PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NRG1 RNF130 26186194 biogrid exp G GP GP G G G G G P GP G G G P G P G G PTCH1 RNF130 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF130 MCOLN3 26186194 biogrid exp G GP P G G G G GP G G G P G G G G G G G G MYC RNF130 21150319 biogrid,i2d,intact exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G ARPC4 RNF130 16169070 hprd,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF130 CDC5L 20467437 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF130 TSPAN18 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G RNF130 HTR3C 26186194 biogrid exp UBE2E1 RNF130 16549277,19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBE2D1 RNF130 16549277,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G RNF130 UBE2E3 19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBE2N RNF130 19690564 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RNF130 TSPAN17 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PON2 RNF130 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G RNF130 TTLL3 16169070 mint exp P GP G G GP GP G GP GP G GP P GP GP G GP GP GP P G GP GP GP P GP G GP GP G CD1B RNF130 26186194 biogrid exp P P G G P P P P P P P P P G GP G P P P P P P P RNF130 UBE2Z 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RNF130 SCN2A 16169070 hprd,mint,intact exp G GP P G GP GP G P P P RNF130 TMEM231 26186194 biogrid exp GP GP G P GP G GP GP G GP P GP P G P GP G P G P GP P P GP P GP GP G RNF130 UBE2D4 19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBC RNF130 16549277 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZACN RNF130 26186194 biogrid exp FGFR3 RNF130 16169070 hprd,biogrid,i2d,mint,intact exp G P G P GP GP G G GP G GP GP G G GP G GP G G GP UBE2D2 RNF130 16549277,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G BTNL8 RNF130 26186194 biogrid exp P G GP P P P P P GP P P P P GP P P SCN1A RNF130 16169070 i2d exp, ortho P P G P GP G P P G P P P P P GP P P P P P P P P P P TGFBR1 RNF130 15761153, 21836163 hprd,i2d exp, pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G UBE2D3 RNF130 16549277,19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G CD4 RNF130 21836163 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G G SCD5 RNF130 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2B RNF130 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4A RNF130 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VWF RNF130 21836163 pred G G G G GP GP G G GP G G G G G G GP G G G G G G G G G G G G PPP1R27 RNF130 23023127 pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G CSNK2A1 RNF130 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CACNA2D4 RNF130 21836163 pred G P G GP GP G GP P GP P P GP GP P GP G GP P GP GP GP GP P P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 Q86XS8 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q86XS8 enzymatic study 16549277 direct interaction X 2 P0CG48 Q86XS8 affinity chromatography technology 21139048 physical association X 2 Q86XS8 A0A087WW00 pull down 16549277 direct interaction X 2 Q86XS8 P62837 pull down 16549277 direct interaction X 2 Q86XS8 A0A024R2K3 pull down 16549277 direct interaction X 2 Q86XS8 two hybrid 16169070 direct interaction X 2 Q86XS8 A0A087WW00 two hybrid 19690564 direct interaction X 2 Q86XS8 P62837 two hybrid 19690564 direct interaction X 2 Q86XS8 A0A024R2K3 two hybrid 19690564 direct interaction X 2 Q86XS8 P61088 two hybrid 19690564 direct interaction X 2 Q86XS8 Q9H832 two hybrid 19690564 direct interaction X 2 Q969T4 Q86XS8 two hybrid 19690564 direct interaction X 2 P01106 Q86XS8 affinity chromatography technology 21150319 physical association X 2 Q86XS8 P61077-3 pull down 16549277 direct interaction X 2 Q86XS8 P61077-3 two hybrid 19690564 direct interaction X 2 Q86XS8 A0A024RA90 two hybrid 19690564 direct interaction X 2 P22607-3 Q86XS8 two hybrid 16169070 - X 2 P22607-3 Q86XS8 two hybrid 16169070 - X 2 Q99250 Q86XS8 two hybrid 16169070 - X 2 Q99250 Q86XS8 two hybrid 16169070 - X 2 P59998 Q86XS8 two hybrid 16169070 - X 2 P59998 Q86XS8 two hybrid 16169070 - X 2 P36897-3 Q86XS8 in vivo 15761153 - X 2 P36897-3 Q86XS8 in vivo 15761153 - X 2 P22607 Q86XS8 two hybrid pooling approach 16169070 physical association X 2 Q86XS8 tandem affinity purification 21150319 association C 87 Q8CZU9 Q86XS8 two hybrid pooling approach 20711500 physical association X 2 Q99250 Q86XS8 two hybrid pooling approach 16169070 physical association X 2 P59998 Q86XS8 two hybrid pooling approach 16169070 physical association X 2 Q5NI89 Q86XS8 two hybrid pooling approach 20711500 physical association X 2 Q86XS8 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q86XS8 A0A024R2K3 two hybrid array 19690564 physical association X 2 Q86XS8 P61088 two hybrid array 19690564 physical association X 2 Q86XS8 Q9H832 two hybrid array 19690564 physical association X 2 Q86XS8 P62837 two hybrid array 19690564 physical association X 2 Q5NI66 Q86XS8 two hybrid pooling approach 20711500 physical association X 2 A0A024QZJ2 Q86XS8 two hybrid array 19690564 physical association X 2 Q969T4 Q86XS8 two hybrid array 19690564 physical association X 2 Q86XS8 A0A024RA90 two hybrid array 19690564 physical association X 2 Q86XS8 Q81TM2 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF130 TTLL3 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_64005|MINT_35028 bait|bait prey|prey RNF130 UBE2D4 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123523 prey bait MYC RNF130 MI:0676(tandem affinity purification)|MI:0401(biochemical) 21150319 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_110256|BIOGRID_252325 bait|bait prey|prey UBE2N RNF130 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123620 bait prey RNF130 UBE2Z MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123716 prey bait TGFBR1 RNF130 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17971 - - NRF1 RNF130 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295504 bait prey FGFR3 RNF130 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0468(hprd) BIOGRID_93559|UniProt_156128|HPRD_28190 bait|bait|- prey|prey|- UBE2D1 RNF130 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123427 bait prey ARPC4 RNF130 MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_157140|HPRD_29938 prey|- bait|- UBE2E1 RNF130 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123546 bait prey RNF130 SCN2A MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint) MINT_64004|HPRD_28852|UniProt_157141|MINT_35027 bait|-|bait|bait prey|-|prey|prey RNF130 UBE2E3 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123565 prey bait UBE2D2 RNF130 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123456 bait prey RNF130 FGFR3 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_65325|MINT_36209 prey|prey bait|bait UBE2D3 RNF130 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123490 bait prey UBC RNF130 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_169254|BIOGRID_224592 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CD1B RNF130 26186194 0004 HT NRG1 RNF130 26186194 0004 HT PON2 RNF130 26186194 0004 HT ZACN RNF130 26186194 0004 HT Q59FG5 RNF130 26186194 0004 HT BTNL8 RNF130 26186194 0004 HT RNF130 MCOLN3 26186194 0004 HT RNF130 HTR3C 26186194 0004 HT RNF130 TSPAN17 26186194 0004 HT RNF130 TSPAN18 26186194 0004 HT RNF130 TMEM231 26186194 0004 HT CD1B RNF130 26186194 0004 HT NRG1 RNF130 26186194 0004 HT PON2 RNF130 26186194 0004 HT ZACN RNF130 26186194 0004 HT Q59FG5 RNF130 26186194 0004 HT BTNL8 RNF130 26186194 0004 HT RNF130 MCOLN3 26186194 0004 HT RNF130 HTR3C 26186194 0004 HT RNF130 TSPAN17 26186194 0004 HT RNF130 TSPAN18 26186194 0004 HT RNF130 TMEM231 26186194 0004 HT UBC RNF130 16549277 0415 LC FGFR3 RNF130 16169070,16169070 0018,0398 HT TGFBR1 RNF130 15761153 0019 HT UBE2D1 RNF130 19690564,19690564 0397,0018 HT UBE2E1 RNF130 19690564,19690564 0397,0018 HT ARPC4 RNF130 16169070,16169070 0018,0398 HT UBE2D3 RNF130 19690564,19690564 0397,0018 HT UBE2N RNF130 19690564,19690564 0397,0018 HT UBE2D2 RNF130 19690564,19690564 0397,0018 HT RNF130 UBE2E3 19690564,19690564 0397,0018 HT RNF130 SCN2A 16169070,16169070 0018,0398 HT RNF130 UBE2Z 19690564,19690564 0397,0018 HT RNF130 UBE2D4 19690564,19690564 0397,0018 HT RNF130 TTLL3 16169070 0018 HT RNF130 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86XS8 P22607 RNF130 FGFR3 0.286 16169070 Q86XS8 P59998 RNF130 ARPC4 0.126 16169070 Q86XS8 Q5NI89 RNF130 LYSU 0.126 20711500 Q8CZU9 Q86XS8 Q8CZU9 RNF130 0.126 20711500 Q9H6L2 Q86XS8 TMEM231 RNF130 0.126 26186194 Q8TDD5 Q86XS8 MCOLN3 RNF130 0.126 26186194 Q9Y2X8 Q86XS8 UBE2D4 RNF130 0.286 19690564 Q86XS8 Q6UX41 RNF130 BTNL8 0.126 26186194 Q86XS8 Q81TM2 RNF130 Q81TM2 0.126 20711500 Q86XS8 P0CG48 RNF130 UBC 0.309 16549277 Q86XS8 P51668 RNF130 UBE2D1 0.507 19690564,16549277 Q86XS8 P51965 RNF130 UBE2E1 0.507 19690564,16549277 Q86XS8 P61077 RNF130 UBE2D3 0.507 19690564,16549277 Q86XS8 P62837 RNF130 UBE2D2 0.507 19690564,16549277 Q86XS8 Q5NI66 RNF130 ACPA 0.126 20711500 Q9H832 Q86XS8 UBE2Z RNF130 0.286 19690564 Q86XS8 P01106 RNF130 MYC 0.236 21150319 Q99459 Q86XS8 CDC5L RNF130 0.236 20467437 Q86XS8 P61088 RNF130 UBE2N 0.286 19690564 Q969T4 Q86XS8 UBE2E3 RNF130 0.286 19690564 Q8WXA8 Q86XS8 HTR3C RNF130 0.126 26186194 Q96FV3 Q86XS8 TSPAN17 RNF130 0.126 26186194 Q86XS8 P29016 RNF130 CD1B 0.126 26186194 Q96SJ8 Q86XS8 TSPAN18 RNF130 0.126 26186194 Q99250 Q86XS8 SCN2A RNF130 0.126 16169070 Q86XS8 Q13635 RNF130 PTCH1 0.126 26186194 Q86XS8 Q15165 RNF130 PON2 0.126 26186194 Q86XS8 Q02297 RNF130 NRG1 0.126 26186194 Q86XS8 Q401N2 RNF130 ZACN 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYC RNF130 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF130 MI:0045 experimental interaction detection MI:0461 interaction database FGFR3 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database CD1B RNF130 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database SREBF1 RNF130 MI:0362 inference MI:0461 interaction database UBE2D1 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database ARPC4 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF130 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database NRG1 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database PTCH1 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database PON2 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database ZACN RNF130 MI:0045 experimental interaction detection MI:0461 interaction database BTNL8 RNF130 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 MCOLN3 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 HTR3C MI:0045 experimental interaction detection MI:0461 interaction database RNF130 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 TSPAN17 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 TSPAN18 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 SCN2A MI:0045 experimental interaction detection MI:0461 interaction database RNF130 CDC5L MI:0045 experimental interaction detection MI:0461 interaction database RNF130 TMEM231 MI:0045 experimental interaction detection MI:0461 interaction database RNF130 UBE2Z MI:0045 experimental interaction detection MI:0461 interaction database RNF130 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database