PTM - CPLM Gene Name UniProt ID Type Position Code WDR75; UTP17 Q8IWA0 Acetylation 466 K WDR75; UTP17 Q8IWA0 Acetylation 226 K WDR75; UTP17 Q8IWA0 Ubiquitination 123 K WDR75; UTP17 Q8IWA0 Ubiquitination 354 K WDR75; UTP17 Q8IWA0 Ubiquitination 466 K WDR75; UTP17 Q8IWA0 Ubiquitination 701 K WDR75; UTP17 Q8IWA0 Ubiquitination 332 K WDR75; UTP17 Q8IWA0 Ubiquitination 281 K WDR75; UTP17 Q8IWA0 Ubiquitination 628 K WDR75; UTP17 Q8IWA0 Ubiquitination 203 K WDR75; UTP17 Q8IWA0 Ubiquitination 821 K WDR75; UTP17 Q8IWA0 Ubiquitination 427 K WDR75; UTP17 Q8IWA0 Ubiquitination 313 K WDR75; UTP17 Q8IWA0 Ubiquitination 136 K WDR75; UTP17 Q8IWA0 Ubiquitination 682 K WDR75; UTP17 Q8IWA0 Ubiquitination 283 K WDR75; UTP17 Q8IWA0 Ubiquitination 226 K WDR75; UTP17 Q8IWA0 Ubiquitination 411 K WDR75; UTP17 Q8IWA0 Ubiquitination 676 K WDR75; UTP17 Q8IWA0 Ubiquitination 671 K WDR75; UTP17 Q8IWA0 Ubiquitination 347 K WDR75; UTP17 Q8IWA0 Ubiquitination 611 K WDR75; UTP17 Q8IWA0 Ubiquitination 483 K WDR75; UTP17 Q8IWA0 Ubiquitination 145 K WDR75; UTP17 Q8IWA0 Ubiquitination 810 K WDR75; UTP17 Q8IWA0 Ubiquitination 455 K

PTM - dbPAF Gene Name UniProt ID Position Type Species WDR75; UTP17 Q8IWA0 192 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 194 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 195 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 196 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 404 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 413 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 551 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 560 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 664 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 672 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 678 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 680 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 692 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 693 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 696 Y Homo sapiens(Human) WDR75; UTP17 Q8IWA0 779 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 782 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 795 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 796 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 798 T Homo sapiens(Human) WDR75; UTP17 Q8IWA0 809 S Homo sapiens(Human) WDR75; UTP17 Q8IWA0 811 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IWA0 K226-ac Acetylation ASGHMDGkIRLWRNF Q8IWA0 K466-ac Acetylation PTLVTASkDGYFKVW Q8IWA0 K483-ac Acetylation TDDSDIykkAVGWTC Q8IWA0 K484-ac Acetylation DDSDIykkAVGWTCD Q8IWA0 S148-p Phosphorylation EVEAkELsFVLDyIN Q8IWA0 Y153-p Phosphorylation ELsFVLDyINQsPKC Q8IWA0 S157-p Phosphorylation VLDyINQsPKCIAFG Q8IWA0 T192-p Phosphorylation KKTTSRFtLsssRNK Q8IWA0 S194-p Phosphorylation TTSRFtLsssRNKKH Q8IWA0 S195-p Phosphorylation TSRFtLsssRNKKHA Q8IWA0 S196-p Phosphorylation SRFtLsssRNKKHAK Q8IWA0 T404-p Phosphorylation CFGNWLAtVEQRQEK Q8IWA0 T413-p Phosphorylation EQRQEKEtELELQMK Q8IWA0 Y482-p Phosphorylation LTDDSDIykkAVGWT Q8IWA0 T551-p Phosphorylation HLCFGRLtCSKYLLG Q8IWA0 T560-p Phosphorylation SKYLLGAtENGILCC Q8IWA0 S664-p Phosphorylation YFLTKSQsLLTFSTk Q8IWA0 S672-p Phosphorylation LLTFSTksPEEkLtP Q8IWA0 T678-p Phosphorylation ksPEEkLtPtSkQLL Q8IWA0 T680-p Phosphorylation PEEkLtPtSkQLLAE Q8IWA0 T692-p Phosphorylation LAEESLPttPFyFIL Q8IWA0 T693-p Phosphorylation AEESLPttPFyFILG Q8IWA0 Y696-p Phosphorylation SLPttPFyFILGkHR Q8IWA0 S779-p Phosphorylation DMEEEKEsEDsDEEN Q8IWA0 S782-p Phosphorylation EEKEsEDsDEENDFT Q8IWA0 T795-p Phosphorylation FTEKVQDtsNtGLGE Q8IWA0 S796-p Phosphorylation TEKVQDtsNtGLGED Q8IWA0 T798-p Phosphorylation KVQDtsNtGLGEDII Q8IWA0 S809-p Phosphorylation EDIIHQLsksEEKEL Q8IWA0 S811-p Phosphorylation IIHQLsksEEKELRK Q8IWA0 Y824-p Phosphorylation RKFRKIDysWIAAL_ Q8IWA0 S825-p Phosphorylation KFRKIDysWIAAL__ Q8IWA0 K427-sm Sumoylation KLWMYNKkTQGFILN Q8IWA0 K123-ub Ubiquitination FVIVNKEkPDIFQLV Q8IWA0 K136-ub Ubiquitination LVSVKLPkSSSQEVE Q8IWA0 K145-ub Ubiquitination SSQEVEAkELsFVLD Q8IWA0 K283-ub Ubiquitination RDATEKNkEFLPRLG Q8IWA0 K332-ub Ubiquitination AVIQGLVkDRSIFTG Q8IWA0 K354-ub Ubiquitination KALVLNGkPGHLQFY Q8IWA0 K466-ub Ubiquitination PTLVTASkDGYFKVW Q8IWA0 K483-ub Ubiquitination TDDSDIykkAVGWTC Q8IWA0 K611-ub Ubiquitination GSDLFVFkPSEPRPL Q8IWA0 K628-ub Ubiquitination QKGISREkVQWGVFV Q8IWA0 K671-ub Ubiquitination sLLTFSTksPEEkLt Q8IWA0 K676-ub Ubiquitination STksPEEkLtPtSkQ Q8IWA0 K682-ub Ubiquitination EkLtPtSkQLLAEES Q8IWA0 K701-ub Ubiquitination PFyFILGkHRQQQDE Q8IWA0 K810-ub Ubiquitination DIIHQLsksEEKELR

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IWA0 466 K Acetylation Swiss-Prot 1010711 19608861 Q8IWA0 779 S Phosphorylation Swiss-Prot 1010711 16565220;17081983;18669648;19413330;19690332 Q8IWA0 782 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19413330;19690332 Q8IWA0 796 S Phosphorylation Swiss-Prot 1010711 16565220;18669648 Q8IWA0 811 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IWA0 779 S Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 782 S Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 796 S Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 811 S Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 795 T Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 798 T Phosphorylation PhosphoELM.10011 18669648 Q8IWA0 123 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q8IWA0 136 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 145 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 283 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 332 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 354 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IWA0 466 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q8IWA0 483 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 611 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 628 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 671 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 676 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 701 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IWA0 810 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWA0 466 K Acetylation Phosphositeplus.1010730 19608861 Q8IWA0 194 S Phosphorylation Phosphositeplus.1010730 20166139 Q8IWA0 195 S Phosphorylation Phosphositeplus.1010730 20166139 Q8IWA0 779 S Phosphorylation Phosphositeplus.1010730 16565220;18669648;19415658;19690332;20068231;20164059;20363803;22115753 Q8IWA0 782 S Phosphorylation Phosphositeplus.1010730 16565220;18669648;19415658;19690332;20068231;20164059;20363803;21406692;22115753 Q8IWA0 796 S Phosphorylation Phosphositeplus.1010730 16565220;18669648;19276368;19664995;19690332;20068231;20815410;21406692;21659604;22115753 Q8IWA0 811 S Phosphorylation Phosphositeplus.1010730 18669648 Q8IWA0 192 T Phosphorylation Phosphositeplus.1010730 20166139 Q8IWA0 795 T Phosphorylation Phosphositeplus.1010730 20815410 Q8IWA0 798 T Phosphorylation Phosphositeplus.1010730 18669648;19276368;20815410 Q8IWA0 466 K Acetylation HPRD 9.0 19608861 Q8IWA0 194 S Phosphorylation HPRD 9.0 20166139 Q8IWA0 195 S Phosphorylation HPRD 9.0 20166139 Q8IWA0 779 S Phosphorylation HPRD 9.0 16565220,18669648,19413330,19415658,19651622,18452278,20068231 Q8IWA0 782 S Phosphorylation HPRD 9.0 16565220,18669648,19413330,19415658,19651622,18452278,20068231 Q8IWA0 796 S Phosphorylation HPRD 9.0 16565220,18669648,19664995,19651622,18452278,20068231 Q8IWA0 811 S Phosphorylation HPRD 9.0 18669648,20068231 Q8IWA0 192 T Phosphorylation HPRD 9.0 20166139 Q8IWA0 795 T Phosphorylation HPRD 9.0 18669648,19651622,18691976,20068231 Q8IWA0 798 T Phosphorylation HPRD 9.0 17081983,18669648,20068231 Q8IWA0 779 S Phosphorylation SysPTM 1.1 18669648;17081983;16565220 Q8IWA0 782 S Phosphorylation SysPTM 1.1 18669648;17081983;16565220 Q8IWA0 796 S Phosphorylation SysPTM 1.1 17081983;18669648;16565220 Q8IWA0 811 S Phosphorylation SysPTM 1.1 18669648 Q8IWA0 798 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References WDR75 192 T Phosphorylation 20166139 WDR75 194 S Phosphorylation 20166139 WDR75 195 S Phosphorylation 20166139 WDR75 466 K Acetylation 19608861 WDR75 779 S Phosphorylation 16565220,18669648,19413330,19415658,19651622,18452278,20068231 WDR75 782 S Phosphorylation 16565220,18669648,19413330,19415658,19651622,18452278,20068231 WDR75 795 T Phosphorylation 18669648,19651622,18691976,20068231 WDR75 796 S Phosphorylation 16565220,18669648,19664995,19651622,18452278,20068231 WDR75 798 T Phosphorylation 17081983,18669648,20068231 WDR75 811 S Phosphorylation 18669648,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8IWA0 795 T 18669648 HTP Phosphorylation Q8IWA0 798 T 18669648 HTP Phosphorylation Q8IWA0 782 S 18669648 HTP Phosphorylation Q8IWA0 811 S 18669648 HTP Phosphorylation Q8IWA0 796 S 18669648 HTP Phosphorylation Q8IWA0 779 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8IWA0 466 N6-acetyllysine 19608861 Q8IWA0 664 Phosphoserine 23186163 Q8IWA0 672 Phosphoserine 23186163 Q8IWA0 779 Phosphoserine 17081983;18669648 Q8IWA0 782 Phosphoserine 17081983;18669648;21406692 Q8IWA0 796 Phosphoserine 18669648;20068231;21406692;23186163 Q8IWA0 811 Phosphoserine 18669648;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type WDR75 IPI00217240 K 466 TLVTASaKDGYFKV acetylation WDR75 IPI00217240 S 779 MEEEKEpSEDSDEE phosphorylation WDR75 IPI00217240 S 782 EKESEDpSDEENDF phosphorylation WDR75 IPI00217240 S 796 EKVQDTpSNTGLGE phosphorylation WDR75 IPI00217240 S 811 IHQLSKpSEEKELR phosphorylation WDR75 IPI00217240 T 798 VQDTSNpTGLGEDI phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 84128 123901 - K Ubiquitination 21139048 84128 123901 - K Ubiquitination 21890473 84128 123901 - K Ubiquitination 21906983 84128 123901 - K Ubiquitination 23000965 84128 123901 - K Sumoylation 25391492

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID WDR75 Homo sapiens (Human) 701; 354; 123; 466 "701,FYFILGKHRQQQD; 354,ALVLNGKPGHLQF; 123,VIVNKEKPDIFQL; 466,TLVTASKDGYFKV" 701:21890473; 354:21890473; 123:21890473; 466:21890473 WDR75 Homo sapiens (Human) 136; 611; 283; 676; 466; 701; 671; 354; 628; 145; 332; 123; 483; 810 "136,VSVKLPKSSSQEV; 611,SDLFVFKPSEPRP; 283,DATEKNKEFLPRL; 676,TKSPEEKLTPTSK; 466,TLVTASKDGYFKV; 701,FYFILGKHRQQQD; 671,LLTFSTKSPEEKL; 354,ALVLNGKPGHLQF; 628,KGISREKVQWGVF; 145,SQEVEAKELSFVL; 332,VIQGLVKDRSIFT; 123,VIVNKEKPDIFQL; 483,DDSDIYKKAVGWT; 810,IIHQLSKSEEKEL" "136:21906983; 611:21906983; 283:21906983; 676:21906983; 466:21890473,21906983; 701:21890473; 671:21906983; 354:21890473; 628:21906983; 145:21906983; 332:21906983; 123:21890473,21906983; 483:21906983; 810:21906983" WDR75 Homo sapiens (Human) 701; 354; 123; 466 "701,FYFILGKHRQQQD; 354,ALVLNGKPGHLQF; 123,VIVNKEKPDIFQL; 466,TLVTASKDGYFKV" 701:21890473; 354:21890473; 123:21890473; 466:21890473