PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus POLR2F DCAF4 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G SOX30 DCAF4 21988832 biogrid,intact exp GP DCAF4 USP7 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 AP5M1 26186194 biogrid exp G GP G G G GP G GP GP G GP G GP GP G GP GP G G G G GP GP G GP G G GP G DCAF4 COPS7A 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DKC1 DCAF4 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P DCAF4 NUDC 25036637 intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G COPS2 DCAF4 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G PIM1 DCAF4 26186194 biogrid exp G GP G G G GP G G GP G GP GP G G G GP GP G G G G GP G G GP G GP GP G NEDD8 DCAF4 21145461, 25402006 innatedb exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 COPS5 19615732,21145461, 25402006 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G COPS6 DCAF4 26186194,19615732,21145461, 25402006 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G CUL4A DCAF4 16949367,21145461,16964240, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 DCAF4 19966799,16949367,16964240, 25402006 biogrid,dip exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 COPS3 26186194, 25402006 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G CUL4B DCAF4 26496610,16949367, 25402006 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G DCAF8 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 DCAF16 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G G GP GP G G G GP GP G DCAF4 DTL 25402006 pred P P G G P G P P P G P GP P P P G G G GP CAND1 DCAF4 25402006 pred G GP G G G G G G GP G GP GP G G G GP G GP G G G G GP G GP G G GP G RBX1 DCAF4 25402006 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G ERCC8 DCAF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF4 DDIT4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G UBXN7 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF10 DCAF4 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G G G G GP G G CDKN1A DCAF4 25402006 pred GP GP G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G DCAF4 VPRBP 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF17 DCAF4 25402006 pred G GP G G G GP G GP G G P G G G GP GP DCAF4 DDB2 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G DCAF4 COPS7B 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G NF2 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G TRPC4AP DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G DCAF4 DCAF5 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 FAF2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF4 TSC1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 PHIP 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF12 DCAF4 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP G GP G G RFWD2 DCAF4 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G DCAF6 DCAF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF4 AMBRA1 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP G MAP3K1 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF11 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G TLE2 DCAF4 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G DCAF4 DCAF13 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G DCAF7 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G UBXN1 DCAF4 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP G GP GP G DCAF4 DDA1 25402006 pred GP GP G G G GP G GP GP G GP GP GP G GP GP GP P G GP GP GP G GP G GP GP G WDTC1 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF4 MAP3K3 25402006 pred G G G G G GP G GP G G GP G GP GP G GP GP G G G GP G G G GP G GP G G DET1 DCAF4 25402006 pred G G G G G GP G G G G G GP GP GP G GP GP G GP G GP G G G GP G GP G G DCAF4 CDT1 25402006 pred P P G G P GP GP P P P P GP P GP GP G P P P GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WV16 x-ray crystallography 19966799 direct interaction X 2 Q8WV16 tandem affinity purification 20360068 physical association C 32 Q9Y266 Q8WV16 luminescence based mammalian interactome mapping 25036637 physical association X 2 O94993 Q8WV16 two hybrid array 21988832 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality DKC1 DCAF4 26186194 0004 HT PIM1 DCAF4 26186194 0004 HT POLR2F DCAF4 26496610,26496610 0007,0004 HT CUL4A DCAF4 16949367,16964240,21145461,16949367 0004,0004,0004,0096 LC,HT CUL4B DCAF4 26496610,16949367,16949367,26496610 0007,0004,0096,0004 HT,LC DDB1 DCAF4 16949367,16964240,16949367 0004,0004,0096 LC Q59EL2 DCAF4 26186194 0004 HT COPS6 DCAF4 19615732,21145461,26186194 0004,0004,0004 HT DCAF4 COPS5 19615732,21145461 0004,0004 HT DCAF4 USP7 19615732 0004 HT DCAF4 AP5M1 26186194 0004 HT DCAF4 COPS7A 26496610,26496610 0007,0004 HT DCAF4 COPS3 26186194 0004 HT DKC1 DCAF4 26186194 0004 HT PIM1 DCAF4 26186194 0004 HT POLR2F DCAF4 26496610,26496610 0007,0004 HT CUL4A DCAF4 21145461 0004 HT CUL4B DCAF4 26496610,26496610 0007,0004 HT Q59EL2 DCAF4 26186194 0004 HT COPS6 DCAF4 19615732,21145461,26186194 0004,0004,0004 HT DCAF4 COPS5 19615732,21145461 0004,0004 HT DCAF4 USP7 19615732 0004 HT DCAF4 AP5M1 26186194 0004 HT DCAF4 COPS7A 26496610,26496610 0007,0004 HT DCAF4 COPS3 26186194 0004 HT CUL4A DCAF4 16949367,16964240,16949367 0004,0004,0096 LC CUL4B DCAF4 16949367,16949367 0004,0096 LC DDB1 DCAF4 16949367,16964240,16949367 0004,0004,0096 LC SOX30 DCAF4 21988832,21988832 0397,0018 HT DDB1 DCAF4 19966799 0114 LC DCAF4 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WV16 P61201 DCAF4 COPS2 0.126 26186194 Q8WV16 O60832 DCAF4 DKC1 0.126 26186194 Q9H0R1 Q8WV16 AP5M1 DCAF4 0.126 26186194 Q9Y266 Q8WV16 NUDC DCAF4 0.126 25036637 Q8WV16 P11309 DCAF4 PIM1 0.126 26186194 Q8WV16 O94993 DCAF4 SOX30 0.286 21988832 Q9UBW8 Q8WV16 COPS7A DCAF4 0.236 26496610 Q92905 Q8WV16 COPS5 DCAF4 0.236 19615732,21145461 Q8WV16 Q3U1J4 DCAF4 DDB1 0.236 20360068 Q8WV16 P61218 DCAF4 POLR2F 0.236 26496610 Q8WV16 Q7L5N1 DCAF4 COPS6 0.332 21145461,26186194,19615732 Q93009 Q8WV16 USP7 DCAF4 0.126 19615732 Q8WV16 Q13620 DCAF4 CUL4B 0.332 26496610,16949367 Q8WV16 Q13619 DCAF4 CUL4A 0.332 16964240,21145461,16949367 Q8WV16 Q16531 DCAF4 DDB1 0.539 16964240,19966799,16949367 Q9UNS2 Q8WV16 COPS3 DCAF4 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DKC1 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database SOX30 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database UBC DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database PIM1 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database COPS2 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database POLR2F DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database CUL4B DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 DCAF4 MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 USP7 MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 AP5M1 MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 COPS7A MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database DCAF4 NUDC MI:0045 experimental interaction detection MI:0461 interaction database