PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP9Y CSNK1E 23455922 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y BABAM1 19214193 intact exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y MAPT 1723470 hprd,bci exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y SIRT1 19343720 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y UBC 23287719 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y PMS1 17148452 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y SHC1 19380743 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G USP9Y VSX1 26186194 biogrid exp USP9Y USP46 23023127 pred G G G G G G G G G G G G G G G G G G G G G USP9Y DDX3Y 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y 25402006 pred USP9Y USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP44 23023127 pred G G USP9Y RAD23B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y FAF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y ZFY 25402006 pred G G G G G G USP9Y KDM5D 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y RPS4Y1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP17L2 23023127 pred USP9Y PARK2 23023127 pred G G G G G G G G G G G G G G G USP9Y CIDEA 23023127 pred G G G G G G USP9Y YOD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y RNF13 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP33 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y USP14 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y UTY 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G USP9Y EIF1AY 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O00507 I6L9H5 affinity chromatography technology 17148452 physical association X 2 P0CG48 O00507 unspecified method 23287719 direct interaction X 2 P0CG48 O00507 affinity chromatography technology 21890473 physical association X 2 P0CG48 O00507 affinity chromatography technology 23000965 physical association X 2 P0CG48 O00507 affinity chromatography technology 22118674 physical association X 2 P0CG48 O00507 affinity chromatography technology 21906983 physical association X 2 P49674 O00507 affinity chromatography technology 23455922 physical association X 2 O00507 P29353-5 affinity chromatography technology 19380743 physical association X 2 O00507 B0QZ35 affinity chromatography technology 19343720 physical association X 2 O00507 in vivo 1723470 - X 2 O00507 in vivo 1723470 - X 2 O00507 pull down 19343720 physical association C 28 O00507 tandem affinity purification 23455922 association C 39 O00507 biochemical 19214193 association C 31 O00507 tandem affinity purification 19380743 association C 29 O00507 Q7CL85 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP9Y HDAC2 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_192815 prey bait USP9Y MAPT MI:0493(in vivo) 1723470 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_37537 - - USP9Y SHC1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19380743 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_99108|BIOGRID_219712 prey|prey bait|bait USP9Y SIRT2 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_193360 prey bait USP9Y CSNK1E MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_277057|UniProt_127601 prey|prey bait|bait USP9Y UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method) 21890473,21906983,22118674,23000965,23287719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_263646|BIOGRID_269207|BIOGRID_160419|BIOGRID_177558|BIOGRID_249561 prey|prey|prey|prey|bait bait|bait|bait|bait|prey USP9Y SIRT1 MI:0004(affinity chromatography technology)|MI:0096(pull down) 19343720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_152891|UniProt_99463 prey|prey bait|bait USP9Y PMS1 MI:0004(affinity chromatography technology) 17148452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122108 prey bait

PPI - HINT Gene A Gene B PMID Method Quality USP9Y SHC1 19380743,19380743 0004,0676 HT USP9Y CSNK1E 23455922,23455922 0004,0676 HT USP9Y VSX1 26186194 0004 HT USP9Y SHC1 19380743,19380743 0004,0676 HT USP9Y CSNK1E 23455922,23455922 0004,0676 HT USP9Y VSX1 26186194 0004 HT USP9Y BABAM1 19214193 0401 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 USP9Y NTN3 MI:0362 inference MI:0461 interaction database USP9Y NTN1 MI:0362 inference MI:0461 interaction database USP9Y UBC MI:0045 experimental interaction detection MI:0461 interaction database USP9Y LAMP1 MI:0362 inference MI:0461 interaction database USP9Y LAMP2 MI:0362 inference MI:0461 interaction database USP9Y PSMB1 MI:0362 inference MI:0461 interaction database USP9Y SHC1 MI:0045 experimental interaction detection MI:0461 interaction database USP9Y CTNNB1 MI:0362 inference MI:0461 interaction database USP9Y CSNK1E MI:0045 experimental interaction detection MI:0461 interaction database USP9Y PPP5C MI:0362 inference MI:0461 interaction database USP9Y PMS1 MI:0045 experimental interaction detection MI:0461 interaction database USP9Y UBE2D2 MI:0362 inference MI:0461 interaction database USP9Y MIB1 MI:0362 inference MI:0461 interaction database USP9Y HSPH1 MI:0362 inference MI:0461 interaction database USP9Y SIRT1 MI:0045 experimental interaction detection MI:0461 interaction database USP9Y BABAM1 MI:0045 experimental interaction detection MI:0461 interaction database USP9Y VSX1 MI:0045 experimental interaction detection MI:0461 interaction database USP9Y EPN1 MI:0362 inference MI:0461 interaction database