PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RAB4B RNF170 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G MYH9 RNF170 26496610 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G PRICKLE3 RNF170 26496610 biogrid,intact exp P P G P P P G P P P P P P G P P GP LPAR1 RNF170 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G FAM134C RNF170 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G RNF170 PARD6B 26496610 biogrid,intact exp P P P P P GP G GP G GP P P GP GP GP GP GP GP GP G PON2 RNF170 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G G GP G GP GP G UBE2U RNF170 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P GP RNF170 CHMP4B 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G RNF170 P2RY12 26186194 biogrid exp G G GP G G GP PSMA6 RNF170 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P TM9SF4 RNF170 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G SGTA RNF170 ortho GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ERLIN2 RNF170 ortho GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ITPR1 RNF170 ortho G G G G G GP G GP G G GP GP G G G GP G G G GP G G G GP GP G UBE2A RNF170 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96K19 Q5VVX9 two hybrid array 19690564 physical association X 2 Q96K19 P60900 two hybrid prey pooling approach 25416956 physical association X 2 Q96K19 P60900 two hybrid array 25416956 physical association X 2 Q96K19 P60900 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality PRICKLE3 RNF170 26496610,26496610 0007,0004 HT MYH9 RNF170 26496610,26496610 0007,0004 HT RAB4B RNF170 26496610,26496610 0007,0004 HT PON2 RNF170 26186194 0004 HT FAM134C RNF170 26186194 0004 HT TM9SF4 RNF170 26496610,26496610 0007,0004 HT LPAR1 RNF170 26186194 0004 HT RNF170 PARD6B 26496610,26496610 0007,0004 HT RNF170 P2RY12 26186194 0004 HT RNF170 CHMP4B 26496610,26496610 0007,0004 HT PRICKLE3 RNF170 26496610,26496610 0007,0004 HT MYH9 RNF170 26496610,26496610 0007,0004 HT RAB4B RNF170 26496610,26496610 0007,0004 HT PON2 RNF170 26186194 0004 HT FAM134C RNF170 26186194 0004 HT TM9SF4 RNF170 26496610,26496610 0007,0004 HT LPAR1 RNF170 26186194 0004 HT RNF170 PARD6B 26496610,26496610 0007,0004 HT RNF170 P2RY12 26186194 0004 HT RNF170 CHMP4B 26496610,26496610 0007,0004 HT PSMA6 RNF170 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2U RNF170 19690564,19690564 0397,0018 HT RNF170 RNF170 25882839 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H244 Q96K19 P2RY12 RNF170 0.126 26186194 Q96K19 Q86VR2 RNF170 FAM134C 0.126 26186194 Q96K19 O94905 RNF170 ERLIN2 0.21 25882839 Q96K19 P06460 RNF170 P06460 0.126 22810586 Q96K19 P06461 RNF170 P06461 0.126 22810586 Q96K19 P06792 RNF170 E5 0.126 22810586 Q96K19 P06927 RNF170 E5 0.126 22810586 Q96K19 Q922S8 RNF170 KIF2C 0.236 26496610 Q96K19 Q92544 RNF170 TM9SF4 0.236 26496610 Q96K19 Q8VDH1 RNF170 FBXO21 0.236 26496610 Q9BYG5 Q96K19 PARD6B RNF170 0.236 26496610 Q9H444 Q96K19 CHMP4B RNF170 0.236 26496610 Q96K19 P35579 RNF170 MYH9 0.236 26496610 Q96K19 O43765 RNF170 SGTA 0.236 unassigned1304 Q96K19 O43900 RNF170 PRICKLE3 0.236 26496610 Q96K19 Q80YR7 RNF170 CLSPN 0.236 26496610 Q96K19 Q8BGZ4 RNF170 CDC23 0.236 26496610 Q96K19 P61018 RNF170 RAB4B 0.236 26496610 Q96K19 Q92633 RNF170 LPAR1 0.126 26186194 Q96K19 P60900 RNF170 PSMA6 0.454 25416956 Q96K19 P62837 RNF170 UBE2D2 0.309 25882839 Q96K19 Q5VVX9 RNF170 UBE2U 0.286 19690564 Q96K19 Q96K19 RNF170 RNF170 0.332 25882839 Q96K19 Q14643 RNF170 ITPR1 0.21 25882839 Q96K19 Q15165 RNF170 PON2 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 KIF2A RNF170 MI:0362 inference MI:0461 interaction database SGTA RNF170 MI:0362 inference MI:0461 interaction database PRICKLE3 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database ERLIN2 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 RNF170 MI:0362 inference MI:0461 interaction database UBC RNF170 MI:0045 experimental interaction detection MI:0461 interaction database MYH9 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A RNF170 MI:0362 inference MI:0461 interaction database PSMA6 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database RAB4B RNF170 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database UBE2B RNF170 MI:0362 inference MI:0461 interaction database ITPR1 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database PON2 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U RNF170 MI:0045 experimental interaction detection MI:0461 interaction database FAM134C RNF170 MI:0045 experimental interaction detection MI:0461 interaction database KIF2B RNF170 MI:0362 inference MI:0461 interaction database TM9SF4 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database LPAR1 RNF170 MI:0045 experimental interaction detection MI:0461 interaction database SGTB RNF170 MI:0362 inference MI:0461 interaction database RNF170 KIF2C MI:0362 inference MI:0461 interaction database RNF170 PARD6B MI:0045 experimental interaction detection MI:0461 interaction database RNF170 P2RY12 MI:0045 experimental interaction detection MI:0461 interaction database RNF170 CHMP4B MI:0045 experimental interaction detection MI:0461 interaction database RNF170 CLSPN MI:0362 inference MI:0461 interaction database RNF170 CDC23 MI:0362 inference MI:0461 interaction database