PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2L3 RNF19B 16709802 biogrid,intact exp GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G RNF19B UCKL1 16709802 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2L6 RNF19B 16709802 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBC RNF19B 16196087 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPP1CC RNF19B 21382349 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G RNF19B BTG4 16709802 biogrid exp G G G DNAJB2 RNF19B 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AA1 RNF19B 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G DIRAS3 RNF19B 26186194 biogrid exp P GP G P GP GP P G GP P P GP GP G GP G P GP P P GP GP P FBL RNF19B 26186194 biogrid exp GP GP G G G GP G G GP G GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AB1 RNF19B 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EZH2 RNF19B ortho GP P G GP GP P GP G GP G P P P GP GP GP GP RNF19B RNF125 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF19B RNF144B 25402006 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G G GP G G GP G RNF19B UPRT 21836163 pred GP G G G G G G GP GP G G G GP G G GP G G G G GP GP GP GP GP G GP P G UBE2C RNF19B 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE3A RNF19B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZMZ0 P36873-2 two hybrid 21382349 physical association X 2 O14933 Q6ZMZ0 anti bait coimmunoprecipitation 16709802 physical association X 2 O14933 Q6ZMZ0 anti tag coimmunoprecipitation 16709802 physical association X 2 O14933 Q6ZMZ0 anti bait coimmunoprecipitation 16709802 physical association X 2 Q6ZMZ0 A0A024R1A4 anti tag coimmunoprecipitation 16709802 physical association X 2 Q6ZMZ0 A0A024R1A4 anti bait coimmunoprecipitation 16709802 physical association X 2 Q6ZMZ0 Q9NWZ5 two hybrid 16709802 physical association X 2 Q6ZMZ0 Q9NWZ5 confocal microscopy 16709802 colocalization X 2 Q6ZMZ0 Q9NWZ5 anti tag coimmunoprecipitation 16709802 physical association X 2 Q6ZMZ0 Q9NWZ5 anti bait coimmunoprecipitation 16709802 physical association X 2 Q6ZMZ0 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NRF1 RNF19B MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294911 bait prey UBE2L6 RNF19B MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16709802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_124800|UniProt_83994|UniProt_83990|UniProt_83992 prey|prey|prey|prey bait|bait|bait|bait HSP90AA1 RNF19B MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255405 bait prey UBE2L3 RNF19B MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16709802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_124799|UniProt_83996|UniProt_83991 prey|prey|prey bait|bait|bait UBC RNF19B MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,21139048,21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_169800|BIOGRID_143265|BIOGRID_263514 bait|bait|bait prey|prey|prey RNF19B UCKL1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16709802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_83998|UniProt_83997|UniProt_83993|UniProt_83995 neutral component|bait|bait|bait neutral component|prey|prey|prey RNF19B BTG4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16709802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_124801|BIOGRID_124802 bait|bait prey|prey PPP1CC RNF19B MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid) 21382349 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_112533|BIOGRID_251692 null|bait prey|prey HSP90AB1 RNF19B MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125084 prey bait

PPI - HINT Gene A Gene B PMID Method Quality DIRAS3 RNF19B 26186194 0004 HT FBL RNF19B 26186194 0004 HT DNAJB2 RNF19B 26186194 0004 HT DIRAS3 RNF19B 26186194 0004 HT FBL RNF19B 26186194 0004 HT DNAJB2 RNF19B 26186194 0004 HT HSP90AB1 RNF19B 22939624 0729 HT PPP1CC RNF19B 21382349 0018 LC RNF19B UCKL1 16709802,16709802,16709802,16709802 0018,0663,0006,0007 LC RNF19B BTG4 16709802,16709802 0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZMZ0 Q53QD7 RNF19B DNAJB2 {ECO:0000312|HGNC:HGNC:5228} 0.126 Q9NWZ5 Q6ZMZ0 UCKL1 RNF19B 0.623 16709802 Q6ZMZ0 P25686 RNF19B DNAJB2 0.126 26186194 Q6ZMZ0 P07900 RNF19B HSP90AA1 0.126 22939624 Q6ZMZ0 P08238 RNF19B HSP90AB1 0.126 22939624 Q6ZMZ0 P0CG48 RNF19B UBC 0.126 16196087 Q6ZMZ0 O95661 RNF19B DIRAS3 0.126 26186194 Q6ZMZ0 O14933 RNF19B UBE2L6 0.61 16709802 Q9NY30 Q6ZMZ0 BTG4 RNF19B 0.454 16709802 Q6ZMZ0 P36873 RNF19B PPP1CC 0.332 21382349 Q6ZMZ0 P68036 RNF19B UBE2L3 0.507 16709802 Q6ZMZ0 P22087 RNF19B FBL 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2L6 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 RNF19B MI:0362 inference MI:1106 pathways database FBXO21 RNF19B MI:0362 inference MI:1106 pathways database DIRAS3 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF19B MI:0362 inference MI:1106 pathways database UBC RNF19B MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 RNF19B MI:0362 inference MI:1106 pathways database FBL RNF19B MI:0045 experimental interaction detection MI:0461 interaction database DNAJB2 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database PPP1CC RNF19B MI:0045 experimental interaction detection MI:0461 interaction database CCNF RNF19B MI:0362 inference MI:1106 pathways database UBE2A RNF19B MI:0362 inference MI:1106 pathways database FBXW4 RNF19B MI:0362 inference MI:1106 pathways database RBX1 RNF19B MI:0362 inference MI:1106 pathways database RPS27A RNF19B MI:0362 inference MI:1106 pathways database UBA52 RNF19B MI:0362 inference MI:1106 pathways database SKP1 RNF19B MI:0362 inference MI:1106 pathways database UBE2L3 RNF19B MI:0045 experimental interaction detection MI:0461 interaction database SKP2 RNF19B MI:0362 inference MI:1106 pathways database CUL1 RNF19B MI:0362 inference MI:1106 pathways database TRIP12 RNF19B MI:0362 inference MI:1106 pathways database EZH2 RNF19B MI:0362 inference MI:0461 interaction database LONRF1 RNF19B MI:0362 inference MI:1106 pathways database HECTD2 RNF19B MI:0362 inference MI:1106 pathways database FBXO31 RNF19B MI:0362 inference MI:1106 pathways database FBXW9 RNF19B MI:0362 inference MI:1106 pathways database FBXW10 RNF19B MI:0362 inference MI:1106 pathways database RNF213 RNF19B MI:0362 inference MI:1106 pathways database FBXL22 RNF19B MI:0362 inference MI:1106 pathways database FBXL19 RNF19B MI:0362 inference MI:1106 pathways database FBXW12 RNF19B MI:0362 inference MI:1106 pathways database RNF19B RNF144B MI:0362 inference MI:1106 pathways database RNF19B RBBP6 MI:0362 inference MI:1106 pathways database RNF19B HUWE1 MI:0362 inference MI:1106 pathways database RNF19B TRIM69 MI:0362 inference MI:1106 pathways database RNF19B SIAH1 MI:0362 inference MI:1106 pathways database RNF19B HERC6 MI:0362 inference MI:1106 pathways database RNF19B UBR2 MI:0362 inference MI:1106 pathways database RNF19B FBXL14 MI:0362 inference MI:1106 pathways database RNF19B FBXW8 MI:0362 inference MI:1106 pathways database RNF19B FBXL16 MI:0362 inference MI:1106 pathways database RNF19B FBXO15 MI:0362 inference MI:1106 pathways database RNF19B ZNRF1 MI:0362 inference MI:1106 pathways database RNF19B FBXL13 MI:0362 inference MI:1106 pathways database RNF19B FBXO22 MI:0362 inference MI:1106 pathways database RNF19B ZNRF2 MI:0362 inference MI:1106 pathways database RNF19B FBXO27 MI:0362 inference MI:1106 pathways database RNF19B FBXO30 MI:0362 inference MI:1106 pathways database RNF19B RNF217 MI:0362 inference MI:1106 pathways database RNF19B DTX3L MI:0362 inference MI:1106 pathways database RNF19B FBXO41 MI:0362 inference MI:1106 pathways database RNF19B LMO7 MI:0362 inference MI:1106 pathways database RNF19B MYLIP MI:0362 inference MI:1106 pathways database RNF19B FBXW7 MI:0362 inference MI:1106 pathways database RNF19B FBXO32 MI:0362 inference MI:1106 pathways database RNF19B FBXW5 MI:0362 inference MI:1106 pathways database RNF19B MIB2 MI:0362 inference MI:1106 pathways database RNF19B SPSB1 MI:0362 inference MI:1106 pathways database RNF19B FBXL8 MI:0362 inference MI:1106 pathways database RNF19B FBXO17 MI:0362 inference MI:1106 pathways database RNF19B FBXL20 MI:0362 inference MI:1106 pathways database RNF19B FBXL18 MI:0362 inference MI:1106 pathways database RNF19B NEDD4L MI:0362 inference MI:1106 pathways database RNF19B PARD6G MI:0362 inference MI:0461 interaction database RNF19B RBCK1 MI:0362 inference MI:1106 pathways database RNF19B FBXL15 MI:0362 inference MI:1106 pathways database RNF19B FBXO44 MI:0362 inference MI:1106 pathways database RNF19B UNKL MI:0362 inference MI:1106 pathways database RNF19B SMURF2 MI:0362 inference MI:1106 pathways database RNF19B PARD6A MI:0362 inference MI:0461 interaction database RNF19B TRIM36 MI:0362 inference MI:1106 pathways database RNF19B FBXO6 MI:0362 inference MI:1106 pathways database RNF19B RNF19A MI:0362 inference MI:1106 pathways database RNF19B RLIM MI:0362 inference MI:1106 pathways database RNF19B UCKL1 MI:0045 experimental interaction detection MI:0461 interaction database RNF19B FBXL12 MI:0362 inference MI:1106 pathways database RNF19B BTG4 MI:0045 experimental interaction detection MI:0461 interaction database RNF19B FBXO40 MI:0362 inference MI:1106 pathways database RNF19B HERC5 MI:0362 inference MI:1106 pathways database RNF19B FBXL7 MI:0362 inference MI:1106 pathways database RNF19B FBXO2 MI:0362 inference MI:1106 pathways database RNF19B FBXO10 MI:0362 inference MI:1106 pathways database RNF19B FBXO9 MI:0362 inference MI:1106 pathways database RNF19B FBXL5 MI:0362 inference MI:1106 pathways database RNF19B FBXL4 MI:0362 inference MI:1106 pathways database RNF19B FBXW11 MI:0362 inference MI:1106 pathways database RNF19B FBXO4 MI:0362 inference MI:1106 pathways database RNF19B FBXL21 MI:0362 inference MI:1106 pathways database RNF19B FBXL3 MI:0362 inference MI:1106 pathways database RNF19B FBXW2 MI:0362 inference MI:1106 pathways database RNF19B BTRC MI:0362 inference MI:1106 pathways database RNF19B FBXO7 MI:0362 inference MI:1106 pathways database RNF19B RNF115 MI:0362 inference MI:1106 pathways database RNF19B RNF114 MI:0362 inference MI:1106 pathways database RNF19B WSB1 MI:0362 inference MI:1106 pathways database