PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus IKZF1 CRBN 24328678,26183205,24292623 biogrid,intact exp G G G G GP G G G G G G G GP G G G G G G G G G G G GP G G G KDM1A CRBN 23455924 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PRKAA1 CRBN 21232561 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GRB2 CRBN 25814554 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CRBN PAK7 25416956 biogrid,intact exp GP G GP P P G P P P GP GP G P P P P P G COPS6 CRBN 19295130,19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBA52 CRBN 25043012 dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MEIS2 CRBN 25043012 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP GP GP G GP GP GP G PSMB4 CRBN 23026050 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP G GTF2F2 CRBN 20195357 intact exp GP P G GP P G GP P G P P P P G P GP G P G P GP GP GP GP P GP GP RBX1 CRBN 20223979 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G PSMA2 CRBN 23026050 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CRBN COPS4 19295130 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CRBN COPS3 19295130 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBPMS CRBN 25416956 biogrid,intact exp GP GP G G G G G G GP G GP GP GP GP G GP G GP G G G GP GP G GP G GP GP G SUV39H1 CRBN 23455924 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4A CRBN 20223979,21145461,16964240 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 CRBN 20223979,25108355,16964240 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIK3R3 CRBN 25814554 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP G GP G GP GP GP GP G CRBN IKZF3 24328678,24292623 biogrid exp G G G G G GP G G G G APPL2 CRBN 25814554 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CLCN1 CRBN 26021757 biogrid exp, ortho G G G G G COPS5 CRBN 21145461, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CLCN4 CRBN ortho P P G P GP G GP P G P GP P P P GP P P G P P GP GP GP P P P G RPN2 CRBN 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LONP1 CRBN 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCD5 CRBN 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G PRSS12 CRBN 21836163 pred G P G P P P P P G G G GP P G G G PSMD6 CRBN 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CC2D1A CRBN 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRPC4AP CRBN 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G RPN1 CRBN 21836163 pred G GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TUSC3 CRBN 21836163 pred GP GP G G GP GP G GP GP G GP P GP G G GP GP GP GP G GP GP GP GP GP GP GP G CUL4B CRBN 25402006 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP GP GP GP G LONRF3 CRBN 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G LONRF2 CRBN 23023127 pred G G G G G G G G G G G G G G G G G G G G G G STT3A CRBN 21836163 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G STT3B CRBN 21836163 pred GP GP G G G GP G GP GP G G G GP G G G GP G GP G GP G G GP G G GP GP G LONRF1 CRBN 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G TRAM1 CRBN 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PMM1 CRBN 21836163 pred GP GP G G G GP G GP G G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RBX1 CRBN MI:0004(affinity chromatography technology) 20223979 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_154034 prey bait PSMA2 CRBN MI:0018(two hybrid) 23026050 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_217574 bait prey COPS6 CRBN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19295130,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_120445|BIOGRID_221803|UniProt_100633 bait|bait|bait prey|prey|prey KDM1A CRBN MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 23455924 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_297399|UniProt_129378 prey|bait bait|prey SUV39H1 CRBN MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 23455924 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_129377|BIOGRID_297400 bait|prey prey|bait GTF2F2 CRBN MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104885 bait prey COPS5 CRBN MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205115 bait prey IKZF1 CRBN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24292623,24328678 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_309448|BIOGRID_307491|BIOGRID_307489 prey|bait|prey bait|prey|bait UBC CRBN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20223979,21139048,21890473,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_174846|BIOGRID_154035|BIOGRID_268330|BIOGRID_170425 bait|prey|bait|bait prey|bait|prey|prey DDB1 CRBN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16964240,20223979 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_122484|BIOGRID_154032 bait|prey prey|bait PSMB4 CRBN MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 23026050 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_217573|BIOGRID_217571|BIOGRID_217572|BIOGRID_217570 bait|prey|prey|prey prey|bait|bait|bait CRBN COPS3 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221760 prey bait CUL4A CRBN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16964240,20223979,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_202946|BIOGRID_154033|BIOGRID_122511 bait|prey|bait prey|bait|prey CRBN COPS4 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221782 prey bait AMPKa1 CRBN MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21232561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_197829|BIOGRID_197828|BIOGRID_197827 bait|prey|prey prey|bait|bait CRBN IKZF3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24292623,24328678 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_307490|BIOGRID_309447 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality RBX1 CRBN 20223979,23983124 0004,0004 LC IKZF1 CRBN 26183205,24328678,24292623 0096,0004,0004 LC CUL4A CRBN 25860244,16964240,23983124,27142104,20223979,21145461,26231201 0004,0004,0004,0004,0004,0004,0004 LC,HT DDB1 CRBN 25860244,16964240,23983124,27142104,20223979,26231201 0004,0004,0004,0004,0004,0004 LC COPS6 CRBN 19615732,19615732,19295130 0004,0007,0004 HT,LC COPS5 CRBN 21145461 0004 HT CRBN IKZF3 24328678,24292623 0004,0004 LC CUL4A CRBN 21145461 0004 HT COPS6 CRBN 19615732,19615732 0004,0007 HT COPS5 CRBN 21145461 0004 HT RBX1 CRBN 20223979,23983124 0004,0004 LC IKZF1 CRBN 26183205,24328678,24292623 0096,0004,0004 LC CUL4A CRBN 25860244,16964240,23983124,27142104,20223979,26231201 0004,0004,0004,0004,0004,0004 LC DDB1 CRBN 25860244,16964240,23983124,27142104,20223979,26231201 0004,0004,0004,0004,0004,0004 LC COPS6 CRBN 19295130 0004 LC CRBN IKZF3 24328678,24292623 0004,0004 LC MEIS2 CRBN 25043012 0415 LC SUV39H1 CRBN 23455924 0018 HT KDM1A CRBN 23455924 0018 HT UBC CRBN 25043012 0808 LC GTF2F2 CRBN 20195357 0034 LC PSMB4 CRBN 23026050,23026050,23026050 0096,0004,0018 LC GRB2 CRBN 25814554,25814554,25814554 0397,0018,1356 HT PRKAA1 CRBN 21232561,21232561 0004,0018 LC TUSC3 CRBN 24685145 0114 LC DDB1 CRBN PDB_4TZ4,25108355 0114,0114 LC APPL2 CRBN 25814554,25814554 0397,0018 HT PIK3R3 CRBN 25814554,25814554 0397,0018 HT RBPMS CRBN 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CRBN PAK7 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96SW2 Q8D015 CRBN Q8D015 0.126 20711500 Q9H9S0 Q96SW2 NANOG CRBN 0.126 26687479 Q96SW2 P25787 CRBN PSMA2 0.21 23026050 Q96SW2 Q7CI00 CRBN FLAF 0.126 20711500 Q96SW2 Q7L190 CRBN DPPA4 0.126 26687479 Q96SW2 P13984 CRBN GTF2F2 0.126 20195357 Q96SW2 O43463 CRBN SUV39H1 0.332 23455924 Q96SW2 P62877 CRBN RBX1 0.376 20223979,23983124 Q96SW2 Q13422 CRBN IKZF1 0.61 24292623,26183205,24328678 Q96SW2 Q8IVT2 CRBN MISP 0.236 unassigned1304 Q9UKT9 Q96SW2 IKZF3 CRBN 0.376 24292623,24328678 Q96SW2 Q3U1J4 CRBN DDB1 0.236 20360068 Q96SW2 Q7L5N1 CRBN COPS6 0.332 19615732,19295130 Q96SW2 P62993 CRBN GRB2 0.376 25814554 Q96SW2 Q13619 CRBN CUL4A 0.814 16964240,21145461,25860244,20223979,26231201,23983124,27142104 Q96SW2 Q92905 CRBN COPS5 0.126 21145461 Q96SW2 Q93062 CRBN RBPMS 0.454 25416956 Q96SW2 P28070 CRBN PSMB4 0.702 23026050 Q96SW2 Q92569 CRBN PIK3R3 0.286 25814554 Q9BSM1 Q96SW2 PCGF1 CRBN 0.126 26687479 Q9BT78 Q96SW2 COPS4 CRBN 0.126 19295130 Q96SW2 Q8NEU8 CRBN APPL2 0.286 25814554 Q96SW2 O14770 CRBN MEIS2 0.309 25043012 Q96SW2 Q3V8F6 CRBN YSUI 0.126 20711500 Q96SW2 O60341 CRBN KDM1A 0.332 23455924 Q96SW2 P35523 CRBN CLCN1 0.21 26021757 Q96SW2 Q13620 CRBN CUL4B 0.21 27142104 Q96SW2 Q8TB93 CRBN PAK7 0.332 25416956 Q9P286 Q96SW2 PAK7 CRBN 0.183 25416956 Q9UKV8 Q96SW2 AGO2 CRBN 0.376 27142104 Q9UNS2 Q96SW2 COPS3 CRBN 0.126 19295130 Q96SW2 Q13131 CRBN PRKAA1 0.569 21232561 Q96SW2 Q01860 CRBN POU5F1 0.126 26687479 Q96SW2 Q16531 CRBN DDB1 0.814 16964240,25108355,25860244,20223979,26231201,23983124,27142104

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MEIS2 CRBN MI:0045 experimental interaction detection MI:0461 interaction database SUV39H1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database KDM1A CRBN MI:0045 experimental interaction detection MI:0461 interaction database CDK1 CRBN MI:0362 inference MI:0461 interaction database UBB CRBN MI:0362 inference MI:0461 interaction database UBC CRBN MI:0045 experimental interaction detection MI:0461 interaction database GTF2F2 CRBN MI:0045 experimental interaction detection MI:0461 interaction database RPA2 CRBN MI:0362 inference MI:0461 interaction database TAF1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database PSMA2 CRBN MI:0045 experimental interaction detection MI:0461 interaction database PSMB4 CRBN MI:0045 experimental interaction detection MI:0461 interaction database CLCN1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database CSNK1A1 CRBN MI:0362 inference MI:0461 interaction database NUDT6 CRBN MI:0362 inference MI:0461 interaction database COPS2 CRBN MI:0362 inference MI:0461 interaction database RBX1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database RPS27A CRBN MI:0362 inference MI:0461 interaction database UBA52 CRBN MI:0362 inference MI:0461 interaction database GRB2 CRBN MI:0045 experimental interaction detection MI:0461 interaction database POU5F1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database GPS1 CRBN MI:0362 inference MI:0461 interaction database PRKAA1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database IKZF1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database CUL4A CRBN MI:0045 experimental interaction detection MI:0461 interaction database CUL4B CRBN MI:0045 experimental interaction detection MI:0461 interaction database DYRK1A CRBN MI:0362 inference MI:0461 interaction database NEDD8 CRBN MI:0362 inference MI:0461 interaction database DDB1 CRBN MI:0045 experimental interaction detection MI:0461 interaction database DPPA4 CRBN MI:0045 experimental interaction detection MI:0461 interaction database COPS6 CRBN MI:0045 experimental interaction detection MI:0461 interaction database APPL2 CRBN MI:0045 experimental interaction detection MI:0461 interaction database PIK3R3 CRBN MI:0045 experimental interaction detection MI:0461 interaction database COPS5 CRBN MI:0045 experimental interaction detection MI:0461 interaction database RBPMS CRBN MI:0045 experimental interaction detection MI:0461 interaction database CRBN COPS8 MI:0362 inference MI:0461 interaction database CRBN PCGF1 MI:0045 experimental interaction detection MI:0461 interaction database CRBN COPS4 MI:0045 experimental interaction detection MI:0461 interaction database CRBN NANOG MI:0045 experimental interaction detection MI:0461 interaction database CRBN PAK7 MI:0045 experimental interaction detection MI:0461 interaction database CRBN COPS7A MI:0362 inference MI:0461 interaction database CRBN IKZF3 MI:0045 experimental interaction detection MI:0461 interaction database CRBN AGO2 MI:0045 experimental interaction detection MI:0461 interaction database CRBN COPS3 MI:0045 experimental interaction detection MI:0461 interaction database