PTM - CPLM Gene Name UniProt ID Type Position Code TFG Q92734 Ubiquitination 47 K TFG Q92734 Ubiquitination 103 K TFG Q92734 Ubiquitination 155 K TFG Q92734 Ubiquitination 172 K TFG Q92734 Ubiquitination 147 K TFG Q92734 Ubiquitination 179 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TFG Q92734 100 S Homo sapiens(Human) TFG Q92734 140 T Homo sapiens(Human) TFG Q92734 148 S Homo sapiens(Human) TFG Q92734 150 S Homo sapiens(Human) TFG Q92734 152 S Homo sapiens(Human) TFG Q92734 164 S Homo sapiens(Human) TFG Q92734 193 S Homo sapiens(Human) TFG Q92734 197 S Homo sapiens(Human) TFG Q92734 204 S Homo sapiens(Human) TFG Q92734 206 T Homo sapiens(Human) TFG Q92734 209 S Homo sapiens(Human) TFG Q92734 212 S Homo sapiens(Human) TFG Q92734 213 S Homo sapiens(Human) TFG Q92734 214 S Homo sapiens(Human) TFG Q92734 215 S Homo sapiens(Human) TFG Q92734 229 Y Homo sapiens(Human) TFG Q92734 230 T Homo sapiens(Human) TFG Q92734 234 T Homo sapiens(Human) TFG Q92734 247 Y Homo sapiens(Human) TFG Q92734 33 Y Homo sapiens(Human) TFG Q92734 369 S Homo sapiens(Human) TFG Q92734 372 T Homo sapiens(Human) TFG Q92734 376 S Homo sapiens(Human) TFG Q92734 381 Y Homo sapiens(Human) TFG Q92734 392 Y Homo sapiens(Human) TFG Q92734 393 T Homo sapiens(Human) TFG Q92734 399 Y Homo sapiens(Human) TFG Q92734 50 S Homo sapiens(Human) TFG Q92734 8 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q92734 K47-ac Acetylation MQRVFRGkLLsNDEV Q92734 K103-ac Acetylation PLESsQVkYLRRELI Q92734 R22-m1 Methylation AQLGEDIrRIPIHNE Q92734 R383-m2 Methylation sGPNPyArNrPPFGQ Q92734 R385-m2 Methylation PNPyArNrPPFGQGy Q92734 R385-m1 Methylation PNPyArNrPPFGQGy Q92734 R400-m1 Methylation tQPGPGyr_______ Q92734 R400-m2 Methylation tQPGPGyr_______ Q92734 S8-p Phosphorylation MNGQLDLsGKLIIKA Q92734 Y33-p Phosphorylation IHNEDITyDELVLMM Q92734 S50-p Phosphorylation VFRGkLLsNDEVTIK Q92734 S100-p Phosphorylation QPRPLESsQVkYLRR Q92734 T140-p Phosphorylation TNIPENDtVdGREEk Q92734 S148-p Phosphorylation VdGREEksAsDsSGk Q92734 S150-p Phosphorylation GREEksAsDsSGkQS Q92734 S152-p Phosphorylation EEksAsDsSGkQSTQ Q92734 S164-p Phosphorylation STQVMAAsMsAFDPL Q92734 S166-p Phosphorylation QVMAAsMsAFDPLkN Q92734 S183-p Phosphorylation EINkNVMsAFGLTDD Q92734 S193-p Phosphorylation GLTDDQVsGPPsAPA Q92734 S197-p Phosphorylation DQVsGPPsAPAEDRs Q92734 S204-p Phosphorylation sAPAEDRsGtPDsIA Q92734 T206-p Phosphorylation PAEDRsGtPDsIAss Q92734 S209-p Phosphorylation DRsGtPDsIAssssA Q92734 S212-p Phosphorylation GtPDsIAssssAAHP Q92734 S213-p Phosphorylation tPDsIAssssAAHPP Q92734 S214-p Phosphorylation PDsIAssssAAHPPG Q92734 S215-p Phosphorylation DsIAssssAAHPPGV Q92734 Y229-p Phosphorylation VQPQQPPytGAQtQA Q92734 T230-p Phosphorylation QPQQPPytGAQtQAG Q92734 T234-p Phosphorylation PPytGAQtQAGQIEG Q92734 Y247-p Phosphorylation EGQMYQQyQQQAGYG Q92734 T372-p Phosphorylation SLPGSTMtPPPsGPN Q92734 S376-p Phosphorylation STMtPPPsGPNPyAr Q92734 Y381-p Phosphorylation PPsGPNPyArNrPPF Q92734 Y392-p Phosphorylation rPPFGQGytQPGPGy Q92734 T393-p Phosphorylation PPFGQGytQPGPGyr Q92734 Y399-p Phosphorylation ytQPGPGyr______ Q92734 K47-ub Ubiquitination MQRVFRGkLLsNDEV Q92734 K103-ub Ubiquitination PLESsQVkYLRRELI Q92734 K147-ub Ubiquitination tVdGREEksAsDsSG Q92734 K155-ub Ubiquitination sAsDsSGkQSTQVMA Q92734 K172-ub Ubiquitination MsAFDPLkNQDEINk Q92734 K179-ub Ubiquitination kNQDEINkNVMsAFG

PTM - dbPTM UniProt ID Position Code Type Resources References Q92734 1 M Acetylation Swiss-Prot 1010711 19413330 Q92734 197 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q92734 197 S Phosphorylation PhosphoELM.10011 18669648 Q92734 142 D Caspase Phosphositeplus.1010730 18724940 Q92734 103 K Ubiquitylation Phosphositeplus.1010730 21890473 Q92734 147 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92734 155 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92734 172 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92734 179 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92734 47 K Ubiquitylation Phosphositeplus.1010730 21890473 Q92734 193 S Phosphorylation Phosphositeplus.1010730 20068231 Q92734 197 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20058876;20068231;20166139;20230923 Q92734 247 Y Phosphorylation Phosphositeplus.1010730 18698806 Q92734 33 Y Phosphorylation Phosphositeplus.1010730 18698806 Q92734 392 Y Phosphorylation Phosphositeplus.1010730 20090780;20736484 Q92734 399 Y Phosphorylation Phosphositeplus.1010730 20090780 Q92734 193 S Phosphorylation HPRD 9.0 20068231 Q92734 197 S Phosphorylation HPRD 9.0 18669648,20230923,20166139,20068231,20058876 Q92734 197 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References TFG 193 S Phosphorylation 20068231 TFG 197 S Phosphorylation 18669648,20230923,20166139,20068231,20058876

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q92734 197 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q92734 1 N-acetylmethionine 19413330;22223895 Q92734 50 Phosphoserine 23186163 Q92734 197 Phosphoserine 18669648;19690332;23186163;24275569 Q92734 385 Omega-N-methylarginine 24129315 Q92734 400 Omega-N-methylarginine 24129315

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TFG IPI00294619 S 193 LTDDQVpSGPPSAP phosphorylation TFG IPI00294619 S 197 QVSGPPpSAPAEDR phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10342 115624 - K Ubiquitination 21139048 10342 115624 - K Ubiquitination 21890473 10342 115624 - K Ubiquitination 21906983 10342 115624 - K Ubiquitination 23000965 10342 115624 - K FAT10ylation 23862649 10342 115624 - K Ubiquitination 24999993 10342 115624 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TFG Homo sapiens (Human) 103; 147; 47 "103,LESSQVKYLRREL; 147,VDGREEKSASDSS; 47,QRVFRGKLLSNDE" 103:21890473; 147:21906983; 47:21890473 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 155:21906983; 172:21906983; 179:21906983; 147:21906983; 47:21890473 TFG Homo sapiens (Human) 147 "147,VDGREEKSASDSS" 147:21906983 TFG Homo sapiens (Human) 155; 172; 179; 147 "155,ASDSSGKQSTQVM; 172,SAFDPLKNQDEIN; 179,NQDEINKNVMSAF; 147,VDGREEKSASDSS" 155:21906983; 172:21906983; 179:21906983; 147:21906983 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 47:21890473 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 47:21890473 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 47:21890473 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 155:21906983; 172:21906983; 179:21906983; 147:21906983; 47:21890473 TFG Homo sapiens (Human) 103; 155; 172; 179; 147 "103,LESSQVKYLRREL; 155,ASDSSGKQSTQVM; 172,SAFDPLKNQDEIN; 179,NQDEINKNVMSAF; 147,VDGREEKSASDSS" 103:21890473; 155:21906983; 172:21906983; 179:21906983; 147:21906983 TFG Homo sapiens (Human) 103; 47 "103,LESSQVKYLRREL; 47,QRVFRGKLLSNDE" 103:21890473; 47:21890473