PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ABTB1 DNTTIP1 19930467 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G P GP GP P GP GP GP GP P G EEF1D ABTB1 21516116 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G EEF1A2 ABTB1 25416956 biogrid,intact exp G G GP G GP G G P G G GP GP G P GP G GP G GP G SMAD2 ABTB1 15231748 hprd,biogrid,i2d,mint,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G SMAD9 ABTB1 15231748 hprd,biogrid,i2d,mint,intact exp GP GP G GP G GP GP G GP GP GP G GP GP G P G GP GP GP GP GP GP GP P G CUL3 ABTB1 25416956,21145461 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G DNAJB1 ABTB1 ortho GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G TLX3 ABTB1 ortho P P P P P P P P P P P P P P P P P P DMRTC2 ABTB1 ortho P P P P P P P P P P P P P DUSP1 ABTB1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G EGR2 ABTB1 21836163 pred G G G G G G G G G G G G G G G G G G G G HCLS1 ABTB1 21836163 pred G G G G G GP G G G G G G GP GP G G GP G G G G G G G G GP G G PTEN ABTB1 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q969K4 Q05639 two hybrid 25416956 direct interaction X 2 Q15796-2 Q969K4 two hybrid 15231748 direct interaction X 2 Q969K4 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q969K4 A0A024R475 two hybrid 25416956 direct interaction X 2 Q9H147 Q969K4 pull down 19930467 direct interaction X 2 Q9H147 Q969K4 affinity chromatography technology 19930467 physical association X 2 Q969K4 two hybrid 15231748 direct interaction X 2 Q969K4 Q05639 two hybrid prey pooling approach 25416956 physical association X 2 Q969K4 Q05639 two hybrid array 25416956 physical association X 2 Q969K4 Q05639 validated two hybrid 25416956 physical association X 2 O15198 Q969K4 two hybrid 15231748 physical association X 2 Q15796 Q969K4 two hybrid 15231748 physical association X 2 Q969K4 A0A024R475 two hybrid prey pooling approach 25416956 physical association X 2 Q969K4 A0A024R475 two hybrid array 25416956 physical association X 2 Q969K4 A0A024R475 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMAD9 ABTB1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_258717|HPRD_2122|MINT_61453|UniProt_79121|MINT_32605 bait|-|bait|bait|bait prey|-|prey|prey|prey CUL3 ABTB1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202062 bait prey ABTB1 DNTTIP1 MI:0096(pull down)|MI:0096(pull down) 19930467 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_146272|BIOGRID_146273 bait|prey prey|bait SMAD2 ABTB1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0468(hprd) UniProt_78592|MINT_60269|MINT_31504|BIOGRID_259196|HPRD_38295 bait|bait|bait|bait|- prey|prey|prey|prey|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q969K4 Q05639 ABTB1 EEF1A2 0.454 25416956 Q969K4 Q13618 ABTB1 CUL3 0.523 25416956,21145461 Q969K4 P53212 ABTB1 HAH1 0.332 27107014 Q969K4 P29692 ABTB1 EEF1D 0.183 21516116 Q969K4 O15198 ABTB1 SMAD9 0.332 15231748 Q969K4 Q15796 ABTB1 SMAD2 0.332 15231748 Q9H147 Q969K4 DNTTIP1 ABTB1 0.454 19930467

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SMAD9 ABTB1 MI:0045 experimental interaction detection MI:0461 interaction database TLX3 ABTB1 MI:0362 inference MI:0461 interaction database DNAJB5 ABTB1 MI:0362 inference MI:0461 interaction database RCC1 ABTB1 MI:0362 inference MI:0461 interaction database DNAJB1 ABTB1 MI:0362 inference MI:0461 interaction database EEF1G ABTB1 MI:0362 inference MI:0461 interaction database EEF1D ABTB1 MI:0045 experimental interaction detection MI:0461 interaction database TCL1A ABTB1 MI:0362 inference MI:0461 interaction database DNAJB13 ABTB1 MI:0362 inference MI:0461 interaction database RBX1 ABTB1 MI:0362 inference MI:0461 interaction database EWSR1 ABTB1 MI:0362 inference MI:0461 interaction database EEF1A2 ABTB1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 ABTB1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 ABTB1 MI:0045 experimental interaction detection MI:0461 interaction database DMRTC2 ABTB1 MI:0362 inference MI:0461 interaction database ABTB1 TACO1 MI:0362 inference MI:0461 interaction database ABTB1 DNTTIP1 MI:0045 experimental interaction detection MI:0461 interaction database ABTB1 DNAJB4 MI:0362 inference MI:0461 interaction database