Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 61465504 rs17007356 G T rs17007356 1.69E-05 CISPLATIN|ETOPOSIDE|CARBOPLATIN R-SNARE PROTEINS|PLATINUM|STXBP5 PROTEIN, HUMAN|NERVE TISSUE PROTEINS Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 G intron GWASdb_drug 2 61586132 rs1584301 T C rs1584301 7.77E-05 CISPLATIN|ETOPOSIDE|CARBOPLATIN R-SNARE PROTEINS|PLATINUM|STXBP5 PROTEIN, HUMAN|NERVE TISSUE PROTEINS Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 T intron GWASdb_drug 2 61604429 rs17008755 A G rs17008755 4.48E-05 CISPLATIN|ETOPOSIDE|CARBOPLATIN R-SNARE PROTEINS|PLATINUM|STXBP5 PROTEIN, HUMAN|NERVE TISSUE PROTEINS Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 A intron GWASdb_drug 2 61618598 rs17008940 C T rs17008940 1.10E-04 CISPLATIN|ETOPOSIDE|CARBOPLATIN R-SNARE PROTEINS|PLATINUM|STXBP5 PROTEIN, HUMAN|NERVE TISSUE PROTEINS Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 C intron GWASdb_drug 2 61618660 rs10496093 C T rs10496093 1.10E-04 CISPLATIN|ETOPOSIDE|CARBOPLATIN R-SNARE PROTEINS|PLATINUM|STXBP5 PROTEIN, HUMAN|NERVE TISSUE PROTEINS Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 C intron GWASdb_drug 2 61427675 rs777587 A G rs777587 2.25E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 2 61462400 rs7591772 C G rs7591772 1.50E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 2 61465504 rs17007356 G T rs17007356 1.69E-05 Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 G intron GWASdb_trait 2 61466603 rs78404002 C T rs78404002 0.0000342 Rheumatoid arthritis HPOID:0001370 DOID:7148 C intron GWASdb_trait 2 61482261 rs10496091 G A rs10496091 9.98E-05 Body Mass Index HPOID:0001507 DOID:9970 G intron GWASdb_trait 2 61482261 rs10496091 G A rs10496091 7.22E-06 Weight HPOID:0004323 DOID:9970 G intron GWASdb_trait 2 61482261 rs10496091 G A rs10496091 7.14E-05 Weight HPOID:0004323 DOID:9970 G intron GWASdb_trait 2 61519408 rs2167566 T G rs2167566 4.90E-05 Squamous cell carcinoma HPOID:0002860 DOID:1749 A intron GWASdb_trait 2 61536740 rs2600672 G A rs2600672 9.66E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 2 61536901 rs2694619 C T rs2694619 2.27E-04 Type 2 diabetes HPOID:0005978 DOID:9352 A intron GWASdb_trait 2 61536984 rs2694618 C T rs2694618 2.36E-04 Type 2 diabetes HPOID:0005978 DOID:9352 A,G intron GWASdb_trait 2 61538054 rs17008218 T A rs17008218 0.0000439 Rheumatoid arthritis HPOID:0001370 DOID:7148 T intron GWASdb_trait 2 61540612 rs11680679 T C rs11680679 5.54E-04 Major depressive disorder HPOID:0000716 DOID:1470 T intron GWASdb_trait 2 61586132 rs1584301 T C rs1584301 7.77E-05 Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 T intron GWASdb_trait 2 61604429 rs17008755 A G rs17008755 4.48E-05 Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 A intron GWASdb_trait 2 61605379 rs10196146 C A rs10196146 1.07E-04 Type 2 diabetes HPOID:0005978 DOID:9352 A intron GWASdb_trait 2 61618598 rs17008940 C T rs17008940 1.10E-04 Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 C intron GWASdb_trait 2 61618660 rs10496093 C T rs10496093 1.10E-04 Response to platinum-based chemotherapy in small-cell lung cancer HPOID:0100526 DOID:5409 C intron GWASdb_trait 2 61629635 rs4387777 C T rs4387777 3.40E-05 Bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 61659199 rs2463100 G C rs2463100 7.12E-04 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 2 61684564 rs778139 G A rs778139 9.91E-04 Alcohol consumption (maxi-drinks) HPOID:0000707 DOID:1574|DOID:0050741 C intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs4353638 2 61499019 61499019 intronic 0.804775 0.09432552325569939 GWAS of prostate cancer rs1823685 2 61435085 61435085 intronic 0.803986 0.09475151365911551 GWAS of prostate cancer rs7591402 2 61437786 61437786 intronic 0.678202 0.16864093383295 GWAS of prostate cancer rs2290324 2 61448776 61448776 intronic 0.663625 0.178077261650787 GWAS of prostate cancer rs4671402 2 61494450 61494450 intronic 0.632411 0.199000584663684

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000115464.14 USP34 615295