chr6:25966926G>C c.176G>C c.(175-177)tGt>tCt p.C59S BLCA 6 25967107 25967107 + Silent SNP A A G TCGA-GC-A3RC-01A-11D-A22Z-08 TCGA-GC-A3RC-10B-01D-A22Z-08 g.chr6:25967107A>G c.357A>G c.(355-357)ccA>ccG p.P119P BLCA 6 25967132 25967132 + Missense_Mutation SNP C C T TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr6:25967132C>T c.382C>T c.(382-384)Ctt>Ttt p.L128F BLCA 6 25972225 25972225 + Silent SNP G G A TCGA-GD-A2C5-01A-12D-A17V-08 TCGA-GD-A2C5-10A-01D-A17V-08 g.chr6:25972225G>A c.636G>A c.(634-636)ctG>ctA p.L212L BLCA 6 25972267 25972267 + Silent SNP C C T TCGA-4Z-AA84-01A-11D-A391-08 TCGA-4Z-AA84-10A-01D-A394-08 g.chr6:25972267C>T c.678C>T c.(676-678)ctC>ctT p.L226L BLCA 6 25973483 25973483 + Missense_Mutation SNP G G A TCGA-DK-AA75-01A-11D-A391-08 TCGA-DK-AA75-10A-01D-A394-08 g.chr6:25973483G>A c.844G>A c.(844-846)Gat>Aat p.D282N BLCA 6 25983672 25983672 + Silent SNP C C A TCGA-UY-A9PB-01A-11D-A38G-08 TCGA-UY-A9PB-10A-01D-A38J-08 g.chr6:25983672C>A c.1155C>A c.(1153-1155)ctC>ctA p.L385L BRCA 6 25966837 25966837 + Missense_Mutation SNP C C G TCGA-A2-A0EQ-01A-11W-A050-09 TCGA-A2-A0EQ-10A-01W-A055-09 g.chr6:25966837C>G c.87C>G c.(85-87)atC>atG p.I29M BRCA 6 25973465 25973465 + Missense_Mutation SNP G G T TCGA-BH-A0AZ-01A-21D-A12Q-09 TCGA-BH-A0AZ-11A-22D-A12Q-09 g.chr6:25973465G>T c.826G>T c.(826-828)Gtt>Ttt p.V276F BRCA 6 25983774 25983774 + Silent SNP G G A TCGA-D8-A1Y1-01A-21D-A14K-09 TCGA-D8-A1Y1-10A-01D-A14K-09 g.chr6:25983774G>A c.1257G>A c.(1255-1257)gaG>gaA p.E419E CESC 6 25972171 25972171 + Silent SNP G G A TCGA-Q1-A5R2-01A-11D-A28B-09 TCGA-Q1-A5R2-10A-01D-A28E-09 g.chr6:25972171G>A c.582G>A c.(580-582)gaG>gaA p.E194E COAD 6 25966902 25966902 + Missense_Mutation SNP A A C TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr6:25966902A>C c.152A>C c.(151-153)cAa>cCa p.Q51P COAD 6 25969574 25969574 + Missense_Mutation SNP A A G TCGA-AA-A01Q-01A-01W-A005-10 TCGA-AA-A01Q-10A-01W-A005-10 g.chr6:25969574A>G c.433A>G c.(433-435)Aca>Gca p.T145A COAD 6 25972315 25972315 + Missense_Mutation SNP G G T TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr6:25972315G>T c.726G>T c.(724-726)caG>caT p.Q242H COAD 6 25983578 25983578 + Missense_Mutation SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr6:25983578G>A c.1061G>A c.(1060-1062)gGc>gAc p.G354D COAD 6 25983838 25983838 + Missense_Mutation SNP T T C TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr6:25983838T>C c.1321T>C c.(1321-1323)Tcc>Ccc p.S441P COADREAD 6 25966902 25966902 + Missense_Mutation SNP A A C TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr6:25966902A>C c.152A>C c.(151-153)cAa>cCa p.Q51P COADREAD 6 25969574 25969574 + Missense_Mutation SNP A A G TCGA-AA-A01Q-01A-01W-A005-10 TCGA-AA-A01Q-10A-01W-A005-10 g.chr6:25969574A>G c.433A>G c.(433-435)Aca>Gca p.T145A COADREAD 6 25972315 25972315 + Missense_Mutation SNP G G T TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr6:25972315G>T c.726G>T c.(724-726)caG>caT p.Q242H COADREAD 6 25983578 25983578 + Missense_Mutation SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr6:25983578G>A c.1061G>A c.(1060-1062)gGc>gAc p.G354D COADREAD 6 25983838 25983838 + Missense_Mutation SNP T T C TCGA-AA-A01R-01A-21W-A096-10 TCGA-AA-A01R-11A-12W-A096-10 g.chr6:25983838T>C c.1321T>C c.(1321-1323)Tcc>Ccc p.S441P DLBC 6 25966909 25966909 + Missense_Mutation SNP G G T TCGA-G8-6326-01A-11D-2210-10 TCGA-G8-6326-10A-01D-2210-10 g.chr6:25966909G>T c.159G>T c.(157-159)agG>agT p.R53S DLBC 6 25983696 25983696 + Nonsense_Mutation SNP T T A TCGA-FF-8062-01A-11D-2210-10 TCGA-FF-8062-10A-01D-2210-10 g.chr6:25983696T>A c.1179T>A c.(1177-1179)taT>taA p.Y393* ESCA 6 25972225 25972225 + Silent SNP G G T TCGA-L5-A4OJ-01A-11D-A27G-09 TCGA-L5-A4OJ-11A-12D-A27G-09 g.chr6:25972225G>T c.636G>T c.(634-636)ctG>ctT p.L212L ESCA 6 25983525 25983525 + Silent SNP C C G TCGA-LN-A4A1-01A-21D-A27G-09 TCGA-LN-A4A1-10A-01D-A27G-09 g.chr6:25983525C>G c.1008C>G c.(1006-1008)gtC>gtG p.V336V ESCA 6 25983831 25983831 + Silent SNP G G T TCGA-VR-A8EX-01A-11D-A36J-09 TCGA-VR-A8EX-10A-01D-A36M-09 g.chr6:25983831G>T c.1314G>T c.(1312-1314)ccG>ccT p.P438P GBM 6 25966964 25966964 + Nonsense_Mutation SNP C C T TCGA-06-0158-01A-01D-1491-08 TCGA-06-0158-10A-01D-1491-08 g.chr6:25966964C>T c.214C>T c.(214-216)Cga>Tga p.R72* GBMLGG 6 25966964 25966964 + Nonsense_Mutation SNP C C T TCGA-06-0158-01A-01D-1491-08 TCGA-06-0158-10A-01D-1491-08 g.chr6:25966964C>T c.214C>T c.(214-216)Cga>Tga p.R72* GBMLGG 6 25967064 25967064 + Missense_Mutation SNP A A T TCGA-WH-A86K-01A-11D-A36O-08 TCGA-WH-A86K-10A-01D-A367-08 g.chr6:25967064A>T c.314A>T c.(313-315)gAa>gTa p.E105V GBMLGG 6 25983700 25983700 + Missense_Mutation SNP G G T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:25983700G>T c.1183G>T c.(1183-1185)Gca>Tca p.A395S HNSC 6 25966997 25966997 + Missense_Mutation SNP G G A TCGA-RS-A6TP-01A-12D-A34J-08 TCGA-RS-A6TP-10A-01D-A34M-08 g.chr6:25966997G>A c.247G>A c.(247-249)Gcc>Acc p.A83T HNSC 6 25983471 25983471 + Silent SNP C C T TCGA-BA-A6DD-01A-12D-A31L-08 TCGA-BA-A6DD-10A-01D-A31J-08 g.chr6:25983471C>T c.954C>T c.(952-954)taC>taT p.Y318Y HNSC 6 25983648 25983648 + Silent SNP G G A TCGA-CN-A63W-01A-11D-A30E-08 TCGA-CN-A63W-10A-01D-A30H-08 g.chr6:25983648G>A c.1131G>A c.(1129-1131)gaG>gaA p.E377E HNSC 6 25983800 25983800 + Missense_Mutation SNP G G T TCGA-CN-A63W-01A-11D-A30E-08 TCGA-CN-A63W-10A-01D-A30H-08 g.chr6:25983800G>T c.1283G>T c.(1282-1284)gGg>gTg p.G428V KIPAN 6 25967011 25967011 + Silent SNP G G C TCGA-BQ-7059-01A-11D-1961-08 TCGA-BQ-7059-11A-01D-1961-08 g.chr6:25967011G>C c.261G>C c.(259-261)acG>acC p.T87T KIRP 6 25967011 25967011 + Silent SNP G G C TCGA-BQ-7059-01A-11D-1961-08 TCGA-BQ-7059-11A-01D-1961-08 g.chr6:25967011G>C c.261G>C c.(259-261)acG>acC p.T87T LGG 6 25967064 25967064 + Missense_Mutation SNP A A T TCGA-WH-A86K-01A-11D-A36O-08 TCGA-WH-A86K-10A-01D-A367-08 g.chr6:25967064A>T c.314A>T c.(313-315)gAa>gTa p.E105V LGG 6 25983700 25983700 + Missense_Mutation SNP G G T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:25983700G>T c.1183G>T c.(1183-1185)Gca>Tca p.A395S LIHC 6 25983702 25983702 + Silent SNP A A T TCGA-UB-A7MB-01A-11D-A33Q-10 TCGA-UB-A7MB-10A-01D-A33Q-10 g.chr6:25983702A>T c.1185A>T c.(1183-1185)gcA>gcT p.A395A LUAD 6 25966891 25966891 + Silent SNP A A T TCGA-50-5930-01A-11D-1753-08 TCGA-50-5930-11A-01D-1753-08 g.chr6:25966891A>T c.141A>T c.(139-141)ccA>ccT p.P47P LUAD 6 25966994 25966994 + Missense_Mutation SNP G G C TCGA-55-8507-01A-11D-2393-08 TCGA-55-8507-10A-01D-2393-08 g.chr6:25966994G>C c.244G>C c.(244-246)Gaa>Caa p.E82Q LUAD 6 25972214 25972214 + Missense_Mutation SNP C C A TCGA-62-A472-01A-11D-A24D-08 TCGA-62-A472-10A-01D-A24F-08 g.chr6:25972214C>A c.625C>A c.(625-627)Ctg>Atg p.L209M LUAD 6 25983445 25983445 + Missense_Mutation SNP G G A TCGA-91-A4BC-01A-11D-A24D-08 TCGA-91-A4BC-10A-01D-A24F-08 g.chr6:25983445G>A c.928G>A c.(928-930)Gat>Aat p.D310N LUAD 6 25983574 25983574 + Missense_Mutation SNP G G T TCGA-55-8506-01A-11D-2393-08 TCGA-55-8506-10A-01D-2393-08 g.chr6:25983574G>T c.1057G>T c.(1057-1059)Gtt>Ttt p.V353F LUSC 6 25967059 25967059 + Silent SNP C C T TCGA-18-3417-01A-01D-1441-08 TCGA-18-3417-11A-01D-1441-08 g.chr6:25967059C>T c.309C>T c.(307-309)ttC>ttT p.F103F LUSC 6 25967109 25967109 + Missense_Mutation SNP A A T TCGA-66-2734-01A-01D-0983-08 TCGA-66-2734-11A-01D-0983-08 g.chr6:25967109A>T c.359A>T c.(358-360)cAg>cTg p.Q120L LUSC 6 25973469 25973469 + Missense_Mutation SNP C C T TCGA-70-6722-01A-11D-1817-08 TCGA-70-6722-10A-01D-1817-08 g.chr6:25973469C>T c.830C>T c.(829-831)tCc>tTc p.S277F LUSC 6 25983517 25983517 + Missense_Mutation SNP C C T TCGA-46-3765-01A-01D-0983-08 TCGA-46-3765-10A-01D-0983-08 g.chr6:25983517C>T c.1000C>T c.(1000-1002)Ccc>Tcc p.P334S LUSC 6 25983831 25983831 + Silent SNP G G T TCGA-34-5240-01A-01D-1441-08 TCGA-34-5240-10A-01D-1441-08 g.chr6:25983831G>T c.1314G>T c.(1312-1314)ccG>ccT p.P438P LUSC 6 25983845 25983845 + Missense_Mutation SNP C C G TCGA-33-4586-01A-01D-1441-08 TCGA-33-4586-11A-01D-1441-08 g.chr6:25983845C>G c.1328C>G c.(1327-1329)tCt>tGt p.S443C PAAD 6 25972122 25972122 + Missense_Mutation SNP A A C TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:25972122A>C c.533A>C c.(532-534)aAa>aCa p.K178T PAAD 6 25972146 25972146 + Missense_Mutation SNP T T G TCGA-XN-A8T3-01A-11D-A36O-08 TCGA-XN-A8T3-10A-01D-A367-08 g.chr6:25972146T>G c.557T>G c.(556-558)cTc>cGc p.L186R PCPG 6 25966899 25966899 + Missense_Mutation SNP A A C TCGA-S7-A7X2-01A-12D-A35I-08 TCGA-S7-A7X2-10A-01D-A35G-08 g.chr6:25966899A>C c.149A>C c.(148-150)aAg>aCg p.K50T SARC 6 25966859 25966859 + Missense_Mutation SNP C C T TCGA-DX-AB2Q-01A-11D-A38Z-09 TCGA-DX-AB2Q-10A-01D-A38Z-09 g.chr6:25966859C>T c.109C>T c.(109-111)Cac>Tac p.H37Y SKCM 6 25966959 25966959 + Missense_Mutation SNP G G A TCGA-D3-A1Q6-06A-11D-A196-08 TCGA-D3-A1Q6-10A-01D-A198-08 g.chr6:25966959G>A c.209G>A c.(208-210)aGc>aAc p.S70N SKCM 6 25973439 25973439 + Missense_Mutation SNP C C T TCGA-EE-A20C-06A-11D-A196-08 TCGA-EE-A20C-10A-01D-A198-08 g.chr6:25973439C>T c.800C>T c.(799-801)tCc>tTc p.S267F SKCM 6 25973440 25973440 + Silent SNP C C T TCGA-EE-A20C-06A-11D-A196-08 TCGA-EE-A20C-10A-01D-A198-08 g.chr6:25973440C>T c.801C>T c.(799-801)tcC>tcT p.S267S SKCM 6 25983438 25983438 + Silent SNP C C T TCGA-D3-A2JD-06A-11D-A19A-08 TCGA-D3-A2JD-10A-01D-A19A-08 g.chr6:25983438C>T c.921C>T c.(919-921)ctC>ctT p.L307L SKCM 6 25983665 25983665 + Missense_Mutation SNP G G T TCGA-FS-A1ZK-06A-11D-A197-08 TCGA-FS-A1ZK-10A-01D-A199-08 g.chr6:25983665G>T c.1148G>T c.(1147-1149)tGg>tTg p.W383L SKCM 6 25983718 25983718 + Missense_Mutation SNP A A G TCGA-EE-A17Z-06A-11D-A196-08 TCGA-EE-A17Z-10A-01D-A198-08 g.chr6:25983718A>G c.1201A>G c.(1201-1203)Act>Gct p.T401A SKCM 6 25983887 25983887 + Missense_Mutation SNP C C T TCGA-EE-A2MS-06A-11D-A197-08 TCGA-EE-A2MS-10A-01D-A199-08 g.chr6:25983887C>T c.1370C>T c.(1369-1371)cCt>cTt p.P457L

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 6 25983843 25983843 single base substitution C G missense_variant F442L 1326C>G BLCA-US 6 25967107 25967107 single base substitution A G synonymous_variant P119P 357A>G BLCA-US 6 25967132 25967132 single base substitution C T missense_variant L128F 382C>T BLCA-US 6 25972225 25972225 single base substitution G A synonymous_variant L212L 636G>A BRCA-EU 6 25958314 25958314 single base substitution G A upstream_gene_variant BRCA-EU 6 25958364 25958364 single base substitution G T upstream_gene_variant BRCA-EU 6 25958783 25958790 deletion of <=200bp ATCGTGGA - upstream_gene_variant BRCA-EU 6 25959043 25959043 single base substitution G A upstream_gene_variant BRCA-EU 6 25960688 25960688 single base substitution G C upstream_gene_variant BRCA-EU 6 25961080 25961080 single base substitution T C upstream_gene_variant BRCA-EU 6 25962898 25962898 single base substitution C G upstream_gene_variant BRCA-EU 6 25963012 25963012 single base substitution C G upstream_gene_variant BRCA-EU 6 25963251 25963252 deletion of <=200bp CT - intron_variant BRCA-EU 6 25963251 25963252 deletion of <=200bp CT - upstream_gene_variant BRCA-EU 6 25963448 25963448 single base substitution C T 5_prime_UTR_variant BRCA-EU 6 25964004 25964004 single base substitution A T intron_variant BRCA-EU 6 25965038 25965038 single base substitution T G intron_variant BRCA-EU 6 25965855 25965855 single base substitution A G intron_variant BRCA-EU 6 25966007 25966007 single base substitution G A intron_variant BRCA-EU 6 25966026 25966026 single base substitution G A intron_variant BRCA-EU 6 25967786 25967786 single base substitution T C intron_variant BRCA-EU 6 25975199 25975199 single base substitution C G intron_variant BRCA-EU 6 25976673 25976673 single base substitution A T intron_variant BRCA-EU 6 25976819 25976819 single base substitution G A intron_variant BRCA-EU 6 25978708 25978708 single base substitution T C intron_variant BRCA-EU 6 25978756 25978756 single base substitution G A intron_variant BRCA-EU 6 25979177 25979177 single base substitution T G intron_variant BRCA-EU 6 25979712 25979712 single base substitution C T intron_variant BRCA-EU 6 25980709 25980709 single base substitution C T intron_variant BRCA-EU 6 25982163 25982163 single base substitution C T intron_variant BRCA-EU 6 25982604 25982604 single base substitution C T intron_variant BRCA-EU 6 25982737 25982737 single base substitution T G intron_variant BRCA-EU 6 25983268 25983268 single base substitution G T intron_variant BRCA-EU 6 25983372 25983372 single base substitution T A intron_variant BRCA-EU 6 25983594 25983594 single base substitution G A stop_gained W359* 1077G>A BRCA-EU 6 25983855 25983855 single base substitution C T synonymous_variant L446L 1338C>T BRCA-EU 6 25985732 25985732 single base substitution T C 3_prime_UTR_variant BRCA-EU 6 25985732 25985732 single base substitution T C downstream_gene_variant BRCA-EU 6 25987029 25987029 single base substitution C T 3_prime_UTR_variant BRCA-EU 6 25987029 25987029 single base substitution C T downstream_gene_variant BRCA-EU 6 25987629 25987629 single base substitution G A downstream_gene_variant BRCA-EU 6 25987864 25987864 single base substitution A G downstream_gene_variant BRCA-EU 6 25988053 25988053 single base substitution C G downstream_gene_variant BRCA-EU 6 25988427 25988427 single base substitution C A downstream_gene_variant BRCA-EU 6 25988622 25988622 single base substitution C G downstream_gene_variant BRCA-EU 6 25988977 25988977 single base substitution C G downstream_gene_variant BRCA-EU 6 25990144 25990144 single base substitution C T downstream_gene_variant BRCA-EU 6 25992348 25992348 single base substitution C T downstream_gene_variant BRCA-FR 6 25962083 25962083 single base substitution G T upstream_gene_variant BRCA-FR 6 25964312 25964312 single base substitution A G intron_variant BRCA-FR 6 25965855 25965855 single base substitution A G intron_variant BRCA-FR 6 25970266 25970266 single base substitution C T intron_variant BRCA-FR 6 25990144 25990144 single base substitution C T downstream_gene_variant BRCA-UK 6 25960688 25960688 single base substitution G C upstream_gene_variant BRCA-UK 6 25961080 25961080 single base substitution T C upstream_gene_variant BRCA-UK 6 25966026 25966026 single base substitution G A intron_variant BRCA-UK 6 25983632 25983632 single base substitution C G missense_variant T372S 1115C>G BRCA-US 6 25966837 25966837 single base substitution C G missense_variant I29M 87C>G BRCA-US 6 25973465 25973465 single base substitution G T missense_variant V276F 826G>T BRCA-US 6 25983774 25983774 single base substitution G A synonymous_variant E419E 1257G>A BTCA-JP 6 25983750 25983750 single base substitution T C synonymous_variant L411L 1233T>C CESC-US 6 25972171 25972171 single base substitution G A synonymous_variant E194E 582G>A CLLE-ES 6 25963233 25963233 single base substitution T G intron_variant CLLE-ES 6 25963233 25963233 single base substitution T G upstream_gene_variant CLLE-ES 6 25966375 25966375 single base substitution G A intron_variant COAD-US 6 25967068 25967068 single base substitution C T synonymous_variant D106D 318C>T COCA-CN 6 25964157 25964157 single base substitution A C intron_variant COCA-CN 6 25969653 25969653 single base substitution G T splice_region_variant COCA-CN 6 25973374 25973374 single base substitution G T intron_variant COCA-CN 6 25983384 25983384 single base substitution T C intron_variant COCA-CN 6 25983503 25983503 single base substitution G T missense_variant R329I 986G>T COCA-CN 6 25983735 25983735 single base substitution T C synonymous_variant H406H 1218T>C COCA-CN 6 25987441 25987441 single base substitution G C downstream_gene_variant COCA-CN 6 25990250 25990250 single base substitution C T downstream_gene_variant EOPC-DE 6 25972730 25972730 single base substitution T A intron_variant EOPC-DE 6 25974631 25974631 single base substitution T G intron_variant ESAD-UK 6 25958263 25958263 single base substitution G A upstream_gene_variant ESAD-UK 6 25958414 25958414 single base substitution T C upstream_gene_variant ESAD-UK 6 25959480 25959480 single base substitution T G upstream_gene_variant ESAD-UK 6 25965807 25965807 single base substitution G T intron_variant ESAD-UK 6 25969497 25969497 single base substitution G A intron_variant ESAD-UK 6 25969865 25969865 single base substitution G T intron_variant ESAD-UK 6 25971235 25971235 single base substitution C T intron_variant ESAD-UK 6 25972678 25972678 single base substitution G C intron_variant ESAD-UK 6 25973641 25973641 single base substitution C G intron_variant ESAD-UK 6 25974348 25974348 single base substitution C G intron_variant ESAD-UK 6 25975991 25975991 single base substitution C G intron_variant ESAD-UK 6 25978272 25978272 single base substitution C T intron_variant ESAD-UK 6 25978308 25978308 insertion of <=200bp - AT intron_variant ESAD-UK 6 25979839 25979839 single base substitution T C intron_variant ESAD-UK 6 25981523 25981523 single base substitution C T intron_variant ESAD-UK 6 25981793 25981793 insertion of <=200bp - T intron_variant ESAD-UK 6 25981994 25981994 single base substitution C T intron_variant ESAD-UK 6 25983300 25983300 single base substitution G A intron_variant ESAD-UK 6 25984753 25984753 single base substitution A G 3_prime_UTR_variant ESAD-UK 6 25986145 25986145 single base substitution A G 3_prime_UTR_variant ESAD-UK 6 25986145 25986145 single base substitution A G downstream_gene_variant ESAD-UK 6 25986608 25986608 single base substitution G C 3_prime_UTR_variant ESAD-UK 6 25986608 25986608 single base substitution G C downstream_gene_variant ESAD-UK 6 25989507 25989507 single base substitution T C downstream_gene_variant GBM-US 6 25966964 25966964 single base substitution C T stop_gained R72* 214C>T KIRP-US 6 25967011 25967011 single base substitution G C synonymous_variant T87T 261G>C LICA-FR 6 25966864 25966864 single base substitution G A synonymous_variant L38L 114G>A LICA-FR 6 25980040 25980040 single base substitution C A intron_variant LIHC-US 6 25983702 25983702 single base substitution A T synonymous_variant A395A 1185A>T LINC-JP 6 25959779 25959779 single base substitution A G upstream_gene_variant LINC-JP 6 25965412 25965412 single base substitution C T intron_variant LINC-JP 6 25969060 25969060 single base substitution G T intron_variant LINC-JP 6 25975264 25975264 single base substitution T C intron_variant LINC-JP 6 25983875 25983875 single base substitution A G missense_variant Y453C 1358A>G LIRI-JP 6 25959660 25959660 single base substitution G A upstream_gene_variant LIRI-JP 6 25962034 25962034 single base substitution G T upstream_gene_variant LIRI-JP 6 25962409 25962409 single base substitution A G upstream_gene_variant LIRI-JP 6 25964172 25964172 insertion of <=200bp - C intron_variant LIRI-JP 6 25965808 25965808 single base substitution C T intron_variant LIRI-JP 6 25966263 25966263 single base substitution A G intron_variant LIRI-JP 6 25968470 25968470 deletion of <=200bp C - intron_variant LIRI-JP 6 25970379 25970379 single base substitution C T intron_variant LIRI-JP 6 25971119 25971119 single base substitution A G intron_variant LIRI-JP 6 25972562 25972562 single base substitution C T intron_variant LIRI-JP 6 25974178 25974178 single base substitution T G intron_variant LIRI-JP 6 25974569 25974569 single base substitution T G intron_variant LIRI-JP 6 25975000 25975000 single base substitution C G intron_variant LIRI-JP 6 25976167 25976167 single base substitution A G intron_variant LIRI-JP 6 25980822 25980822 single base substitution T G intron_variant LIRI-JP 6 25982985 25982985 single base substitution C A intron_variant LIRI-JP 6 25983963 25983963 single base substitution A G 3_prime_UTR_variant LIRI-JP 6 25983990 25983990 single base substitution T C 3_prime_UTR_variant LIRI-JP 6 25987341 25987341 single base substitution T C 3_prime_UTR_variant LIRI-JP 6 25987341 25987341 single base substitution T C downstream_gene_variant LIRI-JP 6 25987350 25987350 single base substitution T C 3_prime_UTR_variant LIRI-JP 6 25987350 25987350 single base substitution T C downstream_gene_variant LIRI-JP 6 25987426 25987426 single base substitution T C downstream_gene_variant LIRI-JP 6 25987890 25987890 single base substitution A G downstream_gene_variant LIRI-JP 6 25990953 25990953 single base substitution A T downstream_gene_variant LIRI-JP 6 25991465 25991465 single base substitution G A downstream_gene_variant LIRI-JP 6 25992064 25992071 deletion of <=200bp GATGTCAC - downstream_gene_variant LUSC-KR 6 25959419 25959419 single base substitution C T upstream_gene_variant LUSC-KR 6 25962820 25962820 single base substitution C A upstream_gene_variant LUSC-KR 6 25964157 25964157 single base substitution A C intron_variant LUSC-KR 6 25975216 25975216 single base substitution G T intron_variant LUSC-KR 6 25976204 25976204 single base substitution T G intron_variant LUSC-KR 6 25976531 25976531 single base substitution T G intron_variant LUSC-KR 6 25977915 25977915 single base substitution T A intron_variant LUSC-KR 6 25979158 25979158 single base substitution C A intron_variant LUSC-KR 6 25983619 25983619 single base substitution G C missense_variant V368L 1102G>C LUSC-KR 6 25989238 25989238 single base substitution G T downstream_gene_variant LUSC-KR 6 25992072 25992072 single base substitution G C downstream_gene_variant LUSC-US 6 25967059 25967059 single base substitution C T synonymous_variant F103F 309C>T LUSC-US 6 25967109 25967109 single base substitution A T missense_variant Q120L 359A>T LUSC-US 6 25973469 25973469 single base substitution C T missense_variant S277F 830C>T LUSC-US 6 25983517 25983517 single base substitution C T missense_variant P334S 1000C>T LUSC-US 6 25983831 25983831 single base substitution G T synonymous_variant P438P 1314G>T LUSC-US 6 25983845 25983845 single base substitution C G missense_variant S443C 1328C>G MALY-DE 6 25959879 25959879 single base substitution C T upstream_gene_variant MALY-DE 6 25962997 25962997 single base substitution A T upstream_gene_variant MALY-DE 6 25964157 25964157 single base substitution A C intron_variant MALY-DE 6 25964162 25964162 single base substitution C A intron_variant MALY-DE 6 25964163 25964163 single base substitution A C intron_variant MALY-DE 6 25978763 25978763 single base substitution G T intron_variant MALY-DE 6 25979600 25979600 single base substitution T C intron_variant MALY-DE 6 25981021 25981021 single base substitution A G intron_variant MALY-DE 6 25982643 25982643 single base substitution A C intron_variant MELA-AU 6 25958457 25958457 single base substitution G A upstream_gene_variant MELA-AU 6 25958567 25958567 single base substitution C T upstream_gene_variant MELA-AU 6 25959062 25959062 single base substitution G A upstream_gene_variant MELA-AU 6 25959063 25959063 single base substitution G A upstream_gene_variant MELA-AU 6 25959115 25959115 single base substitution C T upstream_gene_variant MELA-AU 6 25959231 25959231 single base substitution T A upstream_gene_variant MELA-AU 6 25959243 25959243 single base substitution G A upstream_gene_variant MELA-AU 6 25959293 25959293 single base substitution C T upstream_gene_variant MELA-AU 6 25959550 25959550 single base substitution G A upstream_gene_variant MELA-AU 6 25959687 25959687 single base substitution C T upstream_gene_variant MELA-AU 6 25960092 25960092 single base substitution C T upstream_gene_variant MELA-AU 6 25960622 25960622 single base substitution G T upstream_gene_variant MELA-AU 6 25960699 25960699 single base substitution C T upstream_gene_variant MELA-AU 6 25960746 25960746 single base substitution C T upstream_gene_variant MELA-AU 6 25960954 25960954 single base substitution G A upstream_gene_variant MELA-AU 6 25961033 25961033 single base substitution G A upstream_gene_variant MELA-AU 6 25961310 25961310 single base substitution A G upstream_gene_variant MELA-AU 6 25961784 25961784 single base substitution C T upstream_gene_variant MELA-AU 6 25962043 25962043 single base substitution C T upstream_gene_variant MELA-AU 6 25962378 25962378 single base substitution G A upstream_gene_variant MELA-AU 6 25962538 25962538 single base substitution G A upstream_gene_variant MELA-AU 6 25962697 25962697 single base substitution C T upstream_gene_variant MELA-AU 6 25964162 25964163 multiple base substitution (>=2bp and <=200bp) CA AC intron_variant MELA-AU 6 25964307 25964307 single base substitution G A intron_variant MELA-AU 6 25965070 25965070 single base substitution C T intron_variant MELA-AU 6 25965130 25965130 single base substitution C T intron_variant MELA-AU 6 25965329 25965330 multiple base substitution (>=2bp and <=200bp) CC AT intron_variant MELA-AU 6 25965605 25965605 single base substitution C T intron_variant MELA-AU 6 25966003 25966003 single base substitution G T intron_variant MELA-AU 6 25966072 25966072 single base substitution C T intron_variant MELA-AU 6 25966930 25966930 single base substitution C T synonymous_variant P60P 180C>T MELA-AU 6 25966933 25966933 single base substitution G A synonymous_variant Q61Q 183G>A MELA-AU 6 25967275 25967275 single base substitution C T intron_variant MELA-AU 6 25967284 25967284 single base substitution C T intron_variant MELA-AU 6 25968110 25968110 single base substitution C T intron_variant MELA-AU 6 25968993 25968993 single base substitution C T intron_variant MELA-AU 6 25969026 25969026 single base substitution C T intron_variant MELA-AU 6 25970029 25970029 single base substitution C T intron_variant MELA-AU 6 25970665 25970665 single base substitution C T intron_variant MELA-AU 6 25970959 25970959 single base substitution G T intron_variant MELA-AU 6 25971912 25971912 single base substitution C T intron_variant MELA-AU 6 25972288 25972288 single base substitution G A synonymous_variant L233L 699G>A MELA-AU 6 25972377 25972377 single base substitution T G intron_variant MELA-AU 6 25972749 25972749 single base substitution G A intron_variant MELA-AU 6 25972924 25972924 single base substitution C T intron_variant MELA-AU 6 25972998 25972998 single base substitution C T intron_variant MELA-AU 6 25973092 25973092 single base substitution C T intron_variant MELA-AU 6 25973439 25973440 multiple base substitution (>=2bp and <=200bp) CC TT missense_variant S267F 800CC>TT MELA-AU 6 25973727 25973727 single base substitution T C intron_variant MELA-AU 6 25973881 25973881 single base substitution A G intron_variant MELA-AU 6 25974648 25974648 single base substitution C T intron_variant MELA-AU 6 25974728 25974728 single base substitution C T intron_variant MELA-AU 6 25974756 25974756 single base substitution T G intron_variant MELA-AU 6 25975244 25975247 deletion of <=200bp TTTC - intron_variant MELA-AU 6 25976136 25976136 single base substitution T C intron_variant MELA-AU 6 25976181 25976181 single base substitution C T intron_variant MELA-AU 6 25976326 25976326 single base substitution C T intron_variant MELA-AU 6 25976606 25976606 single base substitution C T intron_variant MELA-AU 6 25976936 25976936 single base substitution C T intron_variant MELA-AU 6 25977071 25977071 single base substitution C A intron_variant MELA-AU 6 25978139 25978139 single base substitution C T intron_variant MELA-AU 6 25978697 25978697 single base substitution G A intron_variant MELA-AU 6 25979395 25979395 single base substitution T C intron_variant MELA-AU 6 25980071 25980071 single base substitution C T intron_variant MELA-AU 6 25980081 25980081 single base substitution C T intron_variant MELA-AU 6 25980437 25980437 single base substitution C T intron_variant MELA-AU 6 25981992 25981992 single base substitution C T intron_variant MELA-AU 6 25982283 25982283 single base substitution C T intron_variant MELA-AU 6 25983254 25983254 single base substitution T C intron_variant MELA-AU 6 25983501 25983501 single base substitution G A synonymous_variant R328R 984G>A MELA-AU 6 25983789 25983789 single base substitution C T synonymous_variant S424S 1272C>T MELA-AU 6 25983969 25983969 single base substitution C T 3_prime_UTR_variant MELA-AU 6 25984012 25984012 single base substitution C T 3_prime_UTR_variant MELA-AU 6 25985915 25985915 single base substitution C T 3_prime_UTR_variant MELA-AU 6 25985915 25985915 single base substitution C T downstream_gene_variant MELA-AU 6 25986101 25986101 single base substitution T G 3_prime_UTR_variant MELA-AU 6 25986101 25986101 single base substitution T G downstream_gene_variant MELA-AU 6 25986534 25986534 single base substitution C T 3_prime_UTR_variant MELA-AU 6 25986534 25986534 single base substitution C T downstream_gene_variant MELA-AU 6 25986846 25986846 single base substitution A G 3_prime_UTR_variant MELA-AU 6 25986846 25986846 single base substitution A G downstream_gene_variant MELA-AU 6 25987197 25987197 single base substitution C T 3_prime_UTR_variant MELA-AU 6 25987197 25987197 single base substitution C T downstream_gene_variant MELA-AU 6 25988037 25988037 single base substitution C T downstream_gene_variant MELA-AU 6 25988285 25988285 single base substitution C T downstream_gene_variant MELA-AU 6 25988943 25988943 single base substitution C T downstream_gene_variant MELA-AU 6 25990001 25990001 single base substitution C T downstream_gene_variant MELA-AU 6 25990541 25990541 single base substitution T C downstream_gene_variant MELA-AU 6 25991207 25991208 multiple base substitution (>=2bp and <=200bp) CT TC downstream_gene_variant MELA-AU 6 25991269 25991269 single base substitution A C downstream_gene_variant MELA-AU 6 25991297 25991297 single base substitution C T downstream_gene_variant MELA-AU 6 25991556 25991556 single base substitution C T downstream_gene_variant MELA-AU 6 25992348 25992348 single base substitution C T downstream_gene_variant OV-AU 6 25969558 25969558 single base substitution G C missense_variant K139N 417G>C OV-AU 6 25972080 25972080 single base substitution T C intron_variant OV-AU 6 25979084 25979084 single base substitution T C intron_variant OV-AU 6 25986173 25986173 single base substitution G A 3_prime_UTR_variant OV-AU 6 25986173 25986173 single base substitution G A downstream_gene_variant OV-AU 6 25986412 25986412 single base substitution A T 3_prime_UTR_variant OV-AU 6 25986412 25986412 single base substitution A T downstream_gene_variant OV-AU 6 25991873 25991873 single base substitution A T downstream_gene_variant PACA-AU 6 25959799 25959799 single base substitution C T upstream_gene_variant PACA-AU 6 25962472 25962472 single base substitution C T upstream_gene_variant PACA-AU 6 25972026 25972026 single base substitution T G intron_variant PACA-AU 6 25973991 25973991 single base substitution C T intron_variant PACA-AU 6 25974851 25974851 single base substitution C T intron_variant PACA-AU 6 25978956 25978956 single base substitution G A intron_variant PACA-AU 6 25989197 25989197 single base substitution A T downstream_gene_variant PACA-CA 6 25958336 25958336 single base substitution A G upstream_gene_variant PACA-CA 6 25959438 25959438 single base substitution C T upstream_gene_variant PACA-CA 6 25961881 25961881 single base substitution T C upstream_gene_variant PACA-CA 6 25961896 25961896 single base substitution G A upstream_gene_variant PACA-CA 6 25964219 25964219 insertion of <=200bp - G intron_variant PACA-CA 6 25965602 25965602 single base substitution A T intron_variant PACA-CA 6 25968687 25968687 single base substitution T G intron_variant PACA-CA 6 25972550 25972550 single base substitution A G intron_variant PACA-CA 6 25977341 25977341 insertion of <=200bp - T intron_variant PACA-CA 6 25980624 25980624 deletion of <=200bp T - intron_variant PACA-CA 6 25981416 25981416 single base substitution C A intron_variant PACA-CA 6 25990036 25990036 single base substitution A T downstream_gene_variant PAEN-AU 6 25985512 25985512 single base substitution C T 3_prime_UTR_variant PAEN-AU 6 25985512 25985512 single base substitution C T downstream_gene_variant PAEN-IT 6 25970044 25970044 single base substitution A G intron_variant PBCA-DE 6 25962282 25962282 deletion of <=200bp C - upstream_gene_variant PBCA-DE 6 25963608 25963608 single base substitution T G intron_variant PBCA-DE 6 25964157 25964157 single base substitution A C intron_variant PBCA-DE 6 25964162 25964162 single base substitution C A intron_variant PBCA-DE 6 25964163 25964163 single base substitution A C intron_variant PBCA-DE 6 25966864 25966864 single base substitution G T missense_variant L38F 114G>T PBCA-DE 6 25971643 25971644 deletion of <=200bp TG - intron_variant PBCA-DE 6 25972250 25972250 single base substitution C T synonymous_variant L221L 661C>T PBCA-DE 6 25973936 25973936 single base substitution G T intron_variant PBCA-DE 6 25984953 25984953 insertion of <=200bp - A 3_prime_UTR_variant PBCA-DE 6 25992220 25992220 single base substitution G T downstream_gene_variant PBCA-DE 6 25992240 25992240 single base substitution T A downstream_gene_variant PRAD-CA 6 25989874 25989874 single base substitution G A downstream_gene_variant PRAD-UK 6 25958987 25958987 single base substitution C G upstream_gene_variant PRAD-UK 6 25969527 25969531 deletion of <=200bp CTTCA - intron_variant PRAD-UK 6 25973482 25973482 single base substitution C A missense_variant F281L 843C>A PRAD-UK 6 25987377 25987377 deletion of <=200bp C - 3_prime_UTR_variant PRAD-UK 6 25987377 25987377 deletion of <=200bp C - downstream_gene_variant PRAD-UK 6 25990973 25990973 single base substitution T A downstream_gene_variant READ-US 6 25972262 25972262 single base substitution G T stop_gained E225* 673G>T RECA-EU 6 25959465 25959465 single base substitution T A upstream_gene_variant RECA-EU 6 25970086 25970086 single base substitution C G intron_variant RECA-EU 6 25970823 25970823 single base substitution G A intron_variant RECA-EU 6 25971130 25971130 single base substitution G A intron_variant RECA-EU 6 25973087 25973087 single base substitution T G intron_variant RECA-EU 6 25977410 25977410 single base substitution C G intron_variant RECA-EU 6 25977992 25977992 single base substitution C A intron_variant SKCA-BR 6 25959483 25959483 single base substitution G T upstream_gene_variant SKCA-BR 6 25959918 25959918 single base substitution C T upstream_gene_variant SKCA-BR 6 25961570 25961570 single base substitution C T upstream_gene_variant SKCA-BR 6 25961714 25961714 single base substitution G A upstream_gene_variant SKCA-BR 6 25961974 25961974 single base substitution G A upstream_gene_variant SKCA-BR 6 25964384 25964384 single base substitution A G intron_variant SKCA-BR 6 25967333 25967333 single base substitution C T intron_variant SKCA-BR 6 25969285 25969285 single base substitution C T intron_variant SKCA-BR 6 25969286 25969286 single base substitution C T intron_variant SKCA-BR 6 25969958 25969958 single base substitution G C intron_variant SKCA-BR 6 25972908 25972908 single base substitution T C intron_variant SKCA-BR 6 25977460 25977460 single base substitution T G intron_variant SKCA-BR 6 25978326 25978326 single base substitution A T intron_variant SKCA-BR 6 25979031 25979031 single base substitution A T intron_variant SKCA-BR 6 25979889 25979889 single base substitution C T intron_variant SKCA-BR 6 25981363 25981363 single base substitution T G intron_variant SKCA-BR 6 25982621 25982621 single base substitution C G intron_variant SKCA-BR 6 25985547 25985547 single base substitution G A 3_prime_UTR_variant SKCA-BR 6 25985547 25985547 single base substitution G A downstream_gene_variant SKCA-BR 6 25987429 25987429 single base substitution T C downstream_gene_variant SKCA-BR 6 25988724 25988724 single base substitution C T downstream_gene_variant SKCA-BR 6 25989738 25989738 insertion of <=200bp - CT downstream_gene_variant SKCM-US 6 25966938 25966938 single base substitution G A missense_variant R63Q 188G>A SKCM-US 6 25966959 25966959 single base substitution G A missense_variant S70N 209G>A SKCM-US 6 25983438 25983438 single base substitution C T synonymous_variant L307L 921C>T SKCM-US 6 25983665 25983665 single base substitution G T missense_variant W383L 1148G>T SKCM-US 6 25983718 25983718 single base substitution A G missense_variant T401A 1201A>G SKCM-US 6 25983887 25983887 single base substitution C T missense_variant P457L 1370C>T STAD-US 6 25966795 25966795 single base substitution C A synonymous_variant T15T 45C>A STAD-US 6 25969609 25969609 single base substitution G A synonymous_variant E156E 468G>A STAD-US 6 25983804 25983804 single base substitution T A missense_variant N429K 1287T>A THCA-SA 6 25963456 25963456 single base substitution A G 5_prime_UTR_variant UCEC-US 6 25966976 25966976 single base substitution C T stop_gained Q76* 226C>T UCEC-US 6 25967011 25967011 single base substitution G A synonymous_variant T87T 261G>A UCEC-US 6 25967119 25967119 single base substitution G A synonymous_variant G123G 369G>A UCEC-US 6 25969632 25969632 single base substitution G A missense_variant R164Q 491G>A UCEC-US 6 25972171 25972171 single base substitution G T missense_variant E194D 582G>T UCEC-US 6 25972210 25972210 single base substitution G T missense_variant Q207H 621G>T UCEC-US 6 25983464 25983464 single base substitution G A missense_variant R316H 947G>A UCEC-US 6 25983480 25983480 single base substitution G T missense_variant E321D 963G>T UCEC-US 6 25983486 25983486 single base substitution G T missense_variant Q323H 969G>T UCEC-US 6 25983666 25983666 single base substitution G T missense_variant W383C 1149G>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand pfg144T COSM4751487 c.756G>C p.L252F Substitution - Missense 6:25973071-25973071 + PD3992a COSM165132 c.1115C>G p.T372S Substitution - Missense 6:25983404-25983404 + 91603 COSM330503 c.11C>T p.T4I Substitution - Missense 6:25966533-25966533 + MD-319 COSM303450 c.114G>T p.L38F Substitution - Missense 6:25966636-25966636 + pfg116T COSM4751486 c.340C>T p.R114C Substitution - Missense 6:25966862-25966862 + TCGA-AA-A010-01 COSM285943 c.726G>T p.Q242H Substitution - Missense 6:25972087-25972087 + AOCS-117-3-3 COSM4153153 c.417G>C p.K139N Substitution - Missense 6:25969330-25969330 + TCGA-D1-A103-01 COSM1076656 c.491G>A p.R164Q Substitution - Missense 6:25969404-25969404 + TCGA-AP-A0LM-01 COSM1076658 c.621G>T p.Q207H Substitution - Missense 6:25971982-25971982 + 2P3 COSM3733672 c.108C>A p.C36* Substitution - Nonsense 6:25966630-25966630 + T2269 COSM4736074 c.610G>T p.E204* Substitution - Nonsense 6:25971971-25971971 + LUAD_E01047 COSM390277 c.1248G>C p.L416L Substitution - coding silent 6:25983537-25983537 + PT21_1 COSM5900901 c.1210C>T p.H404Y Substitution - Missense 6:25983499-25983499 + tumor_4116738 COSM1161604 c.1312C>T p.P438S Substitution - Missense 6:25983601-25983601 + YULONE COSM5404947 c.1351C>T p.Q451* Substitution - Nonsense 6:25983640-25983640 + TCGA-06-0158-01 COSM2150131 c.214C>T p.R72* Substitution - Nonsense 6:25966736-25966736 + PD9604a COSM5792675 c.1077G>A p.W359* Substitution - Nonsense 6:25983366-25983366 + 8 COSM1076654 c.261G>A p.T87T Substitution - coding silent 6:25966783-25966783 + TCGA-D8-A1Y1-01 COSM1487518 c.1257G>A p.E419E Substitution - coding silent 6:25983546-25983546 + 585208 COSM326757 c.338G>A p.W113* Substitution - Nonsense 6:25966860-25966860 + TCGA-34-5240-01 COSM740928 c.1314G>T p.P438P Substitution - coding silent 6:25983603-25983603 + TCGA-D1-A17Q-01 COSM1076662 c.1149G>T p.W383C Substitution - Missense 6:25983438-25983438 + TCGA-DS-A1OC-01 COSM1294205 c.145C>G p.Q49E Substitution - Missense 6:25966667-25966667 + BD109T COSM5500613 c.1233T>C p.L411L Substitution - coding silent 6:25983522-25983522 + YUPLA COSM129894 c.719C>T p.S240L Substitution - Missense 6:25972080-25972080 + ACINAR03 COSM1734069 c.623_624delCT p.L209fs*2 Deletion - Frameshift 6:25971984-25971985 + TCGA-D1-A16X-01 COSM1076656 c.491G>A p.R164Q Substitution - Missense 6:25969404-25969404 + TCGA-B5-A11E-01 COSM1076661 c.969G>T p.Q323H Substitution - Missense 6:25983258-25983258 + TCGA-70-6722-01 COSM740930 c.830C>T p.S277F Substitution - Missense 6:25973241-25973241 + TCGA-66-2734-01 COSM740931 c.359A>T p.Q120L Substitution - Missense 6:25966881-25966881 + 218 COSM4424926 c.907C>T p.H303Y Substitution - Missense 6:25983196-25983196 + TCGA-AP-A051-01 COSM1076653 c.226C>T p.Q76* Substitution - Nonsense 6:25966748-25966748 + BZ04 COSM3860871 c.45C>A p.T15T Substitution - coding silent 6:25966567-25966567 + HCC98 COSM1621272 c.1358A>G p.Y453C Substitution - Missense 6:25983647-25983647 + CHC1747T COSM4788151 c.114G>A p.L38L Substitution - coding silent 6:25966636-25966636 + P127 COSM1736855 c.674A>G p.E225G Substitution - Missense 6:25972035-25972035 + LUAD-2GUGK COSM400662 c.761G>T p.R254M Substitution - Missense 6:25973076-25973076 + 2492704 COSM5730177 c.359_360insGCACAAAGG p.H124_T125insKGH Insertion - In frame 6:25966881-25966882 + PT48 COSM5931914 c.412-7C>T p.? Unknown 6:25969318-25969318 + TCGA-CG-5723-01 COSM3860871 c.45C>A p.T15T Substitution - coding silent 6:25966567-25966567 + Pat_41_B COSM3777381 c.382C>T p.L128F Substitution - Missense 6:25966904-25966904 + T3446 COSM4736075 c.1002C>A p.P334P Substitution - coding silent 6:25983291-25983291 + sysucc-1397T COSM5474916 c.1218T>C p.H406H Substitution - coding silent 6:25983507-25983507 + TCGA-18-3417-01 COSM740932 c.309C>T p.F103F Substitution - coding silent 6:25966831-25966831 + LC_S19 COSM1186971 c.10A>G p.T4A Substitution - Missense 6:25966532-25966532 + TCGA-FS-A1ZK-06 COSM3623425 c.1148G>T p.W383L Substitution - Missense 6:25983437-25983437 + HN_63080 COSM122124 c.60G>C p.L20L Substitution - coding silent 6:25966582-25966582 + PTC-28C COSM3761734 c.318C>T p.D106D Substitution - coding silent 6:25966840-25966840 + 587316 COSM1230331 c.440T>C p.L147P Substitution - Missense 6:25969353-25969353 + TCGA-B5-A11N-01 COSM1076660 c.963G>T p.E321D Substitution - Missense 6:25983252-25983252 + TCGA-UB-A7MB-01 COSM4931790 c.1185A>T p.A395A Substitution - coding silent 6:25983474-25983474 + pfg127T COSM4751485 c.208A>T p.S70C Substitution - Missense 6:25966730-25966730 + TCGA-D3-A2JD-06 COSM3623424 c.921C>T p.L307L Substitution - coding silent 6:25983210-25983210 + TCGA-BS-A0UV-01 COSM1076654 c.261G>A p.T87T Substitution - coding silent 6:25966783-25966783 + TCGA-BR-6452-01 COSM3860873 c.1287T>A p.N429K Substitution - Missense 6:25983576-25983576 + TCGA-Q1-A5R2-01 COSM4850263 c.582G>A p.E194E Substitution - coding silent 6:25971943-25971943 + Pat_14_B COSM5869886 c.863G>A p.R288K Substitution - Missense 6:25973274-25973274 + ICGC_PA84 COSM3670353 c.661C>T p.L221L Substitution - coding silent 6:25972022-25972022 + B109 COSM1754679 c.1326C>G p.F442L Substitution - Missense 6:25983615-25983615 + TCGA-33-4586-01 COSM740927 c.1328C>G p.S443C Substitution - Missense 6:25983617-25983617 + TCGA-06-0158 COSM2150131 c.214C>T p.R72* Substitution - Nonsense 6:25966736-25966736 + J74_T COSM3948868 c.1102G>C p.V368L Substitution - Missense 6:25983391-25983391 + 587270 COSM1230329 c.244G>A p.E82K Substitution - Missense 6:25966766-25966766 + 587226 COSM1230330 c.472A>G p.K158E Substitution - Missense 6:25969385-25969385 + TCGA-A2-A0EQ-01 COSM450992 c.87C>G p.I29M Substitution - Missense 6:25966609-25966609 + TCGA-A3-3380-01 COSM1496237 c.1333A>G p.T445A Substitution - Missense 6:25983622-25983622 + PD18264a COSM5773994 c.1338C>T p.L446L Substitution - coding silent 6:25983627-25983627 + TCGA-GC-A3RC-01 COSM3777380 c.357A>G p.P119P Substitution - coding silent 6:25966879-25966879 + PT45 COSM5927440 c.1339C>T p.R447W Substitution - Missense 6:25983628-25983628 + TCGA-EB-A5UM-01 COSM3623423 c.188G>A p.R63Q Substitution - Missense 6:25966710-25966710 + CSCC-57-T COSM4477290 c.213C>T p.L71L Substitution - coding silent 6:25966735-25966735 + TCGA-AP-A056-01 COSM1076657 c.582G>T p.E194D Substitution - Missense 6:25971943-25971943 + TCGA-GD-A2C5-01 COSM1311856 c.636G>A p.L212L Substitution - coding silent 6:25971997-25971997 + 587298 COSM1230333 c.592C>A p.L198I Substitution - Missense 6:25971953-25971953 + TCGA-EE-A17Z-06 COSM3623426 c.1201A>G p.T401A Substitution - Missense 6:25983490-25983490 + 255 COSM3731741 c.288C>T p.H96H Substitution - coding silent 6:25966810-25966810 + 259610 COSM3725362 c.946C>T p.R316C Substitution - Missense 6:25983235-25983235 + HCC98T COSM1621272 c.1358A>G p.Y453C Substitution - Missense 6:25983647-25983647 + TCGA-BG-A18B-01 COSM1076655 c.369G>A p.G123G Substitution - coding silent 6:25966891-25966891 + PT37 COSM5919179 c.1141G>A p.G381R Substitution - Missense 6:25983430-25983430 + S02328 COSM5692174 c.313G>T p.E105* Substitution - Nonsense 6:25966835-25966835 + STC263 COSM5061680 c.490C>T p.R164* Substitution - Nonsense 6:25969403-25969403 + ICGC_MB126 COSM303450 c.114G>T p.L38F Substitution - Missense 6:25966636-25966636 + TCGA-CD-A4MH-01 COSM3860872 c.468G>A p.E156E Substitution - coding silent 6:25969381-25969381 + TCGA-46-3765-01 COSM740929 c.1000C>T p.P334S Substitution - Missense 6:25983289-25983289 + TCGA-D1-A163-01 COSM1076659 c.947G>A p.R316H Substitution - Missense 6:25983236-25983236 + TCGA-DK-A2I4-01 COSM3777381 c.382C>T p.L128F Substitution - Missense 6:25966904-25966904 + HN_62421 COSM129894 c.719C>T p.S240L Substitution - Missense 6:25972080-25972080 + C086 COSM1161604 c.1312C>T p.P438S Substitution - Missense 6:25983601-25983601 + B109-Tumor COSM1754679 c.1326C>G p.F442L Substitution - Missense 6:25983615-25983615 + CHC1747T COSM4788151 c.114G>A p.L38L Substitution - coding silent 6:25966636-25966636 + SJTALL169 COSM306099 c.644A>G p.Y215C Substitution - Missense 6:25972005-25972005 + D12 COSM5006838 c.137A>C p.N46T Substitution - Missense 6:25966659-25966659 + C086 COSM5540811 c.1313C>T p.P438L Substitution - Missense 6:25983602-25983602 + TCGA-BH-A0AZ-01 COSM450993 c.826G>T p.V276F Substitution - Missense 6:25973237-25973237 + TARGET-30-PASYPX COSM1288620 c.724C>A p.Q242K Substitution - Missense 6:25972085-25972085 + TCGA-AM-5820-01 COSM3761734 c.318C>T p.D106D Substitution - coding silent 6:25966840-25966840 + SJTALL169 COSM306099 c.644A>G p.Y215C Substitution - Missense 6:25972005-25972005 + 030T COSM1731493 c.786delA p.S263fs*21 Deletion - Frameshift 6:25973197-25973197 + 587376 COSM1230332 c.1167A>C p.K389N Substitution - Missense 6:25983456-25983456 + TCGA-BQ-7059-01 COSM3994766 c.261G>C p.T87T Substitution - coding silent 6:25966783-25966783 + TCGA-EI-6917-01 COSM3430387 c.673G>T p.E225* Substitution - Nonsense 6:25972034-25972034 + SA054 COSM214146 c.437A>T p.K146I Substitution - Missense 6:25969350-25969350 + TCGA-EE-A2MS-06 COSM3623427 c.1370C>T p.P457L Substitution - Missense 6:25983659-25983659 + TCGA-D3-A1Q6-06 COSM3921193 c.209G>A p.S70N Substitution - Missense 6:25966731-25966731 + ESCC_144 COSM5644582 c.1027A>G p.T343A Substitution - Missense 6:25983316-25983316 + TCGA-AA-A010-01 COSM285944 c.1061G>A p.G354D Substitution - Missense 6:25983350-25983350 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.584846;Hs.584851 6p21.3 2403582|CGAP|BC026930|A/G|coding|Gly421Arg|1695|Candidate; 262569|dbSNP|BC026930|A/G|non-coding||192|Validated; 611430|dbSNP|BC026930|A/G|non-coding||192|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.T401A c.1201A>G 6 25983718 CM A T Missense p.K146I c.437A>T 6 25969578 BRCA A T Missense p.Q120L c.359A>T 6 25967109 LUSC A T Missense p.T56S c.166A>T 6 25966916 STAD C A Missense p.Q242K c.724C>A 6 25972313 NB CC TT Missense p.S267F c.800_801delinsTT 6 25973439 CM C G Missense p.I29M c.87C>G 6 25966837 BRCA C G Missense p.S443C c.1328C>G 6 25983845 LUSC C G Missense p.T372S c.1115C>G 6 25983632 BRCA C T 3-UTRSNV . c.1395+100C>T 6 25984012 CM C T 3-UTRSNV . c.1395+59C>T 6 25983971 CM C T Missense p.L128F c.382C>T 6 25967132 BLCA C T Missense p.P334S c.1000C>T 6 25983517 LUSC C T Missense p.P438S c.1312C>T 6 25983829 DLBCL C T Missense p.P457L c.1370C>T 6 25983887 CM C T Missense p.S240L c.719C>T 6 25972308 HNSC C T Missense p.S277F c.830C>T 6 25973469 LUSC C T Nonsense p.R72* c.214C>T 6 25966964 GBM C T Synonymous p.F103F c.309C>T 6 25967059 LUSC C T Synonymous p.L221L c.661C>T 6 25972250 PIA C T Synonymous p.L307L c.921C>T 6 25983438 CM G A Missense p.R316H c.947G>A 6 25983464 UCEC G A Missense p.S70N c.209G>A 6 25966959 CM G A Nonsense p.W113* c.338G>A 6 25967088 SCLC G A Synonymous p.E419E c.1257G>A 6 25983774 BRCA G A Synonymous p.G123G c.369G>A 6 25967119 UCEC G A Synonymous p.L212L c.636G>A 6 25972225 BLCA G C Synonymous p.L20L c.60G>C 6 25966810 HNSC G T Missense p.L38F c.114G>T 6 25966864 MB G T Missense p.V276F c.826G>T 6 25973465 BRCA G T Synonymous p.P438P c.1314G>T 6 25983831 LUSC