PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SRPK1 WDR55 23602568 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 CC2D2A 26638075 biogrid,intact exp G GP G G G G G G G G G G GP G G G G G GP G GP G GP G G G G G G MLF2 WDR55 25036637 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPO1 WDR55 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G WDR55 FOXJ2 25609649 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G FOXS1 WDR55 25609649 intact exp GP P P P G GP GP P P P G GP P G P GP P P P P P P GP G ELAVL1 WDR55 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CSNK2A1 WDR55 22113938 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 PPP4R2 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAE WDR55 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RRP9 WDR55 23023127 pred P P P P P P G G P P P P P P P PRPF4 WDR55 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR4 WDR55 23023127 pred G G G G GP G G GP G G GP GP G G GP GP G GP G G GP G GP G G G G GNB2L1 WDR55 23023127 pred P P P P P P P P P P P P P P P P P P RGS9 WDR55 23023127 pred G G G G G G G G WDR53 WDR55 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP ARPC4 WDR55 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G THOC6 WDR55 23023127 pred GP P G GP P P GP P GP GP P G GP P GP P G GP GP P P GP GP GP P G TSR1 WDR55 21836163 pred GP GP G G GP G G G GP G GP GP G GP G GP G GP GP G GP G GP GP GP GP GP GP G WDR55 PRPF19 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR83 WDR55 23023127 pred GP GP G G G GP G GP P G GP GP GP GP GP GP G GP G GP GP G P GP GP GP GP G MAP3K1 WDR55 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 UTP18 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR55 DDX56 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP G GP GP G BOP1 WDR55 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G WDR77 WDR55 23023127 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G WDR36 WDR55 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G TBL3 WDR55 23023127 pred GP GP G G G GP G GP GP G GP GP G GP G GP P G GP G P G G GP GP G GP GP G UTP15 WDR55 23023127 pred G G G G SF3A3 WDR55 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P68400 Q9H6Y2 protein kinase assay 22113938 phosphorylation reaction X 2 Q9H6Y2 Q96SB4 protein kinase assay 23602568 phosphorylation reaction X 2 A8K1F4 Q9H6Y2 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality FOXS1 WDR55 25609649,25609649 0676,0004 HT WDR55 PPP4R2 26344197 0401 HT WDR55 FOXJ2 25609649,25609649 0676,0004 HT WDR55 CC2D2A 26638075,26638075 1314,1313 HT FOXS1 WDR55 25609649,25609649 0676,0004 HT WDR55 PPP4R2 26344197 0401 HT WDR55 FOXJ2 25609649,25609649 0676,0004 HT WDR55 CC2D2A 26638075,26638075 1314,1313 HT A8K1F4 WDR55 25036637 0729 HT CSNK2A1 WDR55 22113938,22113938 0424,0415 LC SRPK1 WDR55 23602568,23602568 0415,0424 LC WDR55 PPP4R2 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE1 Q9H6Y2 MOV10 WDR55 0.126 22658674 Q9NY27 Q9H6Y2 PPP4R2 WDR55 0.081 26344197 Q9H6Y2 A8K1F4 WDR55 A8K1F4 0.126 25036637 Q9H6Y2 Q6P5F9 WDR55 XPO1 0.126 26673895 Q9P2K1 Q9H6Y2 CC2D2A WDR55 0.236 26638075 Q9P0K8 Q9H6Y2 FOXJ2 WDR55 0.236 25609649 Q9H6Y2 Q96SB4 WDR55 SRPK1 0.21 23602568 Q9H6Y2 Q9D287 WDR55 BCAS2 0.236 26496610 Q9H6Y2 Q6ZWV7 WDR55 RPL35 0.236 26496610 Q9H6Y2 O43638 WDR55 FOXS1 0.236 25609649 Q9UBU9 Q9H6Y2 NXF1 WDR55 0.126 22658674 Q9H6Y2 P68400 WDR55 CSNK2A1 0.21 22113938 Q9H6Y2 Q15717 WDR55 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 WDR55 MI:0045 experimental interaction detection MI:0461 interaction database FOXS1 WDR55 MI:0045 experimental interaction detection MI:0461 interaction database BCAS2 WDR55 MI:0362 inference MI:0461 interaction database UBC WDR55 MI:0045 experimental interaction detection MI:0461 interaction database RPL35 WDR55 MI:0362 inference MI:0461 interaction database CSNK2A1 WDR55 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 WDR55 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 WDR55 MI:0362 inference MI:0461 interaction database SRPK1 WDR55 MI:0045 experimental interaction detection MI:0461 interaction database WDR55 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database WDR55 FOXJ2 MI:0045 experimental interaction detection MI:0461 interaction database WDR55 CC2D2A MI:0045 experimental interaction detection MI:0461 interaction database WDR55 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database