PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ITGB5 ZBTB17 12356872 hprd,biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 ZBTB17 17880999 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAH ZBTB17 15580267 mint,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AA1 ZBTB17 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G ZBTB17 DIS3 15231747 hprd,biogrid,i2d,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ZBTB17 ZBTB4 18451802 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G G GP GP G G GP G G GP G GP GP GP G TP53 ZBTB17 19901969 innatedb,biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G HK2 ZBTB17 11068878 hprd,i2d,bci exp GP GP G G G GP G GP GP G P GP GP G GP GP G GP GP GP GP GP GP G GP GP G HSPB1 ZBTB17 25277244 biogrid,intact exp GP GP G G G G G GP GP G GP GP GP G G GP G GP GP G GP GP GP GP GP G GP GP G CDKN2A ZBTB17 19901969 innatedb,biogrid exp G GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G GP GP G G MAX ZBTB17 11283613 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MSX2 ZBTB17 9256341 hprd exp P P P P P P P G P P P GP P P P P P GP G UBE2H ZBTB17 19549727 intact exp GP GP G G G GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AB1 ZBTB17 22939624 intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 KLF5 19419955 innatedb,biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ZBTB17 GFI1 19164764 biogrid,dip exp P P G G P P P P P P P GP P P P P P P P P GP P P MAGEA4 ZBTB17 14739298 biogrid,intact exp P P GP YWHAQ ZBTB17 19786833 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MYCN ZBTB17 21908575,21123453 biogrid exp G G G G G G G G G G G ZBTB17 DNMT3A 15616584,19786833 hprd,biogrid,i2d exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 ZBTB49 25245946 biogrid exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB17 ESR2 11117529 hprd,dip,bci exp GP GP G G GP G GP GP GP GP GP GP G P GP GP GP G GP P GP GP GP GP GP GP PGR ZBTB17 11117529 hprd,dip exp GP G P G G G G G G G P GP P G P G G G G G G G HK3 ZBTB17 11068878 hprd,i2d,bci exp, ortho G G P GP GP GP IRF8 ZBTB17 12904288 innatedb,hprd,biogrid exp, ortho G G G G G G G G G G G G GP GP G G G G G G G G G G G GP G G G ZBTB17 CREBBP 15752756, 25402006 hprd,bci exp, ortho, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYC ZBTB17 17418410,18923429,9312026,11283613,20426839,19786833,16352593, 25402006, 21836163 innatedb,hprd,biogrid,mint,intact,bci exp, ortho, pred GP GP G G P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G GTF2I ZBTB17 12193603, 21836163 hprd exp, pred G G G G G G G G G G G G G G G G G G G HCFC1 ZBTB17 12244100, 25402006, 21836163 hprd,biogrid,intact,bci exp, pred GP GP G G G GP G GP G G GP GP GP G G G GP G G G G GP GP GP G G GP GP G EP300 ZBTB17 11283613,12244100,12840021, 25402006, 21836163 hprd,biogrid,intact,bci exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 HUWE1 16269333, 25402006 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ESR1 ZBTB17 11117529, 25402006 hprd,dip,bci exp, pred GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 TOPBP1 18923429,12408820,17006541, 21836163 hprd,biogrid,mint,intact,bci exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDKN2B ZBTB17 11283613, 21836163 hprd exp, pred GP P GP P P G G GP P G P GP G BCL6 ZBTB17 16142238, 25402006, 23023127 biogrid,i2d,bci exp, pred G G G G G G G G G G G G G GP G G G G G G GP G G G G GP G G G ZBTB17 TMPRSS11A 15095404, 21836163 hprd,biogrid exp, pred ZBTB17 DNMT3B 25402006 ortho, pred GP P G G G GP G GP P GP GP GP P G GP GP GP GP G GP P GP GP GP GP GP GP LEP ZBTB17 25402006 ortho, pred G P P P P P P G P P P GP P P P P P IRF2 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G POU2F1 ZBTB17 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ZBTB17 MMS19 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 THAP11 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 NSD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IGFBP4 ZBTB17 25402006 pred GP G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G ZBTB17 SNIP1 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G HDAC3 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 PDCD2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDK9 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NF1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 HDAC2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HPGDS ZBTB17 25402006 pred G G G G G G G G G P G GP G G G G G G GP G G G G G SP1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 HDAC6 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSMD10 ZBTB17 25402006 pred GP G G G G GP G G GP G G G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G ZBTB17 TRIM28 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 TNFAIP1 23023127 pred G G G G G G G G GP G GP G G G G GP G G GP G G G GP G GP G GP G G ZBTB17 MACF1 23023127 pred ZBTB17 ZBTB3 23023127 pred GP P G G P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G ZBTB17 CDX2 25402006 pred GP GP GP GABPA ZBTB17 25402006 pred GP GP G G G GP G G G G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP ZBTB17 HDAC1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZBTB17 MEF2D 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CTNNB1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ZBTB17 MXD4 21836163 pred P P P P P P P P P YY1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 CREBZF 25402006 pred G G G G G GP G GP GP G GP G GP G G GP GP G G G GP G GP GP GP G GP GP G GATA4 ZBTB17 23023127 pred P P P GP P P GP P P GP P GP GP GP P P P GP P GP GP CCNT1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB7B ZBTB17 23023127 pred GP GP G G P G GP G G G G GP G GP P G GP GP GP G GP G GP P ZBTB17 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G ZBTB17 BRD3 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAPK8 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 ACVR2B 23023127 pred GP GP G G G GP G GP GP G GP G G G G GP GP GP GP G GP G G G GP G GP GP G SLC11A1 ZBTB17 21836163 pred GP GP G G G GP G G P G GP G GP GP G P GP G G G GP G GP GP P GP GP GP G GADD45A ZBTB17 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 BTBD2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 THAP1 25402006 pred G G G G G G G G G G G G G G G G G SMAD3 ZBTB17 25402006 pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G CEBPG ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G ZBTB17 HIC2 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZBTB17 IRF3 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ELK1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP G GP GP GP GP G ZBTB17 SKP2 25402006 pred GP GP G G G GP G GP GP G G GP GP GP G GP GP G GP G GP G G GP GP GP GP GP G ZBTB17 MYNN 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 CHRD 23023127 pred GP GP G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP P G ZBTB17 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G ZBTB48 ZBTB17 23023127 pred G GP G G G P P GP GP GP G GP G G P GP G P G GP P G GP G GP G ZBTB17 KEAP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CER1 ZBTB17 23023127 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G SOCS3 ZBTB17 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G ZBTB17 KAT2A 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G ZBTB17 NFYC 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 LZTR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SETD1A ZBTB17 25402006 pred GP GP G G P GP GP GP P GP G P P P P G GP P P P GP GP GP GP G ZBTB17 KAT2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 KLHL31 23023127 pred GP GP G GP GP GP P P GP G G GP G G GP GP P GP G P G IRF1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G ZBTB17 BAP1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TCF3 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB16 ZBTB17 23023127 pred G GP G G G GP G G GP G G G GP G G GP GP G GP G G GP GP G GP G G GP G ZBTB17 SIN3A 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPI1 ZBTB17 25402006 pred G G P GP GP GP JUN ZBTB17 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G CYBB ZBTB17 25402006 pred G G G G G GP G G G G G G GP G G G GP G G G G G G G G GP G G ZBTB17 SMAD2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB17 THAP3 25402006 pred G G P G P G G G ZBTB17 CALCOCO1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ZBTB17 ZBTB38 23023127 pred GP GP G G G GP G GP G G G GP G G G G GP G G G G GP G G G G GP GP G LRP5 ZBTB17 23023127 pred GP GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP GP GP G GP P G ZBTB17 ARHGEF2 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL18 ZBTB17 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP G GP GP G LRP6 ZBTB17 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GRN ZBTB17 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZBTB17 KLHL38 23023127 pred P P P P P P P P P P P P P P P P P P P P GABPB1 ZBTB17 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IL12A ZBTB17 25402006 pred P P P P P P P P P P G P P P P P P P P P TP73 ZBTB17 25402006 pred G G G G G ZBTB17 RCBTB1 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q13105 coimmunoprecipitation 15616584 association C 3 P41182 Q13105 pull down 16142238 association X 2 Q13105 P06401 biochemical 11117529 physical association X 2 Q99684 Q13105 anti bait coimmunoprecipitation 19164764 physical association X 2 Q13105 Q07120 pull down 19164764 direct interaction X 2 Q13105 Q07120 two hybrid 19164764 direct interaction X 2 Q13105 biochemical 11117529 physical association X 2 Q13105 Q7LCB3 biochemical 11117529 physical association X 2 G4XH65 Q13105 in vitro 11117529 - X 2 G4XH65 Q13105 in vitro 11117529 - X 2 P51610 Q13105 in vitro 12244100 - X 2 P51610 Q13105 in vivo 12244100 - X 2 P51610 Q13105 in vivo 12244100 - X 2 P51610 Q13105 in vitro 12244100 - X 2 Q9Y6K1-3 Q13105 in vitro 15616584 - X 2 Q9Y6K1-3 Q13105 in vivo 15616584 - X 2 Q9Y6K1-3 Q13105 in vitro 15616584 - X 2 Q9Y6K1-3 Q13105 in vivo 15616584 - X 2 P52789 Q13105 in vivo 11068878 - X 2 P52789 Q13105 two hybrid 11068878 - X 2 P52789 Q13105 in vitro 11068878 - X 2 P52789 Q13105 two hybrid 11068878 - X 2 P52789 Q13105 in vitro 11068878 - X 2 P52789 Q13105 in vivo 11068878 - X 2 Q13105 F1D8N3 in vitro 11117529 - X 2 Q13105 P78347-2 two hybrid 12193603 - X 2 Q13105 P78347-2 in vivo 12193603 - X 2 Q13105 P78347-2 in vitro 12193603 - X 2 Q13105 F1D8N3 in vitro 11117529 - X 2 Q13105 P06401 in vitro 11117529 - X 2 Q13105 P78347-2 two hybrid 12193603 - X 2 Q13105 P78347-2 in vitro 12193603 - X 2 Q13105 P78347-2 in vivo 12193603 - X 2 Q13105 P06401 in vitro 11117529 - X 2 Q92547 Q13105 in vivo 12408820,17006541 - X 2 Q92547 Q13105 in vitro 12408820,17006541 - X 2 Q92547 Q13105 in vitro 12408820,17006541 - X 2 Q92547 Q13105 in vivo 12408820,17006541 - X 2 P35548 Q13105 in vitro 9256341 - X 2 P35548 Q13105 in vitro 9256341 - X 2 A0A024R7R1 Q13105 two hybrid 11068878 - X 2 A0A024R7R1 Q13105 in vitro 11068878 - X 2 A0A024R7R1 Q13105 two hybrid 11068878 - X 2 A0A024R7R1 Q13105 in vitro 11068878 - X 2 Q13105 two hybrid 15095404 - X 2 Q13105 in vitro 15095404 - X 2 Q13105 in vivo 15095404 - X 2 Q13105 two hybrid 15095404 - X 2 Q13105 in vivo 15095404 - X 2 Q13105 in vitro 15095404 - X 2 L7RT22 Q13105 two hybrid 12356872 - X 2 L7RT22 Q13105 two hybrid 12356872 - X 2 Q09472 Q13105 in vitro 12840021 - X 2 Q09472 Q13105 in vitro 12840021 - X 2 Q13105 in vitro 16352593,9312026 - X 2 Q13105 two hybrid 16352593,9312026 - X 2 Q13105 in vivo 16352593,9312026 - X 2 Q13105 in vitro 15752756 - X 2 Q13105 two hybrid 15752756 - X 2 Q13105 Q02556 two hybrid 12904288 - X 2 Q13105 Q02556 in vivo 12904288 - X 2 Q13105 in vivo 16352593,9312026 - X 2 Q13105 in vitro 16352593,9312026 - X 2 Q13105 two hybrid 16352593,9312026 - X 2 Q13105 two hybrid 15752756 - X 2 Q13105 in vitro 15752756 - X 2 Q13105 Q02556 in vivo 12904288 - X 2 Q13105 Q02556 two hybrid 12904288 - X 2 Q13105 Q9Y2L1-2 two hybrid 15231747 - X 2 Q13105 Q9Y2L1-2 two hybrid 15231747 - X 2 K7PPU3 Q13105 in vitro 11283613 - X 2 K7PPU3 Q13105 in vivo 11283613 - X 2 K7PPU3 Q13105 in vitro 11283613 - X 2 K7PPU3 Q13105 in vivo 11283613 - X 2 Q13105 anti bait coimmunoprecipitation 18923429 physical association C 3 P51610 Q13105 pull down 12244100 physical association X 2 P51610 Q13105 two hybrid 12244100 physical association X 2 P51610 Q13105 coimmunoprecipitation 12244100 physical association X 2 P51610 Q13105 two hybrid 12244100 physical association X 2 P51610 Q13105 pull down 12244100 physical association X 2 P51610 Q13105 pull down 12244100 physical association X 2 P51610 Q13105 pull down 12244100 physical association X 2 P51610 Q13105 pull down 12244100 physical association X 2 P51610 Q13105 pull down 12244100 physical association X 2 P01106 Q13105 anti bait coimmunoprecipitation 16352593 physical association X 2 P01106 Q13105 anti bait coimmunoprecipitation 16352593 physical association X 2 P01106 Q13105 anti bait coimmunoprecipitation 18923429 physical association X 2 Q13105 A0A024RC12 anti tag coimmunoprecipitation 14739298 physical association X 2 Q13105 A0A024RC12 anti tag coimmunoprecipitation 14739298 physical association X 2 Q13105 A0A024RC12 two hybrid 14739298 physical association X 2 Q13105 A0A024RC12 confocal microscopy 14739298 colocalization X 2 Q13105 A0A024RC12 anti tag coimmunoprecipitation 14739298 physical association X 2 Q13105 A4D1L5 two hybrid 19549727 physical association X 2 Q13105 P04792 reverse ras recruitment system 25277244 physical association X 2 Q92547 Q13105 anti bait coimmunoprecipitation 18923429 physical association X 2 Q09472 Q13105 pull down 12244100 physical association X 2 Q13105 Q9Y2L1 two hybrid 15231747 physical association X 2 Q13105 A0A024R1K7 coimmunoprecipitation 15580267 association X 2 Q13105 A0A024R1K7 coimmunoprecipitation 15580267 association X 2 Q13105 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PGR ZBTB17 MI:0401(biochemical)|MI:0492(in vitro) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0468(hprd) DIP_52940|HPRD_26356 -|- -|- HCFC1 ZBTB17 MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12244100 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_70580|HPRD_5128|UniProt_70582|BIOGRID_113816|BIOGRID_113815|BIOGRID_113814|BIOGRID_113813|UniProt_70579|UniProt_70578|UniProt_70577|UniProt_70576|UniProt_70575|UniProt_70574|UniProt_70573 prey|-|prey|prey|bait|bait|bait|bait|prey|bait|bait|bait|bait|bait bait|-|bait|bait|prey|prey|prey|prey|bait|prey|prey|prey|prey|prey HK2 ZBTB17 MI:0493(in vivo) 11068878 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_35320 - - MYCN ZBTB17 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21908575 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_214144|BIOGRID_214145 bait|prey prey|bait IRF8 ZBTB17 MI:0493(in vivo)|MI:0018(two hybrid) 12904288 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_30615|BIOGRID_211786 -|prey -|bait YWHAQ ZBTB17 MI:0004(affinity chromatography technology) 19786833 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_271715 prey bait ZBTB17 KLF5 MI:0004(affinity chromatography technology) 19419955 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_271670 bait prey HSP90AA1 ZBTB17 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255452 bait prey MAGEA4 ZBTB17 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14739298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_74037|UniProt_74036|UniProt_74038|UniProt_74040|UniProt_74039 bait|bait|prey|bait|neutral component prey|prey|bait|prey|neutral component YWHAH ZBTB17 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 15580267 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_79076|UniProt_80682|MINT_79075|UniProt_80681|MINT_47257|MINT_47256 unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role UBE2H ZBTB17 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100849 bait prey HK3 ZBTB17 MI:0493(in vivo) 11068878 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_35602 - - ZBTB17 DIS3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231747 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_76793|BIOGRID_77958|HPRD_12873 prey|prey|- bait|bait|- ZBTB17 DNMT3A MI:0096(pull down)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 15616584,19786833 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_81546|HPRD_17648|BIOGRID_271716 prey|-|bait bait|-|prey HSP90AB1 ZBTB17 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125123 prey bait CDKN2B ZBTB17 MI:0493(in vivo) 11283613 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_6970 - - ZBTB17 GFI1 MI:0006(anti bait coimmunoprecipitation) 19164764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) MI:0465(dip) DIP_55089 - - ESR1 ZBTB17 MI:0401(biochemical)|MI:0492(in vitro) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0468(hprd) DIP_52941|HPRD_26360 -|- -|- ZBTB17 TOPBP1 MI:0493(in vivo) 12408820 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12874 - - MSX2 ZBTB17 MI:0492(in vitro) 9256341 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24947 - - UBC ZBTB17 MI:0004(affinity chromatography technology) 21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_177790 bait prey ITGB5 ZBTB17 MI:0492(in vitro) 12356872 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36431 - - ZBTB17 TOPBP1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation) 10,12408820,18923429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_74413|MINT_44121|UniProt_98053|BIOGRID_97022|BIOGRID_97021|BIOGRID_97023|MINT_44120|MINT_74411|BIOGRID_97020|UniProt_98051 bait|bait|bait|prey|prey|bait|bait|bait|bait|bait prey|prey|prey|bait|bait|prey|prey|prey|prey|prey ZBTB17 ESR2 MI:0401(biochemical)|MI:0492(in vitro) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0468(hprd) DIP_52942|HPRD_26355 -|- -|- ZBTB17 CREBBP MI:0018(two hybrid) 15752756 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26670 - - GTF2I ZBTB17 MI:0493(in vivo) 12193603 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_9564 - - MYC ZBTB17 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,11283613,16352593,17418410,18923429,19786833,20426839,9312026 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact) BIOGRID_104439|BIOGRID_104438|BIOGRID_104437|BIOGRID_271719|UniProt_82356|BIOGRID_271717|BIOGRID_271718|UniProt_82355|MINT_74415|BIOGRID_271710|MINT_44122|BIOGRID_271712|BIOGRID_271720|BIOGRID_271711|BIOGRID_271714|BIOGRID_271713|UniProt_98052|BIOGRID_100553|HPRD_4051|MINT_74413|MINT_44121|UniProt_98053 prey|prey|prey|bait|prey|prey|bait|bait|prey|prey|prey|bait|prey|prey|prey|bait|prey|prey|-|prey|prey|prey bait|bait|bait|prey|bait|bait|prey|prey|bait|bait|bait|prey|bait|bait|bait|prey|bait|bait|-|bait|bait|bait MAX ZBTB17 MI:0004(affinity chromatography technology) 11283613 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_100554 prey bait ZBTB17 TMPRSS11A MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 15095404 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_30792|BIOGRID_214183|BIOGRID_214182 -|prey|prey -|bait|bait ZBTB17 NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295103 prey bait EP300 ZBTB17 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11283613,12244100,12840021 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(biogrid) HPRD_26638|UniProt_70581|BIOGRID_100555 -|bait|bait -|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality MYC ZBTB17 26766587,26766587,18923429,26766587,16352593,16352593 0007,0096,0006,0006,0006,0018 LC MYC ZBTB17 26766587,26766587,18923429,26766587,16352593,16352593 0007,0096,0006,0006,0006,0018 LC MYC ZBTB17 9312026,16352593,16352593 0018,0006,0018 LC ESR1 ZBTB17 11117529 0401 LC HSPB1 ZBTB17 25277244 0097 LC PGR ZBTB17 11117529 0401 LC HSP90AB1 ZBTB17 22939624 0729 HT ITGB5 ZBTB17 12356872 0018 LC BCL6 ZBTB17 16142238,16142238,16142238 0004,0019,0096 LC MAGEA4 ZBTB17 14739298,14739298,14739298 0007,0018,0663 LC HCFC1 ZBTB17 12244100,12244100,12244100 0019,0018,0096 LC HK2 ZBTB17 11068878,11068878 0018,0004 LC HK3 ZBTB17 11068878,11068878,11068878 0018,0019,0004 LC UBE2H ZBTB17 19549727 0018 HT GTF2I ZBTB17 12193603 0018 LC IRF8 ZBTB17 12904288 0018 LC YWHAH ZBTB17 15580267 0019 LC ZBTB17 ZBTB17 17880999,20493880 0114,0114 LC ZBTB17 TMPRSS11A 15095404 0018 LC ZBTB17 ESR2 11117529 0401 LC ZBTB17 CREBBP 15752756 0018 LC ZBTB17 DIS3 15231747 0018 HT ZBTB17 DNMT3A 15616584,15616584 0019,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q13105 Q0A2H0 ZBTB17 NS 0.126 23853584 Q13105 P07900 ZBTB17 HSP90AA1 0.126 22939624 Q6DP93 Q13105 NS {ECO:0000256|RULEBASE:RU362113, ECO:0000313|EMBL:AAT73394.1} ZBTB17 0.126 23853584 Q88489 Q13105 Q88489 ZBTB17 0.126 22014111 Q13105 P03496 ZBTB17 NS 0.126 23853584 Q13105 P03508 ZBTB17 NS 0.126 23853584 Q96BR9 Q13105 ZBTB8A ZBTB17 0.236 unassigned1304 Q99684 Q13105 GFI1 ZBTB17 0.659 19164764 Q13105 P41182 ZBTB17 BCL6 0.309 16142238 Q13105 P43358 ZBTB17 MAGEA4 0.765 14739298 Q13105 Q07120 ZBTB17 GFI1 0.454 19164764 Q6ZMR5 Q13105 TMPRSS11A ZBTB17 0.523 15095404 Q92547 Q13105 TOPBP1 ZBTB17 0.884 12408820,17006541,18923429 Q13105 P51610 ZBTB17 HCFC1 0.939 12244100 Q13105 P04198 ZBTB17 MYCN 0.853 26766587,21123453,21908575 Q7Z6Z7 Q13105 HUWE1 ZBTB17 0.702 16269333,26212014 Q13105 P01106 ZBTB17 MYC 0.997 19786833,16352593,11283613,20426839,26766587,17418410,18923429,9312026 Q91B85 Q13105 Q91B85 ZBTB17 0.126 22014111 Q9P1Z0 Q13105 ZBTB4 ZBTB17 0.376 18451802 Q13105 P27881 ZBTB17 HK2 0.523 11068878 Q13105 P18084 ZBTB17 ITGB5 0.309 12356872 Q13105 P27348 ZBTB17 YWHAQ 0.21 19786833 Q13105 P08238 ZBTB17 HSP90AB1 0.126 22939624 Q13105 P06401 ZBTB17 PGR 0.033 11117529 Q13105 P04792 ZBTB17 HSPB1 0.286 25277244 Q13105 O14641 ZBTB17 DVL2 0.376 25558878 Q13105 P03372 ZBTB17 ESR1 0.033 11117529 Q13105 P04637 ZBTB17 TP53 0.376 19901969 Q92731 Q13105 ESR2 ZBTB17 0.033 11117529 Q13105 Q04917 ZBTB17 YWHAH 0.21 15580267 Q13105 P27926 ZBTB17 HK3 0.671 11068878 Q13105 P42771 ZBTB17 CDKN2A 0.569 19901969 Q13105 Q02556 ZBTB17 IRF8 0.309 12904288 Q13105 P61244 ZBTB17 MAX 0.309 11283613 Q13105 P62256 ZBTB17 UBE2H 0.332 19549727 Q13887 Q13105 KLF5 ZBTB17 0.21 19419955 Q13105 Q09472 ZBTB17 EP300 0.376 12244100,11283613 Q13105 Q13105 ZBTB17 ZBTB17 0.332 17880999 Q8N726 Q13105 CDKN2A ZBTB17 0.569 19901969 Q6ZSB9 Q13105 ZBTB49 ZBTB17 0.623 25245946 Q9Y2L1 Q13105 DIS3 ZBTB17 0.332 15231747 Q9NYF0 Q13105 DACT1 ZBTB17 0.376 25558878 Q9Y6K1 Q13105 DNMT3A ZBTB17 0.376 19786833,15616584 Q2PJP0 Q13105 NS1 {ECO:0000313|EMBL:ABC48796.1} ZBTB17 0.126 23853584 Q2PJP1 Q13105 NS2 {ECO:0000313|EMBL:ABC48795.1} ZBTB17 0.126 23853584

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DVL1 ZBTB17 MI:0362 inference MI:0461 interaction database DVL2 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database MYC ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database MYCN ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database TP53 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HSPB1 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database ODC1 ZBTB17 MI:0362 inference MI:0461 interaction database TMEM11 ZBTB17 MI:0362 inference MI:0461 interaction database ITGB5 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database EGR1 ZBTB17 MI:0362 inference MI:0461 interaction database TAF1 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database CCND1 ZBTB17 MI:0362 inference MI:0461 interaction database YWHAQ ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database CDKN1A ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database LEP ZBTB17 MI:0362 inference MI:0461 interaction database BCL6 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database CDKN2A ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database MAGEA4 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HCFC1 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HK2 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database HK3 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database FOXG1 ZBTB17 MI:0362 inference MI:0461 interaction database MAX ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database IRF8 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database EP300 ZBTB17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 PMAIP1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 KLF5 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 PCBP1 MI:0362 inference MI:0461 interaction database ZBTB17 VPS72 MI:0362 inference MI:0461 interaction database ZBTB17 GFI1B MI:0362 inference MI:0461 interaction database ZBTB17 TMPRSS11A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 RRM2B MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 HUWE1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 CAMK2N1 MI:0362 inference MI:0461 interaction database ZBTB17 CDKN2A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 DDB2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 TOPBP1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 CREBBP MI:0362 inference MI:0461 interaction database ZBTB17 ATOH1 MI:0362 inference MI:0461 interaction database ZBTB17 DVL3 MI:0362 inference MI:0461 interaction database ZBTB17 GFI1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 DACT1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 ZBTB4 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 DNMT3B MI:0362 inference MI:0461 interaction database ZBTB17 NOCT MI:0362 inference MI:0461 interaction database ZBTB17 DIS3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 DNMT3A MI:0045 experimental interaction detection MI:0461 interaction database