PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FBXO30 NXF1 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AURKA FBXO30 26186194 biogrid exp G G G G G G G G G G G G G G NEDD8 FBXO30 21145461 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO30 C16orf70 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO30 SMURF1 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK1A1 FBXO30 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DYNLL1 FBXO30 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD1 FBXO30 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYO1C FBXO30 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ACVR1 FBXO30 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKP1 FBXO30 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD4 FBXO30 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASQ2 FBXO30 26186194 biogrid exp G G G G G G G G G G G G G G G G G SETDB1 FBXO30 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 FBXO30 19322201 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX19 FBXO30 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 FBXO30 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APC FBXO30 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO30 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G QSOX2 FBXO30 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G PNKD FBXO30 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO30 NANOG ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A090N7U0 Q8TB52 affinity chromatography technology 21145461 physical association X 2 Q8TB52 Q15843 affinity chromatography technology 18247557 physical association X 2 Q8TB52 two hybrid 20936779 direct interaction X 2 P0CG48 Q8TB52 affinity chromatography technology 21139048 physical association X 2 P63168 Q8TB52 affinity chromatography technology 20360068 physical association X 2 D3DPA4 Q8TB52 in vivo 15761153 - X 2 D3DPA4 Q8TB52 in vivo 15761153 - X 2 Q8TB52 A0A024R274 in vivo 15761153 - X 2 Q8TB52 Q15797 in vivo 15761153 - X 2 Q8TB52 Q9HCE7-2 in vivo 15761153 - X 2 Q8TB52 Q15797 in vivo 15761153 - X 2 Q8TB52 A0A024R274 in vivo 15761153 - X 2 Q8TB52 Q9HCE7-2 in vivo 15761153 - X 2 P25054 Q8TB52 two hybrid pooling approach 20936779 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ELAVL1 FBXO30 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187511 bait prey APC FBXO30 MI:0018(two hybrid)|MI:0096(pull down) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_127186|UniProt_110297 bait|bait prey|prey CUL1 FBXO30 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_204504 bait prey ACVR1 FBXO30 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17207 - - FBXO30 SMURF1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17710 - - SMAD4 FBXO30 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17708 - - SMAD1 FBXO30 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17707 - - NEDD8 FBXO30 MI:0004(affinity chromatography technology) 18247557 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_251577 bait prey UBC FBXO30 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_172291 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MYO1C FBXO30 26496610,26496610 0007,0004 HT DNALI1 FBXO30 27173435 0676 HT CASQ2 FBXO30 26186194 0004 HT AURKA FBXO30 26186194 0004 HT PEX19 FBXO30 26186194 0004 HT DYNLL1 FBXO30 26496610 0007 HT SKP1 FBXO30 26496610,26087183,26496610 0007,0004,0004 HT,LC CUL1 FBXO30 21145461 0004 HT SETDB1 FBXO30 26186194 0004 HT DNCL1 FBXO30 26496610 0004 HT QSOX2 FBXO30 26496610,26496610 0007,0004 HT PNKD FBXO30 26186194 0004 HT FBXO30 C16ORF70 26186194 0004 HT MYO1C FBXO30 26496610,26496610 0007,0004 HT DNALI1 FBXO30 27173435 0676 HT CASQ2 FBXO30 26186194 0004 HT AURKA FBXO30 26186194 0004 HT PEX19 FBXO30 26186194 0004 HT DYNLL1 FBXO30 26496610 0007 HT SKP1 FBXO30 26496610,26496610 0007,0004 HT CUL1 FBXO30 21145461 0004 HT SETDB1 FBXO30 26186194 0004 HT DNCL1 FBXO30 26496610 0004 HT QSOX2 FBXO30 26496610,26496610 0007,0004 HT PNKD FBXO30 26186194 0004 HT FBXO30 C16ORF70 26186194 0004 HT SKP1 FBXO30 26087183 0004 LC APC FBXO30 20936779,20936779 0398,0018 HT ACVR1 FBXO30 15761153 0019 HT SMAD4 FBXO30 15761153 0019 HT SMAD1 FBXO30 15761153 0019 HT FBXO30 SMURF1 15761153 0019 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8TB52 O14645 FBXO30 DNALI1 0.236 27173435,unassigned1312 Q8TB52 O14958 FBXO30 CASQ2 0.126 26186194 Q8TB52 O14965 FBXO30 AURKA 0.126 26186194 Q8TB52 Q8N490 FBXO30 PNKD 0.126 26186194 Q9HCE1 Q8TB52 MOV10 FBXO30 0.126 22658674 Q8TB52 P63208 FBXO30 SKP1 0.472 27705803,26087183,26496610 Q9WTX5 Q8TB52 SKP1 FBXO30 0.236 26496610 Q8TB52 O00159 FBXO30 MYO1C 0.236 26496610 Q8TB52 P25054 FBXO30 APC 0.286 20936779 Q8TB52 Q6ZRP7 FBXO30 QSOX2 0.236 26496610 Q8TB52 B2RXC1 FBXO30 TRAPPC11 0.236 26496610 Q8TB52 P63167 FBXO30 DYNLL1 0.236 26496610 Q8TB52 P63168 FBXO30 DYNLL1 0.236 20360068 Q9BSU1 Q8TB52 C16ORF70 FBXO30 0.126 26186194 Q9UBU9 Q8TB52 NXF1 FBXO30 0.126 22658674 Q8TB52 P40855 FBXO30 PEX19 0.126 26186194 Q8TB52 Q13616 FBXO30 CUL1 0.126 21145461 Q8TB52 Q15047 FBXO30 SETDB1 0.126 26186194 Q8TB52 Q15717 FBXO30 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYO1C FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database DNALI1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database CASQ2 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database AURKA FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXO30 MI:0362 inference MI:1106 pathways database FBXO21 FBXO30 MI:0362 inference MI:1106 pathways database UBB FBXO30 MI:0362 inference MI:1106 pathways database UBC FBXO30 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 FBXO30 MI:0362 inference MI:1106 pathways database APC FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database PEX19 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXO30 MI:0362 inference MI:1106 pathways database UBE2A FBXO30 MI:0362 inference MI:1106 pathways database FBXW4 FBXO30 MI:0362 inference MI:1106 pathways database RBX1 FBXO30 MI:0362 inference MI:1106 pathways database RPS27A FBXO30 MI:0362 inference MI:1106 pathways database UBA52 FBXO30 MI:0362 inference MI:1106 pathways database DYNLL1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database SKP1 FBXO30 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ACVR1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXO30 MI:0362 inference MI:1106 pathways database SMAD4 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXO30 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXO30 MI:0362 inference MI:1106 pathways database SETDB1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXO30 MI:0362 inference MI:1106 pathways database HECTD2 FBXO30 MI:0362 inference MI:1106 pathways database FBXO31 FBXO30 MI:0362 inference MI:1106 pathways database FBXW9 FBXO30 MI:0362 inference MI:1106 pathways database FBXW10 FBXO30 MI:0362 inference MI:1106 pathways database RNF213 FBXO30 MI:0362 inference MI:1106 pathways database FBXL22 FBXO30 MI:0362 inference MI:1106 pathways database FBXL19 FBXO30 MI:0362 inference MI:1106 pathways database FBXW12 FBXO30 MI:0362 inference MI:1106 pathways database RNF19B FBXO30 MI:0362 inference MI:1106 pathways database QSOX2 FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database TRAPPC11 FBXO30 MI:0362 inference MI:0461 interaction database RNF144B FBXO30 MI:0362 inference MI:1106 pathways database RBBP6 FBXO30 MI:0362 inference MI:1106 pathways database HUWE1 FBXO30 MI:0362 inference MI:1106 pathways database TRIM69 FBXO30 MI:0362 inference MI:1106 pathways database SIAH1 FBXO30 MI:0362 inference MI:1106 pathways database HERC6 FBXO30 MI:0362 inference MI:1106 pathways database UBR2 FBXO30 MI:0362 inference MI:1106 pathways database FBXL14 FBXO30 MI:0362 inference MI:1106 pathways database FBXW8 FBXO30 MI:0362 inference MI:1106 pathways database FBXL16 FBXO30 MI:0362 inference MI:1106 pathways database PNKD FBXO30 MI:0045 experimental interaction detection MI:0461 interaction database FBXO15 FBXO30 MI:0362 inference MI:1106 pathways database ZNRF1 FBXO30 MI:0362 inference MI:1106 pathways database FBXL13 FBXO30 MI:0362 inference MI:1106 pathways database FBXO22 FBXO30 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO30 MI:0362 inference MI:1106 pathways database FBXO27 FBXO30 MI:0362 inference MI:1106 pathways database FBXO30 RNF217 MI:0362 inference MI:1106 pathways database FBXO30 DTX3L MI:0362 inference MI:1106 pathways database FBXO30 FBXO41 MI:0362 inference MI:1106 pathways database FBXO30 LMO7 MI:0362 inference MI:1106 pathways database FBXO30 MYLIP MI:0362 inference MI:1106 pathways database FBXO30 FBXW7 MI:0362 inference MI:1106 pathways database FBXO30 FBXO32 MI:0362 inference MI:1106 pathways database FBXO30 FBXW5 MI:0362 inference MI:1106 pathways database FBXO30 MIB2 MI:0362 inference MI:1106 pathways database FBXO30 SPSB1 MI:0362 inference MI:1106 pathways database FBXO30 FBXL8 MI:0362 inference MI:1106 pathways database FBXO30 FBXO17 MI:0362 inference MI:1106 pathways database FBXO30 FBXL20 MI:0362 inference MI:1106 pathways database FBXO30 FBXL18 MI:0362 inference MI:1106 pathways database FBXO30 NEDD4L MI:0362 inference MI:1106 pathways database FBXO30 C16orf70 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 RBCK1 MI:0362 inference MI:1106 pathways database FBXO30 FBXL15 MI:0362 inference MI:1106 pathways database FBXO30 FBXO44 MI:0362 inference MI:1106 pathways database FBXO30 UNKL MI:0362 inference MI:1106 pathways database FBXO30 NANOG MI:0362 inference MI:0461 interaction database FBXO30 SMURF2 MI:0362 inference MI:1106 pathways database FBXO30 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 TRIM36 MI:0362 inference MI:1106 pathways database FBXO30 FBXO6 MI:0362 inference MI:1106 pathways database FBXO30 RNF19A MI:0362 inference MI:1106 pathways database FBXO30 RLIM MI:0362 inference MI:1106 pathways database FBXO30 FBXL12 MI:0362 inference MI:1106 pathways database FBXO30 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 FBXO40 MI:0362 inference MI:1106 pathways database FBXO30 HERC5 MI:0362 inference MI:1106 pathways database FBXO30 FBXL7 MI:0362 inference MI:1106 pathways database FBXO30 FBXO2 MI:0362 inference MI:1106 pathways database FBXO30 FBXO10 MI:0362 inference MI:1106 pathways database FBXO30 FBXO9 MI:0362 inference MI:1106 pathways database FBXO30 FBXL5 MI:0362 inference MI:1106 pathways database FBXO30 FBXL4 MI:0362 inference MI:1106 pathways database FBXO30 FBXW11 MI:0362 inference MI:1106 pathways database FBXO30 FBXO4 MI:0362 inference MI:1106 pathways database FBXO30 FBXL21 MI:0362 inference MI:1106 pathways database FBXO30 FBXL3 MI:0362 inference MI:1106 pathways database FBXO30 FBXW2 MI:0362 inference MI:1106 pathways database FBXO30 BTRC MI:0362 inference MI:1106 pathways database FBXO30 FBXO7 MI:0362 inference MI:1106 pathways database FBXO30 RNF115 MI:0362 inference MI:1106 pathways database FBXO30 RNF114 MI:0362 inference MI:1106 pathways database FBXO30 WSB1 MI:0362 inference MI:1106 pathways database