PTM - CPLM Gene Name UniProt ID Type Position Code TRIM24; RNF82; TIF1; TIF1A O15164 Sumoylation 723 K TRIM24; RNF82; TIF1; TIF1A O15164 Ubiquitination 325 K TRIM24; RNF82; TIF1; TIF1A O15164 Ubiquitination 341 K TRIM24; RNF82; TIF1; TIF1A O15164 Ubiquitination 458 K TRIM24; RNF82; TIF1; TIF1A O15164 Ubiquitination 303 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TRIM24; RNF82; TIF1; TIF1A O15164 101 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 1019 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 1025 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 1028 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 1042 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 110 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 148 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 153 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 154 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 209 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 234 Y Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 41 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 452 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 590 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 606 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 612 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 643 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 654 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 657 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 660 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 663 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 664 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 667 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 685 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 687 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 689 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 690 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 693 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 696 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 697 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 699 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 700 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 733 Y Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 744 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 748 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 761 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 762 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 767 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 768 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 770 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 771 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 772 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 773 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 776 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 786 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 797 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 798 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 808 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 811 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 818 T Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 874 S Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 916 Y Homo sapiens(Human) TRIM24; RNF82; TIF1; TIF1A O15164 936 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O15164 R469-m1 Methylation QISLAQLrLQHMQQQ O15164 R481-m1 Methylation QQQVMAQrQQVQRRP O15164 S41-p Phosphorylation ESRQGPDsERGGEAA O15164 T101-p Phosphorylation PMLGSAEtPPPVPAP O15164 S110-p Phosphorylation PPVPAPGsPVSGSSP O15164 T148-p Phosphorylation DNFFVKDtTEVPssT O15164 S153-p Phosphorylation KDtTEVPssTVEKSN O15164 S154-p Phosphorylation DtTEVPssTVEKSNQ O15164 S209-p Phosphorylation VRQKEEVsPEAVGVT O15164 Y234-p Phosphorylation KKEQLKLyCETCDKL O15164 S452-p Phosphorylation SQPPSGLsSNQLSkF O15164 S590-p Phosphorylation STSSTPSsPTITSAA O15164 S606-p Phosphorylation YDGKAFGsPMIDLSS O15164 S654-p Phosphorylation HGQPRPPsNRtVQsP O15164 T657-p Phosphorylation PRPPsNRtVQsPNss O15164 S660-p Phosphorylation PsNRtVQsPNssVPs O15164 S663-p Phosphorylation RtVQsPNssVPsPGL O15164 S664-p Phosphorylation tVQsPNssVPsPGLA O15164 S667-p Phosphorylation sPNssVPsPGLAGPV O15164 S685-p Phosphorylation SVHPPIRsPsASSVG O15164 S687-p Phosphorylation HPPIRsPsASSVGSR O15164 S696-p Phosphorylation SSVGSRGsSGSSSkP O15164 Y733-p Phosphorylation NSGPPENyDFPVVIV O15164 S744-p Phosphorylation VVIVKQEsDEEsRPQ O15164 S748-p Phosphorylation KQEsDEEsRPQNANY O15164 S762-p Phosphorylation YPRSILTsLLLNSsQ O15164 S768-p Phosphorylation TsLLLNSsQSstSEE O15164 S771-p Phosphorylation LLNSsQSstSEEtVL O15164 T772-p Phosphorylation LNSsQSstSEEtVLR O15164 T776-p Phosphorylation QSstSEEtVLRSDAP O15164 T786-p Phosphorylation RSDAPDStGDQPGLH O15164 S797-p Phosphorylation PGLHQDNsSNGkSEW O15164 S808-p Phosphorylation kSEWLDPsQKsPLHV O15164 S811-p Phosphorylation WLDPsQKsPLHVGEt O15164 T818-p Phosphorylation sPLHVGEtRKEDDPN O15164 S874-p Phosphorylation CTFCRDLsKPEVEYD O15164 Y916-p Phosphorylation ERLLLFLyCHEMSLA O15164 Y936-p Phosphorylation PLTVPDYyKIIkNPM O15164 Y996-p Phosphorylation AGIKLENyFEELLKN O15164 S1019-p Phosphorylation KPEFRNEsEDNKFsD O15164 S1025-p Phosphorylation EsEDNKFsDDsDDDF O15164 S1028-p Phosphorylation DNKFsDDsDDDFVQP O15164 S1042-p Phosphorylation PRKKRLKsIEERQLL O15164 K702-sm Sumoylation GsSGSSSkPAGADST O15164 K711-sm Sumoylation AGADSTHkVPVVMLE O15164 K723-sm Sumoylation MLEPIRIkQENSGPP O15164 K801-sm Sumoylation QDNsSNGkSEWLDPs O15164 K940-sm Sumoylation PDYyKIIkNPMDLST O15164 K949-sm Sumoylation PMDLSTIkKRLQEDY O15164 K303-ub Ubiquitination IEVNQNQkQVEQDIK O15164 K325-ub Ubiquitination VEINKKGkALLHQLE O15164 K341-ub Ubiquitination LAKDHRMkLMQQQQE O15164 K458-ub Ubiquitination LsSNQLSkFPTQISL

PTM - dbPTM UniProt ID Position Code Type Resources References O15164 660 S Phosphorylation Swiss-Prot 1010711 18669648 O15164 667 S Phosphorylation Swiss-Prot 1010711 18669648 O15164 687 S Phosphorylation Swiss-Prot 1010711 19413330 O15164 768 S Phosphorylation Swiss-Prot 1010711 17525332;18669648 O15164 808 S Phosphorylation Swiss-Prot 1010711 18669648 O15164 811 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 O15164 1019 S Phosphorylation Swiss-Prot 1010711 18669648 O15164 1025 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O15164 1028 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O15164 660 S Phosphorylation PhosphoELM.10011 18669648 O15164 667 S Phosphorylation PhosphoELM.10011 18669648 O15164 685 S Phosphorylation PhosphoELM.10011 18669648 O15164 768 S Phosphorylation PhosphoELM.10011 18669648;17525332 O15164 773 S Phosphorylation PhosphoELM.10011 18669648 O15164 808 S Phosphorylation PhosphoELM.10011 18669648 O15164 811 S Phosphorylation PhosphoELM.10011 18669648;17081983 O15164 1019 S Phosphorylation PhosphoELM.10011 18669648 O15164 1025 S Phosphorylation PhosphoELM.10011 18669648;17081983 O15164 1028 S Phosphorylation PhosphoELM.10011 18669648;17081983 O15164 723 K Sumoylation Phosphositeplus.1010730 20797634 O15164 303 K Ubiquitylation Phosphositeplus.1010730 21906983 O15164 325 K Ubiquitylation Phosphositeplus.1010730 21890473 O15164 341 K Ubiquitylation Phosphositeplus.1010730 21890473 O15164 458 K Ubiquitylation Phosphositeplus.1010730 21890473 O15164 1019 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803;21406692 O15164 1025 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20164059;20363803;21659604;22115753 O15164 1028 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20068231;20164059;20363803;21406692;21659604;22115753 O15164 1042 S Phosphorylation Phosphositeplus.1010730 20068231;20736484;21406692 O15164 110 S Phosphorylation Phosphositeplus.1010730 20068231 O15164 654 S Phosphorylation Phosphositeplus.1010730 21406692 O15164 660 S Phosphorylation Phosphositeplus.1010730 18669648 O15164 667 S Phosphorylation Phosphositeplus.1010730 18669648 O15164 687 S Phosphorylation Phosphositeplus.1010730 19664995 O15164 744 S Phosphorylation Phosphositeplus.1010730 21406692 O15164 748 S Phosphorylation Phosphositeplus.1010730 21406692 O15164 768 S Phosphorylation Phosphositeplus.1010730 17525332;18669648;20044836;20068231 O15164 771 S Phosphorylation Phosphositeplus.1010730 20044836 O15164 808 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19664995;21406692;22115753 O15164 811 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19664995;20044836;20068231;20363803;20815410;21406692;22115753 O15164 101 T Phosphorylation Phosphositeplus.1010730 20068231 O15164 772 T Phosphorylation Phosphositeplus.1010730 20044836 O15164 818 T Phosphorylation Phosphositeplus.1010730 21406692 O15164 185 K Acetylation HPRD 9.0 19413330 O15164 110 S Phosphorylation HPRD 9.0 20068231 O15164 660 S Phosphorylation HPRD 9.0 18669648,19651622 O15164 667 S Phosphorylation HPRD 9.0 18669648 O15164 685 S Phosphorylation HPRD 9.0 18669648 O15164 687 S Phosphorylation HPRD 9.0 19664995 O15164 768 S Phosphorylation HPRD 9.0 17525332,18669648,20068231 O15164 771 S Phosphorylation HPRD 9.0 20068231 O15164 773 S Phosphorylation HPRD 9.0 18669648 O15164 808 S Phosphorylation HPRD 9.0 18669648,19664995,20068231 O15164 811 S Phosphorylation HPRD 9.0 17081983,18669648,19664995,19651622,18452278,20068231 O15164 1019 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278,20068231 O15164 1025 S Phosphorylation HPRD 9.0 17081983,18669648,19413330,19651622,18452278,20068231 O15164 1028 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19651622,18452278,20068231 O15164 1042 S Phosphorylation HPRD 9.0 18212344,20068231 O15164 101 T Phosphorylation HPRD 9.0 20068231 O15164 772 T Phosphorylation HPRD 9.0 20068231 O15164 818 T Phosphorylation HPRD 9.0 19651622 O15164 660 S Phosphorylation SysPTM 1.1 18669648 O15164 667 S Phosphorylation SysPTM 1.1 18669648 O15164 768 S Phosphorylation SysPTM 1.1 18669648 O15164 808 S Phosphorylation SysPTM 1.1 18669648 O15164 811 S Phosphorylation SysPTM 1.1 18669648;17081983 O15164 1019 S Phosphorylation SysPTM 1.1 17081983;18669648 O15164 1025 S Phosphorylation SysPTM 1.1 17081983;18669648 O15164 1028 S Phosphorylation SysPTM 1.1 17081983;18669648 O15164 1042 S Phosphorylation SysPTM 1.1 18212344

PTM - HPRD Symbol Position Code Type References TRIM24 1008 S Phosphorylation 18212344,20068231 TRIM24 101 T Phosphorylation 20068231 TRIM24 1019 S Phosphorylation 17081983,18669648,19651622,18452278,20068231 TRIM24 1025 S Phosphorylation 17081983,18669648,19413330,19651622,18452278,20068231 TRIM24 1028 S Phosphorylation 17322306,18669648,19413330,19651622,18452278,20068231 TRIM24 1042 S Phosphorylation 18212344,20068231 TRIM24 110 S Phosphorylation 20068231 TRIM24 185 K Acetylation 19413330 TRIM24 626 S Phosphorylation 18669648,19651622 TRIM24 633 S Phosphorylation 18669648 TRIM24 651 S Phosphorylation 18669648 TRIM24 653 S Phosphorylation 19664995 TRIM24 660 S Phosphorylation 18669648,19651622 TRIM24 667 S Phosphorylation 18669648 TRIM24 685 S Phosphorylation 18669648 TRIM24 687 S Phosphorylation 19664995 TRIM24 689 K Sumoylation 11313457 TRIM24 707 K Sumoylation 11313457 TRIM24 734 S Phosphorylation 17525332,18669648,20068231 TRIM24 737 S Phosphorylation 20068231 TRIM24 738 T Phosphorylation 20068231 TRIM24 739 S Phosphorylation 18669648 TRIM24 768 S Phosphorylation 17525332,18669648,20068231 TRIM24 771 S Phosphorylation 20068231 TRIM24 772 T Phosphorylation 20068231 TRIM24 773 S Phosphorylation 18669648 TRIM24 774 S Phosphorylation 18669648,19664995,20068231 TRIM24 777 S Phosphorylation 17081983,18669648,19664995,19651622,18452278,20068231 TRIM24 784 T Phosphorylation 19651622 TRIM24 808 S Phosphorylation 18669648,19664995,20068231 TRIM24 811 S Phosphorylation 17081983,18669648,19664995,19651622,18452278,20068231 TRIM24 818 T Phosphorylation 19651622 TRIM24 985 S Phosphorylation 17081983,18669648,19651622,18452278,20068231 TRIM24 991 S Phosphorylation 17081983,18669648,19413330,19651622,18452278,20068231 TRIM24 994 S Phosphorylation 17322306,18669648,19413330,19651622,18452278,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O15164 660 S 18669648 HTP Phosphorylation O15164 768 S 18669648 HTP Phosphorylation O15164 768 S 17525332 HTP Phosphorylation O15164 1019 S 18669648 HTP Phosphorylation O15164 667 S 18669648 HTP Phosphorylation O15164 1025 S 18669648 HTP Phosphorylation O15164 1025 S 17081983 HTP Phosphorylation O15164 685 S 18669648 HTP Phosphorylation O15164 1028 S 18669648 HTP Phosphorylation O15164 1028 S 17081983 HTP Phosphorylation O15164 811 S 18669648 HTP Phosphorylation O15164 811 S 17081983 HTP Phosphorylation O15164 808 S 18669648 HTP Phosphorylation O15164 773 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O15164 101 Phosphothreonine 20068231 O15164 110 Phosphoserine 20068231 O15164 654 Phosphoserine 23186163 O15164 667 Phosphoserine 18669648 O15164 744 Phosphoserine 21406692;23186163 O15164 768 Phosphoserine 18669648;20068231 O15164 808 Phosphoserine 18669648 O15164 811 Phosphoserine 17081983;18669648;20068231;21406692;23186163 O15164 818 Phosphothreonine 21406692 O15164 1019 Phosphoserine 21406692 O15164 1025 Phosphoserine 17081983;19690332;23186163 O15164 1028 Phosphoserine 17081983;19690332;21406692;23186163 O15164 1042 Phosphoserine 21406692

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TRIM24 IPI00005184 S 1019 PEFRNEpSEDNKFS phosphorylation TRIM24 IPI00005184 S 1025 SEDNKFpSDDSDDD phosphorylation TRIM24 IPI00005184 S 1028 NKFSDDpSDDDFVQ phosphorylation TRIM24 IPI00005184 S 110 PVPAPGpSPVSGSS phosphorylation TRIM24 IPI00005184 S 606 DGKAFGpSPMIDLS phosphorylation TRIM24 IPI00005184 S 768 SLLLNSpSQSSTSE phosphorylation TRIM24 IPI00005184 S 811 LDPSQKpSPLHVGE phosphorylation TRIM24 IPI00005184 T 101 MLGSAEpTPPPVPA phosphorylation TRIM24 IPI00005184 T 772 NSSQSSpTSEETVL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 8805 114333 - K Sumoylation 21693764 8805 114333 - K Ubiquitination 21139048 8805 114333 - K Ubiquitination 21890473 8805 114333 - K Ubiquitination 21906983 8805 114333 - K Sumoylation 19471022 8805 114333 - K Sumoylation 24654937 8805 114333 - K Ubiquitination 24820418 8805 114333 - K Sumoylation 25027693 8805 114333 - K Ubiquitination 25278611

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TRIM24 Homo sapiens (Human) 341; 325; 458; 214 "341,AKDHRMKLMQQQQ; 325,EINKKGKALLHQL; 458,SSNQLSKFPTQIS; 214,EVNQNQKQVEQDI" 341:21890473; 325:21890473; 458:21890473; 214:21906983 TRIM24 Homo sapiens (Human) 325 "325,EINKKGKALLHQL" 325:21890473 TRIM24 Homo sapiens (Human) 341; 325; 458 "341,AKDHRMKLMQQQQ; 325,EINKKGKALLHQL; 458,SSNQLSKFPTQIS" 341:21890473; 325:21890473; 458:21890473 TRIM24 Homo sapiens (Human) 341; 325; 458 "341,AKDHRMKLMQQQQ; 325,EINKKGKALLHQL; 458,SSNQLSKFPTQIS" 341:21890473; 325:21890473; 458:21890473 TRIM24 Homo sapiens (Human) 341; 325; 458; 303 "341,AKDHRMKLMQQQQ; 325,EINKKGKALLHQL; 458,SSNQLSKFPTQIS; 303,EVNQNQKQVEQDI" 341:21890473; 325:21890473; 458:21890473; 303:21906983 TRIM24 Homo sapiens (Human) 341; 325; 458; 303 "341,AKDHRMKLMQQQQ; 325,EINKKGKALLHQL; 458,SSNQLSKFPTQIS; 303,EVNQNQKQVEQDI" 341:21890473; 325:21890473; 458:21890473; 303:21906983 TRIM24 Homo sapiens (Human) 261; 416 "261,EVNQNQKQVEQDI; 416,SSNQLSKFPTQIS" 261:21906983; 416:21890473