PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SIAH2 SCAP 23518348 intact exp G G G G G G G G G G G G G G G G G G G G G G G SCAP LPAR1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G SREBF1 SCAP 9242699 biogrid exp G GP G G G GP G G G G GP G GP GP G G GP G G G GP GP G G G G G G G NCOR1 SCAP 23518348 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SCAP NUDC 25036637 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SCAP MCOLN3 26186194 biogrid exp G GP P G G G G GP G G G P G G G G G G G G SEC24B SCAP 19706601 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SCAP RNF139 19706601 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SCAP BTNL8 26186194 biogrid exp P G GP P P P P P GP P P P P GP P P AR SCAP 23518348 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G GP G ERLIN2 SCAP 24217618,22690709 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP ATP1B4 26186194 biogrid exp P P P P GP P P P P P P P P P P P P GP GP P P P SCAP SCAP 15782218 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GLRA2 SCAP 26186194 biogrid exp G P G G G G G P G G G G G G G G G G SCAP MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SCAP RPTOR 26344197 biogrid exp GP GP G P GP G P P G P GP P GP G P GP P P G GP GP GP GP P GP P GP G SCAP NAALADL2 26186194 biogrid exp P P P P P P P P P P P P P P PGRMC1 SCAP 15782218 hprd,bci exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VCAM1 SCAP 22623428 intact exp G G G G G G G G G G GP G G GP G G G G G G G G G G G GP G GP G SCAP NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HLA-C SCAP 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAP INSIG2 12242332,12482938,16549805, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP INSIG1 SCAP 12242332,17043353,12202038,12842885,23564452,18835813,12482938, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAP MBTPS1 21836163 bci exp, pred G G G G G GP G GP GP G G G GP G G GP GP GP GP G GP G G G GP G GP GP G SCAP SREBF2 9242699,10896675, 25402006, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP G GP GP GP GP GP GP G UBE2I SCAP 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SMAD3 SCAP 25402006 pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G SCAP RTN1 21836163 pred GP G G GP G G G G G G G GP GP G G G G G XBP1 SCAP 21836163 pred GP G G G GP GP G G GP G GP G G G G GP GP G GP G G G GP GP GP GP GP GP G HOXA5 SCAP 23023127 pred GP GP G GP P G P GP GP GP GP GP G GP GP G GP G P GP GP G GP G GP P G SEC61A1 SCAP 21836163 pred G GP G G GP GP G G G G GP GP G G G GP GP G GP G GP G G G GP G GP GP G SCAP BTBD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SP1 SCAP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ENG SCAP 25402006 pred G G G G G GP G G GP G GP G G G G GP GP GP G G GP G G G GP G GP G G SCAP DNAJB11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GPR85 SCAP 21836163 pred G G G G SCAP TRIB3 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AGT SCAP 23023127 pred GP GP G G G GP G G GP G GP GP GP G G G GP GP GP G P GP G G G G GP GP G MAPK3 SCAP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP DAG1 25402006 pred G G G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G SCAP EIF2A 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G G GP GP GP GP G GP GP G LRP1 SCAP 23023127 pred G G G G G GP G G G G G GP GP G G G GP GP G G GP G G G G G G GP G ITGAV SCAP 23023127 pred GP GP G G GP GP G GP GP G GP GP G G G G GP GP GP G GP GP G G G GP GP GP G SCAP SYVN1 21836163 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP ARFGAP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP RNF123 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAP NR1H3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LMNA SCAP 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AP3D1 SCAP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAP MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MBTPS2 SCAP 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PLOD3 SCAP 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP G G GP G G G GP GP GP GP G SCAP ADIPOQ 23023127 pred GP G G G G GP GP P G G G G P G G G GP G G PLA2G4A SCAP 23023127 pred GP GP G GP P GP GP GP P GP G G GP P GP P G GP GP G GP P SCAP ZNF106 23023127 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G GP GP GP GP GP GP G HNF4A SCAP 25402006 pred GP G G G GP GP GP GP G GP G G GP G GP GP P P G SCAP NPRL3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G SCAP EDEM1 21836163 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VCP SCAP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKB1 SCAP 23023127 pred GP G G G GP G G G GP G G G GP GP G GP G G G G GP GP GP G GP GP G GP G GNB2 SCAP 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G G GP G GP G GP GP G SCAP NISCH 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP LDLRAP1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G G GP GP GP G GP G GP GP G GP GP GP G SCAP HDAC6 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SCAP FAF2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FGF19 SCAP 23023127 pred P P P P P P P P P P P P P P P P P P SCAP GTF3C1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP CREBBP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 SCAP 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP SCRIB 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G G GP G GP GP GP G GP G GP GP G ITGB3 SCAP 23023127 pred GP G G G GP GP G GP G G GP G GP G G G GP G G G G G G G G G GP G HMGCR SCAP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCAP DCAF6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAP MED15 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RGS9 SCAP 23023127 pred G G G G G G G G DHH SCAP 23023127 pred P P P P G P P P P P P P P P G P P P P P P P GP SCAP DHX30 25402006 pred G GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP G GP GP G SCAP IGFBP7 23023127 pred G G G G G G G G G G GP G G G G G G G GP G G G G G G G G GP G SCAP WDTC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12770 A0A024RAI2 affinity chromatography technology 12242332 physical association X 2 Q12770 A0A024RAI2 affinity chromatography technology 16549805 physical association X 2 A0A024R1Q0 Q12770 affinity chromatography technology 9242699 physical association X 2 Q8WU17 Q12770 affinity chromatography technology 19706601 physical association X 2 P0CG48 Q12770 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q12770 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q12770 affinity chromatography technology 21906983 physical association X 2 Q12770 P36956-5 affinity chromatography technology 9242699 physical association X 2 Q12770 O15503-2 affinity chromatography technology 12242332 physical association X 2 Q12770 affinity chromatography technology 22690709 physical association X 2 Q12770 affinity chromatography technology 24217618 physical association X 2 Q12770 O15503-2 affinity chromatography technology 23564452 physical association X 2 Q12770 O15503-2 affinity chromatography technology 12842885 physical association X 2 Q12770 O15503-2 affinity chromatography technology 18835813 physical association X 2 Q12770 O15503-2 affinity chromatography technology 17043353 physical association X 2 Q12770 O95487 pull down 19706601 direct interaction X 2 Q12770 O00264 cross-linking study 15782218 association X 2 Q12770 O00264 coimmunoprecipitation 15782218 association X 2 Q12770 O00264 in vivo 15782218 - X 2 Q12770 P70168 in vitro 10896675 - X 2 Q12770 P70168 in vivo 10896675 - X 2 Q12770 P70168 in vitro 10896675 - X 2 Q12770 P70168 in vivo 10896675 - X 2 Q12770 O00264 in vivo 15782218 - X 2 Q12770 in vivo 12242332 - C 3 Q12770 in vivo 12242332 - C 3 Q12770 in vivo 12242332 - C 3 Q12770 O15503-2 in vitro 12202038,12482938,12842885 - X 2 Q12770 O15503-2 in vivo 12202038,12482938,12842885 - X 2 Q12770 B4DQ23 in vitro 12242332,12482938 - X 2 Q12770 B4DQ23 in vivo 12242332,12482938 - X 2 Q12770 Q12770 in vivo 15782218 - X 2 Q12770 O15503-2 in vitro 12202038,12482938,12842885 - X 2 Q12770 O15503-2 in vivo 12202038,12482938,12842885 - X 2 Q12770 B4DQ23 in vitro 12242332,12482938 - X 2 Q12770 B4DQ23 in vivo 12242332,12482938 - X 2 Q12770 cross-linking study 22623428 association C 183 Q12770 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SCAP RNF139 MI:0004(affinity chromatography technology) 19706601 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148302 prey bait SCAP INSIG2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0493(in vivo) 12242332,12482938,16549805 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|- (biogrid)|(biogrid)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_212334|BIOGRID_124608|HPRD_9221|HPRD_40511 prey|prey|-|- bait|bait|-|- PGRMC1 SCAP MI:0493(in vivo) 15782218 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_18195 - - SEC24B SCAP MI:0004(affinity chromatography technology) 19706601 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_148303 prey bait SCAP NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295243 prey bait SREBF1 SCAP MI:0004(affinity chromatography technology) 9242699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211750 prey bait UBC SCAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_177022|BIOGRID_264382|BIOGRID_167587 bait|bait|bait prey|prey|prey INSIG1 SCAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12242332,12842885,17043353,18835813 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_88803|BIOGRID_212333|BIOGRID_142034|BIOGRID_116401|HPRD_9220 bait|bait|bait|bait|- prey|prey|prey|prey|- SCAP SREBF2 MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 10896675,12242332,9242699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|- (biogrid)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_211751|HPRD_7049|HPRD_40511 bait|-|- prey|-|- SCAP SCAP MI:0493(in vivo) 15782218 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_18193 - -

PPI - HINT Gene A Gene B PMID Method Quality INSIG1 SCAP 23564452,12242332,26555173,12242332,17043353,18835813,12842885 0004,0004,0004,0019,0004,0004,0004 LC ERLIN2 SCAP 22690709,24217618 0004,0004 LC GLRA2 SCAP 26186194 0004 HT SCAP HLA-C 26186194 0004 HT SCAP NAALADL2 26186194 0004 HT SCAP BTNL8 26186194 0004 HT SCAP RPTOR 26344197 0401 HT SCAP MCOLN3 26186194 0004 HT SCAP LPAR1 26186194 0004 HT SCAP ATP1B4 26186194 0004 HT SCAP INSIG2 12242332,12242332,16549805 0004,0019,0004 LC GLRA2 SCAP 26186194 0004 HT SCAP HLA-C 26186194 0004 HT SCAP NAALADL2 26186194 0004 HT SCAP BTNL8 26186194 0004 HT SCAP RPTOR 26344197 0401 HT SCAP MCOLN3 26186194 0004 HT SCAP LPAR1 26186194 0004 HT SCAP ATP1B4 26186194 0004 HT INSIG1 SCAP 23564452,12242332,26555173,12242332,17043353,18835813,12842885 0004,0004,0004,0019,0004,0004,0004 LC ERLIN2 SCAP 22690709,24217618 0004,0004 LC SCAP INSIG2 12242332,12242332,16549805 0004,0019,0004 LC PGRMC1 SCAP 15782218,15782218 0030,0019 LC INSIG1 SCAP 12242332,12242332 0004,0019 LC VCAM1 SCAP 22623428 0030 LC SCAP SCAP 15782218 0030 LC SCAP RPTOR 26344197 0401 LC SCAP NUDC 25036637 0729 HT SCAP INSIG2 12242332,12242332 0004,0019 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q58DX5 Q12770 NAALADL2 SCAP 0.126 26186194 Q12770 P23416 SCAP GLRA2 0.126 26186194 Q9HCE1 Q12770 MOV10 SCAP 0.126 22658674 Q8TDD5 Q12770 MCOLN3 SCAP 0.126 26186194 Q6UX41 Q12770 BTNL8 SCAP 0.126 26186194 Q12770 P10321 SCAP HLA-C 0.126 26186194 Q9Y5U4 Q12770 INSIG2 SCAP 0.376 16549805,12242332 Q12770 O94905 SCAP ERLIN2 0.376 22690709,24217618 Q8WU17 Q12770 RNF139 SCAP 0.21 19706601 Q92633 Q12770 LPAR1 SCAP 0.126 26186194 Q9UBU9 Q12770 NXF1 SCAP 0.126 22658674 Q9UN42 Q12770 ATP1B4 SCAP 0.126 26186194 Q9Y266 Q12770 NUDC SCAP 0.126 25036637 Q12772 Q12770 SREBF2 SCAP 0.21 9242699 Q12770 P36956 SCAP SREBF1 0.21 9242699 Q12770 O15503 SCAP INSIG1 0.757 18835813,12842885,23564452,26555173,17043353,12242332 Q12770 O95487 SCAP SEC24B 0.309 19706601 Q12770 P19320 SCAP VCAM1 0.126 22623428

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PGRMC1 SCAP MI:0045 experimental interaction detection MI:0461 interaction database INSIG1 SCAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SIAH2 SCAP MI:0045 experimental interaction detection MI:0461 interaction database NCOR1 SCAP MI:0045 experimental interaction detection MI:0461 interaction database SEC24D SCAP MI:0362 inference MI:1106 pathways database ERLIN2 SCAP MI:0045 experimental interaction detection MI:0461 interaction database SEC31A SCAP MI:0362 inference MI:1106 pathways database SEC24A SCAP MI:0362 inference MI:1106 pathways database SEC24B SCAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC SCAP MI:0045 experimental interaction detection MI:0461 interaction database AR SCAP MI:0045 experimental interaction detection MI:0461 interaction database HLA-C SCAP MI:0045 experimental interaction detection MI:0461 interaction database VCAM1 SCAP MI:0045 experimental interaction detection MI:0461 interaction database GLRA2 SCAP MI:0045 experimental interaction detection MI:0461 interaction database SREBF1 SCAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SEC24C SCAP MI:0362 inference MI:1106 pathways database SEC13 SCAP MI:0362 inference MI:1106 pathways database SCAP SREBF2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SCAP MBTPS1 MI:0362 inference MI:1106 pathways database SCAP SEC23A MI:0362 inference MI:1106 pathways database SCAP SEC23B MI:0362 inference MI:1106 pathways database SCAP NAALADL2 MI:0045 experimental interaction detection MI:0461 interaction database SCAP BTNL8 MI:0045 experimental interaction detection MI:0461 interaction database SCAP MCOLN3 MI:0045 experimental interaction detection MI:0461 interaction database SCAP RNF139 MI:0045 experimental interaction detection MI:0461 interaction database SCAP LPAR1 MI:0045 experimental interaction detection MI:0461 interaction database SCAP MOV10 MI:0045 experimental interaction detection MI:0461 interaction database SCAP SEC31B MI:0362 inference MI:1106 pathways database SCAP SAR1A MI:0362 inference MI:1106 pathways database SCAP NXF1 MI:0045 experimental interaction detection MI:0461 interaction database SCAP ATP1B4 MI:0045 experimental interaction detection MI:0461 interaction database SCAP NUDC MI:0045 experimental interaction detection MI:0461 interaction database SCAP INSIG2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SCAP SAR1B MI:0362 inference MI:1106 pathways database