PTM - CPLM Gene Name UniProt ID Type Position Code COPA P53621 Acetylation 271 K COPA P53621 Ubiquitination 61 K COPA P53621 Ubiquitination 81 K COPA P53621 Ubiquitination 170 K COPA P53621 Ubiquitination 238 K COPA P53621 Ubiquitination 271 K COPA P53621 Ubiquitination 480 K COPA P53621 Ubiquitination 600 K COPA P53621 Ubiquitination 607 K COPA P53621 Ubiquitination 631 K COPA P53621 Ubiquitination 727 K COPA P53621 Ubiquitination 825 K COPA P53621 Ubiquitination 1028 K COPA P53621 Ubiquitination 447 K COPA P53621 Ubiquitination 411 K COPA P53621 Ubiquitination 598 K COPA P53621 Ubiquitination 517 K COPA P53621 Ubiquitination 632 K COPA P53621 Ubiquitination 46 K COPA P53621 Ubiquitination 4 K COPA P53621 Ubiquitination 531 K COPA P53621 Ubiquitination 280 K COPA P53621 Ubiquitination 827 K COPA P53621 Ubiquitination 169 K COPA P53621 Ubiquitination 230 K COPA P53621 Ubiquitination 13 K COPA P53621 Ubiquitination 671 K COPA P53621 Ubiquitination 398 K COPA P53621 Ubiquitination 993 K COPA P53621 Ubiquitination 337 K COPA P53621 Ubiquitination 198 K COPA P53621 Ubiquitination 1184 K COPA P53621 Ubiquitination 1150 K COPA P53621 Ubiquitination 438 K COPA P53621 Ubiquitination 721 K COPA P53621 Ubiquitination 619 K COPA P53621 Ubiquitination 441 K COPA P53621 Ubiquitination 988 K COPA P53621 Ubiquitination 350 K COPA P53621 Ubiquitination 362 K COPA P53621 Ubiquitination 487 K COPA P53621 Ubiquitination 574 K COPA P53621 Ubiquitination 1211 K COPA P53621 Ubiquitination 446 K COPA P53621 Ubiquitination 698 K COPA P53621 Ubiquitination 715 K COPA P53621 Ubiquitination 8 K COPA P53621 Ubiquitination 775 K COPA P53621 Ubiquitination 1197 K COPA P53621 Ubiquitination 782 K COPA P53621 Ubiquitination 643 K

PTM - dbPAF Gene Name UniProt ID Position Type Species COPA P53621 1035 S Homo sapiens(Human) COPA P53621 1146 S Homo sapiens(Human) COPA P53621 1193 S Homo sapiens(Human) COPA P53621 1204 T Homo sapiens(Human) COPA P53621 1205 T Homo sapiens(Human) COPA P53621 1207 T Homo sapiens(Human) COPA P53621 16 S Homo sapiens(Human) COPA P53621 173 S Homo sapiens(Human) COPA P53621 179 S Homo sapiens(Human) COPA P53621 185 T Homo sapiens(Human) COPA P53621 193 T Homo sapiens(Human) COPA P53621 244 T Homo sapiens(Human) COPA P53621 249 Y Homo sapiens(Human) COPA P53621 253 S Homo sapiens(Human) COPA P53621 272 S Homo sapiens(Human) COPA P53621 348 S Homo sapiens(Human) COPA P53621 349 S Homo sapiens(Human) COPA P53621 370 Y Homo sapiens(Human) COPA P53621 402 S Homo sapiens(Human) COPA P53621 413 S Homo sapiens(Human) COPA P53621 434 S Homo sapiens(Human) COPA P53621 458 Y Homo sapiens(Human) COPA P53621 471 S Homo sapiens(Human) COPA P53621 497 S Homo sapiens(Human) COPA P53621 501 S Homo sapiens(Human) COPA P53621 579 Y Homo sapiens(Human) COPA P53621 591 T Homo sapiens(Human) COPA P53621 595 T Homo sapiens(Human) COPA P53621 624 S Homo sapiens(Human) COPA P53621 733 Y Homo sapiens(Human) COPA P53621 80 Y Homo sapiens(Human) COPA P53621 821 T Homo sapiens(Human) COPA P53621 824 S Homo sapiens(Human) COPA P53621 895 S Homo sapiens(Human) COPA P53621 914 T Homo sapiens(Human) COPA P53621 915 S Homo sapiens(Human) COPA P53621 95 Y Homo sapiens(Human) COPA P53621 955 Y Homo sapiens(Human) COPA P53621 962 T Homo sapiens(Human) COPA P53621 963 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P53621 K46-ac Acetylation RMCTLIDkFDEHDGP P53621 K74-ac Acetylation VSGGDDykIKVWNyk P53621 K271-ac Acetylation ILsNSEDksIRVWDM P53621 K956-ac Acetylation VIQFGPYkQLFLQTY P53621 R182-m1 Methylation GAVEsDVrGItGVdL P53621 R206-m1 Methylation HVLEGHDrGVNWAAF P53621 R246-m1 Methylation AWEVDtCrGHyNNVS P53621 R358-m1 Methylation DVAVMQLrSGSkFPV P53621 R423-m1 Methylation LTAVWVArNRFAVLD P53621 R965-m1 Methylation LFLQTYArGRTTYQA P53621 R1217-m1 Methylation GKDVIGLrIsPLQFR P53621 S16-p Phosphorylation SARVkGLsFHPKRPW P53621 Y73-p Phosphorylation FVSGGDDykIKVWNy P53621 Y80-p Phosphorylation ykIKVWNykLRRCLF P53621 Y95-p Phosphorylation TLLGHLDyIRTTFFH P53621 S173-p Phosphorylation GLRkkNLsPGAVEsD P53621 S179-p Phosphorylation LsPGAVEsDVrGItG P53621 T185-p Phosphorylation EsDVrGItGVdLFGT P53621 S222-p Phosphorylation PTMPLIVsGADDRQV P53621 T244-p Phosphorylation SkAWEVDtCrGHyNN P53621 Y249-p Phosphorylation VDtCrGHyNNVSCAV P53621 S266-p Phosphorylation PRQELILsNSEDksI P53621 S272-p Phosphorylation LsNSEDksIRVWDMS P53621 T286-p Phosphorylation SKRTGVQtFRRDHDR P53621 Y370-p Phosphorylation FPVFNMSyNPAENAV P53621 Y394-p Phosphorylation ENSTYDLyTIPkDAD P53621 S402-p Phosphorylation TIPkDADsQNPDAPE P53621 S413-p Phosphorylation DAPEGkRsSGLTAVW P53621 S434-p Phosphorylation AVLDRMHsLLIkNLk P53621 Y458-p Phosphorylation PNCDEIFyAGTGNLL P53621 S497-p Phosphorylation KVKYVIWsADMsHVA P53621 S501-p Phosphorylation VIWsADMsHVALLAK P53621 Y569-p Phosphorylation RTLDLPIyVtRVkGN P53621 T571-p Phosphorylation LDLPIyVtRVkGNNV P53621 Y579-p Phosphorylation RVkGNNVyCLDRECR P53621 T591-p Phosphorylation ECRPRVLtIDPtEFk P53621 T595-p Phosphorylation RVLtIDPtEFkFkLA P53621 S624-p Phosphorylation NAkLVGQsIIAYLQk P53621 S730-p Phosphorylation AEIRkDMsGHyQNAL P53621 Y733-p Phosphorylation RkDMsGHyQNALYLG P53621 S756-p Phosphorylation LkNCGQKsLAYLTAA P53621 T821-p Phosphorylation SkGFFEGtIAskGkG P53621 S824-p Phosphorylation FFEGtIAskGkGGAL P53621 S895-p Phosphorylation LPPELdIsPGAAGGA P53621 S1146-p Phosphorylation QQTRKILsACEKNPT P53621 S1193-p Phosphorylation PLSGACYsPEFKGQI P53621 T1204-p Phosphorylation KGQICRVttVtEIGK P53621 T1205-p Phosphorylation GQICRVttVtEIGKD P53621 T1207-p Phosphorylation ICRVttVtEIGKDVI P53621 S1219-p Phosphorylation DVIGLrIsPLQFR__ P53621 K13-ub Ubiquitination ETKSARVkGLsFHPK P53621 K46-ub Ubiquitination RMCTLIDkFDEHDGP P53621 K61-ub Ubiquitination VRGIDFHkQQPLFVS P53621 K81-ub Ubiquitination kIKVWNykLRRCLFT P53621 K169-ub Ubiquitination WDISGLRkkNLsPGA P53621 K170-ub Ubiquitination DISGLRkkNLsPGAV P53621 K238-ub Ubiquitination IWRMNESkAWEVDtC P53621 K271-ub Ubiquitination ILsNSEDksIRVWDM P53621 K337-ub Ubiquitination GNMLHYVkDRFLRQL P53621 K350-ub Ubiquitination QLDFNSSkDVAVMQL P53621 K362-ub Ubiquitination MQLrSGSkFPVFNMS P53621 K398-ub Ubiquitination YDLyTIPkDADsQNP P53621 K411-ub Ubiquitination NPDAPEGkRsSGLTA P53621 K438-ub Ubiquitination RMHsLLIkNLkNEIT P53621 K441-ub Ubiquitination sLLIkNLkNEITkkV P53621 K446-ub Ubiquitination NLkNEITkkVQVPNC P53621 K447-ub Ubiquitination LkNEITkkVQVPNCD P53621 K480-ub Ubiquitination TLFDVQQkRTLASVK P53621 K517-ub Ubiquitination AIVICNRkLDALCNI P53621 K574-ub Ubiquitination PIyVtRVkGNNVyCL P53621 K598-ub Ubiquitination tIDPtEFkFkLALIN P53621 K600-ub Ubiquitination DPtEFkFkLALINRk P53621 K607-ub Ubiquitination kLALINRkYDEVLHM P53621 K619-ub Ubiquitination LHMVRNAkLVGQsII P53621 K631-ub Ubiquitination sIIAYLQkkGYPEVA P53621 K632-ub Ubiquitination IIAYLQkkGYPEVAL P53621 K671-ub Ubiquitination AAKALDDkNCWEKLG P53621 K698-ub Ubiquitination EMCYQRTkNFDkLSF P53621 K702-ub Ubiquitination QRTkNFDkLSFLYLI P53621 K715-ub Ubiquitination LITGNLEkLRKMMkI P53621 K721-ub Ubiquitination EkLRKMMkIAEIRkD P53621 K727-ub Ubiquitination MkIAEIRkDMsGHyQ P53621 K750-ub Ubiquitination SERVRILkNCGQKsL P53621 K815-ub Ubiquitination WPLLTVSkGFFEGtI P53621 K825-ub Ubiquitination FEGtIAskGkGGALA P53621 K827-ub Ubiquitination GtIAskGkGGALAAD P53621 K988-ub Ubiquitination GYPNRNWkDAGLKNG P53621 K1028-ub Ubiquitination KFEEAVEkFRSILLS

PTM - dbPTM UniProt ID Position Code Type Resources References P53621 173 S Phosphorylation Swiss-Prot 1010711 15302935;16964243;17081983;17924679;18669648;18691976;19007248;19413330;19690332 P53621 249 Y Phosphorylation Swiss-Prot 1010711 15592455 P53621 402 S Phosphorylation Swiss-Prot 1010711 15302935;18669648 P53621 895 S Phosphorylation Swiss-Prot 1010711 18691976 P53621 173 S Phosphorylation PhosphoELM.10011 18669648;16964243;17081983;15302935 P53621 402 S Phosphorylation PhosphoELM.10011 18669648;15302935 P53621 188 D Caspase Phosphositeplus.1010730 18722006 P53621 893 D Caspase Phosphositeplus.1010730 18724940 P53621 1028 K Ubiquitylation Phosphositeplus.1010730 21890473 P53621 13 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 170 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P53621 238 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P53621 271 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P53621 337 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 350 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 362 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 398 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 411 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 438 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 441 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 446 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 480 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P53621 517 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 574 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 598 K Ubiquitylation Phosphositeplus.1010730 21890473 P53621 600 K Ubiquitylation Phosphositeplus.1010730 21890473 P53621 61 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P53621 619 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 698 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 715 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 721 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 727 K Ubiquitylation Phosphositeplus.1010730 21890473 P53621 81 K Ubiquitylation Phosphositeplus.1010730 21890473 P53621 825 K Ubiquitylation Phosphositeplus.1010730 21906983 P53621 173 S Phosphorylation Phosphositeplus.1010730 15302935;16964243;18578522;18669648;18691976;19415658;19664994;19664995;19690332;19691289;20058876;20068231;20363803;20815410;21406692;21659604;22067460;22115753 P53621 402 S Phosphorylation Phosphositeplus.1010730 15302935;18669648;21406692 P53621 895 S Phosphorylation Phosphositeplus.1010730 18691976;20068231 P53621 185 T Phosphorylation Phosphositeplus.1010730 20068231 P53621 591 T Phosphorylation Phosphositeplus.1010730 19664994 P53621 249 Y Phosphorylation Phosphositeplus.1010730 15592455;20736484;21253578 P53621 579 Y Phosphorylation Phosphositeplus.1010730 21394647 P53621 733 Y Phosphorylation Phosphositeplus.1010730 17360941;18083107 P53621 173 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19415658,18691976,17924679,19007248,19664995,19651622,19691289,19664994,16964243,18767875,18578522,20068231,20058876 P53621 402 S Phosphorylation HPRD 9.0 15302935,18669648 P53621 402 S Phosphorylation HPRD 9.0 18669648 P53621 895 S Phosphorylation HPRD 9.0 18691976,20068231 P53621 185 T Phosphorylation HPRD 9.0 20068231 P53621 193 T Phosphorylation HPRD 9.0 20068231 P53621 591 T Phosphorylation HPRD 9.0 19664994 P53621 249 Y Phosphorylation HPRD 9.0 15592455 P53621 245 C S-Nitrosylation HPRD 9.0 16648260 P53621 245 C S-nitrosylation dbSNO 1.0 16648260 P53621 173 S Phosphorylation SysPTM 1.1 16964243;18691976;18669648;17081983 P53621 402 S Phosphorylation SysPTM 1.1 18669648 P53621 895 S Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References COPA 173 S Phosphorylation 17322306,18669648,19413330,19415658,18691976,17924679,19007248,19664995,19651622,19691289,19664994,16964243,18767875,18578522,20068231,20058876 COPA 185 T Phosphorylation 20068231 COPA 193 T Phosphorylation 20068231 COPA 245 C S-Nitrosylation 16648260 COPA 249 Y Phosphorylation 15592455 COPA 402 S Phosphorylation 15302935,18669648 COPA 402 S Phosphorylation 18669648 COPA 591 T Phosphorylation 19664994 COPA 600 T Phosphorylation 19664994 COPA 895 S Phosphorylation 18691976,20068231 COPA 904 S Phosphorylation 18691976,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P53621 402 S 18669648 HTP Phosphorylation P53621 402 S 15302935 HTP Phosphorylation P53621 173 S 18669648 HTP Phosphorylation P53621 173 S 16964243 HTP Phosphorylation P53621 173 S 17081983 HTP Phosphorylation P53621 173 S 15302935 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P53621 173 Phosphoserine 16964243;17081983;18669648;18691976;19690332;20068231;21406692;23186163 P53621 185 Phosphothreonine 20068231 P53621 402 Phosphoserine 18669648;21406692 P53621 591 Phosphothreonine 23186163 P53621 895 Phosphoserine 18691976;24275569 P53621 965 Omega-N-methylarginine 24129315 P53621 1193 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type COPA IPI00295857 S 173 LRKKNLpSPGAVES phosphorylation COPA IPI00295857 S 895 PPELDIpSPGAAGG phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 1314 107709 - K Ubiquitination 16196087 1314 107709 - K Ubiquitination 18781797 1314 107709 - K Ubiquitination 21987572 1314 107709 - K Ubiquitination 21139048 1314 107709 - K Ubiquitination 21890473 1314 107709 - K Ubiquitination 21906983 1314 107709 - K Sumoylation 21252943 1314 107709 - K Ubiquitination 22053931 1314 107709 - K Ubiquitination 21853274 1314 107709 - K Ubiquitination 22505724 1314 107709 - K FAT10ylation 22797925 1314 107709 - K Ubiquitination 21963094 1314 107709 - K Ubiquitination 23000965 1314 107709 - K FAT10ylation 23862649 1314 107709 - K Ubiquitination 24654937 1314 107709 - K Neddylation 24654937 1314 107709 - K Sumoylation 24654937 1314 107709 - K Ubiquitination 24816145 1314 107709 - K Sumoylation 25027693 1314 107709 - K Ubiquitination 25147182 1314 107709 - K Neddylation 18247557

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID COPA Homo sapiens (Human) 411; 337; 619; 350; 825; 1028; 13; 698; 631; 81; 398; 574; 271; 238; 170; 441; 517; 715; 446; 438; 598; 600; 721; 480; 61; 362; 727 "411,PDAPEGKRSSGLT; 337,NMLHYVKDRFLRQ; 619,HMVRNAKLVGQSI; 350,LDFNSSKDVAVMQ; 825,EGTIASKGKGGAL; 1028,FEEAVEKFRSILL; 13,TKSARVKGLSFHP; 698,MCYQRTKNFDKLS; 631,IIAYLQKKGYPEV; 81,IKVWNYKLRRCLF; 398,DLYTIPKDADSQN; 574,IYVTRVKGNNVYC; 271,LSNSEDKSIRVWD; 238,WRMNESKAWEVDT; 170,ISGLRKKNLSPGA; 441,LLIKNLKNEITKK; 517,IVICNRKLDALCN; 715,ITGNLEKLRKMMK; 446,LKNEITKKVQVPN; 438,MHSLLIKNLKNEI; 598,IDPTEFKFKLALI; 600,PTEFKFKLALINR; 721,KLRKMMKIAEIRK; 480,LFDVQQKRTLASV; 61,RGIDFHKQQPLFV; 362,QLRSGSKFPVFNM; 727,KIAEIRKDMSGHY" "411:21906983; 337:21906983; 619:21906983; 350:21906983; 825:21890473,21906983; 1028:21890473; 13:21906983; 698:21906983; 631:21890473; 81:21890473; 398:21906983; 574:21906983; 271:21890473,21906983; 238:21890473,21906983; 170:21890473,21906983; 441:21906983; 517:21906983; 715:21906983; 446:21906983; 438:21906983; 598:21890473; 600:21890473; 721:21906983; 480:21890473,21906983; 61:21890473,21906983; 362:21906983; 727:21890473" COPA Homo sapiens (Human) 411; 609; 1037; 337; 350; 736; 13; 81; 398; 628; 271; 238; 170; 441; 446; 583; 526; 707; 640; 438; 834; 730; 724; 480; 362; 61; 607 "411,PDAPEGKRSSGLT; 609,PTEFKFKLALINR; 1037,FEEAVEKFRSILL; 337,NMLHYVKDRFLRQ; 350,LDFNSSKDVAVMQ; 736,KIAEIRKDMSGHY; 13,TKSARVKGLSFHP; 81,IKVWNYKLRRCLF; 398,DLYTIPKDADSQN; 628,HMVRNAKLVGQSI; 271,LSNSEDKSIRVWD; 238,WRMNESKAWEVDT; 170,ISGLRKKNLSPGA; 441,LLIKNLKNEITKK; 446,LKNEITKKVQVPN; 583,IYVTRVKGNNVYC; 526,IVICNRKLDALCN; 707,MCYQRTKNFDKLS; 640,IIAYLQKKGYPEV; 438,MHSLLIKNLKNEI; 834,EGTIASKGKGGAL; 730,KLRKMMKIAEIRK; 724,ITGNLEKLRKMMK; 480,LFDVQQKRTLASV; 362,QLRSGSKFPVFNM; 61,RGIDFHKQQPLFV; 607,IDPTEFKFKLALI" "411:21906983; 609:21890473; 1037:21890473; 337:21906983; 350:21906983; 736:21890473; 13:21906983; 81:21890473; 398:21906983; 628:21906983; 271:21890473,21906983; 238:21890473,21906983; 170:21890473,21906983; 441:21906983; 446:21906983; 583:21906983; 526:21906983; 707:21906983; 640:21890473; 438:21906983; 834:21890473,21906983; 730:21906983; 724:21906983; 480:21890473,21906983; 362:21906983; 61:21890473,21906983; 607:21890473" COPA Homo sapiens (Human) 447 "447,KNEITKKVQVPNC" 447:22053931