PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KIF21B LEPRE1 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TICAM1 26496610 biogrid,intact exp P P G P P P P P P GP P P P P P P P P P GP P P KIF21B CPSF1 26496610 biogrid,intact exp TBX3 KIF21B 26496610 biogrid,intact exp P P P P P G P P P GP P P P P P P P P GP P P KIF21B TAF12 26496610 biogrid,intact exp P P G GP P P P P P P GP P P P P P P P P P P KIF21B CAPG 26496610 biogrid,intact exp G G GP G G P P GP G GP KIF21B POLE3 26496610 biogrid,intact exp P P G G GP GP P G P GP P GP P P G P P KIF21B MED4 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TK1 21900206 biogrid,mint,intact exp P P G GP P P P P GP P P P P P KIF21B TMEM248 26496610 biogrid,intact exp P P G G GP GP P P G P P GP GP P P P P G P KIF21B UBC 16196087 biogrid exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B WDR75 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P GP P P KIF21B CPSF3 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P G P P KIF21B BAG6 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P SYNCRIP KIF21B 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B HAUS2 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B PRPF6 26496610 biogrid,intact exp P P G G G GP P P G P P GP P GP P P P P P P GP P P KIF21B UBL4A 26496610 biogrid,intact exp P P G G G GP P G P G GP P P G P P KIF21B COL4A5 26496610 biogrid,intact exp G G G G G G G G KIF21B NUDC 25036637 intact exp P P G G GP GP P G P P P GP P GP P P P P P P GP P P KIF21B USF1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P KIF21B FUBP3 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P NUDT21 KIF21B 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P GP P P KIF21B TAF5 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B BTD 26496610 biogrid,intact exp P G G G GP P P G P P G GP G P KIF21B CSTF2 26496610 biogrid,intact exp P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TRIM3 24086586 biogrid exp P P G G GP GP P P G P P P GP P GP P P P P P P G P P KIF21B ZNF281 26496610 biogrid,intact exp G G G GP P G P P G P GP P P P G P P KIF21B KIF21A 26496610, 23023127 biogrid,intact exp, pred P G GP P P G P G GP P P P P P G P P KIF21B YWHAE ortho P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B NDN ortho G G G G G G G G KIF21B TUBB2A 23023127 pred P P G G G GP P G P P P GP P GP P P P P GP P KIF21B KIF27 23023127 pred P P P P P P P P P P P P P P P KIF21B KIF26A 23023127 pred G G GP P G P GP P GP P KIF21B KIF5A 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P P P KIF21B KIF11 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P TUBAL3 KIF21B 23023127 pred P P P P P P P P P KIF1B KIF21B 23023127 pred P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TUBB6 23023127 pred P P G G GP GP P G P P P GP P GP P P P P P GP P P KIF21B TUBB 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF26B 23023127 pred P P GP P P G P P P P P GP P P P P P P P P P KIF21B KIF2B 23023127 pred P P P P P P P P P P P P P P P P P P P P P KIF21B KIF4A 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P KIF21B CENPE 23023127 pred P P G GP P P P P P P P P P P P P P P P P P KIF21B KIF23 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P KIF21B TUBA3E 23023127 pred P P P P P P P P P P P P P P KIF21B KIF15 23023127 pred P P G GP P P P P P P P P P P P P P P P P KIF3C KIF21B 23023127 pred G G G G G G G G KIF5C KIF21B 23023127 pred P P G G GP GP P P G P P GP P GP P P P P P P GP P P KIF21B TUBD1 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF20B 23023127 pred P P G G GP GP P P P P P P GP P P P P P P G P P KIF21B KIF14 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P KIF21B TUBB8 23023127 pred P P P P P P P P P P P P P P P P P P P KIF21B TUBB3 23023127 pred P P G G GP GP P G P P P GP P GP P P P P P P GP P P KIF21B KIF18A 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P KIF21B KIF25 23023127 pred P P G P GP P P G P P P GP P GP P P P P P P P P P P KIF21B KIF19 23023127 pred P P P P G P P P P P P P P P G P KIF21B PTPRN 25402006 pred P G G G GP G G GP P P G P KIF21B KIF20A 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P P KIF21B KIF1A 23023127 pred P G P GP P P G P P P GP P GP P P P P P P P P P KIF21B KIF13A 23023127 pred P P G G GP GP P P G P P GP P GP P P P P P P P G P P KIF21B KIF22 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF13B 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P G P P KIF21B TUBG2 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIFC3 23023127 pred G G G G P G P P GP P G P P P P GP P P KIF21B TUBA1C 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P GP P P KIF1C KIF21B 23023127 pred G GP P P G P P GP P P P P G P KIF21B 23023127 pred KIF21B KIF3A 23023127 pred P G G GP GP P G G GP P P G P P KIF21B TUBE1 23023127 pred P P G G G GP P P G P P P G P GP P P P P P P P G P P KIF21B TUBB1 23023127 pred P P G GP P P P P P P P P P P P P P P GP P P KIF21B KIF16B 23023127 pred P P P P P P P P P P P P P P P P P P P P P P KIF3B KIF21B 23023127 pred P G G G GP P P G P P P GP P GP P P P P P G P P KIF2A KIF21B 23023127 pred P P G G GP GP P G P GP P GP P P P GP P P KIF21B KIF21B 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TUBB4A 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIFC1 23023127 pred P P G GP P P P P P P P P P P P P P P P P P KIF21B TUBA1B 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B TUBA8 23023127 pred P P G GP P P P P P P P P P P P P P P P P P P KIF21B KIF9 23023127 pred P P G P GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIFC2 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P G P P KIF21B PAFAH1B1 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF5B 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF6 23023127 pred P P G P GP P P G P P P P GP P P P P P P P P P P KIF21B KIF4B 23023127 pred P P P P P P P P P P P P P P P P P P P P P P KIF21B TUBA3C, TUBA3D 23023127 pred P P P P P P P P P P P P P P KIF21B TUBB4B 23023127 pred P G G G GP P G GP P GP P P P P P GP P P KIF21B KIF2C 23023127 pred P G G GP GP P P G P P P GP P GP P P P P P P GP P P KIF21B TUBA4A 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P KIF21B KIF17 23023127 pred P P G P GP P P G P P P P GP P P P P P P P GP P P KIF21B KIF24 23023127 pred P P P P P P P P P P P P P P P P KIF21B TUBB2B 23023127 pred P P G P GP P G P P P P P GP P P P P P P P P KIF21B TUBA1A 23023127 pred P P G G GP GP P P G P P P GP P GP P P P P P P P GP P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P04183 O75037 two hybrid 21900206 physical association X 2 O75037 anti tag coimmunoprecipitation 22190034 association C 6 O75037 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KIF21B TRIM3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24086586 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_294082|BIOGRID_294083 bait|bait prey|prey KIF21B TK1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_157324|UniProt_157527|UniProt_178125 prey|prey|prey bait|bait|bait KIF21B UBC MI:0004(affinity chromatography technology) 16196087 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_143066 prey bait

PPI - HINT Gene A Gene B PMID Method Quality B4DU58 KIF21B 26496610 0007 HT TBX3 KIF21B 26496610,26496610 0007,0004 HT NUDT21 KIF21B 26496610,26496610 0007,0004 HT SYNCRIP KIF21B 26496610 0007 HT KIF21B PRPF6 26496610,26496610 0007,0004 HT KIF21B UBL4A 26496610,26496610 0007,0004 HT KIF21B USF1 26496610,26496610 0007,0004 HT KIF21B COL4A5 26496610,26496610 0007,0004 HT KIF21B CSTF2 26496610,26496610 0007,0004 HT KIF21B BTD 26496610,26496610 0007,0004 HT KIF21B BAG6 26496610,26496610 0007,0004 HT KIF21B CPSF1 26496610,26496610 0007,0004 HT KIF21B TAF5 26496610,26496610 0007,0004 HT KIF21B TAF12 26496610,26496610 0007,0004 HT KIF21B P3H1 26496610,26496610 0007,0004 HT KIF21B Q59GL1 26496610 0004 HT KIF21B KIF21A 26496610,26496610 0007,0004 HT KIF21B TICAM1 26496610,26496610 0007,0004 HT KIF21B WDR75 26496610,26496610 0007,0004 HT KIF21B FUBP3 26496610,26496610 0007,0004 HT KIF21B MED4 26496610,26496610 0007,0004 HT KIF21B POLE3 26496610,26496610 0007,0004 HT KIF21B HAUS2 26496610,26496610 0007,0004 HT KIF21B TMEM248 26496610,26496610 0007,0004 HT KIF21B CPSF3 26496610,26496610 0007,0004 HT KIF21B ZNF281 26496610,26496610 0007,0004 HT KIF21B HEL-S-66 26496610 0004 HT B4DU58 KIF21B 26496610 0007 HT TBX3 KIF21B 26496610,26496610 0007,0004 HT NUDT21 KIF21B 26496610,26496610 0007,0004 HT SYNCRIP KIF21B 26496610 0007 HT KIF21B PRPF6 26496610,26496610 0007,0004 HT KIF21B UBL4A 26496610,26496610 0007,0004 HT KIF21B USF1 26496610,26496610 0007,0004 HT KIF21B COL4A5 26496610,26496610 0007,0004 HT KIF21B CSTF2 26496610,26496610 0007,0004 HT KIF21B BTD 26496610,26496610 0007,0004 HT KIF21B BAG6 26496610,26496610 0007,0004 HT KIF21B CPSF1 26496610,26496610 0007,0004 HT KIF21B TAF5 26496610,26496610 0007,0004 HT KIF21B TAF12 26496610,26496610 0007,0004 HT KIF21B P3H1 26496610,26496610 0007,0004 HT KIF21B Q59GL1 26496610 0004 HT KIF21B KIF21A 26496610,26496610 0007,0004 HT KIF21B TICAM1 26496610,26496610 0007,0004 HT KIF21B WDR75 26496610,26496610 0007,0004 HT KIF21B FUBP3 26496610,26496610 0007,0004 HT KIF21B MED4 26496610,26496610 0007,0004 HT KIF21B POLE3 26496610,26496610 0007,0004 HT KIF21B HAUS2 26496610,26496610 0007,0004 HT KIF21B TMEM248 26496610,26496610 0007,0004 HT KIF21B CPSF3 26496610,26496610 0007,0004 HT KIF21B ZNF281 26496610,26496610 0007,0004 HT KIF21B HEL-S-66 26496610 0004 HT KIF21B TRIM3 24086586,24086586 0018,0004 LC KIF21B TK1 21900206 0018 HT KIF21B NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P22415 O75037 USF1 KIF21B 0.126 26496610 Q9NVX0 O75037 HAUS2 KIF21B 0.126 26496610 Q9NWD8 O75037 TMEM248 KIF21B 0.126 26496610 Q9H2C0 O75037 GAN KIF21B 0.126 26460568 O75037 B4DU58 KIF21B B4DU58 0.126 26496610 O75037 O15119 KIF21B TBX3 0.126 26496610 O75037 O60506 KIF21B SYNCRIP 0.126 26496610 O94906 O75037 PRPF6 KIF21B 0.126 26496610 P04183 O75037 TK1 KIF21B 0.332 21900206 P43251 O75037 BTD KIF21B 0.126 26496610 Q15542 O75037 TAF5 KIF21B 0.126 26496610 Q16514 O75037 TAF12 KIF21B 0.126 26496610 Q9Y266 O75037 NUDC KIF21B 0.126 25036637 Q9Y2X9 O75037 ZNF281 KIF21B 0.126 26496610 P0CG48 O75037 UBC KIF21B 0.126 16196087 P04618 O75037 REV KIF21B 0.21 22190034 Q8VE38 O75037 OXNAD1 KIF21B 0.236 26496610 Q10570 O75037 CPSF1 KIF21B 0.236 26496610 P46379 O75037 BAG6 KIF21B 0.236 26496610 P33240 O75037 CSTF2 KIF21B 0.236 26496610 P29400 O75037 COL4A5 KIF21B 0.236 26496610 P11441 O75037 UBL4A KIF21B 0.236 26496610 O75037 O43809 KIF21B NUDT21 0.236 26496610 O75382 O75037 TRIM3 KIF21B 0.454 24086586 Q96I24 O75037 FUBP3 KIF21B 0.236 26496610 Q7Z4S6 O75037 KIF21A KIF21B 0.236 26496610 Q32P28 O75037 LEPRE1 KIF21B 0.236 26496610 Q96HA8 O75037 WDYHV1 KIF21B 0.236 unassigned1304 Q8IUC6 O75037 TICAM1 KIF21B 0.236 26496610 Q8IWA0 O75037 WDR75 KIF21B 0.236 26496610 Q9UKF6 O75037 CPSF3 KIF21B 0.236 26496610 Q9NPJ6 O75037 MED4 KIF21B 0.236 26496610 Q9NRF9 O75037 POLE3 KIF21B 0.236 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TBX3 KIF21B MI:0045 experimental interaction detection MI:0461 interaction database NUDT21 KIF21B MI:0045 experimental interaction detection MI:0461 interaction database SYNCRIP KIF21B MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TRIM3 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B PRPF6 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TK1 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B UBC MI:0045 experimental interaction detection MI:0461 interaction database KIF21B UBL4A MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TCP1 MI:0362 inference MI:0461 interaction database KIF21B USF1 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B COL4A5 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B CSTF2 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B CAPG MI:0045 experimental interaction detection MI:0461 interaction database KIF21B CCT6A MI:0362 inference MI:0461 interaction database KIF21B BTD MI:0045 experimental interaction detection MI:0461 interaction database KIF21B BAG6 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B CCT5 MI:0362 inference MI:0461 interaction database KIF21B CCT3 MI:0362 inference MI:0461 interaction database KIF21B CCT4 MI:0362 inference MI:0461 interaction database KIF21B CALM1 MI:0362 inference MI:0461 interaction database KIF21B YWHAE MI:0362 inference MI:0461 interaction database KIF21B CCT2 MI:0362 inference MI:0461 interaction database KIF21B CPSF1 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B PTP4A2 MI:0362 inference MI:0461 interaction database KIF21B TAF5 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TAF12 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B P3H1 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B KIF21A MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TICAM1 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B WDR75 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B PTP4A1 MI:0362 inference MI:0461 interaction database KIF21B OXNAD1 MI:0362 inference MI:0461 interaction database KIF21B FUBP3 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B NDN MI:0362 inference MI:0461 interaction database KIF21B CCT7 MI:0362 inference MI:0461 interaction database KIF21B GAN MI:0045 experimental interaction detection MI:0461 interaction database KIF21B MED4 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B POLE3 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B HAUS2 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B TMEM248 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B CPSF3 MI:0045 experimental interaction detection MI:0461 interaction database KIF21B NUDC MI:0045 experimental interaction detection MI:0461 interaction database KIF21B ZNF281 MI:0045 experimental interaction detection MI:0461 interaction database