PTM - CPLM Gene Name UniProt ID Type Position Code PPP2CA P67775 Acetylation 4 K PPP2CA P67775 Ubiquitination 41 K PPP2CA P67775 Ubiquitination 8 K PPP2CA P67775 Ubiquitination 21 K PPP2CA P67775 Ubiquitination 29 K PPP2CA P67775 Ubiquitination 283 K PPP2CA P67775 Ubiquitination 74 K PPP2CA P67775 Ubiquitination 4 K PPP2CA P67775 Ubiquitination 34 K PPP2CA P67775 Ubiquitination 36 K PPP2CA P67775 Ubiquitination 136 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PPP2CA P67775 248 Y Homo sapiens(Human) PPP2CA P67775 265 Y Homo sapiens(Human) PPP2CA P67775 284 Y Homo sapiens(Human) PPP2CA P67775 304 T Homo sapiens(Human) PPP2CA P67775 307 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P67775 K4-ac Acetylation ____MDEkVFTkELD P67775 K29-ac Acetylation QLSEsQVkSLCEkAk P67775 K41-ac Acetylation kAkEILTkESNVQEV P67775 R295-m1 Methylation QFDPAPRrGEPHVTR P67775 L309-me Methylation RRtPDyFl_______ P67775 S26-p Phosphorylation ECkQLSEsQVkSLCE P67775 S75-p Phosphorylation LFRIGGksPDtNYLF P67775 T78-p Phosphorylation IGGksPDtNYLFMGD P67775 Y86-p Phosphorylation NYLFMGDyVDRGYYS P67775 S212-p Phosphorylation DRGGWGIsPRGAGYT P67775 Y248-p Phosphorylation HQLVMEGyNWCHDRN P67775 Y265-p Phosphorylation TIFSAPNyCYRCGNQ P67775 Y284-p Phosphorylation ELDDTLkySFLQFDP P67775 T304-p Phosphorylation EPHVTRRtPDyFl__ P67775 Y307-p Phosphorylation VTRRtPDyFl_____ P67775 K4-sm Sumoylation ____MDEkVFTkELD P67775 K4-ub Ubiquitination ____MDEkVFTkELD P67775 K8-ub Ubiquitination MDEkVFTkELDQWIE P67775 K21-ub Ubiquitination IEQLNECkQLSEsQV P67775 K29-ub Ubiquitination QLSEsQVkSLCEkAk P67775 K34-ub Ubiquitination QVkSLCEkAkEILTk P67775 K36-ub Ubiquitination kSLCEkAkEILTkES P67775 K41-ub Ubiquitination kAkEILTkESNVQEV P67775 K74-ub Ubiquitination ELFRIGGksPDtNYL P67775 K136-ub Ubiquitination FYDECLRkYGNANVW P67775 K283-ub Ubiquitination MELDDTLkySFLQFD

PTM - dbPTM UniProt ID Position Code Type Resources References P67775 1 M Acetylation Swiss-Prot 1010711 19608861 P67775 4 K Acetylation Swiss-Prot 1010711 19608861 P67775 307 Y Phosphorylation Swiss-Prot 1010711 1848320 P67775 309 L Methylation Swiss-Prot 1010711 8206937 P67775 304 T Phosphorylation PhosphoELM.10011 17394530;10978272 P67775 307 Y Phosphorylation PhosphoELM.10011 17394530;16286244 P67775 136 K Ubiquitylation Phosphositeplus.1010730 21906983 P67775 21 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P67775 283 K Ubiquitylation Phosphositeplus.1010730 21906983 P67775 29 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P67775 34 K Ubiquitylation Phosphositeplus.1010730 21906983 P67775 41 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P67775 74 K Ubiquitylation Phosphositeplus.1010730 21906983 P67775 8 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P67775 4 K Acetylation Phosphositeplus.1010730 19608861 P67775 309 L Methylation Phosphositeplus.1010730 8206937 P67775 304 T Phosphorylation Phosphositeplus.1010730 10978272;17394530;17635907 P67775 248 Y Phosphorylation Phosphositeplus.1010730 20090780 P67775 265 Y Phosphorylation Phosphositeplus.1010730 20090780 P67775 284 Y Phosphorylation Phosphositeplus.1010730 21253578 P67775 307 Y Phosphorylation Phosphositeplus.1010730 10978272;12921784;1325671;16286244;16387841;17303700;17394530;17635907;18208556;19366811;20352103;20450893;20558158;20636478;20889984;21292165;21554241;21791414;22231169;22299660;22771321 P67775 4 K Acetylation HPRD 9.0 19608861 P67775 266 C S-nitrosylation dbSNO 1.0 19483679

PTM - HPRD Symbol Position Code Type References PPP2CA 4 K Acetylation 19608861

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P67775 307 Y 17394530 LTP Phosphorylation P67775 307 Y 16286244 LTP Phosphorylation P67775 304 T 17394530 LTP Phosphorylation P67775 304 T 10978272 LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P67775 309 Leucine methyl ester 8206937

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PPP2CA IPI00008380 K 4 ___MDEaKVFTKEL acetylation PPP2CA IPI00008380 S 43 EILTKEpSNVQEVR phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 5515 111507 - K Ubiquitination 19818709 5515 111507 - K Ubiquitination 21454489 5515 111507 - K Ubiquitination 20639865 5515 111507 - K Ubiquitination 21987572 5515 111507 - K Ubiquitination 21963094 5515 111507 - K Ubiquitination 21139048 5515 111507 - K Ubiquitination 21890473 5515 111507 - K Ubiquitination 21906983 5515 111507 - K Ubiquitination 22053931 5515 111507 - K Ubiquitination 22505724 5515 111507 - K Ubiquitination 23000965 5515 111507 - K Ubiquitination 24145130 5515 111507 - K Neddylation 24654937 5515 111507 - K Sumoylation 24654937 5515 111507 - K Ubiquitination 24816145 5515 111507 - K Sumoylation 25027693 5515 111507 - K Ubiquitination 25147182 5515 111507 - K Sumoylation 25391492

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PPP2CA Homo sapiens (Human) 34; 136; 21; 36; 8; 283; 41; 29; 74 "34,VKSLCEKAKEILT; 136,YDECLRKYGNANV; 21,EQLNECKQLSESQ; 36,SLCEKAKEILTKE; 8,DEKVFTKELDQWI; 283,ELDDTLKYSFLQF; 41,AKEILTKESNVQE; 29,LSESQVKSLCEKA; 74,LFRIGGKSPDTNY" "34:21906983; 136:21906983; 21:21890473,21906983; 36:21906983; 8:21890473,21906983; 283:21906983,22053931; 41:21890473,21906983,22053931; 29:21890473,21906983; 74:21906983" PPP2CA Homo sapiens (Human) 21; 8; 41; 29 "21,EQLNECKQLSESQ; 8,DEKVFTKELDQWI; 41,AKEILTKESNVQE; 29,LSESQVKSLCEKA" 21:21890473; 8:21890473; 41:21890473; 29:21890473 PPP2CA Homo sapiens (Human) 21; 8; 41; 29 "21,EQLNECKQLSESQ; 8,DEKVFTKELDQWI; 41,AKEILTKESNVQE; 29,LSESQVKSLCEKA" 21:21890473; 8:21890473; 41:21890473; 29:21890473 PPP2CA Homo sapiens (Human) 21; 8; 41; 29 "21,EQLNECKQLSESQ; 8,DEKVFTKELDQWI; 41,AKEILTKESNVQE; 29,LSESQVKSLCEKA" 21:21890473; 8:21890473; 41:21890473; 29:21890473