PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ESR1 SENP5 21217774 i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKAP1 SENP5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CASQ2 SENP5 26186194 biogrid exp G G G G G G G G G G G G G G G G G SENP5 PASK 24778252 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G SENP5 RABGAP1 16608850 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G C1orf186 SENP5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G ZCCHC7 SENP5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ASGR2 SENP5 26186194 biogrid exp G G G G SUMO2 SENP5 16608850, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO3 SENP5 16608850, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NPM1 SENP5 26186194, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61956-2 Q96HI0 enzymatic study 16608850 direct interaction X 2 P55854 Q96HI0 enzymatic study 16608850 direct interaction X 2 P55854 Q96HI0 enzymatic study 16608850 direct interaction X 2 Q96HI0 Q96RG2-2 affinity chromatography technology 24778252 physical association X 2 Q96HI0 Q9Y3P9 enzymatic study 16608850 direct interaction X 2 G4XH65 Q96HI0 phage display 21217774 direct interaction X 2 G4XH65 Q96HI0 two hybrid 21217774 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CASQ2 SENP5 26186194 0004 HT NPM1 SENP5 26186194 0004 HT C1ORF186 SENP5 26186194 0004 HT HBXBP SENP5 26186194 0004 HT ZCCHC7 SENP5 26186194 0004 HT SENP5 HEL-S-81P 26186194 0004 HT CASQ2 SENP5 26186194 0004 HT NPM1 SENP5 26186194 0004 HT C1ORF186 SENP5 26186194 0004 HT HBXBP SENP5 26186194 0004 HT ZCCHC7 SENP5 26186194 0004 HT SENP5 HEL-S-81P 26186194 0004 HT ESR1 SENP5 21217774,21217774 0018,0084 LC SUMO3 SENP5 16608850 0415 LC SUMO2 SENP5 16608850 0415 LC SENP5 RABGAP1 16608850 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96HI0 O14958 SENP5 CASQ2 0.126 26186194 Q96HI0 Q8N3Z6 SENP5 ZCCHC7 0.126 26186194 Q96HI0 Q6ZWK4 SENP5 C1ORF186 0.126 26186194 Q96HI0 Q86WV1 SENP5 SKAP1 0.126 26186194 Q96HI0 P06748 SENP5 NPM1 0.126 26186194 Q96HI0 P07307 SENP5 ASGR2 0.126 26186194 Q96HI0 P55854 SENP5 SUMO3 0.309 16608850 Q96HI0 P61956 SENP5 SUMO2 0.309 16608850 Q9Y3P9 Q96HI0 RABGAP1 SENP5 0.309 16608850 Q96RG2 Q96HI0 PASK SENP5 0.126 24778252

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CASQ2 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database ESR1 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database NR3C1 SENP5 MI:0362 inference MI:0461 interaction database NPM1 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database ASGR2 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database TOP1 SENP5 MI:0362 inference MI:0461 interaction database POLR2B SENP5 MI:0362 inference MI:0461 interaction database SUMO3 SENP5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SUMO2 SENP5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SUMO1 SENP5 MI:0362 inference MI:1106 pathways database ELAVL1 SENP5 MI:0362 inference MI:0461 interaction database C1orf186 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database SKAP1 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database ZCCHC7 SENP5 MI:0045 experimental interaction detection MI:0461 interaction database ZNF655 SENP5 MI:0362 inference MI:0461 interaction database SENP5 EHMT2 MI:0362 inference MI:0461 interaction database SENP5 PASK MI:0045 experimental interaction detection MI:0461 interaction database SENP5 RNF2 MI:0362 inference MI:0461 interaction database SENP5 NKX3-1 MI:0362 inference MI:0461 interaction database SENP5 RABGAP1 MI:0045 experimental interaction detection MI:0461 interaction database